Toxic effects induced by curcumin in human astrocytoma cell lines.

abstract：:In this study, the preventive effects of NGF against colistin-induced autophagy and apoptosis in PC12 cells have been investigated. Fluorescence microscopy, real-time PCR, transmission electron microscopy (TEM), flow cytometery, and western blotting technique were used. The results showed that large amounts of autopha...

journal_title：Toxicology mechanisms and methods

authors： Tian E,Hu W,Miao Y,Muhammad I,Zhang L,Xia C,Ding L,Zhang Q,Li R,Chen C,Li J

更新日期：2019-03-01 00:00:00

abstract：:A potency of newly-developed oximes (K156, K203) and commonly used oximes (obidoxime, HI-6) to reactivate cyclosarin-inhibited acetylcholinesterase and to reduce cyclosarin-induced acute toxic effects was evaluated in this study. In vivo determined percentage of reactivation of cyclosarin-inhibited blood and tissue ac...

journal_title：Toxicology mechanisms and methods

authors： Kassa J,Karasova JZ,Musilek K,Kuca K

更新日期：2009-06-01 00:00:00

abstract：:The objective of this study was to examine the toxicity of 1-(4-morpholinophenyl)-3-(4-fluorophenyl)-propenone (A) and 1-(4-morpholinophenyl)-3-(3-fluorophenyl)-propenone (B) on Spodoptera frugiperda (Sf9) cells and the mechanism of the toxicity. By cell-based thiazolyl blue tetrazolium bromide (MTT) assay, we found t...

journal_title：Toxicology mechanisms and methods

authors： Zhang X,Tao K,Hou T

更新日期：2012-05-01 00:00:00

abstract：:The effects of chlorpyrifos and fenvalerate on the activity of the cellulase, superoxide dismutase (SOD) and catalase (CAT) of the earthworm (Eisenia foetida) were studied. Earthworms were exposed to chlorpyrifos and fenvalerate at a final concentration of 10, 20, and 40 mg/kg dry soil, respectively. Tissues from each...

journal_title：Toxicology mechanisms and methods

authors： Wang JH,Zhu LS,Liu W,Wang J,Xie H

更新日期：2012-04-01 00:00:00

abstract：:ABSTRACT Male Wistar rats with streptozotocin-induced diabetes received a control diet and a pyridoxine-deficient diet. The animals were divided at random into four groups: control rats (CR), control diabetic rats (CDR), diabetic rats receiving a pyridoxine-free diet (DRB6), and diabetic rats receiving saline solution...

journal_title：Toxicology mechanisms and methods

authors： Jordao AA,Dos Santos FL,Marchini JS,Vannucchi H

更新日期：2007-01-01 00:00:00

abstract：CONTEXT:Over expression of renin-angiotensin system (RAS) and nuclear factor-kappaB (NF-κB) has a major role in many cancers. It has been suggested that some angiotensin receptor blockers (ARBs) could reduce the proliferation of cancer cells. The role of NF-κB pathway has been documented in cell proliferation. OBJECTI...

journal_title：Toxicology mechanisms and methods

authors： Bakhtiari E,Hosseini A,Boroushaki MT,Mousavi SH

更新日期：2015-01-01 00:00:00

abstract：:This report explores the direct counting of "hair-like" struc-tures specific for Gram-positive bacteria. Indications show that these structures are intact after removal from the cell and are sufficiently different from species to species of bacteria to give an indication of bacteria type if not actual identification. ...

journal_title：Toxicology mechanisms and methods

authors： Wick CH,Jabbour RE,McCubbin PE,Deshpande SV

更新日期：2006-01-01 00:00:00

abstract：:Chronic hyperglycemia leads to the development of microvascular complications like diabetic nephropathy. The present study investigated the potential effects of the hydroalcoholic extract of Tribulus terrestris, a plant of Zygophyllaceae family, on the renal complications in streptozotocin (STZ)-induced diabetic rats....

journal_title：Toxicology mechanisms and methods

authors： Gandhi S,Srinivasan BP,Akarte AS

更新日期：2013-09-01 00:00:00

abstract：:ABSTRACT The first aim of this study was to evaluate the degree of organophosphorus (OP) pesticides' exposure in viniculture and tobacco production workers via physical examination (neurology and general health aspect) and analysis of paraoxonase (PON1) and butyrylcholinesterase (BuChE) activities. The second aim was ...

journal_title：Toxicology mechanisms and methods

authors： Sözmen B,Peker S,Kaya U,Erkan M,Sözmen EY

更新日期：2007-01-01 00:00:00

abstract：:To explore the toxic effect of T-2 toxin on mouse Leydig cells and its underlying molecular mechanisms, we isolated Leydig cells from mature mice, set-up Leydig cells culture, treated cells with T-2 toxin, evaluated cell proliferation, detected the caspase-3 activity, mitochondrial activity and apoptosis rate, and mea...

