Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake.

abstract：:Charged-hydrophobic mixed mode chromatography methods have been applied to antibody purification for decades and have focused more recently on the specific task of aggregate removal. They exploit various combinations of alkyl and aromatic hydrophobic groups with positively and/or negatively charged residues. Charge an...

journal_title：Current pharmaceutical biotechnology

authors： Gagnon P

更新日期：2009-06-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (also known as statins) are drugs active in the blockade of cholesterol synthesis and thus lowering cholesterol serum levels. Since their discovery, experimental evidence showed that statins strongly reduced atherogenesis and the risk of acute ischem...

journal_title：Current pharmaceutical biotechnology

authors： Montecucco F,Quercioli A,Mirabelli-Badenier M,Viviani GL,Mach F

更新日期：2012-01-01 00:00:00

abstract：:Beyond their originally sole mechanical function, current drug-eluting stents (DES) implement the concept of local drug delivery for the re-opening of stenotic arterial vessels, and for prevention of in-stent restenosis as one of the major limitations of conventional bare metal stents (BMS). Current DES consist of a p...

journal_title：Current pharmaceutical biotechnology

authors： Sternberg K,Grabow N,Petersen S,Weitschies W,Harder C,Ince H,Kroemer HK,Schmitz KP

更新日期：2013-01-01 00:00:00

abstract：:The recent developement of platelet concentrate for surgical use is an evolution of the fibrin glue technologies used since many years. The initial concept of these autologous preparations was to concentrate platelets and their growth factors in a plasma solution, and to activate it into a fibrin gel on a surgical sit...

journal_title：Current pharmaceutical biotechnology

authors： Bielecki T,Dohan Ehrenfest DM

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory disease with a huge impact on a person's quality of life. A correct therapy is required for relieving symptoms, reversing signs and preventing further anatomical changes. OBJECTIVE:The main objective of the present paper is to provide suggestions for t...

journal_title：Current pharmaceutical biotechnology

authors： Borghi A,Corazza M

更新日期：2021-01-01 00:00:00

abstract：:Melanogenesis is simply defined as production of melanin in melanosomes by melanocytes through a complex process. Melanin, a pigment derived from L-tyrosine, comes into two forms, namely eumelanin (brownish to black) and pheomelanin (red to yellow). Melanin synthesis starts via the hydroxylation of L-tyrosine to L-3,4...

journal_title：Current pharmaceutical biotechnology

authors： Orhan IE,Deniz FSS

更新日期：2020-12-10 00:00:00

abstract：:Chitin and chitosan derivatives are used as excipients and drug carriers in the pharmaceutical field. Their derivatization contributed to expansion of application and decrease toxicity. Chitosan is used as an excipient in oral dosage form. Chitosan tablet can exhibit a sustained drug release compared to commercial pro...

journal_title：Current pharmaceutical biotechnology

authors： Kato Y,Onishi H,Machida Y

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The re-emerging of targeting Dihydroorotate Dehydrogenase (DHODH) in cancer treatment particularly Acute Myelogenous Leukemia (AML) has corroborated the substantial role of DHODH in cancer and received the attention of many pharmaceutical industries. OBJECTIVE:The effects of Brequinar Sodium (BQR) and 4SC-1...

journal_title：Current pharmaceutical biotechnology

authors： Kadir MFA,Othman S,Nellore K

更新日期：2020-01-01 00:00:00

abstract：:Cancer is one of the leading causes of death in the United States and accounts for approximately 8 million deaths per year worldwide. Although there is an increasing number of therapeutic options available for patients with cancer, their efficacy is time-limited and non-curative. Approximately 50-60% cancer patients i...

journal_title：Current pharmaceutical biotechnology

authors： Gutheil WG,Reed G,Ray A,Anant S,Dhar A

更新日期：2012-01-01 00:00:00

abstract：:Nitric oxide (NO) participates in the control of the cardiovascular system where two constitutive isoforms of NO-synthase were discovered: endothelial and neuronal. Both isoforms were observed in various cells, however, endothelial NO-synthase is predominantly present in the endothelium. Injury of the endothelium dist...

journal_title：Current pharmaceutical biotechnology

authors： Cacanyiova S

更新日期：2011-09-01 00:00:00

abstract：:Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop. This cleavage of a single phosphodiester bond inactivates the ribosome and leads to protein synthesis inhibition and cell death...

journal_title：Current pharmaceutical biotechnology

authors： Carreras-Sangrà N,Alvarez-García E,Herrero-Galán E,Tomé J,Lacadena J,Alegre-Cebollada J,Oñaderra M,Gavilanes JG,Martínez-Del-Pozo A

更新日期：2008-06-01 00:00:00

abstract：:Blood Brain Barrier (BBB) is the collection of vessels of blood with special properties of permeability that allow a limited range of drug and compounds to pass through it. The BBB plays a vital role in maintaining balance between intracellular and extracellular environment for brain. Brain Capillary Endothelial Cells...

journal_title：Current pharmaceutical biotechnology

authors： Saxena D,Sharma A,Siddiqui MH,Kumar R

更新日期：2019-01-01 00:00:00

abstract：:The idea of cancer stem cell (CSC) has recently moved to the forefront of cancer research. There is still a lack of a widespread consensus on their description and definition. ,The increasing literature on CSCs has compelled researchers worldwide to rewrite the natural history of cancer including those cells as princi...

journal_title：Current pharmaceutical biotechnology

authors： Albini A,Cesana E,Noonan DM

更新日期：2011-02-01 00:00:00

abstract：:With eleven therapeutic antibodies approved worldwide and many more in clinical trials, research on antibody engineering has continued to escalate and expand. This review covers recent progress in generation of antibodies by ex vivo methods, systems for screening these, and the quest for higher affinity, more stable, ...

