Abstract:
BACKGROUND:We recently reported that an S140G mutation in human KCNQ1, an alpha subunit of potassium channels, was involved in the pathogenesis of familial atrial fibrillation (AF), but it is not clear whether the mutation is associated with other cardiac arrhythmias. OBJECTIVE:The purpose of this study was to further explore the association of the KCNQ1 S140G mutation with cardiac arrhythmias. METHODS:We produced a transgenic mouse model with myocardium-specific expression of the human KCNQ1 S140G mutation under the control of an alpha-cardiac myosin heavy chain promoter by standard transgenic procedure and evaluated the relationship between the KCNQ1 mutation and its phenotypes in a human family. RESULTS:Four lines of transgenic mice were established with a high level of human KCNQ1 S140G expression in the heart. Frequent episodes of first-, second-, advanced-, or third-degree atrioventricular block (AVB) occurred in at least 65% of transgenic descendants from the four lines. However, none of the five wild-type transgenic lines presented with AVBs. HMR1556, a KCNQ1-specific blocker, can terminate the AVBs. With the exception of at most three AF individuals, at least 13 AF patients were found to show obviously slow ventricular response, which may be one manifestation of AVBs. Interestingly, AF was not detected in these transgenic mice. CONCLUSION:The results suggest that human KCNQ1 S140G is also likely to be a causative mutation responsible for AVBs. The transgenic mouse model is a potential tool to explore mechanisms of AVBs.
journal_name
Heart Rhythmjournal_title
Heart rhythmauthors
Yang Y,Liu Y,Dong X,Kuang Y,Lin J,Su X,Peng L,Jin Q,He Y,Liu B,Pan Z,Li L,Zhu Q,Lin X,Zhou Q,Pan Q,Eurlings PM,Fei J,Wang Z,Chen YHdoi
10.1016/j.hrthm.2007.01.029subject
Has Abstractpub_date
2007-05-01 00:00:00pages
611-8issue
5eissn
1547-5271issn
1556-3871pii
S1547-5271(07)00107-5journal_volume
4pub_type
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