Lichen sclerosus with vaginal involvement: report of 2 cases and review of the literature.

abstract：Importance:Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective:To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants:A ret...

journal_title：JAMA dermatology

authors： Bronckers IMGJ,Seyger MMB,West DP,Lara-Corrales I,Tollefson M,Tom WL,Hogeling M,Belazarian L,Zachariae C,Mahé E,Siegfried E,Philipp S,Szalai Z,Vleugels RA,Holland K,Murphy R,Baselga E,Cordoro K,Lambert J,Alexopoulos

更新日期：2017-11-01 00:00:00

abstract：Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of sui...

journal_title：JAMA dermatology

authors： Nguyen DD,Marchese M,Cone EB,Paciotti M,Basaria S,Bhojani N,Trinh QD

更新日期：2021-01-01 00:00:00

abstract：Importance:Psoriasis of the scalp, palms and/or soles, and nails is challenging to treat. Objective:To evaluate the effect of guselkumab on psoriasis in specific body regions. Design, Setting, and Participants:VOYAGE 1 and VOYAGE 2 were, double-blind, placebo- and adalimumab-controlled studies of guselkumab conducted...

journal_title：JAMA dermatology

authors： Foley P,Gordon K,Griffiths CEM,Wasfi Y,Randazzo B,Song M,Li S,Shen YK,Blauvelt A

更新日期：2018-06-01 00:00:00

abstract：Importance:Exercise is recommended as an adjuvant treatment for venous leg ulceration (VLU) to improve calf muscle pump function. However, the association of exercise with VLU healing has not been properly aggregated, and the effectiveness of different exercise interventions has not been characterized. Objective:To su...

journal_title：JAMA dermatology

authors： Jull A,Slark J,Parsons J

更新日期：2018-11-01 00:00:00

abstract：IMPORTANCE:Describing the relationship between the availability of free prescription drug samples and dermatologists' prescribing patterns on a national scale can help inform policy guidelines on the use of free samples in a physician's office. OBJECTIVES:To investigate the relationships between free drug samples and ...

journal_title：JAMA dermatology

authors： Hurley MP,Stafford RS,Lane AT

更新日期：2014-05-01 00:00:00

abstract：IMPORTANCE:Ustekinumab is a human monoclonal antibody that binds to the shared p40 subunit of interleukin (IL) 12 and IL-23. It is approved in the United States for adults (>18 years) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. In 1 phase 2 trial of ustekinumab for ...

journal_title：JAMA dermatology

authors： Stamell EF,Kutner A,Viola K,Cohen SR

更新日期：2013-12-01 00:00:00

abstract：Importance:Breslow thickness is a 1-dimensional surrogate prognostic feature for tumor size, yet tissue sections have 2 dimensions. Therefore, a 2-dimensional feature, calculated tumor area (CTA), was devised. Objective:To determine CTA precision and prognostic value. Design, Setting, and Participants:This retrospect...

journal_title：JAMA dermatology

authors： Saldanha G,Yarrow J,Elsheikh S,O'Riordan M,Uraiby H,Bamford M

更新日期：2019-06-26 00:00:00

abstract：Importance:How patients' mental health is associated with their satisfaction with physicians is rarely studied among adults with skin conditions. Objective:To examine the association between mental health comorbidities in patients with psoriasis and their satisfaction with physicians. Design, Setting, and Participant...

journal_title：JAMA dermatology

authors： Read C,Armstrong AW

更新日期：2020-07-01 00:00:00

abstract：IMPORTANCE:Worse survival among patients with melanoma has been demonstrated in middle-aged and older men compared with women, but few studies have explored survival differences by sex in adolescents and young adults, in whom melanoma is the third most common cancer. Focusing on sex disparities in survival among younge...

journal_title：JAMA dermatology

authors： Gamba CS,Clarke CA,Keegan TH,Tao L,Swetter SM

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:Although cutaneous warts are common lesions, full remission is not always achieved with conventional therapies. Laser modalities including carbon dioxide (CO2), erbium:yttrium-aluminum-garnet (Er:YAG), pulsed dye (PDL), and Nd:YAG have been investigated as alternative treatments for warts. OBJECTIVE:To revi...

journal_title：JAMA dermatology

authors： Nguyen J,Korta DZ,Chapman LW,Kelly KM

更新日期：2016-09-01 00:00:00

abstract：Importance:Melanoma risk factors and incidence in renal transplant recipients can inform decision making for both patients and clinicians. Objective:To determine risk factors and characteristics of renal transplant recipients who develop melanoma. Design, Setting, and Participants:This cohort study of a large nationa...

journal_title：JAMA dermatology

authors： Ascha M,Ascha MS,Tanenbaum J,Bordeaux JS

更新日期：2017-11-01 00:00:00

abstract：IMPORTANCE:Solid-organ transplant recipients (OTRs) are at an increased risk for skin cancer. Prior studies have demonstrated a reduced incidence of skin cancer in renal OTRs treated with sirolimus. However, little information exists on the use of sirolimus for the prevention of skin cancer in nonrenal OTRs or those al...

