Abstract:
Importance:Whether computed tomography (CT) radiation is truly carcinogenic remains controversial. Large epidemiological studies that purportedly showed an association between CT radiation and carcinogenesis were limited by confounding by indication and reverse causation, because the reasons for CT examination were unknown. Objective:To measure the risk of hematologic malignant neoplasms associated with perioperative abdominopelvic CT radiation among patients who underwent appendectomy for acute appendicitis. Design, Setting, and Participants:This nationwide population-based cohort study used the National Health Insurance Service claims database in South Korea to assess 825 820 patients who underwent appendectomy for appendicitis from January 1, 2005, to December 31, 2015, and had no underlying risk factors for cancer. Patients were divided into CT-exposed (n = 306 727) or CT-unexposed (n = 519 093) groups. The study was terminated on December 31, 2017, and data were analyzed from October 30, 2018, to September 27, 2020. Exposures:Perioperative abdominopelvic CT examination from 7 days before to 7 days after appendectomy. Main Outcomes and Measures:The primary outcome was the incidence rate ratio (IRR) of hematologic malignant neoplasms for both groups. The secondary outcomes were IRR of abdominopelvic organ cancers and IRR of all cancers. The lag period was 2 years for the primary outcome and 5 years for secondary outcomes. The IRRs were calculated using Poisson regression models with adjustment for age and sex. Results:Among the study population of 825 820 patients (52.9% male; median age, 28 [interquartile range, 15-41] years), hematologic malignant neoplasms developed in 323 patients in the CT-exposed group during 1 486 518 person-years and 500 patients in the CT-unexposed group during 3 422 059 person-years. For all hematologic malignant neoplasms, the IRR for the CT-exposed vs CT-unexposed group was 1.26 (95% CI, 1.09-1.45; P = .002). In terms of individual categories of hematologic malignant neoplasms, the CT-exposed group had an elevated risk only for leukemia (IRR, 1.40 [98.75% CI, 1.04-1.87, adjusted by Bonferroni correction]; P = .005). There was no between-group difference in incidence rate of abdominopelvic organ cancers (IRR, 1.07 [95% CI, 1.00-1.15]; P = .06) and that of all cancers (IRR, 1.04 [95% CI, 0.99-1.09]; P = .14). Conclusions and Relevance:This study controlled for reverse causation bias by defining the reasons for CT scan, and findings suggest that abdominopelvic CT radiation is associated with a higher incidence of hematologic malignant neoplasms. Efforts should be continued for judicious use of CT examinations.
journal_name
JAMA Surgjournal_title
JAMA surgeryauthors
Lee KH,Lee S,Park JH,Lee SS,Kim HY,Lee WJ,Cha ES,Kim KP,Lee W,Lee JY,Lee KHdoi
10.1001/jamasurg.2020.6357subject
Has Abstractpub_date
2021-01-20 00:00:00eissn
2168-6254issn
2168-6262pii
2775351pub_type
杂志文章相关文献
JAMA Surgery文献大全abstract:Importance:Adhesive small-bowel obstruction (aSBO) is a potentially chronic, recurring surgical illness. Although guidelines suggest trials of nonoperative management, the long-term association of this approach with recurrence is poorly understood. Objective:To compare the incidence of recurrence of aSBO in patients u...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2018.5248
更新日期:2019-05-01 00:00:00
abstract:Importance:Autologous fat transfer (AFT or fat grafting) has become an invaluable tool for the correction of disfiguring deformities after breast cancer surgery. However, clinical and animal studies have shown conflicting results regarding its oncologic safety. Objective:To determine whether exposure to AFT vs convent...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2018.3744
更新日期:2019-01-01 00:00:00
abstract:Importance:The United States is experiencing an opioid abuse epidemic. Opioid overprescription by physicians may contribute to this epidemic. Objectives:To determine if there was a correlation between a postoperative patient's 24-hour predischarge opioid use and the amount of opioids prescribed at hospital discharge a...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2017.4859
更新日期:2018-02-21 00:00:00
abstract:Importance:Fluorescent imaging with indocyanine green can be used to visualize lymphatics. Peritumoral injection of indocyanine green may allow for visualization of every draining lymph node from a primary lesion on near-infrared imaging. Objectives:To evaluate the role of fluorescent lymphography using near-infrared ...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2018.4267
更新日期:2019-02-01 00:00:00
abstract::Breast cancer care is complex and requires a multidisciplinary approach. In this study, we provide an overview of current practices for the diagnosis and treatment of breast cancer for surgical practitioners who do not focus on this disease. We include studies published in high-impact, peer-reviewed journals that have...
