Retreatment with omalizumab results in rapid remission in chronic spontaneous and inducible urticaria.

abstract：Importance:Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the su...

journal_title：JAMA dermatology

authors： Donigan JM,Hyde MA,Goldgar DE,Hadley ML,Bowling M,Bowen GM

更新日期：2018-08-01 00:00:00

abstract：IMPORTANCE:Approximately 10% to 25% of patients treated with BRAF inhibitors develop cutaneous squamous cell carcinoma (SCC), but the mechanism responsible has not yet been determined. We report what we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomavirus subtype 17 (HPV-17) w...

journal_title：JAMA dermatology

authors： Falchook GS,Rady P,Hymes S,Nguyen HP,Tyring SK,Prieto VG,Hong DS,Kurzrock R

更新日期：2013-03-01 00:00:00

abstract：Importance:Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN). Objective:To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised w...

journal_title：JAMA dermatology

authors： Fleming NH,Egbert BM,Kim J,Swetter SM

更新日期：2016-12-01 00:00:00

abstract：Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of sui...

journal_title：JAMA dermatology

authors： Nguyen DD,Marchese M,Cone EB,Paciotti M,Basaria S,Bhojani N,Trinh QD

更新日期：2021-01-01 00:00:00

abstract：Importance:Advanced practice professionals (APPs) such as nurse practitioners and physician assistants independently perform a large number and variety of dermatologic procedures, but little is known about how the number and scope of these procedures have changed over time. Objective:To examine the trends in scope and...

journal_title：JAMA dermatology

authors： Zhang M,Zippin J,Kaffenberger B

更新日期：2018-09-01 00:00:00

abstract：IMPORTANCE:Acquired cutis laxa is a rare cutaneous manifestation of hematologic malignancy. We report a case of γ heavy chain deposition disease (HCDD) associated with acquired cutis laxa, renal involvement, and hypocomplementemia and propose a mechanism of elastic fiber degradation in the skin of this patient with HCD...

journal_title：JAMA dermatology

authors： O'Malley JT,D'Agati VD,Sherman WH,Grossman ME

更新日期：2014-11-01 00:00:00

abstract：Importance:Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus,...

journal_title：JAMA dermatology

authors： Mantyh WG,Dyck PJB,Dyck PJ,Engelstad JK,Litchy WJ,Sandroni P,Davis MDP

更新日期：2017-02-01 00:00:00

abstract：IMPORTANCE:Solid-organ transplant recipients (OTRs) are at an increased risk for skin cancer. Prior studies have demonstrated a reduced incidence of skin cancer in renal OTRs treated with sirolimus. However, little information exists on the use of sirolimus for the prevention of skin cancer in nonrenal OTRs or those al...

journal_title：JAMA dermatology

authors： Karia PS,Azzi JR,Heher EC,Hills VM,Schmults CD

更新日期：2016-05-01 00:00:00

abstract：IMPORTANCE:The differential diagnosis for oral lentigines includes several syndromes with important associated systemic findings. McCune-Albright syndrome (MAS), a mosaic condition associated with café au lait pigmentation, is not typically considered a mucosal lentiginosis syndrome. The clinical phenotype of MAS is va...

journal_title：JAMA dermatology

authors： Pichard DC,Boyce AM,Collins MT,Cowen EW

更新日期：2014-07-01 00:00:00

abstract：IMPORTANCE:Mutations driving melanoma growth have diagnostic, prognostic, and therapeutic implications. Traditional classification systems do not correlate optimally with underlying melanoma growth-promoting mutations. Our objective was to determine whether unique dermoscopic growth patterns directly correlate with dri...

journal_title：JAMA dermatology

authors： Sanchez MI,Rabinovitz HS,Oliviero MC,Elgart GW,Perez C,Puig S,Malvehy J,Grichnik JM

更新日期：2014-06-01 00:00:00

abstract：IMPORTANCE:Mobile smartphones are rapidly emerging as an effective means of communicating with many Americans. Using mobile applications (apps), they can access remote databases, track time and location, and integrate user input to provide tailored health information. OBJECTIVE:A smartphone mobile app providing person...

journal_title：JAMA dermatology

authors： Buller DB,Berwick M,Lantz K,Buller MK,Shane J,Kane I,Liu X

更新日期：2015-05-01 00:00:00

abstract：Importance:Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increa...

