Influence of the Preoperative Neurological Status on Survival After the Surgical Treatment of Symptomatic Spinal Metastases With Spinal Cord Compression.


STUDY DESIGN:Consecutive case-series. OBJECTIVE:The main purpose of this study was to analyze the relationship between the preoperative neurological status and subsequent survival of patients undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA:The survival of cancer patients has increased over recent years with improvements in oncologic therapy. As many as 70% of cancer patients develop spinal metastases and ∼10% of all cancer patients are treated for metastatic spinal cord compression. METHODS:We retrospectively analyzed 166 patients who underwent surgery for symptomatic spinal metastases in our department between 2005 and 2012. The evaluated factors were age, primary tumor aggressiveness (slow, moderate, rapid growing), spinal location (cervical, thoracic, lumbar, and sacral), operation type (posterior decompression, anterior or posterior instrumented procedure, and radical combined instrumented surgery), preoperative evaluation using the revised Tokuhashi scoring system (<9, 9-11, and 12-15), pre- and postoperative neurological status according to the Frankel score (A-C and D-E), and the site of the main spinal cord compression (anterior, posterior, or combined). Postoperative complication and recurrence rate were also monitored. RESULTS:The mean age of the patients was 62 ± 12 years. The median survival time after surgery was 16.0 months. Preoperative neurological status influenced survival time significantly; the median survival was 5.1 months in Frankel A-C and 28.2 months in Frankel D-E (P < 0.001). Improvement on the Frankel scale did not influence the survival time (P = 0.131). When the patients' age was <65 years this related to a significantly longer survival time (P = 0.046). The Tokuhashi score predicted patient's survival independently (P < 0.001). The other factors had no statistical significance. CONCLUSION:The most important factors influencing postoperative survival time of these patients with symptomatic spinal metastases was the preoperative neurological condition and the Tokuhashi scoring system, which together represents a useful tool for planning the extent of surgical treatment.


Spine (Phila Pa 1976)




Vanek P,Bradac O,Trebicky F,Saur K,de Lacy P,Benes V




Has Abstract


2015-12-01 00:00:00














  • A comparison of methods for measuring trunk list. A simple plumbline is the best.

    abstract:STUDY DESIGN:Trunk list was measured using three different techniques to compare accuracy, precision, and ease of use. OBJECTIVE:To obtain a reproducible technique for further studies of the nature, cause, and clinical relevance of trunk list. SUMMARY OF BACKGROUND DATA:Gravity-induced trunk list is a clinical sign t...


    pub_type: 杂志文章


    authors: McLean IP,Gillan MG,Ross JC,Aspden RM,Porter RW

    更新日期:1996-07-15 00:00:00

  • The effect of infliximab, a monoclonal antibody against TNF-alpha, on disc herniation resorption: a randomized controlled study.

    abstract:STUDY DESIGN:Randomized, controlled study. OBJECTIVE:To evaluate the effect of infliximab on herniated nucleus pulposus (HNP) resorption. SUMMARY OF BACKGROUND DATA:Although the effects of tumor necrosis factor alpha (TNF-alpha) on HNP resorption are not fully understood, TNF-alpha appears to be an essential mediator...


    pub_type: 杂志文章,随机对照试验


    authors: Autio RA,Karppinen J,Niinimäki J,Ojala R,Veeger N,Korhonen T,Hurri H,Tervonen O

    更新日期:2006-11-01 00:00:00

  • Preoperative MRI analysis of patients with idiopathic scoliosis: a prospective study.

    abstract:STUDY DESIGN:A prospective trial of preoperative MRI study in patients with "idiopathic" scoliosis. OBJECTIVES:To investigate the prevalence of neural axis malformations and the clinical relevance of MRI in the evaluation of patients with idiopathic scoliosis undergoing surgical intervention. SUMMARY OF BACKGROUND DA...


    pub_type: 杂志文章


    authors: Inoue M,Minami S,Nakata Y,Otsuka Y,Takaso M,Kitahara H,Tokunaga M,Isobe K,Moriya H