journal_title：Toxicology mechanisms and methods

authors： Zhang YF,Su PK,Wang LJ,Zheng HQ,Bai XF,Li P,Meng XP,Yang JY

更新日期：2018-01-01 00:00:00

abstract：:In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The su...

journal_title：Toxicology mechanisms and methods

authors： Selvaraju V,Joshi M,Suresh S,Sanchez JA,Maulik N,Maulik G

更新日期：2012-06-01 00:00:00

abstract：:Prochloraz is a broad-spectrum contact imidazol fungicide used against several diseases in wheat, barley and oleaginous plants but also for treatment of flower production. Although prochloraz has endocrine disrupting and hepatocarcinogenic effects, there is lack of data on toxic effects of prochloraz. Therefore, we ai...

journal_title：Toxicology mechanisms and methods

authors： Alpertunga B,Kara M,Abudayyak M,Oztas E,Ozden S,Ozhan G

更新日期：2014-05-01 00:00:00

abstract：:Reported myocardial pathology resulting from increased levels of catecholamines in vivo has led us to investigate the effect of adrenalin on the gap junction proteins connexin 40 (Cx40) and Cx43 and the possible relationship to vascular toxicity. Adrenalin and its known metabolites, adrenochrome and adrenolutin, were ...

journal_title：Toxicology mechanisms and methods

authors： Moreau V,Novak MJ,Moore LK

更新日期：2006-01-01 00:00:00

abstract：:For good performance in clinical and forensic toxicology, it is important to be aware of the signs and symptoms related to xenobiotic exposure since they will assist clinicians to reach a useful and rapid diagnosis. This manuscript highlights and critically analyses clinical and forensic imaging related to ethanol abu...

journal_title：Toxicology mechanisms and methods

authors： Dinis-Oliveira RJ,Magalhães T,Moreira R,Proença JB,Pontes H,Santos A,Duarte JA,Carvalho F

更新日期：2014-02-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of different doses of an adenosine A(1) selective agonist, phenylisopropyl adenosine (PIA), on metamidophos-induced cholinergic symptoms, mortality, diaphragm muscle necrosis, and brain oxidative stress. A LD(50) dose of metamidophos (20 mg/kg body weight, p.o.) was fo...

journal_title：Toxicology mechanisms and methods

authors： Kalkan S,Ozdemir D,Ergur BU,Hazardin NU,Akgun A,Topcu A,Kaplan YC,Hocaoglu N,Oransay K,Tuncok Y

更新日期：2009-02-01 00:00:00

abstract：:ABSTRACT Triptolide is a diterpene triepoxide isolated from the traditional Chinese medicinal vine Trypterygium wilfordii hook f. (T. wilfordii). It possesses multiple biological activities, such as antitumor, immunosuppression, and antifertility. Previous studies suggested that triptolide might be a potential candida...

journal_title：Toxicology mechanisms and methods

authors： Ni B,Zhu T,Jiang Z,Zhang R,Zhang T,Zhang L

更新日期：2008-01-01 00:00:00

abstract：:The advent of the industrial revolution has seen a significant increase in the number of new chemical entities (NCEs) released in the environment. It becomes imperative to check the toxic potential of NCEs to nontarget species before they are released for commercial purposes because some of these may exert genotoxicit...

journal_title：Toxicology mechanisms and methods

authors： Bajpayee M,Pandey AK,Parmar D,Dhawan A

更新日期：2005-01-01 00:00:00

abstract：:Silver and gold nanoparticles (Ag-AuNPs) are currently some of the most manufactured nanomaterials. Accordingly, the hazards associated with human exposure to Ag-AuNPs should be investigated to facilitate the risk assessment process. In particular, because pulmonary exposure to Ag-AuNPs occurs during handling of these...

journal_title：Toxicology mechanisms and methods

authors： Ávalos A,Haza AI,Mateo D,Morales P

更新日期：2015-01-01 00:00:00

abstract：:Abstract The effects of 4-hydroxytamoxifen (OHTAM) on the mitochondrial permeability transition (MPT) induced by Ca(2+) plus peroxynitrite (ONOO(-)) or phenylarsine oxide (PhAsO) were studied to clarify its mechanisms of MPT inhibition. Ca(2+) plus ONOO(-) induced mitochondrial swelling, membrane potential (Delta Psi)...

journal_title：Toxicology mechanisms and methods

authors： Cardoso CM,Almeida LM,Custódio JB

更新日期：2005-01-01 00:00:00

abstract：:In this study, 162 samples were analysed for monomer styrene content with using high performance liquid chromatography (HPLC) method in hot tea, milk, cocoa milk. The monomer styrene content, expressed in microg/l of drink and the level of migration of styrene monomer were varied from 0.61 to 8.15 for hot tea, from 0....

