Vaccines against Clostridium perfringens alpha-toxin.

abstract：:Elaboration of the structure of TRPV1 and its functional relationship with channel activity is a work in progress, with much remaining to be done before the structure-function relationship of TRPV1 is comprehensively elicited. The result is that the present state of knowledge can reasonably be described as a patch-wor...

journal_title：Current pharmaceutical biotechnology

authors： Urban L,White JP,Nagy I

更新日期：2011-01-01 00:00:00

abstract：:Understanding and consequently treating neuropathic pain effectively is a challenge for modern medicine, as unlike inflammation, which can be controlled relatively well, chronic pain due to nerve injury is refractory to most current therapeutics. Here we define a target pathway for a new class of analgesics, tetrahydr...

journal_title：Current pharmaceutical biotechnology

authors： Latremoliere A,Costigan M

更新日期：2011-10-01 00:00:00

abstract：:Most cancer patients will experience moderate to severe pain and/or neuropathy during the course of their disease. Recent improvements in the primary treatment of cancer have increased the life span of cancer patients, but not necessarily their quality of life (QoL). The pain and suffering cancer patients experience m...

journal_title：Current pharmaceutical biotechnology

authors： Knopp KL,Nisenbaum ES,Arneric SP

更新日期：2011-10-01 00:00:00

abstract：:Proliposomes are phospholipid based drug delivery systems that are finding important applications in the field of pharmaceutics. Proliposomes have been extensively studied as a potential carrier for oral delivery of drugs with poor bioavailability, but the mechanism of absorption and cellular uptake pathways has not y...

journal_title：Current pharmaceutical biotechnology

authors： Nekkanti V,Venkatesan N,Betageri GV

更新日期：2015-01-01 00:00:00

abstract：:A review of the developments on the analysis of residues of avermectins and milbemycins (both macrocyclic lactones) is presented. The macrocyclic lactones (MLs) are an important class of chemicals, which are used worldwide as veterinary drugs and as crop protection agents. As a result, residues of MLs are important fr...

journal_title：Current pharmaceutical biotechnology

authors： Danaher M,Radeck W,Kolar L,Keegan J,Cerkvenik-Flajs V

更新日期：2012-05-01 00:00:00

abstract：:Calendula officinalis of family Asteraceae, also known as marigold, has been widely used from time immemorial in Indian and Arabic cultures as an anti-inflammatory agent to treat minor skin wound and infections, burns, bee stings, sunburn and cancer. At a relatively high dose, calendula can lower blood pressure and ch...

journal_title：Current pharmaceutical biotechnology

authors： Ray D,Mukherjee S,Falchi M,Bertelli A,Das DK

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...

journal_title：Current pharmaceutical biotechnology

authors： El-Aziz AMA,Shaker MA,Shaaban MI

更新日期：2019-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical biotechnology

authors： Blum K,Baron D

更新日期：2019-01-01 00:00:00

abstract：:With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, ...

journal_title：Current pharmaceutical biotechnology

authors： Presta LG

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Vancomycin is used mostly to overcome infections caused by methicillinresistant microorganisms. There are no well-established administration protocols for neonates and infants, so the leak of a specific administration regime in that population may lead to serum concentrations beyond the specified range. OBJ...

journal_title：Current pharmaceutical biotechnology

authors： Bidu NS,Fernandes BJD,Dias EJC,Filho JNC,Bastos REA,Godoy ALPC,Azeredo FJ,Pedreira JNR,Couto RD

更新日期：2019-01-01 00:00:00

abstract：:In the past decade, a range of dental products have appeared which make advertising claims around preventing mineral loss or repairing mineral loss. This review examines the requirements for effective protection of tooth structure, and the evidence around technologies now available for preventing tooth structure loss ...

journal_title：Current pharmaceutical biotechnology

authors： Walsh LJ

更新日期：2017-01-01 00:00:00

abstract：:Chronic inflammation and oxidative stress increase with advancing age and appear to be involved in the pathogenesis of coronary heart disease, the leading cause of death worldwide. There is a need for animal models that reflect the increases in pro-inflammatory cytokines and oxidative damage observed during aging in h...

