Delayed granulocyte colony-stimulating factor treatment in rats attenuates mechanical allodynia induced by chronic constriction injury of the sciatic nerve.

Abstract:

STUDY DESIGN:Animal experimental study with intervention. OBJECTIVE:The aim of this study was to elucidate therapeutic effects of delayed granulocyte colony-stimulating factor treatment for mechanical allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. SUMMARY OF BACKGROUND DATA:Granulocyte colony-stimulating factor (G-CSF) is used clinically for patients with hematological disorders. Previous reports showed that immediate G-CSF attenuates neuropathic pain in CCI of the sciatic nerve. However, the acute treatment for neuropathic pain prior to accurate diagnosis is not realistic in clinical settings. METHODS:Adult, female Sprague-Dawley rats were subjected to the CCI model. This model induces mechanical allodynia on the ipsilateral hind paw within the first week after the injury. One week after CCI, rats received intraperitoneal G-CSF (15.0 μg/kg) for 5 consecutive days. Mechanical allodynia was assessed using the von Frey hair test. Immunohistochemistry for phosphorylated p38 mitogen-activated kinase (p-p38MAPK) and OX-42 (a marker for activated microglia) on tissue slides from a subset of rats 2 weeks after surgery. Western blot analyses were carried out to determine protein expression level of p-p38MAPK and interleukin-1 β on spinal cord homogenates 2 weeks after CCI. RESULTS:Results of the von Frey filament test showed that G-CSF significantly attenuates mechanical allodynia induced by the CCI model. Immunohistochemistry revealed that G-CSF reduced the number of p-p38MAPK-positive cells in the ipsilateral dorsal horn compared with that in the vehicle group rats. Immunofluorescent double staining revealed that p-p38MAPK-expressing cells in the spinal cord dorsal horn are mainly microglia. Western blot analysis indicated that G-CSF decreased the expression levels of both p-p38MAPK and interleukin-1 β in the ipsilateral dorsal horn compared with that in the vehicle group rats. CONCLUSION:The present results indicate a beneficial effect of delayed G-CSF treatment in an animal model of peripheral nerve injury-induced neuropathic pain. LEVEL OF EVIDENCE:N/A.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Koda M,Furuya T,Kato K,Mannoji C,Hashimoto M,Inada T,Kamiya K,Ota M,Maki S,Okawa A,Takahashi K,Ishikawa T,Yamazaki M

doi

10.1097/BRS.0000000000000108

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

192-7

issue

3

eissn

0362-2436

issn

1528-1159

journal_volume

39

pub_type

杂志文章

相关文献

SPINE文献大全
  • Stabilizing effect of precontracted neck musculature in whiplash.

    abstract:STUDY DESIGN:This study investigated the effect of neck muscle precontraction in aware occupants in whiplash. Head angulation relative to T1 and facet joint capsular ligament distractions were compared between aware and unaware occupants. OBJECTIVE:To quantify changes in facet joint capsular ligament distractions betw...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000240210.23617.e7

    authors: Stemper BD,Yoganandan N,Cusick JF,Pintar FA

    更新日期:2006-09-15 00:00:00

  • Vertebral rotatory subluxation in degenerative scoliosis: facet joint tropism is related.

    abstract:STUDY DESIGN:A cross-sectional study. OBJECTIVE:To identify facet tropism as one of the possible risk factors leading to vertebral rotatory subluxation (VRS). SUMMARY OF BACKGROUND DATA:VRS has been considered as one of the prognostic factors for degenerative scoliosis. Although several risk factors of VRS, including...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000494

    authors: Bao H,Zhu F,Liu Z,Bentley M,Mao S,Zhu Z,Ding Y,Qiu Y

    更新日期:2014-12-15 00:00:00

  • Accuracy of Patient-Specific 3D-Printed Drill Guides for Pedicle and Lateral Mass Screw Insertion: An Analysis of 76 Cervical and Thoracic Screw Trajectories.

