Abstract:
:The effects of intraperitoneal injections of cholecystokinin (CCK), apelin, ghrelin, and orexin on food intake were examined in the blind cavefish Astyanax fasciatus mexicanus. CCK (50ng/g) induced a decrease in food intake whereas apelin (100ng/g), orexin (100ng/g), and ghrelin (100ng/g) induced an increase in food intake as compared to saline-injected control fish. In order to better understand the central mechanism by which these hormones act, we examined the effects of injections on the brain mRNA expression of two metabolic enzymes, tyrosine hydroxylase (TH), and mechanistic target of rapamycin (mTOR), and of appetite-regulating peptides, CCK, orexin, apelin and cocaine and amphetamine regulated transcript (CART). CCK injections induced a decrease in brain apelin injections, apelin injections induced an increase in TH, mTOR, and orexin brain expressions, orexin treatment increased brain TH expression and ghrelin injections induced an increase in mTOR and orexin brain expressions. CART expression was not affected by any of the injection treatments. Our results suggest that the enzymes TH and mTOR and the hormones CCK, apelin, orexin, and ghrelin all regulate food intake in cavefish through a complex network of interactions.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Penney CC,Volkoff Hdoi
10.1016/j.ygcen.2013.11.015subject
Has Abstractpub_date
2014-01-15 00:00:00pages
34-40eissn
0016-6480issn
1095-6840pii
S0016-6480(13)00456-5journal_volume
196pub_type
杂志文章abstract::Chicken growth hormone (cGH) has been shown to affect chicken skeletal muscle satellite cell proliferation and differentiation in vitro. This study describes the interactions of cGH with basic fibroblast growth factor (bFGF) and insulin-like growth factor I (IGF-I). Both cGH and bFGF induced cGH receptor (cGH-R) gene ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1997.6964
更新日期:1997-10-01 00:00:00
abstract::Acute stress in vertebrates generally stimulates the hypothalamo-pituitary-adrenal axis and is often associated with multiple metabolic changes, such as increased gluconeogenesis, and with behavioral alterations. Little information is available, especially in free-ranging organisms, on the duration of these reversible...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2016.06.020
更新日期:2016-08-01 00:00:00
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journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2018.12.012
更新日期:2019-04-01 00:00:00
abstract::In this study, parathyroid hormone (PTH) receptor binding was examined in the membrane fraction of the endometrium of the shell gland of laying and nonlaying hens by the use of (125)I-PTH-related peptide (PTHrP) binding assays. Specific (125)I-PTHrP binding was found in the endometrium of the shell gland and increased...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1999.7395
更新日期:2000-02-01 00:00:00
abstract::Fluctuations in plasma androgen (testosterone and 5 alpha-dihydrotestosterone), corticosterone (B), and luteinizing hormone (LH) of male bullfrogs in central California were measured during the spring mating season. Androgen and LH levels generally increased in the population prior to the initiation of chorusing and e...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(85)90343-0
更新日期:1985-05-01 00:00:00
abstract::Farnesylacetone, a molecule isolated from the androgenic glands of Carcinus maenas, inhibits vitellogenesis in the ovaries. Here the effect of farnesylacetone on protein and RNA synthesis in cultured organs is described. Both leucine and uridine incorporation in ovaries were inhibited with low concentration of farnesy...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90163-1
更新日期:1984-06-01 00:00:00
abstract::The neurosecretory caudo-dorsal cells (CDC) of the basommatopora Lymnaea stagnalis produce an ovulation hormone (CDCH), which is released at the periphery of the intercerebral commissure (COM). A rapid in vivo bioassay for CDCH has been established and is based on the dose-dependent relationship between the quantity o...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(83)90269-1
更新日期:1983-06-01 00:00:00
abstract::Jawed vertebrates (Gnasthostomes) are broadly separated into cartilaginous fishes (Chondricthyes) and bony vertebrates (Osteichthyes). Cartilaginous fishes are divided into chimaeras (e.g. ratfish, rabbit fish and elephant shark) and elasmobranchs (e.g. sharks, rays and skates). Both cartilaginous fish and bony verteb...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2013.06.021
更新日期:2013-11-01 00:00:00