journal_title:JAMA surgery
pub_type: 杂志文章,评审
doi:10.1001/jamasurg.2013.3393
更新日期:2013-10-01 00:00:00
abstract:Importance:The receipt of surgery in freestanding ambulatory surgery centers (ASCs) is often less costly compared with surgery in hospital-based outpatient departments. Although increasing numbers of surgical procedures are now being performed in freestanding ASCs, questions remain regarding the existence of disparitie...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2020.3318
更新日期:2020-09-09 00:00:00
abstract:IMPORTANCE:Nonsteroidal anti-inflammatory drugs (NSAIDs) have many physiologic effects and are being used more commonly to treat postoperative pain, but recent small studies have suggested that NSAIDs may impair anastomotic healing in the gastrointestinal tract. OBJECTIVE:To evaluate the relationship between postopera...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2014.2239
更新日期:2015-03-01 00:00:00
abstract:IMPORTANCE:Endovascular technology has become ubiquitous in the modern care of abdominal aortic aneurysm (AAA), yet broad estimates of its efficacy among variable hospital and regional settings is not known. OBJECTIVE:To perform a preliminary analysis of hospital effects on mortality following open AAA repair (OAR) an...
journal_title:JAMA surgery
pub_type: 杂志文章,多中心研究
doi:10.1001/jamasurg.2014.3871
更新日期:2015-07-01 00:00:00
abstract:IMPORTANCE:Older adults are at increased risk for adverse events after surgical procedures. Loss of independence (LOI), defined as a decline in function or mobility, increased care needs at home, or discharge to a nonhome destination, is an important patient-centered outcome measure. OBJECTIVE:To evaluate LOI among ol...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2016.1689
更新日期:2016-09-21 00:00:00
abstract:IMPORTANCE:Individualized risk prediction tools have an important role as decision aids for use by patients and surgeons before surgery. Patient-centered outcomes should be incorporated into such tools to widen their appeal and improve their usability. OBJECTIVE:To develop a patient-centered outcome for the American C...
journal_title:JAMA surgery
pub_type: 杂志文章,多中心研究
doi:10.1001/jamasurg.2014.3176
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVES:To describe the current state of the science for operating room (OR) briefings and debriefings, including an overview of key definitions, a review of the evidence of effectiveness, and a summary of our experiences as part of a comprehensive unit-based safety program. OVERVIEW:Use of preoperative briefings h...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2014.172
更新日期:2014-08-01 00:00:00
abstract:Importance:Minimally invasive laparoscopic surgery (MILS) for endometrial cancer reduces surgical morbidity compared with a total abdominal hysterectomy. However, only a minority of women with early-stage endometrial cancer undergo MILS. Objective:To evaluate the association between the Danish nationwide introduction ...
journal_title:JAMA surgery
pub_type: 杂志文章,多中心研究
doi:10.1001/jamasurg.2018.5840
更新日期:2019-06-01 00:00:00
abstract:IMPORTANCE:Morphometric assessment has emerged as a strong predictor of postoperative morbidity and mortality. However, a gap exists in translating this knowledge to bedside decision making. We introduced a novel measure of patient-centered surgical risk assessment: morphometric age. OBJECTIVE:To investigate the relat...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2013.4823
更新日期:2014-04-01 00:00:00
abstract:Importance:Assessment of physical frailty in older trauma patients admitted to the intensive care unit is often not feasible using traditional frailty assessment instruments. The use of opportunistic computed tomography (CT) scans to assess sarcopenia and osteopenia as indicators of underlying frailty may provide compl...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2016.4604
更新日期:2017-02-15 00:00:00
abstract:Importance:Incisional hernia is a frequent complication after open abdominal surgery. Prophylactic mesh implantation in the onlay or sublay position requires dissection of the abdominal wall, potentially leading to wound-associated complications. Objective:To compare the incidence of incisional hernia among patients a...
journal_title:JAMA surgery
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamasurg.2018.4221
更新日期:2019-02-01 00:00:00
abstract:IMPORTANCE:Trauma is known to be one of the strongest risk factors for pulmonary embolism (PE). Current guidelines recommend low-molecular-weight heparin therapy for prevention of PE, but trauma places some patients at risk of excess bleeding. Experts are divided on the role of prophylactic inferior vena cava (IVC) fil...
journal_title:JAMA surgery
pub_type: 杂志文章,meta分析,评审
doi:10.1001/jamasurg.2013.3970
更新日期:2014-02-01 00:00:00
abstract:Importance:Breast reconstruction has the potential to improve a person's body image and quality of life but has important risks. Variations in who undergoes breast reconstruction have led to questions about the quality of patient decisions. Objective:To assess the quality of patient decisions about breast reconstructi...