    abstract:STUDY DESIGN:Single-center retrospective case series. OBJECTIVE:The purpose of this study was to assess the safety and accuracy of three-dimensional (3D)-printed individualized drill guides for pedicle and lateral mass screw insertion in the cervical and upper-thoracic region, by comparing the preoperative 3D surgical...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003747

    authors: Pijpker PAJ,Kraeima J,Witjes MJH,Oterdoom DLM,Vergeer RA,Coppes MH,Groen RJM,Kuijlen JMA

    更新日期:2021-02-01 00:00:00

  • Isolation of mesenchymal stem cells from human ligamentum flavum: implicating etiology of ligamentum flavum hypertrophy.

    abstract:STUDY DESIGN:To demonstrate the existence of mesenchymal stem cells (MSCs) in ligamentum flavum (LF) and their pathogenic role in LF hypertrophy. OBJECTIVE:To isolate and characterize LF-derived MSCs and their response to transforming growth factor-beta 1 (TGF-β1) and trichostatin A (TSA), a histone deacetylase inhibi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182053f58

    authors: Chen YT,Wei JD,Wang JP,Lee HH,Chiang ER,Lai HC,Chen LL,Lee YT,Tsai CC,Liu CL,Hung SC

    更新日期:2011-08-15 00:00:00

  • Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors.

    abstract:STUDY DESIGN:A retrospective review of 10 consecutive patients with a noninflammatory retro-odontoid pseudotumor. OBJECTIVE:To examine the radiographic characteristics in patients with a retro-odontoid pseudotumor and to evaluate the efficacy of posterior fusion. SUMMARY OF BACKGROUND DATA:A retro-odontoid pseudotumo...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31818acd27

    authors: Chikuda H,Seichi A,Takeshita K,Shoda N,Ono T,Matsudaira K,Kawaguchi H,Nakamura K

    更新日期:2009-02-01 00:00:00

  • Factors of thoracic cage deformity that affect pulmonary function in adolescent idiopathic thoracic scoliosis.

    abstract:STUDY DESIGN:This clinical study examined the association between pulmonary function and thoracic cage deformities in scoliosis. OBJECTIVE:To determine the factors in spinal and thoracic cage deformities that affect pulmonary function in scoliosis. SUMMARY OF BACKGROUND DATA:Pulmonary function in scoliosis has genera...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000251005.31255.25

    authors: Takahashi S,Suzuki N,Asazuma T,Kono K,Ono T,Toyama Y

    更新日期:2007-01-01 00:00:00

  • Effect of bone density on vertebral strength and stiffness after percutaneous vertebroplasty.

    abstract:STUDY DESIGN:An ex vivo biomechanical study using cadaveric vertebral bodies. OBJECTIVE:To determine how bone mineral density (BMD) affects mechanical strength and stiffness of the vertebral body after vertebroplasty, and to determine how the association between mechanical properties and BMD varies with amount of ceme...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318133fc73

    authors: Graham J,Ahn C,Hai N,Buch BD

    更新日期:2007-08-15 00:00:00

  • Rib deformities in congenital scoliosis.

    abstract:STUDY DESIGN:Retrospective review. OBJECTIVE:To identify the incidence and characteristics of rib anomalies in patients with congenital scoliosis (CS) in a Chinese population. SUMMARY OF BACKGROUND DATA:Rib deformities and intraspinal anomalies often coexist in individuals with CS. Rib deformities may assist in diagn...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000008

    authors: Xue X,Shen J,Zhang J,Zhao H,Li S,Zhao Y,Liang J,Qiu G,Weng X

    更新日期:2013-12-15 00:00:00

  • A biomechanical definition of spinal segmental instability taking personal and disc level differences into account.

    abstract::The biomechanical definition of spinal segmental instability has not been clarified sufficiently, because of the great personal and level differences in intervertebral disc deformation. This article proposes a new method of judging spinal segmental instability regardless of these differences, using lateral functional ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199311000-00027

    authors: Ito M,Tadano S,Kaneda K

    更新日期:1993-11-01 00:00:00

  • The validity of compliance monitors to assess wearing time of thoracic-lumbar-sacral orthoses in children with spinal cord injury.

