Abstract：
:With the goal to enhance the distribution of cationic Mn porphyrins within mitochondria, the lipophilic Mn(III)meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) has been synthesized and tested in several different model of diseases, where it shows remarkable efficacy at as low as 50 µg/kg single or multiple doses. Yet, in a rat lung radioprotection study, at higher 0.6-1 mg/kg doses, due to its high accumulation and micellar character, it became toxic. To avoid the toxicity, herein the pulmonary radioprotection of MnTnHex-2-PyP(5+) was assessed at 50 µg/kg. Fischer rats were irradiated to their right hemithorax (28 Gy) and treated with 0.05 mg/kg/day of MnTnHex-2-PyP(5+) for 2 weeks by subcutaneously-implanted osmotic pumps, starting at 2 h post-radiation. The body weights and breathing frequencies were followed for 10 weeks post-radiation, when the histopathology and immunohistochemistry were assessed. Impact of MnTnHex-2-PyP(5+) on macrophage recruitment (ED-1), DNA oxidative damage (8-OHdG), TGF-β1, VEGF(A) and HIF-1α were measured. MnTnHex-2-PyP(5+) significantly decreased radiation-induced lung histopathological (H&E staining) and functional damage (breathing frequencies), suppressed oxidative stress directly (8-OHdG), or indirectly, affecting TGF-β1, VEGF (A) and HIF-1α pathways. The magnitude of the therapeutic effects is similar to the effects demonstrated under same experimental conditions with 120-fold higher dose of ~5000-fold less lipophilic Mn(III)meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+).
journal_name
Redox Bioljournal_title
Redox biologyauthors
Gauter-Fleckenstein B,Reboucas JS,Fleckenstein K,Tovmasyan A,Owzar K,Jiang C,Batinic-Haberle I,Vujaskovic Zdoi
10.1016/j.redox.2013.12.017subject
Has Abstractpub_date
2014-01-09 00:00:00pages
400-10issn
2213-2317pii
S2213-2317(13)00105-5journal_volume
2pub_type
杂志文章相关文献
Redox Biology文献大全abstract：:Loneliness and social isolation are common sources of chronic stress in modern society. Epidemiological studies have demonstrated that loneliness and social isolation increase mortality risk as much as smoking or alcohol consumption and more than physical inactivity or obesity. Loneliness in human is associated with h...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101585
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:The Ras family of small GTPases cycle between an inactive, GDP-bound state and an active, GTP-bound state. When bound to GTP, Ras engages and activates a number of effectors that mediate proliferative and survival signals. Ras is mutated in over 30% of human cancers, usually at codons 12, 13, or 61, to remai...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.09.015
更新日期：2015-08-01 00:00:00
abstract：:Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular dise...
journal_title：Redox biology
pub_type： 临床试验,杂志文章
doi：10.1016/j.redox.2016.12.014
更新日期：2017-04-01 00:00:00
abstract：:Cardiovascular disease is the leading cause of the death for both men and women. Although baseline heart physiology and the response to disease are known to differ by sex, little is known about sex differences in baseline molecular signaling, especially with regard to redox biology. In this review, we describe current...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101441
更新日期：2020-04-01 00:00:00
abstract：:Glutathione (GSH), the most abundant vertebrate endogenous redox buffer, plays key roles in organogenesis and embryonic development, however, organ-specific GSH utilization during development remains understudied. Monochlorobimane (MCB), a dye conjugated with GSH by glutathione-s-transferase (GST) to form a fluorescen...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101235
更新日期：2019-09-01 00:00:00
abstract：:Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stress that directly au...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101785
更新日期：2021-01-01 00:00:00
abstract：:Retinal tissue receives its supply of oxygen from two sources - the retinal and choroidal circulations. Decreases in retinal blood flow occur in the early stages of diabetes, with the eventual development of hypoxia thought to contribute to pathological neovascularization. Oxygen consumption in the retina has been fou...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2014.04.006
更新日期：2014-04-18 00:00:00
abstract：:Mechanistic/mammalian target of rapamycin (mTOR) has emerged as a new potential therapeutic target for gastric cancer. Rapamycin and rapamycin analogs are undergoing clinical trials and have produced clinical responses in a subgroup of cancer patients. However, monotherapy with rapamycin at safe dosage fails to induce...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.09.006
更新日期：2016-12-01 00:00:00
abstract：:PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally believed to be attrib...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2018.03.016
更新日期：2018-07-01 00:00:00
abstract：:Obesity and excessive inflammation/oxidative stress are pathophysiological forces associated with kidney dysfunction. Although we recently showed that heme-oxygenase (HO) improves renal functions, the mechanisms are largely unclear. Moreover, the effects of the HO-system on podocyte cytoskeletal proteins like podocin,...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2014.09.001
更新日期：2014-01-01 00:00:00
abstract：:In recent years, the gasotransmitter hydrogen sulphide (H2S), produced by the transsulphuration pathway, has been recognized as a biological mediator playing an important role under normal conditions and in various pathologies in both eukaryotes and prokaryotes. The transsulphuration pathway (TSP) includes the convers...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101654
更新日期：2020-09-01 00:00:00
abstract：:Glucose starvation is one of the major forms of metabolic stress in cancer cells. Deprivation of glucose impairs glycolysis and the pentose phosphate pathway, which elicits oxidative stress due to enhanced production of reactive oxygen species (ROS) and impaired antioxidant system, leading to redox imbalance and cell ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2019.101154
