Abstract:
INTRODUCTION:Magnetic resonance imaging (MRI)-ultrasound fusion targeted prostate biopsy (FB) has been advocated by many experts as a replacement for the standard template biopsy. Herein, we compared pathology results and cancer detection rates of FB with our standard 14-core systematic prostate biopsy (SB) that includes 2 anterior cores. MATERIALS AND METHODS:One hundred two men with elevated prostate-specific antigen and suspicious lesions on multiparametric MRI, Prostate Imaging Reporting And Data System (PI-RADS) v2 score ≥ 3, underwent FB. Each target lesion was biopsied 3 times; our SB was performed concurrently. Biopsy results were compared for overall and clinically significant (cs), defined as Gleason score ≥ 7, cancer detection. RESULTS:Fifty-two percent of patients had positive biopsy results, and of those, 44 had cs prostate cancer (PCa). The overall detection rates for FB and SB were 39% and 50%, respectively, and there was no statistical difference in the detection rate of csPCa detection rate (P = .42). Of 17 patients diagnosed with a high-risk PCa, defined as Gleason score ≥ 8, SB identified 15, whereas FB identified 10. Within the SB group, 21 had positive anterior core biopsies, of which 11 were cs. CONCLUSION:Expanding the standard template prostate biopsies to include 2 anterior horn sampling may be just as effective as FB in men with PI-RADS lesion ≥ 3, thereby mitigating the increased cost associated with FB.
journal_name
Clin Genitourin Cancerjournal_title
Clinical genitourinary cancerauthors
Sterling J,Smith K,Farber N,Nagaya N,Jang TL,Singer EA,Sadimin E,Kim IYdoi
10.1016/j.clgc.2020.09.006subject
Has Abstractpub_date
2020-10-13 00:00:00eissn
1558-7673issn
1938-0682pii
S1558-7673(20)30226-3pub_type
杂志文章abstract:BACKGROUND:Several agents have demonstrated an overall survival (OS) benefit in patients with metastatic castration-resistant prostate cancer (mCRPC); however, the optimal sequencing of these therapies is unknown as a result of a lack of prospective randomized controlled trials. This retrospective study aimed to identi...
journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
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journal_title:Clinical genitourinary cancer
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pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,meta分析
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2014.12.006
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2020-04-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章,多中心研究
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更新日期:2008-09-01 00:00:00
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
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journal_title:Clinical genitourinary cancer
pub_type: 杂志文章
doi:10.1016/j.clgc.2013.07.008
更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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