journal_title：JAMA dermatology

authors： Burns EM,Guroji P,Ahmad I,Nasr HM,Wang Y,Tamimi IA,Stiefel E,Abdelgawwad MS,Shaheen A,Muzaffar AF,Bush LM,Hurst CB,Griffin RL,Elmets CA,Yusuf N

更新日期：2017-10-01 00:00:00

abstract：Importance:Pubic hair grooming is a common practice that can lead to injury and morbidity. Objective:To identify demographic and behavioral risk factors associated with pubic hair grooming-related injuries to characterize individuals with high risk of injury and develop recommendations for safe grooming practices. De...

journal_title：JAMA dermatology

authors： Truesdale MD,Osterberg EC,Gaither TW,Awad MA,Elmer-DeWitt MA,Sutcliffe S,Allen I,Breyer BN

更新日期：2017-11-01 00:00:00

abstract：Importance:Because moisturizer use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists. Objective:To determine the product performance characteristics and ingredients of best-selling moisturizers. Design and Settin...

journal_title：JAMA dermatology

authors： Xu S,Kwa M,Lohman ME,Evers-Meltzer R,Silverberg JI

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE:Atopic dermatitis (AD) is a common skin condition treated by dermatologists, allergists, pediatricians, and primary care physicians. Several treatment guidelines and therapeutic parameters exist for the management of this disease. Health care professionals may be unaware of guidelines created by specialty or...

journal_title：JAMA dermatology

authors： Mohan GC,Lio PA

更新日期：2015-09-01 00:00:00

abstract：Importance:Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective:To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants:This cohort study of a large nationa...

journal_title：JAMA dermatology

authors： Ascha M,Ascha MS,Tanenbaum J,Bordeaux JS

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE:Topical corticosteroids are the current first-line therapy for vulvar lichen sclerosus (VLS). UV-A1 phototherapy may be a promising alternative treatment option, but controlled studies are lacking. OBJECTIVE:To compare the efficacy of high-potent topical corticosteroids with UV-A1 phototherapy in the treatm...

journal_title：JAMA dermatology

authors： Terras S,Gambichler T,Moritz RK,Stücker M,Kreuter A

更新日期：2014-06-01 00:00:00

abstract：IMPORTANCE:Lichen sclerosus (LS) is an uncommon chronic inflammatory disease that most commonly affects anogenital skin of postmenopausal women. It typically manifests as atrophic white plaques, which may be accompanied by purpura or fissuring. Rarely, LS has been observed to affect mucosal tissues in the mouth and the...

journal_title：JAMA dermatology

authors： Zendell K,Edwards L

更新日期：2013-10-01 00:00:00

abstract：IMPORTANCE:Treatment outcomes depend on adherence to the prescribed regimen. Primary nonadherence refers to not obtaining and starting to take a prescribed medication. The frequency of primary nonadherence to acne treatment has not been well characterized. The complexity of multidrug acne regimens may add to this probl...

journal_title：JAMA dermatology

authors： Anderson KL,Dothard EH,Huang KE,Feldman SR

更新日期：2015-06-01 00:00:00

abstract：Importance:Necrobiotic xanthogranuloma (NXG) is a non-Langerhans cell histiocytosis classically associated with paraproteinemia attributable to plasma-cell dyscrasias or lymphoproliferative disorders. Despite the morbidity of NXG, the literature is limited to case reports and small studies, and diagnostic criteria are ...

journal_title：JAMA dermatology

authors： Nelson CA,Zhong CS,Hashemi DA,Ashchyan HJ,Brown-Joel Z,Noe MH,Imadojemu S,Micheletti RG,Vleugels RA,Wanat KA,Rosenbach M,Mostaghimi A

更新日期：2020-03-01 00:00:00

abstract：Importance:Hemophagocytic lymphohistiocytosis (HLH) has been reported as a serious complication of cutaneous T-cell lymphoma (CTCL). Despite available diagnostic guidelines, it remains a diagnostic and therapeutic challenge in this patient population. Objectives:To examine the characteristics of CTCL associated with H...

