High expression of AT-rich interactive domain 3A (ARID3A) is associated with good prognosis in colorectal carcinoma.

Abstract:

BACKGROUND:AT-rich interactive domain 3A (ARID3A) is a member of the ARID family of DNA-binding proteins. Previous reports have shown that ARID3A controls cell growth in a p53-dependent manner. Recently, it has been reported that expression of the ARID3A protein was markedly increased in colon cancer tissue compared with matched normal colonic mucosa. However, little is currently known about the role of ARID3A in colorectal cancer (CRC). The aim of this study was to investigate the clinical significance of ARID3A expression in CRC. METHODS:We examined ARID3A expression in 690 CRC patients using tissue microarray and immunohistochemistry. Kaplan-Meier analysis and Cox proportional hazard models were used to estimate the impact of ARID3A expression on overall survival. RESULTS:Of the 690 cases, 195 tumors were strongly positive for ARID3A, 187 were weakly positive, and 308 were negative. ARID3A expression in CRC was significantly correlated with age, degree of differentiation, depth of invasion, lymph node metastasis, distant metastasis, tumor-node-metastasis stage, status of microsatellite instability, and carcinoembryonic antigen levels. The overall survival of CRC patients with strong ARID3A expression was significantly longer than that of patients with weak or negative ARID3A expression. We also performed an additional survival analysis on 388 colon cancer patients and 302 rectal cancer patients. In doing so, a favorable prognostic effect of ARID3A expression was revealed only in the colon cancer group (p = 0.002), not in rectal cancer. Moreover, we showed that the effect of ARID3A on the survival was correlated with p53 status. Using multivariate analysis, we found that strong expression of ARID3A was an independent predictor for better prognosis in CRC. CONCLUSIONS:Our data suggested that strong expression of ARID3A may predict a good prognosis in patients with CRC.

journal_name

Ann Surg Oncol

authors

Song M,Kim H,Kim WK,Hong SP,Lee C,Kim H

doi

10.1245/s10434-013-3435-2

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

S481-9

eissn

1068-9265

issn

1534-4681

journal_volume

21 Suppl 4

pub_type

杂志文章
  • Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas.

    abstract:BACKGROUND:Genetic and epigenetic alterations during development of pancreatic ductal adenocarcinomas (PDAC) are well known. Genetic and epigenetic data were correlated with tumor biology to find specific alterations responsible for invasion and metastasis in pancreatic ductal adenocarcinomas. METHODS:A total of 16 hu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0531-4

    authors: Mees ST,Mardin WA,Sielker S,Willscher E,Senninger N,Schleicher C,Colombo-Benkmann M,Haier J

    更新日期:2009-08-01 00:00:00

  • Comparison of cases captured in the national cancer data base with those in population-based central cancer registries.

    abstract:BACKGROUND:The National Cancer Data Base (NCDB) is a large, geographically diverse hospital-based cancer registry that has been used to study factors related to cancer diagnosis, treatment, and survival. The primary purpose of this study was to compare the case counts and characteristics of patients in NCDB with popula...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2901-1

    authors: Lerro CC,Robbins AS,Phillips JL,Stewart AK

    更新日期:2013-06-01 00:00:00

  • How to approach thyroid nodules with indeterminate cytology.

    abstract:BACKGROUND:Ultrasound (US)-guided fine-needle aspiration biopsy (FNAB) is an accurate, reliable, and simple procedure to perform, and it is nowadays accepted as a standard diagnostic method for the differential diagnosis of thyroid nodules. However, a major limitation of US-FNAB is indeterminate cytology results at a t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0992-5

    authors: Yoon JH,Kwak JY,Kim EK,Moon HJ,Kim MJ,Kim JY,Koo HR,Kim MH

    更新日期:2010-08-01 00:00:00

  • Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma.

