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Ablation of frequent PVC in patients meeting criteria for primary prevention ICD implant: Safety of withholding the implant.

Abstract：

BACKGROUND:Premature ventricular complex (PVC) ablation has been shown to improve left ventricular ejection fraction (LVEF) and New York Heart Association functional class in patients with left ventricular dysfunction. Both are considered key variables in predicting risk of sudden cardiac death. OBJECTIVE:The objective of this study was to assess whether ablation might remove the primary prevention (PP) implantable cardioverter-defibrillator (ICD) indication in patients with frequent PVC. METHODS:Sixty-six consecutive patients with PP-ICD indication and frequent PVC [33 (50%) men; mean age 53 ± 13 years; 11 (17%) with ischemic heart disease] underwent PVC ablation. The ICD was withheld and the indication was reevaluated at 6 and 12 months. RESULTS:LVEF progressively improved from 28% ± 4% at baseline to 42% ± 12% at 12 months (P < .001). New York Heart Association functional class improved from 2 patients with NYHA functional class I (3%) at baseline to 35 (53%) at 12 months (P < .001). The brain natriuretic peptide level decreased from 246 ± 187 to 176 ± 380 pg/mL (P = .004). The PP-ICD indication was removed in 42 patients (64%) during follow-up, from 38 (92%) of them at 6 months, showing an independent association with baseline PVC burden and successful sustained ablation. In patients with successful sustained ablation, a cutoff value of 13% PVC burden had a sensitivity of 100% and a specificity of 93% (area under the curve 99%) for removing ICD indication postablation. No sudden cardiac deaths or malignant ventricular arrhythmias were observed. CONCLUSION:In patients with frequent PVC and PP-ICD indication, ablation improves LVEF and, in most cases, allows removal of the indication. Withholding the ICD and reevaluating within 6 months of ablation seems to be a safe and appropriate strategy.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Penela D,Acosta J,Aguinaga L,Tercedor L,Ordoñez A,Fernández-Armenta J,Andreu D,Sánchez-Millán PJ,Cabanelas N,Tolosana JM,Vassanelli F,Cabrera M,Korshunov V,Sitges M,Brugada J,Mont L,Berruezo A

doi

10.1016/j.hrthm.2015.09.011

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

2434-42

issue

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(15)01178-9

journal_volume

pub_type

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Ablation of frequent PVC in patients meeting criteria for primary prevention ICD implant: Safety of withholding the implant.