Abstract:
:Preimplantation genetic diagnosis and screening improves the chances of achieving a viable pregnancy, not only free of undesired single-gene defects but also aneuploidy. In addition, improvements in vitrification provide an efficient means of preserving embryos (blastocysts). By combining trophectoderm biopsy with recent improvements in vitrification methods, only those embryos that have proved themselves viable and potentially more competent are tested. Using array comparative genomic hybridization (aCGH) to assess all 24 chromosomes, aneuploidy rates were compared between day-3 blastomere biopsy and day-5 trophectoderm biopsy. Of those 1603 embryos, 31% were euploid, 62% were aneuploid and 7% not analysable. A significantly larger proportion of embryos were euploid on day-5 biopsy (42%) compared with day-3 biopsy (24%, P<0.0001). The number of euploid embryos per patient was not significantly different. Combining extended culture, trophectoderm biopsy and aneuploidy assessment by aCGH and subsequent vitrification can provide a more efficient means of achieving euploid pregnancies in IVF.
journal_name
Reprod Biomed Onlinejournal_title
Reproductive biomedicine onlineauthors
Adler A,Lee HL,McCulloh DH,Ampeloquio E,Clarke-Williams M,Wertz BH,Grifo Jdoi
10.1016/j.rbmo.2013.11.018subject
Has Abstractpub_date
2014-04-01 00:00:00pages
485-91issue
4eissn
1472-6483issn
1472-6491pii
S1472-6483(13)00636-6journal_volume
28pub_type
杂志文章abstract::The aims of this study were to investigate the relationship between inhibins, activin A and follistatin in first trimester fetal fluids, maternal serum, placenta and decidua, and to investigate if these hormones are present in the circulation of the early second trimester human fetus. Amniotic and coelomic fluid, mate...
journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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doi:10.1016/s1472-6483(10)60599-8
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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更新日期:2011-10-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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更新日期:2006-06-01 00:00:00
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 临床试验,杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.rbmo.2009.12.019
更新日期:2010-04-01 00:00:00
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journal_title:Reproductive biomedicine online
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更新日期:2009-04-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
doi:10.1016/j.rbmo.2013.12.005
更新日期:2014-04-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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更新日期:2011-01-01 00:00:00
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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更新日期:2008-04-01 00:00:00
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journal_title:Reproductive biomedicine online
pub_type: 杂志文章,评审
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更新日期:2003-07-01 00:00:00
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journal_title:Reproductive biomedicine online
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更新日期:2018-06-01 00:00:00