journal_title：Current pharmaceutical biotechnology

authors： Schiborr C,Eckert GP,Weissenberger J,Müller WE,Schwamm D,Grune T,Rimbach G,Frank J

更新日期：2010-12-01 00:00:00

abstract：:Comprehensive analytical technologies are rapidly becoming a cornerstone of modern nutritional sciences. Two of these technologies, mass spectrometry (MS) and nuclear magnetic resonance (NMR), have proven highly informative for the global analysis of metabolites, commonly referred to as metabolomics. Metabolomics prov...

journal_title：Current pharmaceutical biotechnology

authors： Zulyniak MA,Mutch DM

更新日期：2011-07-01 00:00:00

abstract：:Tinospora cordifolia (Giloy) is a medicinal plant used in folk and Ayurvedic medicines throughout India since ancient times. All the parts of the plant are immensely useful due to the presence of different compounds of pharmaceutical importance belonging to various groups as alkaloids, diterpenoid lactones, glycosides...

journal_title：Current pharmaceutical biotechnology

authors： Kumar P,Kamle M,Mahato DK,Bora H,Sharma B,Rasane P,Bajpai VK

更新日期：2020-01-01 00:00:00

abstract：:Momordica balsamina, African pumpkin (Cucurbitaceae), is a tendril-bearing, wild climber containing wide spectrum of medicinal and nutritional values and has been used as a traditional folk medicine in many countries. The leaves, fruits, seeds, and bark of the plant contains resins, alkaloids, flavonoids, glycosides, ...

journal_title：Current pharmaceutical biotechnology

authors： Thakur GS,Bag M,Sanodiya BS,Bhadouriya P,Debnath M,Prasad GB,Bisen PS

更新日期：2009-11-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is widely used to promote tissue repair and accelerate osteogenesis, but there is no agreement about its mechanism of action. We characterized the modulatory effect of PRP on the in vitro osteoblast model SaOS-2, by using cell motility/chemoattraction and osteogenesis/mineralization assays, ...

journal_title：Current pharmaceutical biotechnology

authors： Martinotti S,Mazzucco L,Balbo V,Patrone M,Mozzati M,Ranzato E,Burlando B

更新日期：2014-01-01 00:00:00

abstract：:Charged-hydrophobic mixed mode chromatography methods have been applied to antibody purification for decades and have focused more recently on the specific task of aggregate removal. They exploit various combinations of alkyl and aromatic hydrophobic groups with positively and/or negatively charged residues. Charge an...

journal_title：Current pharmaceutical biotechnology

authors： Gagnon P

更新日期：2009-06-01 00:00:00

abstract：:Essential oils have increased interest as promising ingredients for novel pharmaceutical dosage forms. These oils are reported to provide synergistic effects of their active ingredients, in parallel with their biodegradable properties. In addition, essential oils may also have therapeutic effects in diabetes, inflamma...

journal_title：Current pharmaceutical biotechnology

authors： Severino P,Andreani T,Chaud MV,Benites CI,Pinho SC,Souto EB

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is the most common disease in Egypt. In this context, Beta vulgaris subspecies cicla L. var. flavescens is an edible plant that has been used in traditional medicine as a therapy for treating some diseases. OBJECTIVES:The current study was performed to evaluate the antibacterial and potent...

journal_title：Current pharmaceutical biotechnology

authors： Mohammed HS,Abdel-Aziz MM,Abu-Baker MS,Saad AM,Mohamed MA,Ghareeb MA

更新日期：2019-01-01 00:00:00

abstract：:In recent years, many systems biology approaches have been used with various cancers. The materials described here can be used to build bases to discover novel cancer therapy targets in connection with computer-aided drug design (CADD). A deeper understanding of the mechanisms of cancer will provide more choices and c...

journal_title：Current pharmaceutical biotechnology

authors： Wong YH,Chiu CC,Lin CL,Chen TS,Jheng BR,Lee YC,Chen J,Chen BS

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries. OBJECTIVE:The effects of Brequinar Sodium (BQR) and 4SC-1...

