Abstract：
:Cocaine dependence is a chronically relapsing disorder for which its predominant behavioral therapies are associated with only partial efficacy. The goal of this study was to determine if the N-methyl-d-aspartate (NMDA) glutamate receptor partial agonist and cognitive enhancer, d-cycloserine (DCS), could boost the cocaine abstinence and treatment retention goals of cognitive behavioral therapy (CBT). This study employed a placebo-controlled, randomized double-blind trial design of 44 cocaine-dependent men enrolled in a 4-week outpatient Substance Abuse Treatment Program (SATP) at the Atlanta Veteran's Administration Medical Center. Subjects received 50mg of DCS or placebo prior to four weekly sessions of a condensed version of a manual-based CBT for cocaine dependence. Cocaine abstinence and treatment retention measures represented primary outcome variables. Relative to a 12-step based treatment-as-usual, an under-dosed CBT was associated with significant improvements in drug abstinence and treatment retention at 4-weeks and for maintenance of drug abstinence after four more weeks of follow-up. The robust response to the under-dosed CBT was not enhanced by the adjunct administration of DCS at either the 4- or 8-week endpoints. This controlled clinical trial failed to demonstrate an ability of DCS to boost the relapse prevention or treatment retention goals of CBT.
journal_name
Addict Behavjournal_title
Addictive behaviorsauthors
Kennedy AP,Gross RE,Whitfield N,Drexler KP,Kilts CDdoi
10.1016/j.addbeh.2012.03.008subject
Has Abstractpub_date
2012-08-01 00:00:00pages
900-7issue
8eissn
0306-4603issn
1873-6327pii
S0306-4603(12)00095-0journal_volume
37pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Chronic use of heroin typically leads to numerous negative life consequences and serious clinical impairment. Increased negative consequences can result in poor treatment outcomes as well as adverse health effects and impaired social functioning. Certain risk factors, including early substance use initiation...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.07.027
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Opioid agonist therapy (OAT) models are generally provided without consideration of how pre-treatment characteristics may be associated with outcome. Therefore, we aimed to first characterize longitudinal trajectories of opioid use before initiating OAT. Then we explored the impact of OAT on opioid use acros...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106655
更新日期：2021-01-01 00:00:00
abstract：:A sample of 226 drug-dependent individuals consecutively admitted to treatment in the major therapeutic programmes in Greece were assessed at intake with the EuropASI and SCL-90-R. At 4 to 6 weeks, 173 who were continuing treatment were reassessed with the SCL-90-R and interviewed with the SCID-R and the CIDI. Mean ag...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：:Sensitivity to the initial smoking experience, upon initial smoking experimentation, is associated with youth smoking. We determined the association between exposure to smoking from peers and family members on the symptoms of the initial smoking experience of adolescents. Data from a survey of 3280 high school student...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.04.019
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:Adolescents susceptible to late-onset smoking (becoming regular smokers at age 18 or later) are an understudied population. Social support is a promising target for intervention, but it is important to distinguish between implicit social support (reminders that one belongs to a network of valued others) and exp...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2016.06.017
更新日期：2016-11-01 00:00:00
abstract：:The prevalence of bulimic symptomatology was determined in the female population of a state-funded chemical dependency treatment unit. Sixty women, 39 Caucasian and 21 Native American, all diagnosed with a psychoactive substance use disorder, were evaluated using both the Bulit-R and the eating disorder section of the...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(92)90069-8
更新日期：1992-11-01 00:00:00
abstract：:Building upon previous research establishing a positive association between grandiose and vulnerable narcissism and problematic social networking use, the present study tests a model that explains how grandiose and vulnerable narcissists might develop Facebook (Fb) addiction symptoms through the need for admiration an...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.08.038
更新日期：2018-01-01 00:00:00
abstract：:Despite the widespread use of cannabis among young people, little research attention has been given to the development of psychometrically sound measures specific to cannabis related problems in this group. The aim of this study was to explore the reliability, validity and factor structure of a multi-dimensional measu...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2006.03.001
更新日期：2006-12-01 00:00:00
abstract：:Treatment studies provide minimal support for nicotine replacement therapy (NRT) with youth; however, survey studies suggest that adolescents use NRT, and may engage in inappropriate use. The current study sought to examine patterns of NRT use and risk factors for use to further aid smoking cessation efforts including...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2009.09.024
更新日期：2010-02-01 00:00:00
abstract：:Steady (daily, continuous) versus nonsteady (binge, episodic, bout, intermittent) drinking pattern have been influential Jellinek's (1960) formulation of delta and gamma drinkers, and are used as variables in various typological systems and drinker profiles. However, definitions of drinking patterns vary widely across...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验,评审
doi：10.1016/0306-4603(94)00043-x
更新日期：1995-01-01 00:00:00
abstract：:Based on Wells and Matthews' (1994) theory of psychological dysfunction and prior empirical studies, it was hypothesized that negative emotion would mediate the relationship between maladaptive metacognition and alcohol dependence, and maladaptive metacognition would moderate the relationship between negative emotion ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2011.02.010
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:There is growing recognition that marijuana use among college students is associated with marijuana-related problems. Yet little work has examined whether use is associated with mental health problems and whether there is a dose effect such that individuals engaging in more frequent use evince relatively gre...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2010.04.001
更新日期：2010-09-01 00:00:00
abstract：:Consumer protection tools such as activity statements, deposit limits, and temporary self-exclusion are provided by most Internet gambling websites to minimise gambling related harms through the prevention of problems and enhancement of controls for those at risk of disordered gambling. However, customer engagement wi...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.106050
更新日期：2019-12-01 00:00:00
abstract：:The effects of a cognitive (cognitive rehearsal) in the treatment of obesity were evaluated in a 16-week weight reduction programme by comparison against two other treatments, cue avoidance, and social pressure. Fifty-three obese females, categorised (on the basis of their weight loss after 3 weeks of dieting) as eith...