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular reactive oxygen species (ROS) are generated, further amplifying the platelet activation response. Th...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.10.009
更新日期：2015-12-01 00:00:00
abstract：:Oxidation-reduction chemistry is fundamental to the metabolism of all living organisms, and hence quantifying the principal redox players is important for a comprehensive understanding of cell metabolism in normal and pathological states. In mammalian cells, this is accomplished by measuring oxygen partial pressure (p...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101549
更新日期：2020-07-01 00:00:00
abstract：:Ferroptosis is an outcome of metabolic disorders and closely linked to liver cancer. However, the mechanism underlying the fine regulation of ferroptosis in liver cancer remains unclear. Here, we have identified two categories of genes: ferroptosis up-regulated factors (FUF) and ferroptosis down-regulated factors (FDF...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101211
更新日期：2019-06-01 00:00:00
abstract：:Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations, ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to increased strength from hypertrophy. While exercise is necessary to trigger and stimulate muscle adaptations, the post-exercise recovery period...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101480
更新日期：2020-08-01 00:00:00
abstract：:Premature senescence, a death escaping pathway for cells experiencing stress, is conducive to aging and cardiovascular diseases. The molecular switch between senescent and apoptotic fate remains, however, poorly recognized. Nrf2 is an important transcription factor orchestrating adaptive response to cellular stress. H...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101304
更新日期：2020-01-01 00:00:00
abstract：:Exposure to the space radiation environment poses risks for a range of deleterious health effects due to the unique types of radiation encountered. Galactic cosmic rays are comprised of a spectrum of highly energetic nuclei that deposit densely ionizing tracks of damage along the particle trajectory. These tracks are ...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.03.001
更新日期：2015-08-01 00:00:00
abstract：:Mitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal cells, with H2O2 being the predominant ROS released from mitochondria; however, it has been recently demonstrated that energized brain mitochondria may act as stabilizers of H2O2 concentration (Starkov et al. [1]) based on the...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2015.05.001
更新日期：2015-08-01 00:00:00
abstract：:This review focuses on the hypothetical mechanisms for enhanced vulnerability of African Americans to SARS-CoV-2 infection, COVID-19 severity, and increased deaths. A disproportionately higher number of African Americans are afflicted with autoimmune and inflammatory diseases (e.g., diabetes, hypertension, obesity), a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101721
更新日期：2020-10-01 00:00:00
abstract：:Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident, that advanced glycation end products (AGEs) tri...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101546
更新日期：2020-07-01 00:00:00
abstract：:Preeclampsia affects one in twelve of the 130 million pregnancies a year. The lack of an effective therapeutic to prevent or treat it is responsible for an annual global cost burden of 100 billion US dollars. Preeclampsia also affects these women later in life as it is a recognised risk factor for cardiovascular disea...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101768
更新日期：2021-01-01 00:00:00
abstract：:Metabolic control of cellular function is significant in the context of inflammation-induced metabolic dysregulation in immune cells. Generation of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide are one of the critical events that modulate the immune response in neutrophils. When activated, neu...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2016.06.003
更新日期：2016-10-01 00:00:00
abstract：:Products of ultraviolet (UV) irradiation such as reactive oxygen species (ROS) and nitric oxide (NO) stimulate melanin synthesis. Reactive sulfur species (RSS) have been shown to have strong ROS and NO scavenging effects. However, the instability and low retention of RSS limit their use as inhibitors of melanin synthe...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2017.10.007
更新日期：2018-04-01 00:00:00
abstract：:Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral a...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2017.04.040
更新日期：2017-08-01 00:00:00
abstract：:Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. E...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101531
更新日期：2020-08-01 00:00:00
abstract：:Oxidative stress resulting from the accumulation of high levels of reactive oxygen species is a salient feature of, and a well-recognised pathological factor for, diverse pathologies. One common mechanism for oxidative stress damage is via the disruption of intracellular ion homeostasis to induce cell death. TRPM2 is ...
journal_title：Redox biology
pub_type： 杂志文章,评审
doi：10.1016/j.redox.2020.101755
更新日期：2020-10-01 00:00:00
abstract：:Microglia-mediated neuroinflammation plays a crucial role in the pathophysiological process of multiple neurological disorders such as ischemic stroke, yet lacks effective therapeutic agents. Previously, we discovered one novel synthetic compound, tanshinol borneol ester (DBZ), possesses anti-inflammatory and anti-ath...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101644
更新日期：2020-09-01 00:00:00
abstract：:Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2019.101344
更新日期：2020-01-01 00:00:00
abstract：:Fanconi Anemia (FA) is a disease characterized by bone marrow (BM) failure and aplastic anemia. In addition to a defective DNA repair system, other mechanisms are involved in its pathogenesis, such as defective mitochondrial metabolism, accumulation of lipids, and increment of oxidative stress production. To better un...
journal_title：Redox biology
pub_type： 杂志文章
doi：10.1016/j.redox.2020.101618
更新日期：2020-09-01 00:00:00