    abstract:INTRODUCTION:Actual 5-year survival rates of 10-18% have been reported for patients with resected pancreatic adenocarcinoma (PC), but the use of multimodality therapy was uncommon in these series. We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0295-2

    authors: Katz MH,Wang H,Fleming JB,Sun CC,Hwang RF,Wolff RA,Varadhachary G,Abbruzzese JL,Crane CH,Krishnan S,Vauthey JN,Abdalla EK,Lee JE,Pisters PW,Evans DB

    更新日期:2009-04-01 00:00:00

  • The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy.

    abstract::Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecula...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-999-0528-z

    authors: Bland KI

    更新日期:1999-09-01 00:00:00

  • Multicenter institutional experience of surgically resected thymic epithelial tumors (TETs): an observational report on behalf of F.O.N.I.C.A.P. (Forza Operativa Nazionale Interdisciplinare Contro il Cancro del Polmone).

    abstract:BACKGROUND:This multicenter analysis evaluated patient outcome and clinical pathologic features of thymic epithelial tumors after complete surgical resection and adjuvant treatment. METHODS:Histologic classification and clinical staging were performed according to WHO classification and Masaoka staging system, respect...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-013-3018-2

    authors: Genestreti G,Ampollini L,Burgio MA,Rolli L,Sanna S,Scarpi E,Monti M,Burgio SL,Giannone L,Santo A,Mezzetti M,Casanova C,Buosi R,Rusca M,Amadori D,Gavelli G

    更新日期:2013-09-01 00:00:00

  • Morbidity of sentinel node biopsy: relationship between number of excised lymph nodes and patient perceptions of lymphedema.

    abstract:BACKGROUND:Sentinel lymph node biopsy (SLNB) is associated with reduced morbidity, although lymphedema remains a significant complication. Previously, we found no association between number of excised lymph nodes (LNs) and measured lymphedema in SLNB patients. In this analysis, we examined the relationship between numb...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1688-1

    authors: Goldberg JI,Riedel ER,Morrow M,Van Zee KJ

    更新日期:2011-10-01 00:00:00

  • Gastric cancer: establishing predictors of biologic behavior with use of population-based data.

    abstract:BACKGROUND:Tumor thickness and nodal status are important predictors of survival following curative resection for gastric cancer. Lymphovascular invasion (LVI) is a potential predictor of biological behavior. The relationship between LVI and tumor thickness (T status) has not been established in population-based studie...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/ASO.2004.09.002

    authors: Dicken BJ,Saunders LD,Jhangri GS,de Gara C,Cass C,Andrews S,Hamilton SM

    更新日期:2004-06-01 00:00:00

  • Intraoperative examination of sentinel nodes in breast cancer: is the glass half full or half empty?

    abstract:BACKGROUND:Intraoperative identification of positive sentinel lymph nodes in patients with breast cancer may avoid a return to the operating room. METHODS:In a group of 402 consecutive patients with primary breast cancer who underwent sentinel lymph node biopsy, an intraoperative examination (IE) was obtained in 236 c...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/ASO.2004.12.005

    authors: Fortunato L,Amini M,Farina M,Rapacchietta S,Costarelli L,Piro FR,Alessi G,Pompili P,Bianca S,Vitelli CE

    更新日期:2004-11-01 00:00:00

  • The impact of the introduction of total mesorectal excision on local recurrence rate and survival in rectal cancer: long-term results.

    abstract:PURPOSE:To investigate the influence of the introduction of total mesorectal excision (TME) on local recurrence rate and survival in patients with rectal cancer. METHODS:A total of 171 consecutive patients underwent anterior or abdominoperineal resection for primary rectal cancer. When the TME technique was introduced...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1571-0

    authors: Maurer CA,Renzulli P,Kull C,Käser SA,Mazzucchelli L,Ulrich A,Büchler MW

    更新日期:2011-07-01 00:00:00

  • Factors affecting survival after complete response to isolated limb perfusion in patients with in-transit melanoma.