    更新日期:2005-01-01 00:00:00

  • Elderly as a Predictor for Perioperative Complications in Patients Undergoing Multilevel Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Regression Modeling Study.

    abstract:STUDY DESIGN:This was a single-institute retrospective study. OBJECTIVE:To describe perioperative and postoperative complications in elderly who underwent multilevel minimally invasive transforaminal lumbar interbody fusion (MIS TLIF) while identifying predictors of complications. SUMMARY OF BACKGROUND DATA:The numbe...


    pub_type: 杂志文章


    authors: Claus CF,Lytle E,Tong D,Bahoura M,Garmo L,Yoon E,Jasinski J,Kaufmann A,Richards B,Soo TM

    更新日期:2020-06-01 00:00:00

  • Comparison of Smith-Petersen versus pedicle subtraction osteotomy for the correction of fixed sagittal imbalance.

    abstract:STUDY DESIGN:Clinical, radiographic, and outcomes assessment comparing two surgical techniques. Clinical data were collected prospectively. The radiographic analysis was done retrospectively. OBJECTIVES:Smith-Petersen (chevron type) osteotomy (SPO) and pedicle subtraction osteotomy (PSO) have been used to correct fixe...


    pub_type: 杂志文章


    authors: Cho KJ,Bridwell KH,Lenke LG,Berra A,Baldus C

    更新日期:2005-09-15 00:00:00

  • Radiation exposure to the spine surgeon in lumbar and thoracolumbar fusions with the use of an intraoperative computed tomographic 3-dimensional imaging system.

    abstract:STUDY DESIGN:A prospective clinical research article. OBJECTIVE:The primary goals were to determine (1) radiation exposure to the spine surgeon with the use of an intraoperative 3-dimensional imaging system and (2) to define the safe distance from the computed tomographic scanner. SUMMARY OF BACKGROUND:Intraoperative...


    pub_type: 临床试验,杂志文章


    authors: Abdullah KG,Bishop FS,Lubelski D,Steinmetz MP,Benzel EC,Mroz TE

    更新日期:2012-08-01 00:00:00

  • Spine update. Impaired cognitive functioning after whiplash injury of the cervical spine.

    abstract::To enhance the awareness of physicians treating whiplash patients, findings from previous research regarding cognitive functioning of these patients are discussed and recommendations for assessment provided. Cognitive disturbances (i.e., deficient attentional functioning and impairment of memory) are frequent complain...


    pub_type: 杂志文章,评审


    authors: Radanov BP,Dvorak J

    更新日期:1996-02-01 00:00:00

  • Potential Selection Bias in Observational Studies Comparing Cervical Disc Arthroplasty to Anterior Cervical Discectomy and Fusion.

    abstract:STUDY DESIGN:Retrospective study using a national administrative database. OBJECTIVE:To define the cohort differences in patient characteristics between patients undergoing cervical disc arthroplasty (CDA) and anterior cervical discectomy and fusion (ACDF) in a large national sample, and to describe the impact of thos...


    pub_type: 杂志文章


    authors: Goz V,Martin BI,Donnally CJ 3rd,Brodke D,Spina N,Lawrence B,Spiker WR

    更新日期:2020-07-15 00:00:00

  • Computed tomography in assessment of myelographic nerve root compression in the lateral recess.

    abstract::Thirty patients with myelographic shortening of a single nerve root sheath without indentation of the dural sac were studied by CT. Lateral disc herniation was diagnosed by CT in 18 patients. The myelograms of these patients were considered suspicious of disc herniation in three patients, uncertain in seven, and misin...


    pub_type: 杂志文章


    authors: Johansen JG

    更新日期:1986-06-01 00:00:00

  • A biomechanical assessment of thoracic spine stapling.

    abstract:STUDY DESIGN:An in vitro immature bovine study of thoracic spine fixation using shape memory alloy for minimally invasive adolescent scoliosis treatment. OBJECTIVE:The purpose of this study was to detect differences in thoracic spine range of motion due to the placement of spinal staples manufactured from a common sha...


