当前位置： SCI文献检索 > HEART RHYTHM期刊下所有文献 > Early temporal and spatial regularization of persistent atrial fibrillation predicts termination and arrhythmia-free outcome.

Early temporal and spatial regularization of persistent atrial fibrillation predicts termination and arrhythmia-free outcome.

Abstract：

BACKGROUND:Termination of persistent atrial fibrillation (AF) is a valuable ablation endpoint but is difficult to anticipate. We evaluated whether temporal and spatial indices of AF regularization predict intraprocedural AF termination and outcome. OBJECTIVE:The purpose of this study was to test whether temporospatial organization of AF after pulmonary vein isolation (PVI) predicts whether subsequent stepwise ablation will terminate persistent AF or predict outcome. METHODS:In 75 patients with persistent AF, we measured AF cycle length (AFCL), temporal regularity index (TRI, a spectral measure of timing regularity), and spatial regularity index (SRI, cycle-to-cycle variations in spatial vector) between right atrial appendage and proximal and distal coronary sinus before and during stepwise ablation to the endpoint of AF termination. RESULTS:AF termination was achieved in 59 patients (79%) by ablation. AF terminated during PVI in 11 patients, who were excluded from analysis. In the remaining 48 patients, TRI and SRI increased during stepwise ablation, as compared with 16 patients without termination (P<.05). AFCL was prolonged in both groups. From receiver operating characteristics analysis of the first 22 patients (training set), a post-PVI TRI increase predicted AF termination in the latter 42 patients (test set) with a positive predictive value of 96%, negative predictive value of 53%, sensitivity of 71%, and specificity of 91%. Results were similar for SRI. After 36 months, higher arrhythmia-free outcome was observed in patients in whom PVI caused temporospatial regularization in AF. CONCLUSIONS:Temporal and spatial regularization of persistent AF after PVI identifies patients in whom stepwise ablation subsequently terminates AF and prevents recurrence.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Forclaz A,Narayan SM,Scherr D,Linton N,Jadidi AS,Nault I,Rivard L,Miyazaki S,Uldry L,Wright M,Shah AJ,Liu X,Xhaet O,Derval N,Knecht S,Sacher F,Jaïs P,Hocini M,Haïssaguerre M

doi

10.1016/j.hrthm.2011.05.008

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1374-82

issue

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(11)00557-1

journal_volume

pub_type

杂志文章

在线工具

Early temporal and spatial regularization of persistent atrial fibrillation predicts termination and arrhythmia-free outcome.