Incidence of pulmonary vein conduction recovery in patients without clinical recurrence after ablation of paroxysmal atrial fibrillation: mechanistic implications.


BACKGROUND:Pulmonary vein (PV) isolation has become the mainstay acute procedural end point for paroxysmal atrial fibrillation (AF) ablation. OBJECTIVE:To examine the incidence of conduction recovery in the PVs in patients without clinical recurrence of AF after paroxysmal AF ablation. METHODS:From August 2008 to March 2011, 392 patients with drug-refractory PAF underwent catheter ablation in our center, a wide area circumferential ablation approach guided with a circular mapping catheter was performed with the intended endpoint of entrance block in all PVs. 276 (70.4%) of them were free from recurrence at one year follow-up, and 32 of them were enrolled to assess the incidence of PV reconnection. Forty-three patients with clinical recurrence after ablation were analyzed for comparison. The regions of gap were mapped and characterized in all of the reconnected PVs. RESULTS:Among patients without recurrence, recovery of PV conduction was observed in 29 of 32 (90.6%) patients: 10/32 (31.2%) reconnection in 4 veins, 7/32 (21.9%) in 3 veins, 10/32 (31.2%) in 2 veins, and 2/32 (6.2%) in 1 vein. No anatomic propensity was seen because reconnection was evenly distributed throughout all veins (left superior pulmonary vein 21, left inferior pulmonary vein 20, right superior pulmonary vein 19, and right inferior pulmonary vein 23). When compared to patients with recurrence, no significant differences were seen in the proportion of patients with reconnection (P = 1.0) or in left atrium-PV intervals (73.4 ± 43.3 ms vs 61.9 ± 31.8 ms; P > .05). CONCLUSION:A high incidence of PV reconnection was similarly observed in patients with and without recurrence of AF, suggesting that sustained PV isolation may not be required for freedom from clinical recurrence of AF.


Heart Rhythm


Heart rhythm


Jiang RH,Po SS,Tung R,Liu Q,Sheng X,Zhang ZW,Sun YX,Yu L,Zhang P,Fu GS,Jiang CY




Has Abstract


2014-06-01 00:00:00














  • Nonspecific intraventricular conduction delay: Definitions, prognosis, and implications for cardiac resynchronization therapy.

    abstract::Cardiac resynchronization therapy (CRT) is an electrical treatment of heart failure with reduced ejection fraction and wide QRS. It aims to correct the electrical dyssynchrony present in 30% to 50% of patients in this population. Dyssynchrony results in widening of the QRS complex on the electrocardiogram (ECG). CRT w...

    journal_title:Heart rhythm

    pub_type: 杂志文章,评审


    authors: Eschalier R,Ploux S,Ritter P,Haïssaguerre M,Ellenbogen KA,Bordachar P

    更新日期:2015-05-01 00:00:00

  • Radiofrequency ablation of atrial fibrillation under therapeutic international normalized ratio: a safe and efficacious periprocedural anticoagulation strategy.

    abstract:BACKGROUND:The best periprocedural anticoagulation strategy at the time of pulmonary vein isolation (PVI) is not known. Most centers stop administering warfarin (Coumadin) and use bridging with heparin or enoxaparin. OBJECTIVE:The purpose of this study was to evaluate the efficacy and safety of PVI under therapeutic i...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Hussein AA,Martin DO,Saliba W,Patel D,Karim S,Batal O,Banna M,Williams-Andrews M,Sherman M,Kanj M,Bhargava M,Dresing T,Callahan T,Tchou P,Di Biase L,Beheiry S,Lindsay B,Natale A,Wazni O

    更新日期:2009-10-01 00:00:00

  • Improving long QT syndrome diagnosis by a polynomial-based T-wave morphology characterization.

    abstract:BACKGROUND:Diagnosing long QT syndrome (LQTS) remains challenging because of a considerable overlap in QT interval between patients with LQTS and healthy subjects. Characterizing T-wave morphology might improve LQTS diagnosis. OBJECTIVE:The purpose of this study was to improve LQTS diagnosis by combining new polynomia...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Hermans BJM,Bennis FC,Vink AS,Koopsen T,Lyon A,Wilde AAM,Nuyens D,Robyns T,Pison L,Postema PG,Delhaas T

    更新日期:2020-05-01 00:00:00

  • Left bundle branch-Purkinje system in patients with bundle branch reentrant tachycardia: lessons from catheter ablation and electroanatomic mapping.

