Abstract:
:Iran, despite its size, geographic location and past cultural influence, has largely been a blind spot for human population genetic studies. With only sparse genetic information on the Iranian population available, we pursued its genome-wide and geographic characterization based on 1021 samples from eleven ethnic groups. We show that Iranians, while close to neighboring populations, present distinct genetic variation consistent with long-standing genetic continuity, harbor high heterogeneity and different levels of consanguinity, fall apart into a cluster of similar groups and several admixed ones and have experienced numerous language adoption events in the past. Our findings render Iran an important source for human genetic variation in Western and Central Asia, will guide adequate study sampling and assist the interpretation of putative disease-implicated genetic variation. Given Iran's internal genetic heterogeneity, future studies will have to consider ethnic affiliations and possible admixture.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Mehrjoo Z,Fattahi Z,Beheshtian M,Mohseni M,Poustchi H,Ardalani F,Jalalvand K,Arzhangi S,Mohammadi Z,Khoshbakht S,Najafi F,Nikuei P,Haddadi M,Zohrehvand E,Oladnabi M,Mohammadzadeh A,Jafari MH,Akhtarkhavari T,Gooshki ESdoi
10.1371/journal.pgen.1008385subject
Has Abstractpub_date
2019-09-24 00:00:00pages
e1008385issue
9eissn
1553-7390issn
1553-7404pii
PGENETICS-D-19-00213journal_volume
15pub_type
杂志文章相关文献
PLoS Genetics文献大全abstract::The cooperative developmental system of the social amoeba Dictyostelium discoideum is susceptible to exploitation by cheaters-strains that make more than their fair share of spores in chimerae. Laboratory screens in Dictyostelium have shown that the genetic potential for facultative cheating is high, and field surveys...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000854
更新日期:2010-02-26 00:00:00
abstract::Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA repression in the molecular feedback loop. In Drosophila, nuclear entry of the clock proteins, PERIOD (PER) and TIMELESS (TIM), is tightly controlled, and impair...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004974
更新日期:2015-02-12 00:00:00
abstract::Stem cells in tissues reside in and receive signals from local microenvironments called niches. Understanding how multiple signals within niches integrate to control stem cell function is challenging. The Drosophila testis stem cell niche consists of somatic hub cells that maintain both germline stem cells and somatic...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004713
更新日期:2014-11-06 00:00:00
abstract::Blood vessels are vital to sustain life in all vertebrates. While it is known that mural cells (pericytes and smooth muscle cells) regulate vascular integrity, the contribution of other cell types to vascular stabilization has been largely unexplored. Using zebrafish, we identified sclerotome-derived perivascular fibr...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008800
更新日期:2020-10-26 00:00:00
abstract::The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, the underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate systemic lipid metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006555
更新日期:2017-01-17 00:00:00
abstract::Determining how facultative anaerobic organisms sense and direct cellular responses to electron acceptor availability has been a subject of intense study. However, even in the model organism Escherichia coli, established mechanisms only explain a small fraction of the hundreds of genes that are regulated during electr...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004264
更新日期:2014-04-03 00:00:00
abstract::Abnormal accumulation of the microtubule-interacting protein tau is associated with neurodegenerative diseases including Alzheimer's disease (AD). β-amyloid (Aβ) lies upstream of abnormal tau behavior, including detachment from microtubules, phosphorylation at several disease-specific sites, and self-aggregation into ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005917
更新日期:2016-03-29 00:00:00
abstract::Beckwith-Wiedemann syndrome (BWS) is a fetal overgrowth and human imprinting disorder resulting from the deregulation of a number of genes, including IGF2 and CDKN1C, in the imprinted gene cluster on chromosome 11p15.5. Most cases are sporadic and result from epimutations at either of the two 11p15.5 imprinting centre...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000423
更新日期:2009-03-01 00:00:00
abstract::Type-III protein secretion systems are utilized by gram-negative pathogens to secrete building blocks of the bacterial flagellum, virulence effectors from the cytoplasm into host cells, and structural subunits of the needle complex. The flagellar type-III secretion apparatus utilizes both the energy of the proton moti...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004800
更新日期:2014-11-13 00:00:00
abstract::The inability of native Saccharomyces cerevisiae to convert xylose from plant biomass into biofuels remains a major challenge for the production of renewable bioenergy. Despite extensive knowledge of the regulatory networks controlling carbon metabolism in yeast, little is known about how to reprogram S. cerevisiae to...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006372
更新日期:2016-10-14 00:00:00
abstract::The rate of germline mutation varies widely between species but little is known about the extent of variation in the germline mutation rate between individuals of the same species. Here we demonstrate that an allele that increases the rate of germline mutation can result in a distinctive signature in the genomic regio...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006549
更新日期:2017-01-17 00:00:00
abstract::Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted deletions of parasite secreted effector proteins using a genetically tra...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006189
更新日期:2016-07-22 00:00:00
abstract::Prostate cancer incidence is increasing in younger men. We investigated whether men diagnosed with Gleason 7 (3+4) T2 prostate cancer at younger ages (≤ 45 years, young cohort) had different mRNA and miRNA expression profiles than men diagnosed at older ages (71-74 years, older cohort). We identified differentially ex...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006477
更新日期:2016-12-27 00:00:00
abstract::The lipopolysaccharide O-antigen structure expressed by the European Helicobacter pylori model strain G27 encompasses a trisaccharide, an intervening glucan-heptan and distal Lewis antigens that promote immune escape. However, several gaps still remain in the corresponding biosynthetic pathway. Here, systematic mutage...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008497
