Abstract:
BACKGROUND:Predictors of risk of lethal arrhythmic events (LAE) is poorly understood and may differ from adults in children with hypertrophic cardiomyopathy (HCM). OBJECTIVE:The purpose of this study was to determine predictors of LAE in children with HCM. METHODS:A retrospective data collection was performed on 446 children and teenagers 20 years and younger (290 [65%] male; mean age 10.1 ± 5.7 years) with idiopathic HCM from 35 centers. Patients were classified as group 1 (HCM with LAE) if having a secondary prevention implantable cardioverter-defibrillator (ICD) or primary prevention ICD with appropriate interventions or group 2 (HCM without LAE) if having a primary prevention ICD without appropriate interventions. RESULTS:There were 152 children (34%) in group 1 and 294 (66%) in group 2. Risk factors for group 1 by univariate analysis were septal thickness, posterior left ventricular (LV) wall thickness, lower LV outflow gradient, and Q wave > 3 mm in inferior electrocardiographic leads. Factors not associated with LAE were family history of SCD, abnormal blood pressure response to exercise, and ventricular tachycardia on ambulatory electrocardiographic monitoring. Risk factors for SCD by multivariate analysis were age at ICD placement (hazard ratio [HR] 0.9; P = .0025), LV posterior wall thickness z score (HR 1.02; P < .005), and LV outflow gradient < 30 mm Hg (HR 2.0; P < .006). LV posterior wall thickness z score ≥ 5 was associated with LAE. CONCLUSION:Risk factors for LAE appear different in children compared to adults. Conventional adult risk factors were not significant in children. Further prospective studies are needed to improve risk stratification for LAE in children with HCM.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Balaji S,DiLorenzo MP,Fish FA,Etheridge SP,Aziz PF,Russell MW,Tisma S,Pflaumer A,Sreeram N,Kubus P,Law IH,Kantoch MJ,Kertesz NJ,Strieper M,Erickson CC,Moore JP,Nakano SJ,Singh HR,Chang P,Cohen M,Fournier A,Ilinadoi
10.1016/j.hrthm.2019.04.040subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1462-1467issue
10eissn
1547-5271issn
1556-3871pii
S1547-5271(19)30369-8journal_volume
16pub_type
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