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A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.

Abstract：

BACKGROUND:T-peak to T-end (TPE) interval on the electrocardiogram is a measure of myocardial dispersion of repolarization and is associated with an increased risk of ventricular arrhythmias. The genetic factors affecting the TPE interval are largely unknown. OBJECTIVE:To identify common genetic variants that affect the duration of the TPE interval in the general population. METHODS:We performed a genome-wide association study on 1870 individuals of Finnish origin participating in the Health 2000 Study. The TPE interval was measured from T-peak to T-wave end in leads II, V(2), and V(5) on resting electrocardiograms, and the mean of these TPE intervals was adjusted for age, sex, and Cornell voltage-duration product. We sought replication for a genome-wide significant result in the 3745 subjects from the Framingham Heart Study. RESULTS:We identified a locus on 17q24 that was associated with the TPE interval. The minor allele of the common variant rs7219669 was associated with a 1.8-ms shortening of the TPE interval (P = 1.1 × 10(-10)). The association was replicated in the Framingham Heart Study (-1.5 ms; P = 1.3 × 10(-4)). The overall effect estimate of rs7219669 in the 2 studies was -1.7 ms (P = 5.7 × 10(-14)). The common variant rs7219669 maps downstream of the KCNJ2 gene, in which rare mutations cause congenital long and short QT syndromes. CONCLUSION:The common variant rs7219669 is associated with the TPE interval and is thus a candidate to modify repolarization-related arrhythmia susceptibility in individuals carrying the major allele of this polymorphism.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Marjamaa A,Oikarinen L,Porthan K,Ripatti S,Peloso G,Noseworthy PA,Viitasalo M,Nieminen MS,Toivonen L,Kontula K,Peltonen L,Havulinna AS,Jula A,O'Donnell CJ,Newton-Cheh C,Perola M,Salomaa V

doi

10.1016/j.hrthm.2012.02.019

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

1099-103

issue

7

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(12)00125-7

journal_volume

9

pub_type

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