更新日期:2019-11-20 00:00:00
abstract::There is growing evidence that gene expression profiling of peripheral blood cells is a valuable tool for assessing gene signatures related to exposure, drug-response, or disease. However, the true promise of this approach can not be estimated until the scientific community has robust baseline data describing variatio...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1000873
更新日期:2010-03-12 00:00:00
abstract::Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and differentiation. Prior work established doublesex- and mab-3-related transcription factor 1 (Dmrt1) as a conserved transcriptional regulator of male sexual diff...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1006293
更新日期:2016-09-01 00:00:00
abstract::Development of a functional musculoskeletal system requires coordinated generation of muscles, bones, and tendons. However, how axial tendon cells (tenocytes) are generated during embryo development is still poorly understood. Here, we show that axial tenocytes arise from the sclerotome in zebrafish. In contrast to mo...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1007775
更新日期:2018-11-02 00:00:00
abstract::In the oocytes of many animals including humans, the meiotic spindle assembles without centrosomes. It is still unclear how multiple pathways contribute to spindle microtubule assembly, and whether they are regulated differently in mitosis and meiosis. Augmin is a γ-tubulin recruiting complex which "amplifies" spindle...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003562
更新日期:2013-06-01 00:00:00
abstract::As a consequence of the accumulation of insertion events over evolutionary time, mobile elements now comprise nearly half of the human genome. The Alu, L1, and SVA mobile element families are still duplicating, generating variation between individual genomes. Mobile element insertions (MEI) have been identified as cau...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002236
更新日期:2011-08-01 00:00:00
abstract::The combination of large-scale population genomic analyses and trait-based mapping approaches has the potential to provide novel insights into the evolutionary history and genome organization of crop plants. Here, we describe the detailed genotypic and phenotypic analysis of a sunflower (Helianthus annuus L.) associat...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003378
更新日期:2013-03-01 00:00:00
abstract::70 kDa heat shock proteins (Hsp70) are essential chaperones of the protein quality control network; vital for cellular fitness and longevity. The four cytosolic Hsp70's in yeast, Ssa1-4, are thought to be functionally redundant but the absence of Ssa1 and Ssa2 causes a severe reduction in cellular reproduction and acc...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008951
更新日期:2021-01-11 00:00:00
abstract::The cerebellum is a pivotal centre for the integration and processing of motor and sensory information. Its extended development into the postnatal period makes this structure vulnerable to a variety of pathologies, including neoplasia. These properties have prompted intensive investigations that reveal not only devel...
journal_title:PLoS genetics
pub_type: 杂志文章,评审
doi:10.1371/journal.pgen.1008630
更新日期:2020-04-16 00:00:00
abstract::Mimulus guttatus and M. nasutus are an evolutionary and ecological model sister species pair differentiated by ecology, mating system, and partial reproductive isolation. Despite extensive research on this system, the history of divergence and differentiation in this sister pair is unclear. We present and analyze a po...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1004410
更新日期:2014-06-26 00:00:00
abstract::Organisms perceive changes in their dietary environment and enact a suite of behavioral and metabolic adaptations that can impact motivational behavior, disease resistance, and longevity. However, the precise nature and mechanism of these dietary responses is not known. We have uncovered a novel link between dietary f...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002668
更新日期:2012-01-01 00:00:00
abstract::The assimilation of nitrate, a most important soil nitrogen source, is tightly regulated in microorganisms and plants. In Aspergillus nidulans, during the transcriptional activation process of nitrate assimilatory genes, the interaction between the pathway-specific transcription factor NirA and the exportin KapK/CRM1 ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1005297
更新日期:2015-07-01 00:00:00
abstract::Dimethylation of histone H3 lysine 9 (H3K9m2) and trimethylation of histone H3 lysine 27 (H3K27m3) are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG) proteins and is associated with silent protein-coding genes, while H3K9m2 is correla...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1003062
更新日期:2012-01-01 00:00:00
abstract::Checkpoint pathways regulate genomic integrity in part by blocking anaphase until all chromosomes have been completely replicated, repaired, and correctly aligned on the spindle. In Saccharomyces cerevisiae, DNA damage and mono-oriented or unattached kinetochores trigger checkpoint pathways that bifurcate to regulate ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002176
更新日期:2011-07-01 00:00:00
abstract::Pregnancy-induced noncoding RNA (PINC) and retinoblastoma-associated protein 46 (RbAp46) are upregulated in alveolar cells of the mammary gland during pregnancy and persist in alveolar cells that remain in the regressed lobules following involution. The cells that survive involution are thought to function as alveolar...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1002840
更新日期:2012-01-01 00:00:00
abstract::Many microbes exhibit quorum sensing (QS) to cooperate, share and perform a social task in unison. Recent studies have shown the emergence of reversible phenotypic heterogeneity in the QS-responding pathogenic microbial population under laboratory conditions as a possible bet-hedging survival strategy. However, very l...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.1008395
更新日期:2019-09-17 00:00:00
abstract::Studies in model organisms suggest that epistasis may play an important role in the etiology of complex diseases and traits in humans. With the era of large-scale genome-wide association studies fast approaching, it is important to quantify whether it will be possible to detect interacting loci using realistic sample ...
journal_title:PLoS genetics
pub_type: 杂志文章
doi:10.1371/journal.pgen.0020157
更新日期:2006-09-22 00:00:00