    pub_type: 杂志文章


    authors: Puttlitz CM,Masaru F,Barkley A,Diab M,Acaroglu E

    更新日期:2007-04-01 00:00:00

  • MRI Signal Intensity Classification in Cervical Ossification of the Posterior Longitudinal Ligament: Predictor of Surgical Outcomes.

    abstract:STUDY DESIGN:Prospective cohort study. OBJECTIVE:To investigate whether classification of increased signal intensity (ISI) on magnetic resonance imaging (MRI) of spinal cord in patients with cervical ossification of the posterior longitudinal ligament (C-OPLL) reflects severity of myelopathy and surgical outcome. SUM...


    pub_type: 杂志文章


    authors: Ito K,Imagama S,Ito K,Ito Z,Ando K,Kobayashi K,Hida T,Tsushima M,Ishikawa Y,Matsumoto A,Machino M,Nishida Y,Ishiguro N,Kato F

    更新日期:2017-01-15 00:00:00

  • Anterior interbody fusion of the cervical spine with coralline hydroxyapatite.

    abstract:STUDY DESIGN:A nonrandomized, retrospective human study of patients requiring anterior discectomy and reconstruction from C3 to T1. The pattern of incorporation, presence or absence of disc space collapse, maintenance of correction, and clinical outcomes were considered. OBJECTIVE:To determine the efficacy of corallin...


    pub_type: 杂志文章


    authors: Thalgott JS,Fritts K,Giuffre JM,Timlin M

    更新日期:1999-07-01 00:00:00

  • Long-term results of Harrington instrumentation in idiopathic scoliosis.

    abstract::The long-term effect of Harrington instrumentation was investigated using posteroanterior radiographs and computed tomographic measurements preoperatively, postoperatively, and at a mean follow-up at 10.8 years in 33 patients with idiopathic scoliosis. No patient was lost from long-term follow-up. At follow-up, the me...


    pub_type: 杂志文章


    authors: Willers U,Hedlund R,Aaro S,Normelli H,Westman L

    更新日期:1993-05-01 00:00:00

  • The quality of randomized controlled trial reporting in spine literature.

    abstract:STUDY DESIGN:Retrospective literature review. OBJECTIVE:To assess the quality of randomized controlled trial reporting in spine surgery. SUMMARY OF BACKGROUND DATA:The use of the Consolidated Standards of Reporting Trials (CONSORT) criteria in clinical trials aims to improve adherence to a set of generally accepted p...


    pub_type: 杂志文章,评审


    authors: Naunheim MR,Walcott BP,Nahed BV,Simpson AK,Agarwalla PK,Coumans JV

    更新日期:2011-07-15 00:00:00

  • The biomechanical advantage of lordosis and hip extension for upright activity. Man as compared with other anthropoids.

    abstract::The mechanics of the muscle-ligament system for a weight lift in man is described. The adaptations of the human spine and the hip to this mechanism are indicated. The efficiency of this mechanism in the human is compared with other primates showing the vast superiority of man in this aspect over his nearest relatives....


    pub_type: 杂志文章


    authors: Farfan HF

    更新日期:1978-12-01 00:00:00

  • Immunohistochemical and histological study of human uncovertebral joints: a preliminary investigation.

    abstract:STUDY DESIGN:A descriptive cadaveric study. OBJECTIVE:To investigate the anatomy and innervation of the uncovertebral joint to determine if it is synovial in nature and capable of generating pain. SUMMARY OF BACKGROUND DATA:There is controversy with regard to the anatomic and histological makeup of the uncovertebral ...


    pub_type: 杂志文章


    authors: Brismée JM,Sizer PS Jr,Dedrick GS,Sawyer BG,Smith MP

    更新日期:2009-05-20 00:00:00

  • Methodological systematic review: mortality in elderly patients with cervical spine injury: a critical appraisal of the reporting of baseline characteristics, follow-up, cause of death, and analysis of risk factors.