journal_title：Addictive behaviors
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0306-4603(86)90051-1
更新日期：1986-01-01 00:00:00
abstract：:Despite a growing body of research examining correlates and consequences of COVID-19, few findings have been published among military veterans. This limitation is particularly concerning as preliminary data indicate that veterans may experience a higher rate of mortality compared to their civilian counterparts. One fa...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106692
更新日期：2021-02-01 00:00:00
abstract：:The present study examined daughter and parent variables associated with bulimia nervosa, including attitudes about body image, eating and dieting histories, and self-esteem. Subjects were female undergraduates (bulimic, subclinical bulimic, and normal) their parents. Daughters differed in bodymass, with bulimics larg...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(95)00007-y
更新日期：1995-07-01 00:00:00
abstract：INTRODUCTION:Some fear that distribution of naloxone to persons at risk of experiencing an opioid overdose may reduce the perceived negative consequences of drug use, leading to riskier patterns of use. This study assessed whether participation in naloxone/overdose training altered drug use frequency, quantity or sever...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.03.008
更新日期：2017-08-01 00:00:00
abstract：:The commodity model of social support and features of Nondirective Support may clarify varied results of support interventions for smoking cessation. A commodity model views social support as attractive in and of itself and as an alternative to high-risk choices such as smoking. If such support is easily accessible, a...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/s0306-4603(97)00064-6
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Research investigating the unique impacts associated with engaging in nonmedical prescription opioid use (NMPOU) among males and females who also use illicit drugs is needed. METHODS:Data were collected between 2013 and 2017 from two linked prospective cohort studies in Vancouver: the At-Risk Youth Study an...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.05.022
更新日期：2019-10-01 00:00:00
abstract：:This paper investigated how depressive symptoms moderate the role of peer cannabis use on developmental patterns of individual cannabis use from adolescence to young adulthood, controlling for a broad set of individual and family factors. Data from two sources were analyzed separately: two saturated schools in the Nat...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2017.07.019
更新日期：2018-01-01 00:00:00
abstract：:Male Sprague-Dawley rats were raised from weaning in one of the three housing conditions: one, two or four per housing unit. At 60 days of age, animals were moved to individual cages and tested in the open field. Following a baseline period in which animals were allowed to adapt to their new housing condition, animals...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(84)90015-7
更新日期：1984-01-01 00:00:00
abstract：:This study provides a comparative test of the one- and two-component theories of planned behavior (TPB) in the context of university undergraduates' binge-drinking. Participants (N=120) self-completed questionnaire measures of all TPB constructs at time 1 and subsequent binge-drinking at time 2 (two-weeks later). The ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2011.09.005
更新日期：2012-01-01 00:00:00
abstract：:Because there are few proven smoking cessation approaches for young adults, it is critical to consider the potential of e-cigarettes as an option. Evidence from 2012 to 2013 in the United States (U.S.) suggested that current e-cigarette use was associated with a higher probability of daily smoking and a lower probabil...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2020.106675
更新日期：2021-02-01 00:00:00
abstract：:Although both screen time (ST) and physical activity (PA) are associated with stress, independent and combined associations between ST and PA, and perceived stress among college students, have remained unclear. The present study included 1137 undergraduate medical students from a university in Shenyang, Northeast Chin...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2019.106224
更新日期：2020-04-01 00:00:00
abstract：:In an attempt to find an optimum age during adolescence to target weight control programs successfully, 189 adolescents were surveyed using measures of eating self-efficacy and body-weight attributions. The sensitivity of the attribution measures was assessed in a pilot study using 100 adolescents. The major experimen...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(91)90042-g
更新日期：1991-01-01 00:00:00
abstract：:The role of the endocannabinoid system in nicotine addiction is being increasingly acknowledged. We conducted a pilot, randomised double blind placebo controlled study set out to assess the impact of the ad-hoc use of cannabidiol (CBD) in smokers who wished to stop smoking. 24 smokers were randomised to receive an inh...
journal_title：Addictive behaviors
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.addbeh.2013.03.011
更新日期：2013-09-01 00:00:00
abstract：AIMS:Do assessments of alcohol dependence demonstrate similarly validity across Hispanics and non-Hispanic Caucasians? This investigation examined this question. METHOD:It employed confirmatory factor analyses for ordered-categorical measures to search for measurement bias on the AUDADIS, a standardized measure of alc...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2008.08.004
更新日期：2009-01-01 00:00:00
abstract：:The current study was designed to investigate the perceived consequences of cigarette smoking among a sample of college students. Participants (N=206) rated the negative consequences of smoking higher than the positive consequences on both the Decisional Balance Measure and the Smoking Consequences Questionnaire. Whil...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2005.10.007
更新日期：2006-08-01 00:00:00
abstract：AIMS:Children of alcoholics (COAs) are at higher risk for developing an alcohol use disorder and substance-related problems than non-COAs. This study examined (i) the relationships between sleep rhythmicity in childhood (aged 3-5) and behavioral control in adolescence (aged 9-14) and (ii) whether sleep rhythmicity and ...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/j.addbeh.2018.02.006
更新日期：2018-07-01 00:00:00
abstract：:The tendency to become addicted across a number of different substances or activities was determined for a sample of 573 subjects, including college students and their parents. Four components of addiction were defined: craving, tolerance, withdrawal and lack of control. Subjects rated the extent to which each of thes...
journal_title：Addictive behaviors
pub_type： 杂志文章
doi：10.1016/0306-4603(93)90011-w
更新日期：1993-01-01 00:00:00