    abstract:STUDY DESIGN:Prospective multicenter observation. OBJECTIVE:To determine the validity of 3 commercially available at recording thoracic-lumbar-sacral orthosis (TLSO) wearing time of children with spinal cord injury (SCI) and to assess each monitor's function during daily activities. SUMMARY OF BACKGROUND DATA:A major...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0b013e318178864e

    authors: Hunter LN,Sison-Williamson M,Mendoza MM,McDonald CM,Molitor F,Mulcahey MJ,Betz RR,Vogel LC,Bagley A

    更新日期:2008-06-15 00:00:00

  • Changes in lumbar disc angles of Chinese subjects from upright to flexion.

    abstract:STUDY DESIGN:This study analyzed the sizes and angles of vertebrae and discs in Chinese subjects. Lateral lumbar spine radiograph films were taken of subjects in upright and 60 degrees flexion positions to evaluate disc height and angle changes. OBJECTIVES:This study sought to gather data regarding the contribution of...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199407000-00013

    authors: Chen MW,Yang SW,Lee MC

    更新日期:1994-07-01 00:00:00

  • Prevalence, Comorbidities, and Risk of Perioperative Complications in Human Immunodeficiency Virus-Positive Patients Undergoing Cervical Spine Surgery.

    abstract:STUDY DESIGN:Retrospective database analysis. OBJECTIVE:To evaluate outcomes of human immunodeficiency virus (HIV) positive patients after cervical spine surgery. SUMMARY OF BACKGROUND DATA:Highly active antiretroviral medications have qualitatively altered the natural history of HIV, thus increasing the number of HI...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001103

    authors: Lovy AJ,Guzman JZ,Skovrlj B,Cho SK,Hecht AC,Qureshi SA

    更新日期:2015-11-01 00:00:00

  • Torulopsis glabrata spinal osteomyelitis involving two contiguous vertebrae. A case report.

    abstract:STUDY DESIGN:A case report and literature review of the five previous case reports. OBJECTIVES:To outline the features of Torulopsis glabrata spinal osteomyelitis, including its risk factors, diagnosis, and recommended treatments. SUMMARY OF BACKGROUND DATA:Fungal infections in general and Torulopsis glabrata in part...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-199604010-00019

    authors: Curran MP,Lenke LG

    更新日期:1996-04-01 00:00:00

  • Anterior extension of the thoracic vertebral bodies in Scheuermann's kyphosis. An anatomic study.

    abstract::Changes consistent with Scheuermann's kyphosis were noted in 103 specimens (7.4%) of a sample of 1,384 thoracic spines in the Hamann-Todd collection of human skeletons. In 94% of the affected vertebrae, a distinct anterior elongation of the vertebral centrum was present. This anterior extension was composed of mature ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198907000-00011

    authors: Digiovanni BF,Scoles PV,Latimer BM

    更新日期:1989-07-01 00:00:00

  • Safety and Efficacy of Reconstruction of Complex Cervical Spine Pathology Using Pedicle Screws Inserted with Stealth Navigation and 3D Image-Guided (O-Arm) Technology.

    abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To determine safety and efficacy of cervical pedicle screw placement using O-Arm and Stealth Navigation in patients with cervicothoracic spinal deformities and revision subaxial cervical pathology. SUMMARY OF BACKGROUND DATA:Cervical pedicle screws are biomechanically ad...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001026

    authors: Theologis AA,Burch S

    更新日期:2015-09-15 00:00:00

  • Is the Readability of Spine-Related Patient Education Material Improving?: An Assessment of Subspecialty Websites.

    abstract:STUDY DESIGN:Analysis of spine-related patient education materials (PEMs) from subspecialty websites. OBJECTIVE:The aim of this study was to assess the readability of spine-related PEMs and compare to readability data from 2008. SUMMARY OF BACKGROUND DATA:Many spine patients use the Internet for health information. S...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001446

    authors: Eltorai AEM,Cheatham M,Naqvi SS,Marthi S,Dang V,Palumbo MA,Daniels AH

    更新日期:2016-06-01 00:00:00

  • Progression of idiopathic thoracolumbar scoliosis after breast reconstruction with a latissimus dorsi flap: a case report.