journal_title：Current pharmaceutical biotechnology

authors： Presta LG

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:A variety of technologies can be used in the detection of contagious pathogens. In the early stage of an outbreak of a new infectious disease, rtPCR is advantageous over many other assays. The rtPCR can be developed either using low fidelity DNA polymerase or high fidelity DNA polymerase. The application of high fidel...

journal_title：Current pharmaceutical biotechnology

authors： Li K,Xiao L,Liu C,Zhang J,Sirois P

更新日期：2010-01-01 00:00:00

abstract：:The prospect of mobilizing the power of the immune system in the fight against cancer has fascinated generations of immunologists. After decades of sporadic successes scattered amongst frequent failures, the field of tumor immunology is now poised to take advantage of a greatly improved understanding of the molecular ...

journal_title：Current pharmaceutical biotechnology

authors： Rabinovich BA,Radu CG

更新日期：2010-09-01 00:00:00

abstract：:The biliary secretion of bile acids is critical for multiple liver functions including digesting fatty nutrients and driving bile flow. When this process is impaired, the accumulating bile acids cause inflammatory liver injury. Multiple ABC transporters in the liver are key players to safeguard the hepatocyte and avoi...

journal_title：Current pharmaceutical biotechnology

authors： Wang R,Sheps JA,Ling V

更新日期：2011-04-01 00:00:00

abstract：:Conventional biochemical assays are performed via an averaging procedure with the lysate of a large number of target cells; however, the averaged data lose information regarding the heterogeneity of individual cells. For quantitative assay of single cells, it is necessary to isolate single cells, extract cellular comp...

journal_title：Current pharmaceutical biotechnology

authors： Sasaki A,Sakata H,Kinjo M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:L2-based Human Papillomavirus (HPV) prophylactic vaccines, containing epitopes from HPV minor capsid proteins, are under investigation as second-generation HPV vaccines. No such vaccine has passed clinical trials yet, mainly due to the low immunogenicity of peptide vaccines; so efforts are being continued. A...

journal_title：Current pharmaceutical biotechnology

authors： Negahdaripour M,Nezafat N,Heidari R,Erfani N,Hajighahramani N,Ghoshoon MB,Shoolian E,Rahbar MR,Najafipour S,Dehshahri A,Morowvat MH,Ghasemi Y

更新日期：2020-01-01 00:00:00

abstract：:Increasing evidence shows that the interaction between neoplastic cells and the surrounding stroma is a critical factor in solid tumor growth. The tumor stroma is made up of diverse cellular populations including macrophages, lymphocytes, vascular cells, and carcinoma-associated fibroblasts. The complex interactions b...

journal_title：Current pharmaceutical biotechnology

authors： Anton K,Glod J

更新日期：2009-02-01 00:00:00

abstract：:Excessive cell proliferation contributes to the pathobiology of human diseases with a high health and socio-economic impact, including cancer and vascular occlusive diseases (e. g., atherosclerosis, in-stent restenosis, transplant vasculopathy, and vessel bypass graft failure). Recent advances in the understanding of ...

journal_title：Current pharmaceutical biotechnology

authors： Ivorra C,Samyn H,Edo MD,Castro C,Sanz-González SM,Déez-Juan A,Andrés V

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Despite the extended laboratory and clinical study of sepsis, its diagnosis remains a clinical challenge. The initiation of sepsis activates many different biochemical and immunological pathways being expressed by alterations of various molecules in human tissues. The detection and measurement of the concent...

journal_title：Current pharmaceutical biotechnology

authors： Giannakopoulos K,Hoffmann U,Ansari U,Bertsch T,Borggrefe M,Akin I,Behnes M

更新日期：2017-01-01 00:00:00

abstract：:Higher plants produce diverse classes of metabolites. Metabolic engineering offers tremendous potential to improve the production and quality of these chemicals. This report summarizes the possibility of using metabolic engineering in benzylisoquinoline alkaloid biosynthesis. Benzylisoquinoline alkaloids, such as morp...

journal_title：Current pharmaceutical biotechnology

authors： Sato F,Inui T,Takemura T

更新日期：2007-08-01 00:00:00

abstract：AIMS:Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present st...

journal_title：Current pharmaceutical biotechnology

authors： Paul S,Mohanram K,Kannan I

更新日期：2018-01-01 00:00:00

abstract：:Coagulase-negative staphylococci (CoNS) are part of the microbiota of human skin and rarely linked with soft tissue infections. In recent years, CoNS species considered as one of the major nosocomial pathogens and can cause several infections such as catheter-acquired sepsis, skin infection, urinary tract infection, e...

journal_title：Current pharmaceutical biotechnology

authors： Noshak MA,Rezaee MA,Hasani A,Mirzaii M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：:Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

journal_title：Current pharmaceutical biotechnology

authors： Jalink K,Adjobo-Hermans MJ

更新日期：2014-01-01 00:00:00

abstract：:Discovery of disease specific biomarkers in human body fluids has become an important challenge in clinical proteomics. Facing the increasing threat of degenerative and disabling diseases like cancer, cardiovascular, neurological and inflammatory diseases in large parts of the world's population, there is an urgent ne...

journal_title：Current pharmaceutical biotechnology

authors： Berven FS,Flikka K,Berle M,Vedeler C,Ulvik RJ

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Fractalkine (FKN) in its free and membrane bound-forms and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of Single Nucleotide Polymorphisms (SNPs) in FKN and CX3CR1genes with the Coronary Artery Disease (CAD) risk showed conflicting results in different populations. The ...

journal_title：Current pharmaceutical biotechnology

authors： Hassan DS,Hashad IM,Abdel Rahman MF,Abdel-Maksoud SM

更新日期：2018-01-01 00:00:00