Sex differences in resting state neural networks of nicotine-dependent cigarette smokers.

Abstract:

:Although several sex differences in nicotine dependence have been identified, the neural mechanisms underlying these sex differences are not clear. The present study examines sex differences in resting-state brain activity using an arterial spin labeling (ASL) perfusion imaging technique. Fifty-one (31 males) sated nicotine-dependent cigarette smokers underwent perfusion functional magnetic resonance imaging during the resting state. Using functionally defined hippocampus/amygdala (HIP/AMY) seed regions, we observed sex differences in correlation strength between the HIP/AMY and the bilateral anterior insula, rostral anterior cingulate cortex, and inferior parietal lobule with females showing stronger functional coupling than males. This pattern of synchronous variations in dynamic cerebral blood flow is consistent with recent models of nicotine dependence, and as such, our findings provide a novel perspective on the neural mechanisms that may contribute to sex differences in nicotine dependence.

journal_name

Addict Behav

journal_title

Addictive behaviors

authors

Wetherill RR,Jagannathan K,Shin J,Franklin TR

doi

10.1016/j.addbeh.2014.01.006

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

789-92

issue

4

eissn

0306-4603

issn

1873-6327

pii

S0306-4603(14)00007-0

journal_volume

39

pub_type

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