journal_title:JAMA surgery
pub_type: 临床试验,杂志文章
doi:10.1001/jamasurg.2017.0977
更新日期:2017-08-01 00:00:00
abstract::Over the past decade, minimally invasive surgery has been introduced as a means to allow manipulation of delicate tissues with outstanding visualization of the surgical field. The purpose of this article is to review the available literature regarding early postoperative outcomes and the technical challenges of minima...
journal_title:JAMA surgery
pub_type: 杂志文章,评审
doi:10.1001/jamasurg.2013.366
更新日期:2013-12-01 00:00:00
abstract:IMPORTANCE:Thoracic endovascular aortic repair (TEVAR) is used in the treatment of type B aortic dissections. Information related to aortic morphologic findings and the condition of the abdominal aorta after TEVAR is limited. OBJECTIVE:To analyze aortic morphologic findings after TEVAR for type B aortic dissections. ...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2014.1327
更新日期:2014-09-01 00:00:00
abstract:Importance:Varices are one of the main clinical manifestations of cirrhosis and portal hypertension. Gastric varices are less common than esophageal varices but are often associated with poorer prognosis, mainly because of their higher propensity to bleed. Observations:Currently, treatments used to control and manage ...
journal_title:JAMA surgery
pub_type: 杂志文章,评审
doi:10.1001/jamasurg.2019.0407
更新日期:2019-06-01 00:00:00
abstract:Importance:Women are disproportionately underrecognized as award winners within medical societies. The presence of this disparity has not been investigated in training programs. Objective:To determine the presence of a gender disparity in award winners in general surgery residency programs. Design, Setting, and Parti...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2020.3518
更新日期:2020-09-02 00:00:00
abstract:IMPORTANCE:In an era of accountable care, understanding variation in health care costs is critical to reducing health care spending. OBJECTIVE:To identify factors associated with increased hospital costs and quantify variations in costs among individual hospitals in patients undergoing liver and pancreatic surgery in ...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2015.3618
更新日期:2016-02-01 00:00:00
abstract:Importance:BRAF mutations are reportedly associated with aggressive tumor biology. However, in contrast with primary colorectal cancer, the association of V600E and non-V600E BRAF mutations with survival and recurrence after resection of colorectal liver metastases (CRLM) has not been well studied. Objective:To invest...
journal_title:JAMA surgery
pub_type: 杂志文章,多中心研究
doi:10.1001/jamasurg.2018.0996
更新日期:2018-07-18 00:00:00
abstract:Importance:Surgical care is widely unavailable in developing countries; advocates recommend that countries evaluate and report on access to surgical care to improve availability and aid health planners in decision making. Objective:To analyze the infrastructure, capacity, and availability of surgical care in Zambia to...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2016.2303
更新日期:2016-11-01 00:00:00
abstract:IMPORTANCE:Maintaining perioperative normothermia has been shown to decrease the rate of surgical site infection (SSI) after segmental colectomy and is part of the World Health Organization's Guidelines for Safe Surgery. However, strong evidence supporting this association is lacking, and an exact definition of normoth...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2015.77
更新日期:2015-06-01 00:00:00
abstract:Importance:All events that transpire during laparoscopic cholecystectomy (LC) cannot be adequately reproduced in the operative note. Video recording is already known to add important information regarding this operation. Objective:It is hypothesized that additional audio recordings can provide an even better procedura...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2020.0741
更新日期:2020-07-01 00:00:00
abstract:Importance:Resection of perihilar cholangiocarcinoma (PHC) is high-risk surgery, with reported operative mortality up to 17%. Therefore, preoperative risk assessment is needed to identify high-risk patients and anticipate postoperative adverse outcomes. Objective:To provide external validation of the Estimation of Phy...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2016.2305
更新日期:2016-12-01 00:00:00
abstract:IMPORTANCE:Although prospective randomized data are available to guide the multidisciplinary management of soft tissue sarcoma (STS) of the extremities, controversy exists regarding adjuvant chemotherapy and radiation therapy. OBJECTIVE:To determine if clinical specialty introduces bias in recommendations for multimod...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2013.113
更新日期:2013-07-01 00:00:00
abstract:Importance:Liposomal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltration in total knee arthroplasty (TKA). Athough liposomal bupivacaine is widely used, it is unknown if the benefits justify the cost in the veteran population at our institution. Objective:To evaluate ...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2016.3474
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:IMPORTANCE It is not known whether hospital and surgeon volumes have an association with readmission among patients undergoing pancreatoduodenectomy. OBJECTIVE:To evaluate patient-, surgeon-, and hospital-level factors associated with readmission. DESIGN, SETTING, AND PARTICIPANTS:Retrospective cohort stud...
journal_title:JAMA surgery
pub_type: 杂志文章
doi:10.1001/jamasurg.2013.2509
更新日期:2013-12-01 00:00:00