Raman molecular imaging of cells and tissues: towards functional diagnostic imaging without labeling.

abstract：BACKGROUND:Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spo...

journal_title：Current pharmaceutical biotechnology

authors： Luchetti MM,Benfaremo D,Gabrielli A

更新日期：2017-01-01 00:00:00

abstract：:Interleukin (IL)-7 is a cytokine inducing the Janus Kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway. As a consequence of IL-7 activating this pathway, STAT5 is phosphorylated. In pharmaceutical quality control, the potency of biopharmaceuticals is commonly assessed by proliferation assays....

journal_title：Current pharmaceutical biotechnology

authors： Zumpe C,Engel K,Wiedemann N,Metzger AU,Pischetsrieder M,Bachmann CL

更新日期：2011-10-01 00:00:00

abstract：:Cancer, as the most serious threat to human health, poses millions of deaths in the world each year. In vitro cancer cell and biomarker detection is of great importance for early cancer diagnosis and therapy, which needs highly sensitive, selective and quantitative diagnosis platforms. Threedimensional paper-based ele...

journal_title：Current pharmaceutical biotechnology

authors： Li Z,Hu J,Xu F,Li F

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：:Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-te...

journal_title：Current pharmaceutical biotechnology

authors： Nagahama M

更新日期：2013-01-01 00:00:00

abstract：:It is now widely believed that tumors originate from normal cells as a result of accumulated genetic/epigenetic changes. These alterations affect the signaling pathways at transcriptional and post-transcriptional level that drive cells into uncontrolled cell division, growth, and migration. Recent advancement of molec...

journal_title：Current pharmaceutical biotechnology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2008-10-01 00:00:00

abstract：:3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (also known as statins) are drugs active in the blockade of cholesterol synthesis and thus lowering cholesterol serum levels. Since their discovery, experimental evidence showed that statins strongly reduced atherogenesis and the risk of acute ischem...

journal_title：Current pharmaceutical biotechnology

authors： Montecucco F,Quercioli A,Mirabelli-Badenier M,Viviani GL,Mach F

更新日期：2012-01-01 00:00:00

abstract：:Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

journal_title：Current pharmaceutical biotechnology

authors： Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

更新日期：2016-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical biotechnology

authors： Blum K,Baron D

更新日期：2019-01-01 00:00:00

abstract：:Silkworm pupae protein is a good source of high quality protein. The hydrolyzates of silkworm pupae protein catalyzed by neutrase, pepsin, acidic protease (Asperqiius usamii NO. 537), flavourzyme, alcalase, and trypsin with inhibitory activity on angiotensin I-converting enzyme (ACE) were identified by HPLC. The hydro...

journal_title：Current pharmaceutical biotechnology

authors： Wang W,Shen S,Chen Q,Tanga B,He G,Ruan H,Das UN

更新日期：2008-08-01 00:00:00

abstract：:Carbon nanotubes are nano sized cylindrical chicken wire like structures made of carbon atoms. Carbon nanotubes have applications in electronics, energy storage, electromagnetic devices, environmental remediation and in medicine as well. The biomedical applications of carbon nanotubes can be owed to features like low ...

journal_title：Current pharmaceutical biotechnology

authors： Wani TU,Mohi-Ud-Din R,Wani TA,Hassan R,Itoo AM,Sheikh FA,Khan NA,Pottoo FH

更新日期：2020-11-10 00:00:00

abstract：:Polyphenols are a widely distributed group of natural products found in fruits, vegetables, nuts, seeds, stems and flowers. Such compounds, especially dietary flavonoids and tannins, have been shown to exert antioxidant, antiinflammatory, anti-cancer and antibacterial effects and may have beneficial effects on human h...

journal_title：Current pharmaceutical biotechnology

authors： Coppo E,Marchese A

更新日期：2014-01-01 00:00:00

abstract：:CNS disorders are the third major problem of health in developed countries, with approximately 10% of direct costs associated with a pharmacological treatment of doubtful cost-effectiveness. There is an alarming abuse of psychotropic drugs worldwide and only 20-30% of patients with CNS disorders appropriately respond ...

journal_title：Current pharmaceutical biotechnology

authors： Cacabelos R,Martinez-Bouza R,Carril JC,Fernandez-Novoa L,Lombardi V,Carrera I,Corzo L,McKay A

更新日期：2012-04-01 00:00:00

abstract：:Ivermectin is a broad spectrum antiparasitic veterinary drug introduced in human medicine in 1987. It is considered the drug of choice in onchocerciasis and strongyloidiasis infections, and remains as a therapeutic option for mass treatment in lymphatic filariasis, for which it has widely proved its efficacy. While re...

journal_title：Current pharmaceutical biotechnology

authors： González P,González FA,Ueno K

更新日期：2012-05-01 00:00:00

abstract：:Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop. This cleavage of a single phosphodiester bond inactivates the ribosome and leads to protein synthesis inhibition and cell death...

journal_title：Current pharmaceutical biotechnology

authors： Carreras-Sangrà N,Alvarez-García E,Herrero-Galán E,Tomé J,Lacadena J,Alegre-Cebollada J,Oñaderra M,Gavilanes JG,Martínez-Del-Pozo A

更新日期：2008-06-01 00:00:00

abstract：:The most challenging and fruitful biomedical research endeavor of this decade will be the mapping of cell signaling systems and establishing their linkages to normal and disease-related processes. Amongst other things, the Human Genome Sequencing Project has greatly facilitated MALDI-TOF mass spectrometry identificati...

