Childhood vaccination associated adverse events by sex: a literature review.

Abstract:

BACKGROUND:Most approved medicines, including vaccines can be associated with adverse events. A vaccine adverse event is defined as any untoward medical occurrence which follows vaccination, but which does not necessarily have a causal relationship with the administration of the vaccine. METHODS:The objective of this structured literature review is to analyse the adverse events reported with vaccinations usually done during childhood and adolescence: human papilloma virus vaccine, hepatitis B vaccine and measles-mumps-rubella vaccine. We evaluated the vaccine literature on children and adolescents by sex. We searched the Cochrane Database, Medline (Pubmed) and Embase using predefined terms. RESULTS:Of the 417 publications retrieved from searches in the 3 databases, 89 papers (21%) were identified as potentially relevant to the review. On further scrutiny 41 of these satisfied the criteria for inclusion in the analysis. Serious adverse events related to vaccinations were rare. We found some possible sex related vaccine adverse events. Few trials however reported adverse events by age and sex and very few analyses evaluated the observed differences. CONCLUSIONS:Despite earlier calls for sex-specific analyses of clinical studies, we found that vaccine trials were rarely reported and published by sex. Prospectively collated vaccine safety data in children and adolescents should be analysed by age and sex, so that clinical trial results can form an evidence base for vaccine practice recommendations.

journal_name

Travel Med Infect Dis

authors

Weber SK,Schlagenhauf P

doi

10.1016/j.tmaid.2014.01.008

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

459-80

issue

5

eissn

1477-8939

issn

1873-0442

pii

S1477-8939(14)00043-X

journal_volume

12

pub_type

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