Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain.

Abstract:

STUDY DESIGN:Changes in expression of voltage-dependent ion channel subunits were examined in the radicular pain state. Furthermore, antinociceptive effects of gabapentin on radicular pain were compared with effects on peripheral neuropathic pain. OBJECTIVES:To clarify molecular substrates involved in the development of radicular pain, and to investigate the responsiveness of radicular pain to gabapentin. SUMMARY OF BACKGROUND DATA:Peripheral nerve injuries are known to induce dynamic changes of voltage-dependent Na+ and Ca2+ channel subunits expression in dorsal root ganglion neurons. However, the expression profiles of Na+ and Ca2+ channel subunits in the radicular pain state have not been examined. METHODS:Two radicular pain models and one peripheral neuropathic pain model were prepared. By using semiquantitative reverse transcriptase-polymerase chain reaction, the expression levels of several Na+ and Ca2+ channel subunits in the dorsal root ganglions of these pain model rats were investigated. The antinociceptive effects of gabapentin were examined in a behavioral study using the aforementioned pain models. RESULTS:All three neuropathic pain operations induced comparable mechanical allodynia and thermal hyperalgesia. The upregulation of the Na(v)1.3 Na+ channel and Ca(v)alpha2delta Ca2+ channel subunits was observed only in the peripheral nerve injury model. A downregulation of the Na(v)1.9 channel was observed in all three pain model rats. A lower dose of gabapentin was significantly more effective in alleviating the mechanical allodynia of rats with radicular pain. CONCLUSIONS:The reduction of Na(v)1.9 found in all three models may link to the neuropathic pain state, including radicular pain. The lower sensitivity to gabapentin in rats with peripheral neuropathic pain might be partly explained by the marked upregulation of Ca(v)alpha2delta in the dorsal root ganglions, suggesting that gabapentin may be more effective in radicular pain treatment.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Abe M,Kurihara T,Han W,Shinomiya K,Tanabe T

doi

10.1097/00007632-200207150-00007

keywords:

subject

Has Abstract

pub_date

2002-07-15 00:00:00

pages

1517-24; discussion 1525

issue

14

eissn

0362-2436

issn

1528-1159

pii

00007632-200207150-00007

journal_volume

27

pub_type

杂志文章

相关文献

SPINE文献大全
  • Timing of activation of the erector spinae and hamstrings during a trunk flexion and extension task.

    abstract:STUDY DESIGN:Timing of activation of the hamstrings and erector spinae was assessed using surface electromyography. OBJECTIVES:To investigate the influence of posture and movement speed during trunk flexion-extension on the flexion-relaxation response and trunk muscle activation patterns. SUMMARY OF BACKGROUND DATA:T...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200102150-00019

    authors: McGorry RW,Hsiang SM,Fathallah FA,Clancy EA

    更新日期:2001-02-15 00:00:00

  • Prospective comparative study of intradiscal high-dose and low-dose collagenase versus chymopapain.

    abstract::The mixed results of two studies on intradiscal therapy with collagenase versus chymopapain are presented. The first study was performed from January 1983 to March 1984 and consisted of 71 patients treated with collagenase injection (600 ABC units) and 93 patients treated with chymopapain injection (4,000 units) into ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198705000-00016

    authors: Hedtmann A,Steffen R,Krämer J

    更新日期:1987-05-01 00:00:00

  • Preoperative Factors Predict Postoperative Trajectories of Pain and Disability Following Surgery for Degenerative Lumbar Spinal Stenosis.

    abstract:STUDY DESIGN:Longitudinal analysis of prospectively collected data. OBJECTIVE:Investigate potential predictors of poor outcome following surgery for degenerative lumbar spinal stenosis (LSS). SUMMARY OF BACKGROUND DATA:LSS is the most common reason for an older person to undergo spinal surgery, yet little information...

