Immune reconstitution reactions in human immunodeficiency virus-negative patients: report of a case and review of the literature.

abstract：Importance:Population-level disease metrics are critical to guide the distribution of resources and implementation of public health initiatives. Internet search data reflect population interest in health topics and may be an alternative metric of disease characteristics when traditional sources are lacking, such as in ...

journal_title：JAMA dermatology

authors： Wehner MR,Nead KT,Linos E

更新日期：2017-09-01 00:00:00

abstract：Importance:Skin cancer, the most common cancer in the United States, is highly associated with outdoor and indoor tanning behaviors. Although indoor tanning has been suggested to be more common among sexual minority (self-reported as homosexual, gay, or bisexual) men compared with heterosexual men, whether rates of ski...

journal_title：JAMA dermatology

authors： Mansh M,Katz KA,Linos E,Chren MM,Arron S

更新日期：2015-12-01 00:00:00

abstract：IMPORTANCE:Lichen sclerosus (LS) is an uncommon chronic inflammatory disease that most commonly affects anogenital skin of postmenopausal women. It typically manifests as atrophic white plaques, which may be accompanied by purpura or fissuring. Rarely, LS has been observed to affect mucosal tissues in the mouth and the...

journal_title：JAMA dermatology

authors： Zendell K,Edwards L

更新日期：2013-10-01 00:00:00

abstract：Importance:Increased rates of autoimmune conditions have been reported in association with systemic lupus erythematosus (SLE). Little is known about coexisting autoimmune conditions in patients with cutaneous lupus erythematosus (CLE) without SLE. Objective:To determine the prevalence and risk factors of having coexis...

journal_title：JAMA dermatology

authors： Kunzler E,Hynan LS,Chong BF

更新日期：2018-06-01 00:00:00

abstract：Importance:Hidradenitis suppurativa (HS) places a significant burden on the health-related quality of life (HRQOL) of patients, many of whom have depression. Resilience can play a role in mitigating the negative stressors, such as the symptoms of HS, on patients' mental health. Objective:To investigate the correlation...

journal_title：JAMA dermatology

authors： Kirby JS,Butt M,Esmann S,Jemec GBE

更新日期：2017-12-01 00:00:00

abstract：Importance:Necrobiotic xanthogranuloma (NXG) is a non-Langerhans cell histiocytosis classically associated with paraproteinemia attributable to plasma-cell dyscrasias or lymphoproliferative disorders. Despite the morbidity of NXG, the literature is limited to case reports and small studies, and diagnostic criteria are ...

journal_title：JAMA dermatology

authors： Nelson CA,Zhong CS,Hashemi DA,Ashchyan HJ,Brown-Joel Z,Noe MH,Imadojemu S,Micheletti RG,Vleugels RA,Wanat KA,Rosenbach M,Mostaghimi A

更新日期：2020-03-01 00:00:00

abstract：Importance:Cutaneous squamous cell carcinoma (cSCC) has metastatic potential, but the prognostic value of current staging systems in nonselected patients is uncertain. Objective:To assess the effect of risk factors for metastasis and to evaluate validity and usefulness of 4 staging systems for cSCC using population-ba...

journal_title：JAMA dermatology

authors： Roscher I,Falk RS,Vos L,Clausen OPF,Helsing P,Gjersvik P,Robsahm TE

更新日期：2018-04-01 00:00:00

abstract：Importance:There is limited information regarding the influence of patient demographics, tumor characteristics, and treatment type on the survival of patients with dermatofibrosarcoma protuberans (DFSP). Objective:To assess prognostic factors and to evaluate the influence of treatment modality on overall survival of p...

journal_title：JAMA dermatology

authors： Criscito MC,Martires KJ,Stein JA

更新日期：2016-12-01 00:00:00

abstract：Clinical Question:Which treatments have been shown to be effective in randomized clinical trials (RCTs) for hidradenitis suppurativa (HS) in adults? Bottom Line:There is high-quality evidence of benefit from adalimumab given weekly, while every other week dosing is ineffective, with reductions in Dermatology Life Qual...

journal_title：JAMA dermatology

authors： Ingram JR

更新日期：2017-05-01 00:00:00

abstract：Importance:Erythropoietic protoporphyria (EPP) is a rare hereditary disease of heme biosynthesis that manifests as severe photosensitivity and hepatotoxicity. There have been no effective treatments to date. Cimetidine has been shown to inhibit heme biosynthesis and results in symptomatic improvement in patients with a...

journal_title：JAMA dermatology

authors： Tu JH,Sheu SL,Teng JM

更新日期：2016-11-01 00:00:00

abstract：IMPORTANCE:Omalizumab has emerged as a novel and effective treatment option for patients with antihistamine-resistant chronic urticaria. It is unclear whether patients with recurrent urticaria symptoms after discontinuation of omalizumab treatment can benefit from retreatment. OBJECTIVE:To assess the response of patie...