abstract::The role of stress in the decline of Steller sea lions has become of interest in the identification of factors leading to their drastic decline and subsequent failure to recover. Serum cortisol was validated as a potential indicator of stress in three sub-populations inhabiting the majority of the Steller sea lions ra...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2009.06.006
更新日期:2010-01-01 00:00:00
abstract::Isospecific injections of intercerebral commissure (COM) extracts of L. stagnalis, L. palustris, and L. ovata (Lymnaeidae) and of extracts of COM/mediodorsal bodies complexes (COM/DB) of Bulinus truncatus (Bulinidae) and Biomphalaria glabrata (Planorbidae) induced oviposition in a high percentage of the experimental s...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(83)90164-8
更新日期:1983-10-01 00:00:00
abstract::Lampreys diverged from the jawed vertebrate lineage approximately 500million years ago. Lampreys undergo sex differentiation much later than most other vertebrates, and ovarian differentiation occurs several years before testicular differentiation. The genetic basis of lamprey sex differentiation is of particular inte...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.08.019
更新日期:2014-11-01 00:00:00
abstract::GPCRs are the largest family of receptors accounting for about 30% of the current drug targets. However, it is difficult to fully elucidate the mechanisms regulating intracellular GPCR signal regulation. It is thus important to consider and investigate GPCRs with respect to endogenous situations. Our group has been in...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.ygcen.2020.113474
更新日期:2020-07-01 00:00:00
abstract::Chronic confinement for 1 month caused a significant elevation of plasma cortisol but suppressed the levels of plasma testosterone and 11-ketotestosterone in sexually mature male brown trout. An acute handling stress for 1 hr elevated blood cortisol and ACTH levels and also suppressed circulating androgens. This andro...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/0016-6480(87)90036-0
更新日期:1987-11-01 00:00:00
abstract::The hybrids of carp (Cyprinus carpio) and goldfish (Carassius auratus) collected from the lower Great Lakes between 1978 and 1981 exhibited epizootics of gonadal neoplasm which were rare in the parental species. The pituitary glands of hybrids were, on average, 2.5 times larger than that of carp of similar body size. ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(88)90017-2
更新日期:1988-02-01 00:00:00
abstract::Steelhead Trout (Oncorhynchus mykiss) display a varied life-history, including precocious male maturation at age-1 or age-2. In wild fish, precocious male maturation represents an important component of a diverse life-history portfolio. In hatchery programs, however, it is undesirable if rearing practices increase rat...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2019.05.010
更新日期:2019-09-15 00:00:00
abstract::In goldfish, plasma gonadotropin levels increase during spawning in both males and females (GTH surge). A female-typical GTH surge induces ovulation (ovulatory surge), and a male-typical surge triggers milt production in response to sex pheromones released from ovulatory females. This study examined whether the male-t...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1997.6993
更新日期:1997-12-01 00:00:00
abstract::Anuran amphibians do not drink orally but absorb water osmotically through the highly permeable ventral skin. In this cutaneous water absorption, roles of the putative cerebral osmoreceptors and functions of arginine vasotocin (AVT) were examined in the central nervous system of the Japanese treefrog, Hyla japonica. I...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2008.04.014
更新日期:2008-06-01 00:00:00
abstract::Skin pigmentation pattern is a species-specific characteristic that depends on the number and the spatial combination of several types of chromatophores. This feature can change during life, for example in the metamorphosis or reproductive cycle, or as a response to biotic and/or abiotic environmental cues (nutrition,...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2020.113662
更新日期:2021-01-15 00:00:00
abstract::A technique is described for the measurement of cytoplasmic free calcium concentration ([Ca2+]c) in a suspension of goby intestinal epithelial cells using the fluorescent probe quin2. For 18 cell suspensions, [Ca2+]c was determined to be 142 +/- 14 nM. The caudal neurosecretory peptide urotensin II at 10(-7) to 10(-6)...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(86)90068-7
更新日期:1986-12-01 00:00:00
