Improved solubility and stability of 7-hydroxy-4-methylcoumarin at different temperatures and pH values through complexation with sulfobutyl ether-β-cyclodextrin.

Abstract:

:The inclusion complex of 7-hydroxy-4-methylcoumarin (7H4MC) with sulfobutyl ether-β-cyclodextrin (SBE-β-CD) was investigated by means of UV-vis, circular dichroism and (1)H NMR spectroscopy in phosphate buffer solutions at different temperatures and pH values. The stoichiometric ratio of the complexation was found to be 1:1 and the stability constants (KC) were estimated from phase solubility analysis. The thermodynamic parameters of standard Gibbs free energy change, ΔG(o), enthalpy change, ΔH(o), and entropy change, ΔS(o), for the complexation process were obtained by using the van't Hoff equation and Gibbs-Helmholtz equation. The large negative ΔH(o) and the small negative or positive ΔS(o) (|ΔH(o)|>|TΔS(o)|) demonstrated that the inclusion interaction was an enthalpy-driven process. The positive signal of circular dichroism indicated that 7H4MC penetrated the cavity in such a way that the transition moment of the guest chromophore was parallel to the long axis of SBE-β-CD cavity. Moreover, the (1)H NMR spectrum showed that the entire 7H4MC molecule, except the hydroxyl group, was included in the SBE-β-CD cavity.

journal_name

Food Chem

journal_title

Food chemistry

authors

Liu M,Chen A,Wang Y,Wang C,Wang B,Sun D

doi

10.1016/j.foodchem.2014.07.061

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

270-5

eissn

0308-8146

issn

1873-7072

pii

S0308-8146(14)01094-2

journal_volume

168

pub_type

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