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Binding of NF-κB to nucleosomes: effect of translational positioning, nucleosome remodeling and linker histone H1.

Abstract：

:NF-κB is a key transcription factor regulating the expression of inflammatory responsive genes. How NF-κB binds to naked DNA templates is well documented, but how it interacts with chromatin is far from being clear. Here we used a combination of UV laser footprinting, hydroxyl footprinting and electrophoretic mobility shift assay to investigate the binding of NF-κB to nucleosomal templates. We show that NF-κB p50 homodimer is able to bind to its recognition sequence, when it is localized at the edge of the core particle, but not when the recognition sequence is at the interior of the nucleosome. Remodeling of the nucleosome by the chromatin remodeling machine RSC was not sufficient to allow binding of NF-κB to its recognition sequence located in the vicinity of the nucleosome dyad, but RSC-induced histone octamer sliding allowed clearly detectable binding of NF-κB with the slid particle. Importantly, nucleosome dilution-driven removal of H2A-H2B dimer led to complete accessibility of the site located close to the dyad to NF-κB. Finally, we found that NF-κB was able to displace histone H1 and prevent its binding to nucleosome. These data provide important insight on the role of chromatin structure in the regulation of transcription of NF-κB dependent genes.

journal_name

PLoS Genet

journal_title

PLoS genetics

authors

Lone IN,Shukla MS,Charles Richard JL,Peshev ZY,Dimitrov S,Angelov D

doi

10.1371/journal.pgen.1003830

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

e1003830

issue

9

eissn

1553-7390

issn

1553-7404

pii

PGENETICS-D-13-00923

journal_volume

9

pub_type

杂志文章

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