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Stem cell origin of testicular seminoma.

Abstract：

INTRODUCTION:A major question concerning cancer is its cells of origin. We hypothesized that distinct cancer subtypes arise from unique cancer-initiating cells. By performing a microarray meta-analysis of seminomas and spermatogonial stem cells, we investigated a putative cell of origin for seminoma. MATERIALS AND METHODS:We obtained published microarray data for 6 human adult germ cell lines, 16 embryonic stem cell lines, 3 normal testicular tissue samples, and 40 seminomas from the Gene Expression Omnibus database. By assessing correlations between various tissue microarrays, we determined the number of transitional events and the distance between seminomas and human spermatogonial stem cells. RESULTS:Our meta-analysis showed that spermatogonial stem cells correlated similarly with seminoma (95% CI of Spearman ρ, 0.33-0.44) and with normal somatic testicular tissue cells (95% CI, 0.39-0.40), which suggests parallel paths of cellular origins. CONCLUSION:Analysis of our results suggests that a unique cancer subtype, namely seminoma, may have originated from an undifferentiated cell with stemness features rather than from a differentiated cell that acquired stemness features.

journal_name

Clin Genitourin Cancer

journal_title

Clinical genitourinary cancer

authors

Som A,Wen S,Tu SM

doi

10.1016/j.clgc.2013.04.015

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

489-94

issue

4

eissn

1558-7673

issn

1938-0682

pii

S1558-7673(13)00076-1

journal_volume

11

pub_type

杂志文章,meta分析

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