journal_title：Current pharmaceutical biotechnology

authors： Pelech S

更新日期：2004-02-01 00:00:00

abstract：:Levels of high density lipoprotein (HDL) and its major protein component, apolipoprotein (apo) A-I, are strongly inversely correlated to risk of atherosclerosis and other vascular diseases. A number of properties of apo A-I may contribute to this protection, including removal of cholesterol from peripheral tissues to ...

journal_title：Current pharmaceutical biotechnology

authors： Garber DW,Handattu SP,Datta G,Mishra VK,Gupta H,White CR,Anantharamaiah GM

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:We have developed a high-pH, pH-shift refolding "Ph-Fold technology", both for academic research and industrial protein drug development applications. Using this technology, we were able to refold some "difficult-to-refold" proteins, some of which are proven important drug targets and protein drug candidates. The tech...

journal_title：Current pharmaceutical biotechnology

authors： Lin X,Umetsu T

更新日期：2010-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs), a form of adult stem cells, are known to have a self-renewing property and the potential to specialize into a multitude of cells and tissues such as adipocytes, cartilage cells, and fibroblasts. MSCs can migrate and home to the desired target zone where inflammation is present. The uniqu...

journal_title：Current pharmaceutical biotechnology

authors： Saeedi M,Nezhad MS,Mehranfar F,Golpour M,Esakandari MA,Rashmeie Z,Ghorbani M,Nasimi F,Hoseinian SN

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:Epithelial-mesenchymal transition (EMT) is a molecular reprogramming that leads to an increased ability to migrate, which can promote invasion and metastasis. EMT can be initiated in response to the activity of signaling pathways such as Wnt as well as miRNAs. OBJECTIVE:The aim of the study was to determine...

journal_title：Current pharmaceutical biotechnology

authors： Zmarzły N,Hermyt E,Kruszniewska-Rajs C,Gola J,Witek A,Mazurek U,Ostenda A,Boroń D

更新日期：2020-12-18 00:00:00

abstract：:Malignant glioma is a primary tumor of the central nervous system, representing a major cause of mortality in a young, productive subset of population. The management of this neoplasm requires aggressive treatments, including radiotherapy. Accurate imaging plays a central role in treatment planning process with curati...

journal_title：Current pharmaceutical biotechnology

authors： Marvaso G,Barone A,Amodio N,Cascini GL,Scotti V,Bianco C

更新日期：2014-01-01 00:00:00

abstract：:The design and development of novel biological drugs are among the most exciting new areas of biotechnology which are gaining the attention of scientists. In the last few decades several fabrication processes have been proposed and developed for the production of recombinant growth factors. However, traditional produc...

journal_title：Current pharmaceutical biotechnology

authors： Laura W,Pablo L,Arantxa A,Isabel B,Alberto R,Silvia J,Noelia C,de Francisco Ana,Raquel C,Gorka O

更新日期：2016-01-01 00:00:00

abstract：:Many theoretical models of molecular interactions, biochemical and chemical reactions are described on the single-molecule level, although our knowledge about the biochemical/chemical structure and dynamics primarily originates from the investigation of many-molecule systems. At present, there are four experimental pl...

journal_title：Current pharmaceutical biotechnology

authors： Földes-Papp Z,Baumann G,Demel U,Tilz GP

更新日期：2004-04-01 00:00:00

abstract：:Lipid nanocapsules with their unique composition represent a promising biocompatible drug delivery platform in nanometer range with narrow size distribution. They are highly stable in comparison to other nano-vectors and were found to impart very desirable characteristics to the therapeutic molecule being delivered wi...

journal_title：Current pharmaceutical biotechnology

authors： Nasr M,Abdel-Hamid S

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Frequent administrations for DPPIV-resistant GLP-1 analogs are necessary to maintain the blood concentrations due to the short half-life of less than 5 minutes. However, most delivery systems that possess the ability of sustainable release of GLP-1 have drawbacks such as low yield, high cost and undesirable s...

journal_title：Current pharmaceutical biotechnology

authors： Fan L,Fan Y,Fan H,Huang K

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of the work was to evaluate the effect of moderate physical exercise on the response of circulating phagocytes to the antineoplastic drug NSC 631570. METHODS:Eight healthy adult men aged 23 ± 2 years were recruited to participate in the study; NSC 631570 was administered i.v. in a single therapeutic ...

journal_title：Current pharmaceutical biotechnology

authors： Skivka LM,Fedorchuk OG,Susak YM,Susak MY,Malanchuk OM,Rudyk MP,Nowicky YW

更新日期：2015-01-01 00:00:00

abstract：:Nitric oxide (NO) participates in the control of the cardiovascular system where two constitutive isoforms of NO-synthase were discovered: endothelial and neuronal. Both isoforms were observed in various cells, however, endothelial NO-synthase is predominantly present in the endothelium. Injury of the endothelium dist...

journal_title：Current pharmaceutical biotechnology

authors： Cacanyiova S

更新日期：2011-09-01 00:00:00

abstract：:Assessment of immunogenicity is a major aspect in evaluating the safety of biological therapeutic proteins. It is important to evaluate the immunogenic potential of the biologics in an appropriate fashion using clearly defined strategy and clinical trials. The studies must include the appropriate risk assessment proce...

journal_title：Current pharmaceutical biotechnology

authors： Kaliyaperumal A,Jing S

更新日期：2009-06-01 00:00:00

abstract：:Using gene knockout mice of particular genes is one of the most effective methods in conducting successful study on the mode of action of target gene products in targeted organs. So called the knockout technology is now a powerful tool that can lead us to find clear understanding on difficult questions such as the eff...

journal_title：Current pharmaceutical biotechnology

authors： Miyamoto N,Namiki K,Tokuhara N,Uesugi M,Takahashi E,Kuromitsu J,Kasuya Y

更新日期：2009-02-01 00:00:00