    journal_title:Spine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/BRS.0000000000003587

    authors: Hébert JJ,Abraham E,Wedderkopp N,Bigney E,Richardson E,Darling M,Hall H,Fisher CG,Rampersaud YR,Thomas KC,Jacobs WB,Johnson M,Paquet J,Attabib N,Jarzem P,Wai EK,Rasoulinejad P,Ahn H,Nataraj A,Stratton A,Manson N

    更新日期:2020-11-01 00:00:00

  • Anterior cervical plate fixation: a biomechanical study to evaluate the effects of plate design, endplate preparation, and bone mineral density.

    abstract:STUDY DESIGN:A biomechanical study using multidirectional flexibility testing in a human cadaveric cervical spine model of a flexion-distraction injury. OBJECTIVES:To compare the immediate postoperative stabilizing effect of dynamic and rigid anterior cervical plates and to assess the confounding effects of bone miner...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000152154.57171.92

    authors: Dvorak MF,Pitzen T,Zhu Q,Gordon JD,Fisher CG,Oxland TR

    更新日期:2005-02-01 00:00:00

  • Aortic flap valve presenting as neurogenic claudication: a case report.

    abstract:STUDY DESIGN:A case report of a patient who presented with pain in both lower limbs related with walking and standing as a result of an unusual vascular etiology. OBJECTIVES:To describe the pathology and treatment of an unusual case of vascular claudication. SUMMARY OF BACKGROUND DATA:Symptoms of neurogenic claudicat...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000109763.77854.9b

    authors: Lakdawala RH,Rahmat R,Tan L,Wong HK

    更新日期:2004-02-15 00:00:00

  • National Trends in Ambulatory Surgery for Intervertebral Disc Disorders and Spinal Stenosis: A 12-Year Analysis of the National Surveys of Ambulatory Surgery.

    abstract:STUDY DESIGN:A descriptive epidemiology study. OBJECTIVE:The aim of this study is to investigate changes in the utilization of ambulatory surgical procedures performed for intervertebral disc disorders and spinal stenosis between 1994 and 2006 in the United States. SUMMARY OF BACKGROUND DATA:Understanding trends in t...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001109

    authors: Best MJ,Buller LT,Eismont FJ

    更新日期:2015-11-01 00:00:00

  • American Society of Anesthesiologists' Status Association With Cost and Length of Stay in Lumbar Laminectomy and Fusion: Results From an Institutional Database.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The objective of this study was to characterize the costs associated with American Society of Anesthesiologists (ASA) class, and to determine the extent to which ASA status is a predictor of increased cost and LOS following lumbar laminectomy and fusion (LLF). SUMMAR...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003257

    authors: Bronheim RS,Caridi JM,Steinberger J,Hunter S,Neifert SN,Deutsch BC,DeMaria S Jr,Hermann L,Gal JS

    更新日期:2020-03-01 00:00:00

  • The Effect of Axial Torsion on the Mechanical Properties of the Annulus Fibrosus.

    abstract:STUDY DESIGN:In-vitro study of the tissue mechanics of annulus fibrosus. OBJECTIVE:To determine the effect of axial torsion on the mechanical properties of the inter- and intralamellar matrices. SUMMARY OF BACKGROUND DATA:Axial torsion, when combined with repetitive flexion, has been associated with an increased risk...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002803

    authors: Harvey-Burgess M,Gregory DE

    更新日期:2019-02-15 00:00:00

  • Predictors of Extended Length of Hospital Stay in Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Segmental Instrumented Fusion: An Analysis of 407 Surgeries Performed at a Large Academic Center.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The aims of this study were to (1) compare patient and procedure-specific characteristics among those who had short versus long hospital stays and (2) identify independent risk factors that may correlate with extended length of hospital stay (LOS) in patients with ado...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002919

    authors: Sultan AA,Berger RJ,Cantrell WA,Samuel LT,Ramanathan D,Churchill J,Minkara AA,Golubovsky J,Bachour S,Pasadyn S,Karnuta JM,Tamer P,Kuivila TE,Gurd DP,Goodwin RC