abstract::Two aspects of hormonal control of aggressive territorial behavior in male mountain spiny lizards Sceloporus jarrovi were studied. First, testosterone (T) implants were given to free-living castrated males during the breeding season. These implants fully restored breeding season levels of aggressive and sexual behavio...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(88)90121-9
更新日期:1988-06-01 00:00:00
abstract::Determination of serum progesterone concentrations over a period of 2 years in female camels during various reproductive stages (estrus, pregnant, nonpregnant, and lactating) suggests that the progesterone levels exceeding 1 ng/ml are reached only if mating is fertile. A cycling camel does not have a luteal phase and ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90248-x
更新日期:1984-02-01 00:00:00
abstract::We studied the in vitro effects of JH III and ecdysterone on RNA synthesis and secretory activities of the left colleterial gland (LCG) in mature females of Periplaneta americana during the reproductive cycle. We found that RNA synthesis is a cyclic and highly dynamic process. The major increases in poly(A)- RNA synth...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(88)90301-2
更新日期:1988-07-01 00:00:00
abstract::Big dynorphin (prodynorphin 209-240), dynorphin A (prodynorphin 209-225), dynorphin B (prodynorphin 228-240), beta-endorphin (beta-lipotrophin 61-90), or Met-enkephalin, each infused into the third ventricle, were tested for their effect on PRL release in the anesthetized turkey hen. Laying hens that received big dyno...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1121
更新日期:1993-08-01 00:00:00
abstract::The occurrence of myoendocrine-like cells investing the ampullar draining region of Malpighian tubules and neighboring midgut and hindgut regions of the ant Formica polyctena is reported. These striated muscle cells show small electron-dense endocrine-like granules (130 +/- 0.95 nm) in addition to myofilaments and ord...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1110
更新日期:1994-07-01 00:00:00
abstract::Maintaining energy balance and reproducing are important for fitness, yet animals have evolved mechanisms by which the hypothalamus-pituitary-adrenal/interrenal (HPA/HPI) axis can shut these activities off. While HPA/HPI axis inhibition of feeding and reproduction may have evolved as a predator defense, to date there ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.ygcen.2016.04.006
更新日期:2016-05-01 00:00:00
abstract::Wrasse species exhibit a definite daily rhythm in locomotor activity and bury themselves in the sand at the bottom of the ocean at night. It remains unclear how their behavior in locomotor activity is endogenously regulated. The aim of the present study was to clarify the involvement of melatonin and clock genes (Per1...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.01.007
更新日期:2012-05-15 00:00:00
abstract::Testosterone has been suggested to be involved in the regulation of male territorial behavior. For example, seasonal peaks in testosterone typically coincide with periods of intense competition between males for territories and mating partners. However, some species also express territorial behavior outside a breeding...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.11.027
更新日期:2013-04-01 00:00:00
abstract::The effects of thyroid hormone on the production of vitamin A(2) retinoids from vitamin A(1) precursor were investigated in retinal pigmented epithelial (RPE) cells obtained from juvenile coho salmon. Specifically, changes in the production of both the storage and the free forms of radiolabeled 3,4-didehydroretinoids ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.2001.7667
更新日期:2001-08-01 00:00:00
abstract::Several antisera specific to neuropeptides of vertebrates were applied to sections of the earthworm Eisenia fetida Sav. Some of them were able to reveal specific neurones of the supraoesophageal ganglion: h-GHRF, CRF, Leu- and Met-enkephalin, dynorphin, substance P, CCK-8, and CCK-8S. A map of different areas or nucle...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(87)90132-8
更新日期:1987-03-01 00:00:00
abstract::1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the hormonally active metabolite of vitamin D3 interacts with its nuclear/cytosolic receptor to induce biological responses in target tissues. Naked mole rats appear to be naturally deficient in vitamin D. The questions arise whether these animals possess the 1,25(OH)2D3 recepto...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1993.1089
更新日期:1993-06-01 00:00:00