journal_title：JAMA dermatology

authors： Karia PS,Azzi JR,Heher EC,Hills VM,Schmults CD

更新日期：2016-05-01 00:00:00

abstract：Importance:Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer that develops in the deep dermis to subcutaneous adipose tissues. A COL1A1-PDGFB gene fusion, leading to the constitutive expression of PDGFB, is the tumorigenic mechanism in most DFSP cases. Objectives:To evaluate the specificity of PDGFB express...

journal_title：JAMA dermatology

authors： Nakamura I,Kariya Y,Okada E,Yasuda M,Matori S,Ishikawa O,Uezato H,Takahashi K

更新日期：2015-12-01 00:00:00

abstract：Importance:Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis. Objective:To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. Design, Setting, and ...

journal_title：JAMA dermatology

authors： El Sharouni MA,Aivazian K,Witkamp AJ,Sigurdsson V,van Gils CH,Scolyer RA,Thompson JF,van Diest PJ,Lo SN

更新日期：2020-12-23 00:00:00

abstract：Importance:Erythromelalgia is a clinical diagnosis based on intermittent warmth, erythema, and pain in the distal extremities. One problem facing physicians is how to objectively test for this disease. Given that other painful conditions of the distal extremities (ie, neuropathy related to human immunodeficiency virus,...

journal_title：JAMA dermatology

authors： Mantyh WG,Dyck PJB,Dyck PJ,Engelstad JK,Litchy WJ,Sandroni P,Davis MDP

更新日期：2017-02-01 00:00:00

abstract：IMPORTANCE:While monotherapy with biologic agents is effective for many patients with psoriasis, some patients require combination therapy. Evidence-based recommendations on combination therapy provide guidance for treating appropriately selected patients with psoriasis. OBJECTIVE:To make evidence-based, best-practice...

journal_title：JAMA dermatology

authors： Armstrong AW,Bagel J,Van Voorhees AS,Robertson AD,Yamauchi PS

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE:Sarcoidosis is a chronic granulomatous disease for which there are limited therapeutic options. This is the first randomized, placebo-controlled study to demonstrate that antimycobacterial therapy reduces lesion diameter and disease severity among patients with chronic cutaneous sarcoidosis. OBJECTIVE:To ev...

journal_title：JAMA dermatology

authors： Drake WP,Oswald-Richter K,Richmond BW,Isom J,Burke VE,Algood H,Braun N,Taylor T,Pandit KV,Aboud C,Yu C,Kaminski N,Boyd AS,King LE

更新日期：2013-09-01 00:00:00

abstract：IMPORTANCE:Cryolipolysis is the noninvasive reduction of fat with localized cutaneous cooling. Since initial introduction, over 650,000 cryolipolysis treatment cycles have been performed worldwide. We present a previously unreported, rare adverse effect following cryolipolysis: paradoxical adipose hyperplasia. OBSERVA...

journal_title：JAMA dermatology

authors： Jalian HR,Avram MM,Garibyan L,Mihm MC,Anderson RR

更新日期：2014-03-01 00:00:00

abstract：IMPORTANCE:Mitotic rate is now recognized as having independent prognostic significance in melanoma survival. However, its clinicopathologic associations have not been the focus of any previous study. OBJECTIVE:To identify a set of patient and tumor characteristics associated with high-mitotic-rate melanoma with the a...

journal_title：JAMA dermatology

authors： Shen S,Wolfe R,McLean CA,Haskett M,Kelly JW

更新日期：2014-10-01 00:00:00

abstract：Importance:Dermatologists, pulmonologists, and rheumatologists study and treat patients with sarcoidosis with cutaneous manifestations. The validity of cutaneous sarcoidosis outcome instruments for use across medical specialties remains unknown. Objective:To assess the reliability and validity of cutaneous sarcoidosis...

journal_title：JAMA dermatology

authors： Yeung H,Farber S,Birnbaum BK,Dunham J,Ogdie A,Patterson KC,Payne AS,Porteous MK,Rossman MD,Sharim R,Takeshita J,Werth VP,Shin DB,Price S,Rosenbach M

更新日期：2015-12-01 00:00:00

abstract：Importance:The dupilumab regimen of 300 mg every 2 weeks is approved for uncontrolled, moderate to severe atopic dermatitis (AD). Objective:To assess the efficacy and safety of different dupilumab regimens in maintaining response after 16 weeks of initial treatment. Design, Setting, and Participants:The Study to Conf...

journal_title：JAMA dermatology

authors： Worm M,Simpson EL,Thaçi D,Bissonnette R,Lacour JP,Beissert S,Kawashima M,Ferrándiz C,Smith CH,Beck LA,Chan KC,Chen Z,Akinlade B,Hultsch T,Staudinger H,Gadkari A,Eckert L,Davis JD,Rajadhyaksha M,Graham NMH,Pirozzi