    abstract:BACKGROUND:Isolated limb perfusion (ILP) results in complete response (CR) rates of 60% to 90% in patients with regionally advanced melanoma. Survival after a CR may be influenced by various factors, particularly out-of-field disease in iliac lymph nodes (ILN) identified during lower-extremity ILP. We examined clinical...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/s10434-001-0771-4

    authors: Zogakis TG,Bartlett DL,Libutti SK,Liewehr DJ,Steinberg SM,Fraker DL,Alexander HR

    更新日期:2001-12-01 00:00:00

  • Barriers to the Interpretation of Body Composition in Colorectal Cancer: A Review of the Methodological Inconsistency and Complexity of the CT-Defined Body Habitus.

    abstract:BACKGROUND:Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been identified as predictive of survival in colorectal cancer (CRC). We performed a systematic review of contemporary studies to characterize this association and highl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-018-6395-8

    authors: Hopkins JJ,Skubleny D,Bigam DL,Baracos VE,Eurich DT,Sawyer MB

    更新日期:2018-05-01 00:00:00

  • Association Between Patient Satisfaction and Short-Term Outcomes After Major Cancer Surgery.

    abstract:OBJECTIVE:The aim of this study was to investigate whether patient satisfaction, as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey, is associated with short-term outcomes after major cancer surgery. MATERIALS AND METHODS:We first used national Medicare claims to identi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6049-2

    authors: Kaye DR,Richardson CR,Ye Z,Herrel LA,Ellimoottil C,Miller DC

    更新日期:2017-11-01 00:00:00

  • Sarcopenia and Short-Term Outcomes After Esophagectomy: A Meta-analysis.

    abstract:BACKGROUND:This meta-analysis aimed to investigate the value of preoperative sarcopenia in predicting complications after esophagectomy. Clinicopathologic characteristics of sarcopenia patients, which may support sarcopenia management, also were studied. METHODS:This study searched for articles describing an associati...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08236-9

    authors: Wang PY,Xu LD,Chen XK,Xu L,Yu YK,Zhang RX,Sun HB,Wu HL,Li Y

    更新日期:2020-08-01 00:00:00

  • Molecular profiling of direct xenograft tumors established from human pancreatic adenocarcinoma after neoadjuvant therapy.

    abstract:BACKGROUND:Pancreatic adenocarcinoma is among the most resistant of human cancers, yet specific mechanisms of treatment resistance remain poorly understood. Models to study pancreatic cancer resistance remain limited and should reflect in vivo changes that occur within patient tumors. We sought to identify consistent, ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1839-4

    authors: Kim MP,Truty MJ,Choi W,Kang Y,Chopin-Lally X,Gallick GE,Wang H,McConkey DJ,Hwang R,Logsdon C,Abbruzzesse J,Fleming JB

    更新日期:2012-07-01 00:00:00

  • A Population-Based Analysis of Three Treatment Modalities for Malignant Obstruction of the Proximal Colon: Acute Resection Versus Stent or Stoma as a Bridge to Surgery.

    abstract:BACKGROUND:Malignant obstruction of the proximal colon (MOPC) traditionally has been treated with acute resection. However, morbidity and mortality rates following these emergency surgeries are high. Initial bowel decompression by stent placement or stoma construction has been used for distal obstructions as an alterna...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5247-7

    authors: Amelung FJ,Consten ECJ,Siersema PD,Tanis PJ

    更新日期:2016-10-01 00:00:00

  • Her-2/neu gene amplification in esophageal adenocarcinoma and its influence on survival.

    abstract:BACKGROUND:HER-2/neu (c-erbB-2, HER2) gene amplification and protein overexpression have been associated with poor prognosis in several solid tumors, including breast and gastric cancer. Its incidence and significance in esophageal adenocarcinoma is unknown. MATERIALS AND METHODS:Tissue microarrays were successfully c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1554-1

    authors: Thompson SK,Sullivan TR,Davies R,Ruszkiewicz AR

    更新日期:2011-07-01 00:00:00

  • Functional outcome of arthrodesis with a vascularized fibular graft and a rotational latissimus dorsi flap after proximal humerus sarcoma resection.