    abstract:BACKGROUND:The mechanism of bundle branch reentrant tachycardia has been described, and ablation of the right bundle branch (RBB) is a curative approach. OBJECTIVE:The purpose of this study was to evaluate the left bundle branch (LBB)-Purkinje system during sinus rhythm and to test the feasibility of ablating the LBB ...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Schmidt B,Tang M,Chun KR,Antz M,Tilz RR,Metzner A,Koektuerk B,Xie P,Kuck KH,Ouyang F

    更新日期:2009-01-01 00:00:00

  • Autonomic regulation therapy suppresses quantitative T-wave alternans and improves baroreflex sensitivity in patients with heart failure enrolled in the ANTHEM-HF study.

    abstract:BACKGROUND:Autonomic regulation therapy (ART) with chronic vagus nerve stimulation improves ventricular function in patients with chronic heart failure, but its effects on quantitative T-wave alternans (TWA), ventricular tachycardia (VT), baroreflex sensitivity, and autonomic tone remained unknown. OBJECTIVE:Effects o...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Libbus I,Nearing BD,Amurthur B,KenKnight BH,Verrier RL

    更新日期:2016-03-01 00:00:00

  • Right bundle branch block-type wide QRS complex tachycardia with a reversed R/S complex in lead V6: Development and validation of electrocardiographic differentiation criteria.

    abstract:BACKGROUND:Differentiation of supraventricular tachycardia (SVT) with a right bundle branch block (RBBB) pattern from ventricular tachycardia (VT) is difficult, particularly when the R/S ratio in lead V6 is below 1.0. OBJECTIVE:We sought to investigate the electrocardiographic criteria for distinguishing between these...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Kim M,Kwon CH,Lee JH,Hwang KW,Choi HO,Kim YG,Lee KN,Ahn J,Park HS,Nam GB

    更新日期:2020-09-11 00:00:00

  • Impact of atrial prevention pacing on atrial fibrillation burden: primary results of the Study of Atrial Fibrillation Reduction (SAFARI) trial.

    abstract:BACKGROUND:The role of atrial-based pacing algorithms in preventing atrial fibrillation (AF) remains controversial. The inconsistent results noted in previous trials may be due in part to differences in endpoints, pacing algorithms, and study design. SAFARI, a worldwide, prospective, randomized clinical trial, was desi...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Gold MR,Adler S,Fauchier L,Haffajee C,Ip J,Kainz W,Kawasaki R,Prakash A,Táborský M,Waller T,Wilson V,Li S,Hoffmann E,SAFARI Investigators.

    更新日期:2009-03-01 00:00:00

  • Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms.

    abstract:BACKGROUND:Heterogeneity of depolarization and repolarization underlies the development of lethal arrhythmias. OBJECTIVE:We investigated whether quantification of spatial depolarization and repolarization heterogeneity identifies individuals at risk for sudden cardiac death (SCD). METHODS:Spatial R-, J-, and T-wave h...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究


    authors: Kenttä TV,Nearing BD,Porthan K,Tikkanen JT,Viitasalo M,Nieminen MS,Salomaa V,Oikarinen L,Jula A,Kontula K,Newton-Cheh C,Huikuri HV,Verrier RL

    更新日期:2016-03-01 00:00:00

  • Endocardial (Watchman) vs epicardial (Lariat) left atrial appendage exclusion devices: Understanding the differences in the location and type of leaks and their clinical implications.

    abstract:BACKGROUND:Watchman and Lariat left atrial appendage (LAA) occlusion devices are associated with LAA leaks postdeployment. OBJECTIVE:The purpose of this study was to compare the incidence, characteristics, and clinical significance of these leaks. METHODS:We performed a multicenter prospective observational study of ...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究


    authors: Pillarisetti J,Reddy YM,Gunda S,Swarup V,Lee R,Rasekh A,Horton R,Massumi A,Cheng J,Bartus K,Badhwar N,Han F,Atkins D,Bommana S,Earnest M,Nath J,Ferrell R,Bormann S,Dawn B,Di Biase L,Mansour M,Natale A,Lakkired

    更新日期:2015-07-01 00:00:00

  • The effect of vagally induced dispersion of action potential duration on atrial arrhythmogenesis.