    更新日期:2019-05-15 00:00:00

  • Long-term follow-up of lower lumbar fusion patients.

    abstract::To determine the long-term effects of lower lumbar fusion, 94 subjects were catalogued from medical records. They had a lumbar arthrodesis at the third lumbar level or below and their operations were performed before 1964. Twenty-four were not located and 8 were deceased. Sixty-two subjects (72% of available sample) c...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198703000-00004

    authors: Lehmann TR,Spratt KF,Tozzi JE,Weinstein JN,Reinarz SJ,el-Khoury GY,Colby H

    更新日期:1987-03-01 00:00:00

  • Revision spinal fusion in patients older than 75: is it worth the risks?

    abstract:STUDY DESIGN:Retrospective clinical study of a prospective database. OBJECTIVE:This study aims to determine whether revision spinal fusion surgery is worthwhile in patients older than 75 from a risk-benefit perspective. SUMMARY OF BACKGROUND DATA:The benefits of spinal fusion in patients older than 65 is well documen...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000067

    authors: Chang MS,Chang YH,Revella J,Crandall DG

    更新日期:2014-01-01 00:00:00

  • An outcomes analysis of the treatment of cervical pseudarthrosis with posterior fusion.

    abstract:STUDY DESIGN:A retrospective review of 33 consecutive patients treated with posterior fusion and selective nerve root decompression for the treatment of pseudarthrosis following anterior cervical discectomy and fusion. OBJECTIVES:Use standardized outcome measures to evaluate the results of posterior fusion with select...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000184314.26543.7d

    authors: Kuhns CA,Geck MJ,Wang JC,Delamarter RB

    更新日期:2005-11-01 00:00:00

  • Vibration and the human spine.

    abstract::Vibrational effects have been found to be associated with increased frequency of low-back pain in various industries, and because of this the study herein reported was conducted to assess the physiologic response of the spinal system to sinusoidal vibrations. A device replicating industrial vibration was constructed a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198205000-00008

    authors: Wilder DG,Woodworth BB,Frymoyer JW,Pope MH

    更新日期:1982-05-01 00:00:00

  • Differentiation of intervertebral notochordal cells through live automated cell imaging system in vitro.

    abstract:STUDY DESIGN:We demonstrated the differentiation of notochordal cells by direct observation using a live automated cell imaging system. We also hypothesized that notochordal cells have characteristics of chondrocyte-like cells. OBJECTIVE:To determine characteristics of notochordal cells by matrix protein expression an...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181b26ed1

    authors: Kim JH,Deasy BM,Seo HY,Studer RK,Vo NV,Georgescu HI,Sowa GA,Kang JD

    更新日期:2009-11-01 00:00:00

  • The reliability of measurements of the lumbar spine using ultrasound B-scan.

    abstract::Diagnostic ultrasound is used in research and clinical settings to determine the size of the lumbar spinal canal. When the technique was first introduced, measurements were obtained directly from an A-scan while concurrently viewing a B-scan. However, measurements obtained directly from a B-scan are now commonly used ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-198603000-00008

    authors: Battié MC,Hansson TH,Engel JM,Zeh J,Bigos SJ,Spengler DM

    更新日期:1986-03-01 00:00:00

  • Low Intensity Pulsed Ultrasound Promotes the Extracellular Matrix Synthesis of Degenerative Human Nucleus Pulposus Cells Through FAK/PI3K/Akt Pathway.

    abstract:STUDY DESIGN:In vitro experimental study. OBJECTIVE:To investigate the effect of low-intensity pulsed ultrasound (LIPUS) on the extracellular matrix (ECM) synthesis of degenerative human nucleus pulposus cells and explore the molecular mechanism. SUMMARY OF BACKGROUND DATA:LIPUS has been used successfully for bone fr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001220

    authors: Zhang X,Hu Z,Hao J,Shen J

    更新日期:2016-03-01 00:00:00

  • Clinical Evaluation of the Spinal Instability Neoplastic Score in Patients Treated With Radiotherapy for Symptomatic Spinal Bone Metastases.

    abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:To determine the predictive value of the Spinal Instability Neoplastic Score (SINS) in a cohort of patients treated with radiotherapy for spinal bone metastases. SUMMARY OF BACKGROUND DATA:Assessment of spinal stability in metastatic disease is challenging and is mos...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000002058

    authors: Bollen L,Groenen K,Pondaag W,van Rijswijk CSP,Fiocco M,Van der Linden YM,Dijkstra SPD

    更新日期:2017-08-15 00:00:00

  • Two-year follow-up evaluation of surgical treatment for thoracolumbar fracture-dislocation.

    abstract:STUDY DESIGN:A randomized, controlled clinical trial. OBJECTIVE:This randomized controlled clinical trial was aimed at comparing the clinical outcomes of combined posteroanterior (P-A) fusion and transforaminal thoracic interbody fusion (TTIF) in cases of thoracolumbar fracture-dislocation. SUMMARY OF BACKGROUND DATA...

    journal_title:Spine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/BRS.0000000000000529

    authors: Hao D,Wang W,Duan K,Ma M,Jiang Y,Liu T,He B

    更新日期:2014-10-01 00:00:00

  • Latent psoas abscess after anterior spinal fusion.

    abstract::This case is presented to emphasize that late infection should be considered in all postoperative patients as a cause of pain. A psoas abscess may remain dormant for many years after an anterior spinal procedure. It should be considered in the differential diagnosis of back pain and lumbar radiculopathy after anterior...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199205000-00019

    authors: Hresko MT,Hall JE

    更新日期:1992-05-01 00:00:00

  • Spine update. Percutaneous lumbar disc surgery.

    abstract::Various techniques of percutaneous lumbar disc surgery have become popular for treating lumbar disc herniations. There is a vast and increasing body of literature on this topic that consists mainly of retrospective, uncontrolled clinical studies, technical articles, and case reports. A literature analysis revealed two...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:

    authors: Mayer HM

    更新日期:1994-12-01 00:00:00

  • Distraction Arthrodesis of the C1-C2 Facet Joint with Preservation of the C2 Root for the Management of Intractable Occipital Neuralgia Caused by C2 Root Compression.

    abstract:STUDY DESIGN:Prospective observational cohort study. OBJECTIVE:To compare the outcomes of our new technique, distraction arthrodesis of C1-C2 facet joint with C2 root preservation (Study group), to those of conventional C1-C2 fusion with C2 root transection (Control group) for the management of intractable occipital n...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001031

    authors: Yeom JS,Riew KD,Kang SS,Yi J,Lee GW,Yeom A,Chang BS,Lee CK,Kim HJ

    更新日期:2015-10-15 00:00:00

  • Virtual fluoroscopy: computer-assisted fluoroscopic navigation.

    abstract:STUDY DESIGN:In vitro accuracy assessment of a novel virtual fluoroscopy system. OBJECTIVES:To investigate a new technology combining image-guided surgery with C-arm fluoroscopy. SUMMARY OF BACKGROUND DATA:Fluoroscopy is a useful and familiar technology to all musculoskeletal surgeons. Its limitations include radiati...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200102150-00009

    authors: Foley KT,Simon DA,Rampersaud YR

    更新日期:2001-02-15 00:00:00

  • A cross-sectional study correlating cervical radiographic degenerative findings to pain and disability.

    abstract:STUDY DESIGN:A cross-sectional design was used to correlate cervical radiographic findings of spinal degeneration to neck pain and disability. OBJECTIVES:The results were correlated to assess the clinical importance of radiographic spinal degeneration. SUMMARY OF BACKGROUND DATA:Past investigations suggest little ass...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199612010-00007

    authors: Marchiori DM,Henderson CN

    更新日期:1996-12-01 00:00:00

  • Rosai-Dorman disease causing cervical myelopathy.

