Abstract：
:Neuroprotective reagents to protect the nerve cells against oxidative stress and other damages are potentially effective for the medical treatment of Parkinson's disease. Petasites japonicus, a wild vegetable, belongs to the family Compositae and its extract has shown the neuroprotective effects. A further phytochemical investigation of P. japonicus for neuroprotective substances led to the isolation of eight new (1-8) and two known (9 and 10) sesquiterpenes. Their structures were elucidated on the basis of extensive 1D and 2D NMR (HMQC, HMBC, (1)H-(1)H COSY, and NOESY) spectroscopic data analyses, and the structure of 1 was confirmed by X-ray crystallography. The neuroprotective activities of these sesquiterpenes were evaluated against cobalt chloride (CoCl2)-induced neuronal cell death in human dopaminergic SH-SY5Y cells. Five compounds showed a neuroprotective activity.
journal_name
Food Chemjournal_title
Food chemistryauthors
Wang S,Jin DQ,Xie C,Wang H,Wang M,Xu J,Guo Ydoi
10.1016/j.foodchem.2013.04.116subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2075-82issue
3eissn
0308-8146issn
1873-7072pii
S0308-8146(13)00576-1journal_volume
141pub_type
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