journal_title：JAMA dermatology

authors： Lee DE,Martinez-Escala ME,Serrano LM,Zhou XA,Kaplan JB,Pro B,Choi J,Guitart J

更新日期：2018-07-01 00:00:00

abstract：Importance:Sun-protective behavior affects skin cancer prevention. Shade works by physically shielding skin from direct harmful UV rays; however, skin may still remain exposed to reflected and indirect UV rays. There is no current standard metric to evaluate shade for its effectiveness in sun protection, and there is i...

journal_title：JAMA dermatology

authors： Ou-Yang H,Jiang LI,Meyer K,Wang SQ,Farberg AS,Rigel DS

更新日期：2017-03-01 00:00:00

abstract：IMPORTANCE:Ustekinumab is a human monoclonal antibody that binds to the shared p40 subunit of interleukin (IL) 12 and IL-23. It is approved in the United States for adults (>18 years) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. In 1 phase 2 trial of ustekinumab for ...

journal_title：JAMA dermatology

authors： Stamell EF,Kutner A,Viola K,Cohen SR

更新日期：2013-12-01 00:00:00

abstract：IMPORTANCE:Recently, a group of melanocytic tumors with loss of BAP1 expression has been described. The lesions may occur sporadically or as part of a familial cancer syndrome. They have distinct histopathologic features characterized by a nevus like silhouette and cytologic composition of large epithelioid melanocytes...

journal_title：JAMA dermatology

authors： Busam KJ,Wanna M,Wiesner T

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Immune reconstitution inflammatory syndrome (IRIS) is a phenomenon initially described in patients with human immunodeficiency virus. Upon initiation of combination antiretroviral therapy, recovery of cellular immunity triggers inflammation to a preexisting infection or antigen that causes paradoxical worsen...

journal_title：JAMA dermatology

authors： Scharschmidt TC,Amerson EH,Rosenberg OS,Jacobs RA,McCalmont TH,Shinkai K

更新日期：2013-01-01 00:00:00

abstract：Importance:The risk for skin cancer has been well characterized in white organ transplant recipients (OTRs); however, most patients on the waiting list for organ transplant in the United States are nonwhite. Little is known about cutaneous disease and skin cancer risk in this OTR population. Objective:To compare the i...

journal_title：JAMA dermatology

authors： Chung CL,Nadhan KS,Shaver CM,Ogrich LM,Abdelmalek M,Cusack CA,Malat GE,Pritchett EN,Doyle A

更新日期：2017-06-01 00:00:00

abstract：Importance:How patients' mental health is associated with their satisfaction with physicians is rarely studied among adults with skin conditions. Objective:To examine the association between mental health comorbidities in patients with psoriasis and their satisfaction with physicians. Design, Setting, and Participant...

journal_title：JAMA dermatology

authors： Read C,Armstrong AW

更新日期：2020-07-01 00:00:00

abstract：Importance:Chronic urticaria (CU) affects 0.1% to 0.3% of children. Most cases have no identifiable trigger and are classified as chronic spontaneous urticaria (CSU). At least half of patients with CSU may have an autoimmune etiology that can be determined in vitro using the basophil activation test (BAT). While 30% to...

journal_title：JAMA dermatology

authors： Netchiporouk E,Sasseville D,Moreau L,Habel Y,Rahme E,Ben-Shoshan M

更新日期：2017-12-01 00:00:00

abstract：Importance:Cutaneous squamous cell carcinoma (cSCC) has metastatic potential, but the prognostic value of current staging systems in nonselected patients is uncertain. Objective:To assess the effect of risk factors for metastasis and to evaluate validity and usefulness of 4 staging systems for cSCC using population-ba...

journal_title：JAMA dermatology

authors： Roscher I,Falk RS,Vos L,Clausen OPF,Helsing P,Gjersvik P,Robsahm TE

更新日期：2018-04-01 00:00:00

abstract：IMPORTANCE:Worse survival among patients with melanoma has been demonstrated in middle-aged and older men compared with women, but few studies have explored survival differences by sex in adolescents and young adults, in whom melanoma is the third most common cancer. Focusing on sex disparities in survival among younge...

journal_title：JAMA dermatology

authors： Gamba CS,Clarke CA,Keegan TH,Tao L,Swetter SM

更新日期：2013-08-01 00:00:00