更新日期：2020-02-01 00:00:00

abstract：Importance:Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. Objective:T...

journal_title：JAMA dermatology

authors： Mansouri B,Kivelevitch D,Natarajan B,Joshi AA,Ryan C,Benjegerdes K,Schussler JM,Rader DJ,Reilly MP,Menter A,Mehta NN

更新日期：2016-11-01 00:00:00

abstract：Importance:Necrobiotic xanthogranuloma (NXG) is a non-Langerhans cell histiocytosis classically associated with paraproteinemia attributable to plasma-cell dyscrasias or lymphoproliferative disorders. Despite the morbidity of NXG, the literature is limited to case reports and small studies, and diagnostic criteria are ...

journal_title：JAMA dermatology

authors： Nelson CA,Zhong CS,Hashemi DA,Ashchyan HJ,Brown-Joel Z,Noe MH,Imadojemu S,Micheletti RG,Vleugels RA,Wanat KA,Rosenbach M,Mostaghimi A

更新日期：2020-03-01 00:00:00

abstract：Importance:Hemophagocytic lymphohistiocytosis (HLH) has been reported as a serious complication of cutaneous T-cell lymphoma (CTCL). Despite available diagnostic guidelines, it remains a diagnostic and therapeutic challenge in this patient population. Objectives:To examine the characteristics of CTCL associated with H...

journal_title：JAMA dermatology

authors： Lee DE,Martinez-Escala ME,Serrano LM,Zhou XA,Kaplan JB,Pro B,Choi J,Guitart J

更新日期：2018-07-01 00:00:00

abstract：IMPORTANCE:Recent data demonstrated somatic mutations in GJB2 that were present in affected porokeratotic eccrine ostial and dermal duct nevus (PEODDN) tissue but absent in unaffected skin. Recognizing that PEODDN lesions can also appear in individuals with keratitis-ichthyosis-deafness syndrome and finding somatic mut...

journal_title：JAMA dermatology

authors： Levinsohn JL,McNiff JM,Antaya RJ,Choate KA

更新日期：2015-06-01 00:00:00

abstract：Importance:High-cost biologic therapies have transformed the management of immune-mediated inflammatory diseases. To optimize outcomes and reduce costs, dose adjustment informed by measurement of circulating drug levels has been shown to be effective in various settings. However, limited evidence exists for this approa...

journal_title：JAMA dermatology

authors： Tsakok T,Wilson N,Dand N,Loeff FC,Bloem K,Baudry D,Duckworth M,Pan S,Pushpa-Rajah A,Standing JF,de Vries A,Alsharqi A,Becher G,Murphy R,Wahie S,Wright A,Griffiths CEM,Reynolds NJ,Barker J,Warren RB,Burden AD,Ris

更新日期：2019-09-18 00:00:00

abstract：IMPORTANCE:Omalizumab has emerged as a novel and effective treatment option for patients with antihistamine-resistant chronic urticaria. It is unclear whether patients with recurrent urticaria symptoms after discontinuation of omalizumab treatment can benefit from retreatment. OBJECTIVE:To assess the response of patie...

journal_title：JAMA dermatology

authors： Metz M,Ohanyan T,Church MK,Maurer M

更新日期：2014-03-01 00:00:00

abstract：IMPORTANCE:Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. OBJECTIVE:To describe the clinical features and outcome of hydroxychloroquine (HCQ)-induced pigmentation in patients with...

journal_title：JAMA dermatology

authors： Jallouli M,Francès C,Piette JC,Huong du LT,Moguelet P,Factor C,Zahr N,Miyara M,Saadoun D,Mathian A,Haroche J,De Gennes C,Leroux G,Chapelon C,Wechsler B,Cacoub P,Amoura Z,Costedoat-Chalumeau N,Plaquenil LUpus Systemic

更新日期：2013-08-01 00:00:00

abstract：IMPORTANCE:The efficacy of treatment for psoriasis must be balanced against potential adverse events. OBJECTIVE:To determine the effect of treatment on the risk of serious infections in patients with psoriasis. DESIGN, SETTING, AND PARTICIPANTS:A multicenter, longitudinal, disease-based registry (Psoriasis Longitudin...

journal_title：JAMA dermatology

authors： Kalb RE,Fiorentino DF,Lebwohl MG,Toole J,Poulin Y,Cohen AD,Goyal K,Fakharzadeh S,Calabro S,Chevrier M,Langholff W,You Y,Leonardi CL

更新日期：2015-09-01 00:00:00

abstract：IMPORTANCE:Mutations driving melanoma growth have diagnostic, prognostic, and therapeutic implications. Traditional classification systems do not correlate optimally with underlying melanoma growth-promoting mutations. Our objective was to determine whether unique dermoscopic growth patterns directly correlate with dri...

journal_title：JAMA dermatology

authors： Sanchez MI,Rabinovitz HS,Oliviero MC,Elgart GW,Perez C,Puig S,Malvehy J,Grichnik JM

更新日期：2014-06-01 00:00:00