    abstract:OBJECTIVE:The purpose of this study is to ascertain the effects of spatially variable ACh distributions on arrhythmogenesis in a morphologically realistic computer model of canine atria. BACKGROUND:Vagal stimulation releases acetylcholine (ACh), which causes a dose-dependent reduction in action potential duration (APD...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Vigmond EJ,Tsoi V,Kuo S,Arevalo H,Kneller J,Nattel S,Trayanova N

    更新日期:2004-09-01 00:00:00

  • Bi-stable wave propagation and early afterdepolarization-mediated cardiac arrhythmias.

    abstract:BACKGROUND:In normal atrial and ventricular tissue, the electrical wavefronts are mediated by the fast sodium current (I(Na)), whereas in sinoatrial and atrioventricular nodal tissue, conduction is mediated by the slow L-type calcium current (I(Ca,L)). However, it has not been shown whether the same tissue can exhibit ...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Chang MG,Sato D,de Lange E,Lee JH,Karagueuzian HS,Garfinkel A,Weiss JN,Qu Z

    更新日期:2012-01-01 00:00:00

  • Subcutaneous versus transvenous implantable defibrillator: An updated meta-analysis.

    abstract:BACKGROUND:Implantable cardioverter-defibrillator (ICD) placement is a well-established therapy for prevention of sudden cardiac death. The subcutaneous implantable cardioverter-defibrillator (S-ICD) was specifically designed to overcome some of the complications related to the transvenous implantable cardioverter-defi...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Rordorf R,Casula M,Pezza L,Fortuni F,Sanzo A,Savastano S,Vicentini A

    更新日期:2020-11-16 00:00:00

  • Left ventricular regional remodeling and lead position during cardiac resynchronization therapy.

    abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) induces segmental left ventricular (LV) remodeling. The LV lead position (LV-LP) affects response to CRT and remodeling. OBJECTIVE:We aimed to assess segmental remodeling concordant, adjacent, and remote to LV-LP using cardiac computed tomography (CT). METHODS:We inc...

    journal_title:Heart rhythm

    pub_type: 杂志文章,随机对照试验


    authors: Kronborg MB,Sommer A,Fyenbo DB,Norgaard BL,Gerdes C,Jensen JM,Jensen HK,Kristensen J,Nielsen JC

    更新日期:2018-10-01 00:00:00

  • Arterial hypertension drives arrhythmia progression via specific structural remodeling in a porcine model of atrial fibrillation.

    abstract:BACKGROUND:Arterial hypertension (HT) contributes to progression of atrial fibrillation (AF) via unknown mechanisms. OBJECTIVE:We aimed to characterize electrical and structural changes accounting for increased AF stability in a large animal model of rapid atrial pacing (RAP)-induced AF combined with desoxycorticoster...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Manninger M,Zweiker D,van Hunnik A,Alogna A,Prassl AJ,Schipke J,Zeemering S,Zirngast B,Schönleitner P,Schwarzl M,Herbst V,Thon-Gutschi E,Huber S,Rohrer U,Ebner J,Brussee H,Pieske BM,Heinzel FR,Verheule S,Antoons G,

    更新日期:2018-09-01 00:00:00

  • Characterization and predictors of first and subsequent inappropriate ICD therapy by heart rate ranges: Result of the MADIT-RIT efficacy analysis.

    abstract:BACKGROUND:Data on inappropriate implantable cardioverter-defibrillator (ICD) therapy and effects of programming by heart rate are lacking. OBJECTIVE:We aimed to characterize inappropriate ICD therapy and assess the effects of novel programming by heart rate. METHODS:Incidence and causes of inappropriate therapy by h...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kutyifa V,Daubert JP,Olshansky B,Huang DT,Zhang C,Ruwald AC,McNitt S,Zareba W,Moss AJ,Schuger C

    更新日期:2015-09-01 00:00:00

  • A novel radiofrequency ablation catheter using contact force sensing: Toccata study.

    abstract:OBJECTIVES:The aim of this multicenter study was to evaluate the device- and procedure-related safety of a novel force-sensing radiofrequency (RF) ablation catheter capable of measuring the real-time contact force (CF) and to present CF data and its possible implications on patient safety. BACKGROUND:The clinical outc...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究


    authors: Kuck KH,Reddy VY,Schmidt B,Natale A,Neuzil P,Saoudi N,Kautzner J,Herrera C,Hindricks G,Jaïs P,Nakagawa H,Lambert H,Shah DC

    更新日期:2012-01-01 00:00:00

  • Electrocardiographic and electrophysiologic characteristics of anteroseptal, midseptal, and posteroseptal accessory pathways.