journal_title：JAMA dermatology

authors： Metz M,Ohanyan T,Church MK,Maurer M

更新日期：2014-03-01 00:00:00

abstract：IMPORTANCE:Atopic dermatitis (AD) is a common skin condition treated by dermatologists, allergists, pediatricians, and primary care physicians. Several treatment guidelines and therapeutic parameters exist for the management of this disease. Health care professionals may be unaware of guidelines created by specialty or...

journal_title：JAMA dermatology

authors： Mohan GC,Lio PA

更新日期：2015-09-01 00:00:00

abstract：Importance:Incidence rates of skin cancer are increasing globally, and the correct classification of skin lesions (SLs) into benign and malignant tissue remains a continuous challenge. A collective intelligence approach to skin cancer detection may improve accuracy. Objective:To evaluate the performance of 2 well-know...

journal_title：JAMA dermatology

authors： Kurvers RH,Krause J,Argenziano G,Zalaudek I,Wolf M

更新日期：2015-12-01 00:00:00

abstract：Importance:Melanoma treatment has been revolutionized with the development of immune-based therapies that offer durable clinical responses in a subset of patients. Clinical outcomes after treatment by immunotherapy can be influenced by the host's immune system. The immune system is modified with age by age-related immu...

journal_title：JAMA dermatology

authors： Perier-Muzet M,Gatt E,Péron J,Falandry C,Amini-Adlé M,Thomas L,Dalle S,Boespflug A

更新日期：2018-01-01 00:00:00

abstract：Importance:Psoriasis of the scalp, palms and/or soles, and nails is challenging to treat. Objective:To evaluate the effect of guselkumab on psoriasis in specific body regions. Design, Setting, and Participants:VOYAGE 1 and VOYAGE 2 were, double-blind, placebo- and adalimumab-controlled studies of guselkumab conducted...

journal_title：JAMA dermatology

authors： Foley P,Gordon K,Griffiths CEM,Wasfi Y,Randazzo B,Song M,Li S,Shen YK,Blauvelt A

更新日期：2018-06-01 00:00:00

abstract：IMPORTANCE:Mobile smartphones are rapidly emerging as an effective means of communicating with many Americans. Using mobile applications (apps), they can access remote databases, track time and location, and integrate user input to provide tailored health information. OBJECTIVE:A smartphone mobile app providing person...

journal_title：JAMA dermatology

authors： Buller DB,Berwick M,Lantz K,Buller MK,Shane J,Kane I,Liu X

更新日期：2015-05-01 00:00:00

abstract：IMPORTANCE:Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), occurs in elderly patients and has been considered as a lymphoma with a poor prognosis, with estimated 5-year specific survival rates of approximately 50%. The hypothesis of an improvement in prognosis over time has not been studied. OB...

journal_title：JAMA dermatology

authors： Grange F,Joly P,Barbe C,Bagot M,Dalle S,Ingen-Housz-Oro S,Maubec E,D'Incan M,Ram-Wolff C,Dalac S,Templier I,Esteve E,Quereux G,Machet L,Leduc M,Dereure O,Laroche L,Saiag P,Vergier B,Beylot-Barry M

更新日期：2014-05-01 00:00:00

abstract：Importance:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) have a dynamic relationship not yet fully understood. Investigation has been limited thus far by a paucity of data on the overlap of these disorders in pediatric patients. Objective:To use data from the Pediatric Contact Dermatitis Registry to elu...

journal_title：JAMA dermatology

authors： Jacob SE,McGowan M,Silverberg NB,Pelletier JL,Fonacier L,Mousdicas N,Powell D,Scheman A,Goldenberg A

更新日期：2017-08-01 00:00:00

abstract：Importance:The dupilumab regimen of 300 mg every 2 weeks is approved for uncontrolled, moderate to severe atopic dermatitis (AD). Objective:To assess the efficacy and safety of different dupilumab regimens in maintaining response after 16 weeks of initial treatment. Design, Setting, and Participants:The Study to Conf...

journal_title：JAMA dermatology

authors： Worm M,Simpson EL,Thaçi D,Bissonnette R,Lacour JP,Beissert S,Kawashima M,Ferrándiz C,Smith CH,Beck LA,Chan KC,Chen Z,Akinlade B,Hultsch T,Staudinger H,Gadkari A,Eckert L,Davis JD,Rajadhyaksha M,Graham NMH,Pirozzi

更新日期：2020-02-01 00:00:00

abstract：Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of sui...