journal_title：Toxicology mechanisms and methods

authors： Khaksar MR,Ghazi-Khansari M

更新日期：2009-03-01 00:00:00

abstract：:Timolol is a medication used widely to treat glaucoma. Regarding Ca2+ signaling, timolol was shown to modulate Ca2+-related physiology in various cell types, however, the effect of timolol on Ca2+ homeostasis and cell viability has not been explored in human prostate cancer cells. The aim of this study was to explore ...

journal_title：Toxicology mechanisms and methods

authors： Wang JL,Chou CT,Liang WZ,Wu CJ,Kuo CC,Hao LJ,Shieh P,Jan CR

更新日期：2019-02-01 00:00:00

abstract：CONTEXT:The critical role of CaMKIIδ isoforms in cardiac hypertrophy is well documented. OBJECTIVE:This study was aimed to investigate the possible inhibitory effects of aliskiren (ALS) and/or carvedilol (CAV) on CaMKIIδ isoforms expression in experimental cardiac hypertrophy. MATERIALS AND METHODS:Male Wistar albino...

journal_title：Toxicology mechanisms and methods

authors： Bin-Dayel AF,Abdel Baky NA,Fadda LM,Mohammad RA,Al-Mohanna F

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Oxytocin (OT) injections have been indiscriminately used to milk cattle in dairy industries. There is no study available regarding surveillance of OT in market milk samples. MATERIAL AND METHODS:OT from milk samples was extracted by precipitation with trichloroacetic acid and passed through the solid phase ...

journal_title：Toxicology mechanisms and methods

authors： Mishra M,Ali S,Das M

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer) in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation. METHODS:In this study, different concentrations of arsenic w...

journal_title：Toxicology mechanisms and methods

authors： Phan NN,Li KL,Lin YC

更新日期：2018-07-01 00:00:00

abstract：:Ethanol metabolism is accompanied by generation of free radicals that damage cell components, especially lipids. The present study was designed to investigate the efficacy of the preventive effect of black tea on the lipid oxidative modifications in different tissues (plasma, liver, brain, kidney, stomach, lung, intes...

journal_title：Toxicology mechanisms and methods

authors： Luczaj W,Welerowicz T,Skrzydlewska E,Buszewski B

更新日期：2008-07-01 00:00:00

abstract：:The specific properties of silver nanoparticles (AgNPs), such as antimicrobial activity and electrical conductivity, allow them to be used in many fields. However, their expanding application is also raising health, environmental and safety concerns. Previous in vivo AgNP toxicity studies have indicated a gender-diffe...

journal_title：Toxicology mechanisms and methods

authors： Dong MS,Choi JY,Sung JH,Kim JS,Song KS,Ryu HR,Lee JH,Bang IS,An K,Park HM,Song NW,Yu IJ

更新日期：2013-07-01 00:00:00

abstract：:The present study was designed for determining the exact mechanism of cytotoxic action of aluminum phosphide (AlP) in the presence of iron sucrose as the proposed antidote. Rats received AlP (12 mg/kg) and iron sucrose (5-30 mg/kg) in various sets and were connected to cardiovascular monitoring device. After identific...

journal_title：Toxicology mechanisms and methods

authors： Solgi R,Baghaei A,Golaghaei A,Hasani S,Baeeri M,Navaei M,Ostad SN,Hosseini R,Abdollahi M

更新日期：2015-01-01 00:00:00

abstract：:Renal disease is a common complication of diabetes mellitus. The pathogenesis of diabetic nephropathy is not well understood, but hyperglycemia seems to be a crucial factor. Recent evidence indicates that the overproduction of reactive oxygen species, observed in both clinical and experimental diabetes, and mitochondr...

journal_title：Toxicology mechanisms and methods

authors： Seiça R,Santos DL,Palmeira CM,Moreno AJ,Sena C,Cunha MF,Santos MS

更新日期：2005-01-01 00:00:00

abstract：:Oral cocaine administration results in hepatic necrosis, increased plasma transaminase concentration, and decreased antioxidative capability, which is potentiated by lipopolysaccharide (LPS) in male CF-1 mice. Females administered the same treatment regimen display none of the hepatotoxic effects seen in their male co...

journal_title：Toxicology mechanisms and methods

authors： Visalli T,Turkall R,Abdel-Rahman MS

更新日期：2005-01-01 00:00:00

abstract：:Fusarium mycotoxin toxicosis has been implicated in the etiology of Keshan disease, an endemic mitochondrial cardiomyopathy prevailing in certain areas of China. Butenolide (4-acetamido-4-hydroxy-2-butenoic acid gamma-lactone) is one of the Fusarium mycotoxins which are frequently detected from cereal grains in endemi...

journal_title：Toxicology mechanisms and methods

authors： Wang YM,Liu JB,Peng SQ

更新日期：2009-02-01 00:00:00