    abstract:STUDY DESIGN:Methodologic systematic review. OBJECTIVE:To determine the validity of reported risk factors for mortality in elderly patients with cervical spine injury. SUMMARY OF BACKGROUND DATA:In elderly patients with cervical spine injury, mortality has frequently been associated with the type of treatment. To dat...


    pub_type: 杂志文章,评审


    authors: van Middendorp JJ,Albert TJ,Veth RP,Hosman AJ

    更新日期:2010-05-01 00:00:00

  • Strategies of medical intervention in the management of acute spinal cord injury.

    abstract:STUDY DESIGN:: Literature review. OBJECTIVE:: The purpose of this paper is to review clinical treatment strategies and future developments in the treatment of acute spinal cord injury. SUMMARY OF BACKGROUND DATA:: The treatment of acute spinal cord injury continues to be supportive. The search for specialized pharmac...


    pub_type: 杂志文章,评审


    authors: Hurlbert RJ

    更新日期:2006-05-15 00:00:00

  • Impact of Living With Scoliosis: A utility Outcome Score Assessment.

    abstract:STUDY DESIGN:Survey. OBJECTIVE:The aim of this study was to objectify the burden of adolescent idiopathic scoliosis (AIS) to better advocate for scoliosis care in the future. SUMMARY OF BACKGROUND DATA:AIS is a common spinal deformity that can affect individuals on many levels. Patients with big curves usually seek m...


    pub_type: 杂志文章


    authors: Aldebeyan S,Sinno H,Makhdom A,Ouellet JA,Saran N

    更新日期:2017-01-15 00:00:00

  • Holocord astrocytoma: a two-staged operative approach.

    abstract::Biopsy or subtotal resection followed by radiation for intramedullary astrocytomas of the spinal cord offer palliation but not cure. A treatment modality using an ultrasonic suction device has revolutionized the treatment of these tumors and has been extended to include the treatment of intramedullary tumors involving...


    pub_type: 杂志文章


    authors: Benzel EC,Mirfarkhraee M,Hadden T,Fowler M

    更新日期:1987-10-01 00:00:00

  • The injured canine cervical spine after six months of healing. An in vitro three-dimensional study.

    abstract::The cervical spine is a common site of spinal injuries. The stability of an injured cervical spine is not only dependent on injury severity, but also on the degree of healing time. Using a canine model, three injuries of varying degrees of severity were surgically produced at the C4-C5 level and allowed to heal for 6 ...


    pub_type: 杂志文章


    authors: Crisco JJ,Panjabi MM,Wang E,Price MA,Pelker RR

    更新日期:1990-10-01 00:00:00

  • A new magnetic resonance imaging analysis method for the measurement of disc height variations.

    abstract:STUDY DESIGN:A new magnetic resonance image analysis method is proposed which is based on the definition of the borders of the vertebral bodies adjacent to the intervertebral disc and their varying relationships. The reproducibility of this method (the so-called "centroid" method) was assessed by consecutive measuremen...


    pub_type: 杂志文章


    authors: Boos N,Wallin A,Aebi M,Boesch C

    更新日期:1996-03-01 00:00:00

  • Genetic Variants of ABO and SOX6 are Associated With Adolescent Idiopathic Scoliosis in Chinese Han Population.

    abstract:STUDY DESIGN:A genetic association study. OBJECTIVE:The aim of this study was to determine whether variants of ABO, SOX6, and CDH13 are associated with the susceptibility of AIS in Chinese Han population. SUMMARY OF BACKGROUND DATA:A recent large-scale genome-wide association study reported three novel loci in CDH13,...


    pub_type: 杂志文章


    authors: Wu Z,Wang Y,Dai Z,Qiu Y,Xu L,Zhu Z

    更新日期:2019-09-01 00:00:00

  • Quality of Life and Slip Progression in Degenerative Spondylolisthesis Treated Nonoperatively.

    abstract:STUDY DESIGN:A prospective cohort study of consecutive patients. OBJECTIVE:Determination of the quality of life (QoL) and prevalence of slip progression in patients with degenerative lumbar spondylolisthesis managed nonoperatively. SUMMARY OF BACKGROUND DATA:Lumbar spinal stenosis secondary to degenerative lumbar spo...