journal_title：Current pharmaceutical biotechnology

authors： Kadir MFA,Othman S,Nellore K

更新日期：2020-01-01 00:00:00

abstract：:Until recently, most research efforts aimed at developing anti-cancer tools were focusing on small molecules. Alternative compounds are now being increasingly assessed for their potential anti-cancer properties, including peptides and their derivatives. One earlier limitation to the use of peptides was their limited c...

journal_title：Current pharmaceutical biotechnology

authors： Barras D,Widmann C

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:RA is one of autoimmune diseases, has drawn great attention of the world. Currently, the anti- IL-1β monoclonal antibody Canakinumab (ACZ885) for treatment of RA has entered into clinical trials. However, Full length antibody has large molecular weight, and is difficult to penetrate the tissue or the nidus. I...

journal_title：Current pharmaceutical biotechnology

authors： Li T,Xu L,Ren G,Yin C,Zhou B,Ye X,Li Q,Li N,Li D

更新日期：2013-01-01 00:00:00

abstract：:Tumor immune surveillance paradigm presumes that most pre-malignant cells or early malignant lesions can be eliminated (or at least controlled) by cells of the immune system. A critical feature that distinguishes advanced tumors from early neoplastic lesions is their capability to evade immune control. As a consequenc...

journal_title：Current pharmaceutical biotechnology

authors： Klener P Jr,Otáhal P,Lateckova L,Klener P

更新日期：2015-01-01 00:00:00

abstract：:Chitin and chitosan derivatives are used as excipients and drug carriers in the pharmaceutical field. Their derivatization contributed to expansion of application and decrease toxicity. Chitosan is used as an excipient in oral dosage form. Chitosan tablet can exhibit a sustained drug release compared to commercial pro...

journal_title：Current pharmaceutical biotechnology

authors： Kato Y,Onishi H,Machida Y

更新日期：2003-10-01 00:00:00

abstract：:Tryparedoxin peroxidase (TryP) is a key enzyme of the trypanothione-dependent metabolism for removal of oxidative stress in leishmania. These enzymes function as antioxidants through their peroxidase and peroxynitrite reductase activities. Inhibitors of this enzyme are presumed to be antilesihmania drugs and structura...

journal_title：Current pharmaceutical biotechnology

authors： Singh BK,Dubey VK

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Terminalia arjuna (TA) has been reported and explored traditionally for its cardiotonic properties while the mechanism of antihypertensive effect of TA has not been clearly reported. METHOD:The oxidative stress is a major cause for hypertension, hence different extracts of TA having variable marker yield we...

journal_title：Current pharmaceutical biotechnology

authors： Khatkar S,Nanda A,Ansari SH

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Bacteriophages are viruses, which are obligate parasites of specific bacteria for the completion of their lifecycle. Bacteriophages could be the possible alternative to antibioticresistant bacterial diseases. With this objective, extensive research in different fields is published which are discussed in this...

journal_title：Current pharmaceutical biotechnology

authors： Adhikari N,Acharya KP

更新日期：2020-01-01 00:00:00

abstract：:Celiac Disease (CD) is an immune-mediated enteropathy, generally of the proximal intestine, that occurs in genetically susceptible individuals triggered by the ingestion of gluten. The incidence and frequency of CD are increasing, and it is predicted that CD affects approximately 1% of the people worldwide. The common...

journal_title：Current pharmaceutical biotechnology

authors： Azimi T,Nasser A,Shariati A,Shiadeh SMJ,Safari H,Alizade-Sani M,Taghipour A,Dehghan A

更新日期：2020-01-01 00:00:00

abstract：:Raman spectroscopy has long been used as a powerful tool for chemical composition analyses. Raman scattering light measurement has the advantage of being able to examine biomolecules in a nondestructive and non-labeling manner. However, molecular imaging of cells and tissues by using Raman microscopy had been hampered...

journal_title：Current pharmaceutical biotechnology

authors： Harada Y,Takamatsu T

更新日期：2013-01-01 00:00:00