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Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women.

Abstract：

OBJECTIVES:Resistance exercise is used as a non-pharmacological tool to elicit both gains in and maintenance of physical function in the elderly. Thus, the present study examined the acute response of creatine kinase and interleukin-6 following an eccentric resistance exercise session in elderly obese women classified as high responders or normal responders. DESIGN:Cross-sectional field study. METHODS:Ninety elderly obese women (69.4 ± 6.01 years) were tested for a 10 repetition maximum on the leg extension exercise and then completed an acute eccentric resistance exercise session consisting of seven sets of 10 repetitions at 110% of 10 repetition maximum with a rest of 3 min between sets. Subjects were divided into normal response or high response on the basis of the peak serum interleukin-6 (NR = 59 and HR = 7) and creatine kinase (NR = 81 and HR = 9) concentration being greater than (HR) or less than (NR) the 90th percentile. RESULTS:Creatine kinase was higher at 0 h, 3h, 24h and 48 h following the ERE for the HR group. The peak creatine kinase was significantly higher in HR group versus the normal response group. The average increase in the serum interleukin-6 Δ for the HR group (∼ 850%) was significantly higher versus the normal response group (∼ 55%). Serum interleukin-6 was significantly higher at 0 h and 24h following eccentric resistance exercise only for the high response group, while peak levels were significantly higher in high response group versus the normal response group (p ≤ 0.005). Only one subject met the criteria to be classified as high response for both creatine kinase and interleukin-6 responsiveness. CONCLUSIONS:Elderly individuals classified as high response experienced greater creatine kinase and interleukin-6 responses to ERE. Thus, a prudent approach for eccentric resistance exercise prescription might be programming additional recovery days and/or lower intensity training, especially in the beginning stages of a program.

journal_name

J Sci Med Sport

journal_title

Journal of science and medicine in sport

authors

Tajra V,Tibana RA,Vieira DC,de Farias DL,Teixeira TG,Funghetto SS,Silva AO,de Sousa NM,Willardson J,Karnikowski MG,Prestes J

doi

10.1016/j.jsams.2013.09.012

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

662-6

issue

eissn

1440-2440

issn

1878-1861

pii

S1440-2440(13)00229-6

journal_volume

pub_type

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Identification of high responders for interleukin-6 and creatine kinase following acute eccentric resistance exercise in elderly obese women.