    abstract:STUDY DESIGN:A report of a patient in whom progressive symptomatic thoracolumbar scoliosis developed after breast reconstruction with a latissimus dorsi myocutaneous flap. OBJECTIVES:To present the first reported case of progressive symptomatic scoliosis after breast reconstruction with a latissimus dorsi myocutaneous...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200003010-00014

    authors: Kim DH,Glazer PA

    更新日期:2000-03-01 00:00:00

  • Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.

    abstract:STUDY DESIGN:Changes in expression of voltage-dependent ion channel subunits were examined in the radicular pain state. Furthermore, antinociceptive effects of gabapentin on radicular pain were compared with effects on peripheral neuropathic pain. OBJECTIVES:To clarify molecular substrates involved in the development ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200207150-00007

    authors: Abe M,Kurihara T,Han W,Shinomiya K,Tanabe T

    更新日期:2002-07-15 00:00:00

  • The Pennsylvania Plan. An algorithm for the management of lumbar degenerative disc disease.

    abstract::An algorithm for the sequential management of the patient with low-back pain has been formulated from evaluation of treatment outcomes. Patients presenting with back pain complaints and cauda equina syndrome are evaluated with immediate myelography. Without this complication, back pain patients are treated with 6 week...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Holmes HE,Rothman RH

    更新日期:1979-03-01 00:00:00

  • Influence of the Preoperative Neurological Status on Survival After the Surgical Treatment of Symptomatic Spinal Metastases With Spinal Cord Compression.

    abstract:STUDY DESIGN:Consecutive case-series. OBJECTIVE:The main purpose of this study was to analyze the relationship between the preoperative neurological status and subsequent survival of patients undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA:The survival of cancer patients ha...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001141

    authors: Vanek P,Bradac O,Trebicky F,Saur K,de Lacy P,Benes V

    更新日期:2015-12-01 00:00:00

  • Twenty-eight-year follow-up of anterior and posterior fusion for congenital kyphosis. A case report.

    abstract:STUDY DESIGN:Case report and long-term follow-up. OBJECTIVES:To answer the question of whether the operation performed was worthwhile and lasting. SUMMARY OF BACKGROUND DATA:Congenital kyphosis due to defects of vertebral body formation has a high incidence of paraplegia if not surgically stabilized. Traditional post...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199709150-00018

    authors: Winter RB,Turek-Shay LA

    更新日期:1997-09-15 00:00:00

  • The incidence of Klippel-Feil syndrome in patients with congenital scoliosis and kyphosis.

    abstract::A retrospective review of the radiographs of 1215 patients with congenital scoliosis and kyphosis disclosed 298 (25%) to have segmentation defects in the cervical spine. A single level defect was seen in 82 patients, 52 of which were at C2-C3. Of the 298 patients, 235 had scoliosis, (6 cervical, 42 cervicothoracic, 75...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198405000-00006

    authors: Winter RB,Moe JH,Lonstein JE

    更新日期:1984-05-01 00:00:00

  • Similar radiologic lesions of localized Scheuermann's disease of the lumbar spine in twin sisters.

    abstract:SUMMARY OF BACKGROUND DATA:Hereditary and mechanical factors are considered to be the principal etiologic factors of Scheuermann's disease. OBJECTIVES:The authors report identical twins presenting similar lesions of localized lumbar osteochondrosis, which were worse in the one twin that practiced strenuous sports acti...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199404150-00020

    authors: van Linthoudt D,Revel M

    更新日期:1994-04-15 00:00:00

  • Impact of Living With Scoliosis: A utility Outcome Score Assessment.