    abstract:STUDY DESIGN:A case report of a rare disease entity and review of the literature. OBJECTIVES:To illustrate the occurrence of an unusual disease affecting the spine and spinal canal. SUMMARY OF BACKGROUND DATA:Rosai-Dorman disease is considered an idiopathic benign lymphoproliferative disease that typically occurs in ...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/00007632-200006010-00020

    authors: Hollowell JP,Wolfla CE,Shah NC,Mark LP,Whittaker MH

    更新日期:2000-06-01 00:00:00

  • Evidence of an inherited predisposition for cervical spondylotic myelopathy.

    abstract:STUDY DESIGN:A retrospective, population-based study cross-referencing a genealogic database of over 2 million Utah residents with 10 years of clinical diagnosis data from a large tertiary hospital. OBJECTIVE:The objective of this study is to determine the presence or absence of an inherited predisposition to the deve...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3182102ede

    authors: Patel AA,Spiker WR,Daubs M,Brodke DS,Cannon-Albright LA

    更新日期:2012-01-01 00:00:00

  • Denosumab Treatment for Giant Cell Tumor of the Spine Including the Sacrum.

    abstract:STUDY DESIGN:This was a subanalysis of an international, multicenter, open-label study. OBJECTIVE:The aim of this study was to assess the efficacy and safety of denosumab in a subset of patients with giant cell tumors of bone (GCTB) of the spine including the sacrum from an international, open-label, single-arm, phase...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003728

    authors: Bukata SV,Blay JY,Rutkowski P,Skubitz K,Henshaw R,Seeger L,Dai T,Jandial D,Chawla S

    更新日期:2020-10-08 00:00:00

  • Lymphangiomatosis of the spine: two cases requiring surgical intervention.

    abstract:STUDY DESIGN:Two cases of lymphangiomatosis of the spine are presented. OBJECTIVES:To report two cases of lymphangiomatosis of the spine requiring surgical intervention and to review the literature. SUMMARY OF BACKGROUND INFORMATION:Lymphangiomatosis is a rare childhood disease characterized by abnormal lymph tissue ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000042235.41817.04

    authors: Watkins RG 4th,Reynolds RA,McComb JG,Tolo VT

    更新日期:2003-02-01 00:00:00

  • How does free rod-sliding affect the posterior instrumentation for a dynamic stabilization using a bovine calf model?

    abstract:STUDY DESIGN:A biomechanical cadaveric study in lumbar calf spine. OBJECTIVE:Evaluation of the effects of selected degrees of freedom (df) on the dynamic stabilization of the spine in terms of segmental range of motion (RoM), center of rotation (CoR), and implant loadings. SUMMARY OF BACKGROUND DATA:For dorsal stabil...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000702

    authors: Schulze M,Hartensuer R,Gehweiler D,Vordemvenne T,Raschke MJ,Trautwein F,Heuer F

    更新日期:2015-02-01 00:00:00

  • Concurrent measurement of isokinetic muscle strength of the trunk, knees, and ankles in patients with lumbar disc herniation with sciatica.

    abstract:STUDY DESIGN:A cross-sectional study comparing normal subjects and patients with lumbar disc herniation (LDH) with sciatica. OBJECTIVE:To simultaneously measure the isokinetic muscle strength of the trunk, knees, and ankles in both groups. SUMMARY OF BACKGROUND DATA:Coordination between the trunk and lower extremity ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181d12642

    authors: Chen LC,Kuo CW,Hsu HH,Chang ST,Ni SM,Ho CW

    更新日期:2010-12-15 00:00:00

  • Biomechanical role of lumbar spine ligaments in flexion and extension: determination using a parallel linkage robot and a porcine model.

    abstract:STUDY DESIGN:Porcine lumbar spine specimens were cyclically loaded in flexion and extension with a pure moment. The resistance to flexion and extension of the individual spinal elements was quantified using a sequential resection procedure. OBJECTIVE:To determine the biomechanical contribution of the individual poster...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200406010-00010

    authors: Gillespie KA,Dickey JP

    更新日期:2004-06-01 00:00:00