    abstract:BACKGROUND:Approximately 30% of all accessory pathways (APs) are located in the septal area, and understanding the electrocardiographic and electrophysiologic of these APs is crucial for safe and effective ablation of these pathways. OBJECTIVE:In this study, the electrocardiographic and electrophysiologic characterist...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Haghjoo M,Kharazi A,Fazelifar AF,Alizadeh A,Emkanjoo Z,Sadr-Ameli MA

    更新日期:2007-11-01 00:00:00

  • Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-Year follow-up outcome data of the EWOLUTION trial.

    abstract:BACKGROUND:Left atrial appendage (LAA) occlusion with WATCHMAN has emerged as viable alternative to vitamin K antagonists in randomized controlled trials. OBJECTIVE:EWOLUTION was designed to provide data in routine practice from a prospective multicenter registry. METHODS:A total of 1025 patients scheduled for a WATC...

    journal_title:Heart rhythm

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Boersma LV,Ince H,Kische S,Pokushalov E,Schmitz T,Schmidt B,Gori T,Meincke F,Protopopov AV,Betts T,Foley D,Sievert H,Mazzone P,De Potter T,Vireca E,Stein K,Bergmann MW,EWOLUTION Investigators.

    更新日期:2017-09-01 00:00:00

  • Mechanism for action potential alternans: the interplay between L-type calcium current and transient outward current.

    abstract:BACKGROUND:The ionic mechanisms underlying action potential duration alternans are not established. OBJECTIVES:The purpose of this study was to explore the mechanisms underlying action potential alternans. METHODS:Computer simulations were performed using a model of a single ischemic myocyte. To emulate ischemia, ext...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Hopenfeld B

    更新日期:2006-03-01 00:00:00

  • Incidence and causes of in-hospital outcomes and 30-day readmissions after percutaneous left atrial appendage closure: A US nationwide retrospective cohort study using claims data.

    abstract:BACKGROUND:Percutaneous left atrial appendage closure (pLAAC) emerged as an option for stroke prevention in patients with atrial fibrillation ineligible for long-term anticoagulation. Real-world data on pLAAC's in-hospital and 30-day readmission measures are limited. OBJECTIVE:We sought to report the nationwide incide...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Vuddanda VLK,Turagam MK,Umale NA,Shah Z,Lakkireddy DR,Bartus K,McCausland FR,Velagapudi P,Mansour M,Heist EK

    更新日期:2020-03-01 00:00:00

  • Implantable cardioverter-defibrillator therapy and risk of congestive heart failure or death in MADIT II patients with atrial fibrillation.

    abstract:BACKGROUND:Atrial fibrillation (AF) contributes to increased risk of morbidity and mortality. Data regarding the effectiveness of implantable cardioverter-defibrillator (ICD) therapy in AF patients are limited. OBJECTIVES:The purpose of this study was to evaluate the effectiveness of ICD therapy in patients with AF en...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Zareba W,Steinberg JS,McNitt S,Daubert JP,Piotrowicz K,Moss AJ,MADIT II Investigators.

    更新日期:2006-06-01 00:00:00

  • Pulmonary vein antrum isolation.

    abstract::Pulmonary vein antrum isolation offers safe and effective treatment of atrial fibrillation by eliminating the potential triggers of this arrhythmia. The pulmonary vein antra encompass, in addition to the pulmonary veins, the left atrial roof and posterior wall and, in the case of the right pulmonary vein antra, a port...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Kanj M,Wazni O,Natale A

    更新日期:2007-03-01 00:00:00

  • Bodyweight fluctuation is associated with increased risk of incident atrial fibrillation.

    abstract:BACKGROUND:Obesity and weight gain are established risk factors for atrial fibrillation (AF). OBJECTIVE:The purpose of this study was to investigate whether bodyweight variability is also a risk factor for AF development. METHODS:A nationwide population-based cohort of 8,091,401 adults from the Korean National Health...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Lee HJ,Choi EK,Han KD,Lee E,Moon I,Lee SR,Cha MJ,Oh S,Lip GYH

    更新日期:2020-03-01 00:00:00

  • Respiratory cycle-dependent atrial tachycardia: prevalence, electrocardiographic and electrophysiologic characteristics, and outcome after catheter ablation.

