Abstract:
:Fibroepithelial lesions (FELs) are a common histologic finding on core needle biopsy (CNB) of the breast. Fibroepithelial lesions include fibroadenoma and phyllodes tumor, which can be difficult to distinguish with an initial CNB. An institutional experience was reviewed from February 12, 2001, to January 4, 2007, to determine the safety of selective rather than routine excision of FELs and to determine the factors associated with upgrading diagnosis of FELs to phyllodes tumors without definitive phyllodes tumor diagnosis by CNB. Of 313 patients, 261 (83%) with FELs diagnosed by CNB received observation with long-term follow-up (mean, 8 years). Of the observed patients, 3 (1%) were diagnosed with phyllodes tumor on follow-up. Eighteen of 52 patients (35%) who received excision had an upgrade of diagnosis to phyllodes tumor. Sensitivity and specificity of the pathologist's comment of concern for phyllodes tumor on a CNB demonstrating FELs without definitive phyllodes tumor diagnosis were 82% and 93%, respectively. Our policy of selective excision of FELs without definitive phyllodes tumor diagnosis resulted in safe avoidance of many surgical procedures.
journal_name
JAMA Surgjournal_title
JAMA surgeryauthors
Van Osdol AD,Landercasper J,Andersen JJ,Ellis RL,Gensch EM,Johnson JM,De Maiffe B,Marcou KA,Al-Hamadani M,Vang CAdoi
10.1001/jamasurg.2014.73subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1081-5issue
10eissn
2168-6254issn
2168-6262pii
1899992journal_volume
149pub_type
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