journal_title：JAMA dermatology

authors： Nguyen DD,Marchese M,Cone EB,Paciotti M,Basaria S,Bhojani N,Trinh QD

更新日期：2021-01-01 00:00:00

abstract：Importance:A phase 2 trial comparing talimogene laherparepvec plus ipilimumab vs ipilimumab monotherapy in patients with advanced unresectable melanoma found no differential benefit in progression-free survival (PFS) but noted objective response rates (ORRs) of 38.8% (38 of 98 patients) vs 18.0% (18 of 100 patients), r...

journal_title：JAMA dermatology

authors： Almutairi AR,Alkhatib NS,Oh M,Curiel-Lewandrowski C,Babiker HM,Cranmer LD,McBride A,Abraham I

更新日期：2019-01-01 00:00:00

abstract：IMPORTANCE:Recently, a group of melanocytic tumors with loss of BAP1 expression has been described. The lesions may occur sporadically or as part of a familial cancer syndrome. They have distinct histopathologic features characterized by a nevus like silhouette and cytologic composition of large epithelioid melanocytes...

journal_title：JAMA dermatology

authors： Busam KJ,Wanna M,Wiesner T

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:To calculate sunbed use prevalence rates, to investigate the motivations for tanning, and to identify typical target groups for interventions to prevent skin cancer. DESIGN:Cross-sectional, representative, population-based study, primary analysis of the SUN-Study 2012 (Sunbed-Use: Needs for Action-Study). ...

journal_title：JAMA dermatology

authors： Schneider S,Diehl K,Bock C,Schlüter M,Breitbart EW,Volkmer B,Greinert R

更新日期：2013-01-01 00:00:00

abstract：Importance:Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis. Objective:To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. Design, Setting, and ...

journal_title：JAMA dermatology

authors： El Sharouni MA,Aivazian K,Witkamp AJ,Sigurdsson V,van Gils CH,Scolyer RA,Thompson JF,van Diest PJ,Lo SN

更新日期：2020-12-23 00:00:00

abstract：Importance:Patients with vascular malformations (VAMs) and vascular overgrowth syndromes have lower health-related quality of life (HRQoL) attributable to social stigmatization, poor mental health, severity, and pain. However, the factors that contribute to this decreased HRQoL are not clear. Objective:To perform a sy...

journal_title：JAMA dermatology

authors： Nguyen HL,Bonadurer GF 3rd,Tollefson MM

更新日期：2018-06-01 00:00:00

abstract：Importance:Pubic hair grooming is a common practice that can lead to injury and morbidity. Objective:To identify demographic and behavioral risk factors associated with pubic hair grooming-related injuries to characterize individuals with high risk of injury and develop recommendations for safe grooming practices. De...

journal_title：JAMA dermatology

authors： Truesdale MD,Osterberg EC,Gaither TW,Awad MA,Elmer-DeWitt MA,Sutcliffe S,Allen I,Breyer BN

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE:Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. OBJECTIVE:To describe the clinical features and outcome of hydroxychloroquine (HCQ)-induced pigmentation in patients with...

journal_title：JAMA dermatology

authors： Jallouli M,Francès C,Piette JC,Huong du LT,Moguelet P,Factor C,Zahr N,Miyara M,Saadoun D,Mathian A,Haroche J,De Gennes C,Leroux G,Chapelon C,Wechsler B,Cacoub P,Amoura Z,Costedoat-Chalumeau N,Plaquenil LUpus Systemic

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:The efficacy of treatment for psoriasis must be balanced against potential adverse events. OBJECTIVE:To determine the effect of treatment on the risk of serious infections in patients with psoriasis. DESIGN, SETTING, AND PARTICIPANTS:A multicenter, longitudinal, disease-based registry (Psoriasis Longitudin...

journal_title：JAMA dermatology

authors： Kalb RE,Fiorentino DF,Lebwohl MG,Toole J,Poulin Y,Cohen AD,Goyal K,Fakharzadeh S,Calabro S,Chevrier M,Langholff W,You Y,Leonardi CL

更新日期：2015-09-01 00:00:00

abstract：Importance:Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases. Objectives:To evaluate the specificity of PDGFB express...

journal_title：JAMA dermatology

authors： Nakamura I,Kariya Y,Okada E,Yasuda M,Matori S,Ishikawa O,Uezato H,Takahashi K

更新日期：2015-12-01 00:00:00

abstract：Importance:Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. Objective:T...

journal_title：JAMA dermatology

authors： Mansouri B,Kivelevitch D,Natarajan B,Joshi AA,Ryan C,Benjegerdes K,Schussler JM,Rader DJ,Reilly MP,Menter A,Mehta NN

更新日期：2016-11-01 00:00:00