    pub_type: 杂志文章


    authors: Cushnie D,Johnstone R,Urquhart JC,Gurr KR,Bailey SI,Bailey CS

    更新日期:2018-05-15 00:00:00

  • Magnetic resonance imaging assessment of trunk muscles during prolonged bed rest.

    abstract:STUDY DESIGN:Prospective longitudinal study. OBJECTIVE.: To investigate, using magnetic resonance imaging (MRI), the influence of bed rest on the lumbopelvic musculature. SUMMARY OF BACKGROUND DATA:Reduced gravitational loading and inactivity (bed rest) are known to result in significant change in musculoskeletal func...


    pub_type: 杂志文章


    authors: Hides JA,Belavý DL,Stanton W,Wilson SJ,Rittweger J,Felsenberg D,Richardson CA

    更新日期:2007-07-01 00:00:00

  • Tandem interbody fusion grafting after cervical vertebrectomy.

    abstract:STUDY DESIGN:A case is presented with clinical and radiologic follow-up assessment to evaluate the possible effectiveness of tandem interbody fusion grafting. OBJECTIVE:To design a technique for rescuing a long iliac crest bone autograft that is too short or must be shortened because of the undesirable shape some long...


    pub_type: 杂志文章


    authors: Telfeian AE,Marcotte P

    更新日期:2001-06-01 00:00:00

  • Predictors of Vertebral Artery Injury in Isolated C2 Fractures Based on Fracture Morphology Using CT Angiography.

    abstract:STUDY DESIGN:Retrospective database analysis. OBJECTIVE:To determine C2 fracture patterns associated with vertebral artery injury (VAI) as assessed by computed tomography angiography. SUMMARY OF BACKGROUND DATA:The incidence of C2 fracture hospitalizations has increased significantly in the last decade. The vertebral...


    pub_type: 杂志文章


    authors: Durand D,Wu X,Kalra VB,Abbed KM,Malhotra A

    更新日期:2015-06-15 00:00:00

  • Spinal Fusion in Parkinson's Disease Patients: A Propensity Score-Matched Analysis With Minimum 2-Year Surveillance.

    abstract:STUDY DESIGN:Retrospective analysis. OBJECTIVE:To compare outcomes and complication rates between patients with and without Parkinson's disease (PD) patients undergoing surgery for adult spinal deformity (ASD). SUMMARY OF BACKGROUND DATA:There is limited literature evaluating the impact of PD on long-term outcomes af...


    pub_type: 杂志文章


    authors: Shah NV,Beyer GA,Solow M,Liu S,Tarabichi S,Stroud SG,Hollern DA,Bloom LR,Liabaud B,Agarwal S,Passias PG,Paulino CB,Diebo BG

    更新日期:2019-07-15 00:00:00

  • 1987 Volvo award in clinical sciences. A new clinical model for the treatment of low-back pain.

    abstract::Because there is increasing concern about low-back disability and its current medical management, this analysis attempts to construct a new theoretic framework for treatment. Observations of natural history and epidemiology suggest that low-back pain should be a benign, self-limiting condition, that low back-disabilit...


    pub_type: 杂志文章,评审


    authors: Waddell G

    更新日期:1987-09-01 00:00:00

  • Guidelines for management of scoliosis in Rett syndrome patients based on expert consensus and clinical evidence.

    abstract:STUDY DESIGN:Modified Delphi technique. OBJECTIVE:To develop guidelines for the clinical management of scoliosis in Rett syndrome through evidence review and consensus expert panel opinion. SUMMARY OF BACKGROUND DATA:Rett syndrome is a rare disorder and clinical expertise is thus with small case series. Scoliosis is ...


    pub_type: 杂志文章,实务指引


    authors: Downs J,Bergman A,Carter P,Anderson A,Palmer GM,Roye D,van Bosse H,Bebbington A,Larsson EL,Smith BG,Baikie G,Fyfe S,Leonard H

    更新日期:2009-08-01 00:00:00