Abstract:
IMPORTANCE:The field of transplantation has made tremendous progress since the first successful kidney transplant in 1954. OBJECTIVE:To determine the survival benefit of solid-organ transplant as recorded during a 25-year study period in the United Network for Organ Sharing (UNOS) database and the Social Security Administration Death Master File. DESIGN, SETTING, AND PARTICIPANTS:In this retrospective analysis of UNOS data for solid-organ transplant during a 25-year period (September 1, 1987, through December 31, 2012), we reviewed the records of 1,112,835 patients: 533,329 recipients who underwent a transplant and 579 506 patients who were placed on the waiting list but did not undergo a transplant. MAIN OUTCOMES AND MEASURES:The primary outcome was patient death while on the waiting list or after transplant. Kaplan-Meier survival functions were used for time-to-event analysis. RESULTS:We found that 2,270,859 life-years (2,150,200 life-years from the matched analysis) were saved to date during the 25 years of solid-organ transplant. A mean of 4.3 life-years were saved (observed to date) per solid-organ transplant recipient. Kidney transplant saved 1,372,969 life-years; liver transplant, 465,296 life-years; heart transplant, 269,715 life-years; lung transplant, 64,575 life-years; pancreas-kidney transplant, 79,198 life-years; pancreas transplant, 14,903 life-years; and intestine transplant, 4402 life-years. CONCLUSIONS AND RELEVANCE:Our analysis demonstrated that more than 2 million life-years were saved to date by solid-organ transplants during a 25-year study period. Transplants should be supported and organ donation encouraged.
journal_name
JAMA Surgjournal_title
JAMA surgeryauthors
Rana A,Gruessner A,Agopian VG,Khalpey Z,Riaz IB,Kaplan B,Halazun KJ,Busuttil RW,Gruessner RWdoi
10.1001/jamasurg.2014.2038subject
Has Abstractpub_date
2015-03-01 00:00:00pages
252-9issue
3eissn
2168-6254issn
2168-6262pii
2100153journal_volume
150pub_type
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