    abstract:BACKGROUND:The prognosis of humeral sarcomas has improved greatly in the past 20 years. As a result, the challenges for orthopedic oncologists include long-term handicap and local morbidity. METHODS:Shoulder reconstruction after the resection of sarcomas with the proximal humerus was evaluated for 55 patients from 199...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1443-z

    authors: Wang J,Shen J,Dickinson IC

    更新日期:2011-07-01 00:00:00

  • The usefulness of neoadjuvant chemoradiation therapy for locally advanced esophageal cancer with multiple lymph-node metastases.

    abstract:BACKGROUND:The prognosis of patients with esophageal squamous-cell cancer (ESCC) and multiple lymph-node metastases is quite poor. We examined whether neoadjuvant chemoradiation therapy (CRT) has a beneficial effect in such patients. METHODS:A total of 50 consecutive patients with T3-4 tumors and without organ metasta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3688-4

    authors: Okumura H,Uchikado Y,Omoto I,Kita Y,Sasaki K,Arigami T,Uenosono Y,Matsushita D,Hiraki Y,Owaki T,Ishigami S,Natsugoe S

    更新日期:2014-09-01 00:00:00

  • Nomogram predicting severe adverse events after musculoskeletal tumor surgery: analysis of a national administrative database.

    abstract:BACKGROUND:There have been no nationwide surveys of postoperative adverse events (AEs) after musculoskeletal tumor surgery focusing on their severity. Therefore, we developed a nomogram to predict severe AEs after musculoskeletal tumor surgery. METHODS:We identified patients in the Diagnosis Procedure Combination data...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3760-0

    authors: Ogura K,Yasunaga H,Horiguchi H,Fushimi K,Tanaka S,Kawano H

    更新日期:2014-10-01 00:00:00

  • ASO Author Reflections: Omentoplasty to Improve Perineal Wound Healing After Abdominoperineal Resection.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6799-5

    authors: Blok RD,Tanis PJ

    更新日期:2018-12-01 00:00:00

  • Long-term outcomes comparing surgery to embolization-ablation for treatment of solitary HCC

    abstract:BACKGROUND:Resection has been the standard of care for patients with solitary hepatocellular carcinoma (HCC). Transarterial embolization and percutaneous ablation are alternative therapies often reserved for suboptimal surgical candidates. Here we compare long-term outcomes of patients with solitary HCC treated with re...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2961-2

    authors: Elnekave E,Erinjeri JP,Brown KT,Thornton RH,Petre EN,Maybody M,Maluccio MA,Hsu M,Sofocleous CT,Getrajdman GI,Brody LA,Solomon SB,Alago W,Fong Y,Jarnagin WR,Covey AM

    更新日期:2013-09-01 00:00:00

  • Aggressive Hemihepatectomy Combined with Resection and Reconstruction of Middle Hepatic Vein for Intrahepatic Cholangiocarcinoma.

    abstract:BACKGROUND:Major hepatectomy for intrahepatic cholangiocarcinoma (ICC) sometimes involves resection of major hepatic veins, which might result in the future liver remnant (FLR) congestion. The necessity and efficacy of resection and reconstruction of the middle hepatic vein (MHV) during right or left hemihepatectomy fo...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5384-z

    authors: Miyata A,Sakamoto Y,Yamamoto S,Akamatsu N,Arita J,Kaneko J,Hasegawa K,Kokudo N

    更新日期:2016-08-01 00:00:00

  • The prognostic significance of nonsentinel lymph node metastasis in melanoma.

    abstract:BACKGROUND:We hypothesized that metastasis beyond the sentinel lymph nodes (SLN) to the nonsentinel nodes (NSN) is an important predictor of survival. MATERIALS AND METHODS:Analysis was performed of a prospective multi-institutional study that included patients with melanoma ≥ 1.0 mm in Breslow thickness. All patients...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1245/s10434-010-1208-8

    authors: Brown RE,Ross MI,Edwards MJ,Noyes RD,Reintgen DS,Hagendoorn LJ,Stromberg AJ,Martin RC,McMasters KM,Scoggins CR