    abstract:STUDY DESIGN:Survey. OBJECTIVE:The aim of this study was to objectify the burden of adolescent idiopathic scoliosis (AIS) to better advocate for scoliosis care in the future. SUMMARY OF BACKGROUND DATA:AIS is a common spinal deformity that can affect individuals on many levels. Patients with big curves usually seek m...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001708

    authors: Aldebeyan S,Sinno H,Makhdom A,Ouellet JA,Saran N

    更新日期:2017-01-15 00:00:00

  • Measurement Properties of the Functional Rating Index: A Systematic Review and Meta-analysis.

    abstract:STUDY DESIGN:A systematic review and meta-analysis. OBJECTIVE:To assess the measurement properties of the Functional Rating Index (FRI) and determine whether its measurement properties are comparable with other region-specific questionnaires. SUMMARY OF BACKGROUND DATA:In addition to low back pain (LBP) and neck pain...

    journal_title:Spine

    pub_type: 杂志文章,meta分析

    doi:10.1097/BRS.0000000000002690

    authors: Bai Z,Shu T,Lu J,Niu W

    更新日期:2018-11-15 00:00:00

  • Kinematics of the upper cervical spine in rotation: in vivo three-dimensional analysis.

    abstract:STUDY DESIGN:Kinematics of the upper cervical spine during head rotation were investigated using three-dimensional magnetic resonance imaging (MRI) in healthy volunteers. OBJECTIVES:To demonstrate in vivo intervertebral coupled motions of the upper cervical spine. SUMMARY OF BACKGROUND DATA:Although various in vivo a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000116998.55056.3c

    authors: Ishii T,Mukai Y,Hosono N,Sakaura H,Nakajima Y,Sato Y,Sugamoto K,Yoshikawa H

    更新日期:2004-04-01 00:00:00

  • Prolonged upright posture induces degenerative changes in intervertebral discs in rat lumbar spine.

    abstract:STUDY DESIGN:Both forelimbs of rats were amputated, and these rats were kept in the custom-made cages that kept the rats in prolonged upright posture. Pathologic changes were observed in the lumbar spine at different time points after the surgery. OBJECTIVE:To investigate the effect of upright posture on intervertebra...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318183f949

    authors: Liang QQ,Zhou Q,Zhang M,Hou W,Cui XJ,Li CG,Li TF,Shi Q,Wang YJ

    更新日期:2008-09-01 00:00:00

  • Surgical Consent of Children and Guardians for the Treatment of Adolescent Idiopathic Scoliosis is Incompletely Informed.

    abstract:STUDY DESIGN:Prospective, multicenter cohort analysis. OBJECTIVE:Assess children and guardian's comprehension of surgical consent for adolescent idiopathic scoliosis (AIS) surgery and factors associated with their comprehension. SUMMARY OF BACKGROUND DATA:Informed consent is essential to the ethical practice of surge...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000001162

    authors: Theologis AA,Anaya A,Sabatini C,Sucato DJ,Parent S,Erickson M,Diab M

    更新日期:2016-01-01 00:00:00

  • Spinal Gout Without Spinal Symptom in a Junior School Student: A Case Report.

    abstract:STUDY DESIGN:Case report. OBJECTIVE:We report a case of a 16-year-old boy with intermittent and migratory polyarthralgia, who made a diagnostic dilemma. SUMMARY OF BACKGROUND DATA:Spinal involvement without spinal symptom in gout seems to be rare. However, the relationship of spinal gout to symptoms is poorly underst...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002403

    authors: Wu D,Ma J,Li S,Zhao J,Li L

    更新日期:2018-04-15 00:00:00

  • Cervical stability with lateral mass plating: unicortical versus bicortical screw purchase.

    abstract:STUDY DESIGN:A biomechanical study using human cadaveric cervical spines was conducted. OBJECTIVE:To determine whether the cervical stability achieved with lateral mass fixation using unicortical screw purchase is comparable with that obtained with lateral mass fixation using bicortical screw purchase. SUMMARY OF BAC...

    journal_title:Spine

    pub_type: 杂志文章

    doi:

    authors: Muffoletto AJ,Yang J,Vadhva M,Hadjipavlou AG

    更新日期:2003-04-15 00:00:00