    abstract:BACKGROUND:Little is known about the tachyarrhythmias relating to respiration. Case reports presented patients with respiratory cycle-dependent atrial tachycardias (RCATs), which cyclically emerge after starting inspiration and cease during expiration. OBJECTIVE:The aim of the present study was to elucidate the preval...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Yamamoto T,Hayashi M,Miyauchi Y,Murata H,Horie T,Igawa O,Kato T,Mizuno K

    更新日期:2011-10-01 00:00:00

  • Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits.

    abstract:BACKGROUND:Ranolazine exhibits a synergistic effect in combination with class III drugs to suppress atrial fibrillation. OBJECTIVE:To investigate whether a combination therapy affects repolarization and provokes ventricular tachyarrhythmias (VT) in a sensitive model of proarrhythmia. METHODS:Thirty-seven rabbits were...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Frommeyer G,Kaiser D,Uphaus T,Kaese S,Osada N,Rajamani S,Belardinelli L,Breithardt G,Eckardt L,Milberg P

    更新日期:2012-12-01 00:00:00

  • Extraction of transvenous leads in the operating room versus electrophysiology laboratory: a comparative study.

    abstract:BACKGROUND:Although risks and life-threatening complications associated with lead extraction are well characterized, practice patterns vary regarding whether procedures are performed in an operating room (OR) or electrophysiology (EP) laboratory with cardiothoracic surgical backup. OBJECTIVE:Our objective was to compa...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究


    authors: Franceschi F,Dubuc M,Deharo JC,Mancini J,Pagé P,Thibault B,Koutbi L,Prévôt S,Khairy P

    更新日期:2011-07-01 00:00:00

  • Catheter ablation using the third-generation cryoballoon provides an enhanced ability to assess time to pulmonary vein isolation facilitating the ablation strategy: Short- and long-term results of a multicenter study.

    abstract:BACKGROUND:Limited data exist on cryoablation of atrial fibrillation (Cryo-AF) using the newly available third-generation (Arctic Front Advance-Short Tip [AFA-ST]) cryoballoon. OBJECTIVE:In this multicenter study, we evaluated the safety and efficacy of Cryo-AF using the AFA-ST vs the second-generation (Arctic Front A...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究


    authors: Aryana A,Kowalski M,O'Neill PG,Koo CH,Lim HW,Khan A,Hokanson RB,Bowers MR,Kenigsberg DN,Ellenbogen KA,Cryo-DOSING Investigators.

    更新日期:2016-12-01 00:00:00

  • Profound differences in prognostic impact of left ventricular reverse remodeling after cardiac resynchronization therapy relate to heart failure etiology.

    abstract:BACKGROUND:An ischemic etiology of heart failure (HF) has been associated with reduced left ventricular reverse remodeling after cardiac resynchronization therapy (CRT). OBJECTIVE:The purpose of this study was to assess the relationship between the etiology of HF and reverse remodeling and outcome after CRT. METHODS:...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Martens P,Nijst P,Verbrugge FH,Dupont M,Tang WHW,Mullens W

    更新日期:2018-01-01 00:00:00

  • High-density substrate-guided ventricular tachycardia ablation: role of activation mapping in an attempt to improve procedural effectiveness.

    abstract:BACKGROUND:Advanced techniques of electroanatomical mapping efficiently guide ventricular tachycardia (VT) ablation strategies; in this context, the adjunctive value of combining activation mapping (AMap) to improve accuracy has not been elucidated. OBJECTIVE:To investigate whether conventional AMap further contribute...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Carbucicchio C,Ahmad Raja N,Di Biase L,Volpe V,Dello Russo A,Trivedi C,Bartoletti S,Zucchetti M,Casella M,Russo E,Santangeli P,Moltrasio M,Tundo F,Fassini G,Natale A,Tondo C

    更新日期:2013-12-01 00:00:00

  • Low incidence of complications after cephalic vein cutdown for pacemaker lead implantation in children weighing less than 10 kilograms: A single-center experience with long-term follow-up.

    abstract:BACKGROUND:Only a few studies on the cephalic vein cutdown technique for pacemaker lead implantation in children weighing ≤10 kg have been reported even though the procedure is widely accepted in adults. OBJECTIVE:The purpose of this study was to prove that cephalic vein cutdown for pacemaker lead implantation is a re...

    journal_title:Heart rhythm

    pub_type: 杂志文章


    authors: Kircanski B,Vasic D,Savic D,Stojanov P

    更新日期:2015-08-01 00:00:00