    更新日期:2010-12-01 00:00:00

  • Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer.

    abstract:BACKGROUND:The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze cl...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5448-0

    authors: Kim HW,Kim JH,Lim BJ,Kim H,Kim H,Park JJ,Youn YH,Park H,Noh SH,Kim JW,Choi SH

    更新日期:2016-12-01 00:00:00

  • Long-term outcomes in patients with calciphylaxis from hyperparathyroidism.

    abstract:BACKGROUND:Calciphylaxis is a rare condition associated with chronic renal failure and entails a very poor prognosis. Pathogenesis is poorly understood but involves abnormalities in calcium and phosphorus metabolism that lead to vascular and extravascular calcification. Patients present with painful ulcerating plaques ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/ASO.2006.03.042

    authors: Duffy A,Schurr M,Warner T,Chen H

    更新日期:2006-01-01 00:00:00

  • OSNA-Assisted Molecular Staging in Colorectal Cancer: A Prospective Multicenter Trial in Japan.

    abstract:BACKGROUND:We previously reported that the one-step nucleic acid amplification (OSNA) assay provided a judgment performance for colorectal cancer equivalent to a 2-mm-interval histopathological examination of lymph nodes (concordance 97.1 %, n = 385 lymph nodes). In this prospective multicenter study, we uncovered an O...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-015-4880-x

    authors: Yamamoto H,Tomita N,Inomata M,Furuhata T,Miyake Y,Noura S,Kato T,Murata K,Hayashi S,Igarashi S,Itabashi M,Kameoka S,Matsuura N

    更新日期:2016-02-01 00:00:00

  • In Patients with Localized and Resectable Gastric Cancer, What is the Optimal Extent of Lymph Node Dissection-D1 Versus D2 Versus D3?

    abstract:BACKGROUND:Despite advances in the treatment of patients with gastric cancer, the debate over the optimal extent of lymphadenectomy continues. METHOD:A review of the classification, rationale for, and boundaries of lymphadenectomy is presented. A review of the available literature comparing D1 versus D2 versus D3 lymp...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07417-5

    authors: Mogal H,Fields R,Maithel SK,Votanopoulos K

    更新日期:2019-09-01 00:00:00

  • Patterns of Local Recurrence and Oncologic Outcomes in T3 Low Rectal Cancer (≤5 cm from the Anal Verge) Treated With Short-Course Radiotherapy With Delayed Surgery : Outcomes in T3 Low Rectal Cancer Treated With Short-Course Radiotherapy With Delayed Surg

    abstract:BACKGROUND:Short-course radiotherapy with delayed surgery (SRT-delay) is still under clinical investigation for its efficacy in treating low rectal cancer (≤5 cm from the anal verge). This study was designed to assess the pattern of local recurrence and oncologic outcomes in T3 low rectal cancer treated with SRT-delay....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5604-6

    authors: Beppu N,Kimura F,Aihara T,Doi H,Tomita N,Yanagi H,Yamanaka N

    更新日期:2017-01-01 00:00:00

  • Re-excision rates of invasive ductal carcinoma with lobular features compared with invasive ductal carcinomas and invasive lobular carcinomas of the breast.

    abstract:BACKGROUND:Invasive ductal carcinoma (IDC) with lobular features (IDC-L) is not recognized as a subtype of breast cancer. We previously showed that IDC-L may be a variant of IDC with clinicopathological characteristics more similar to invasive lobular carcinoma (ILC). We sought to determine the re-excision rates of IDC...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3871-7

    authors: Arps DP,Jorns JM,Zhao L,Bensenhaver J,Kleer CG,Pang JC

    更新日期:2014-12-01 00:00:00