Abstract：
:The discovery and elucidation of prostaglandin (PG) pathways, particularly the molecular and clinical role of cyclooxygenase-2 (COX-2) function, has been found to have an important role in neoplasia. Current understanding of the role of COX-2 activity and therefore the potential clinical usefulness of COX-2-specific inhibitors in prostate cancer will be discussed herein. The discovery of PG pathways, the molecular and clinical roles of COX-2 function, and the corresponding application to neoplasia were reviewed in the scientific literature from 1960 through the present time. In addition, thorough review of recent abstract presentations at scientific meetings (American Urological Association and American Society of Clinical Oncology annual meetings from 1998 to the present) was undertaken regarding the potential role of COX-2 in urologic cancers. Reduced apoptosis, increased angiogenesis, and immunosuppression are just some of the known sequelae of COX-2 overexpression, and each effect could have an important role in tumor formation and progression. Preclinical research and pilot clinical studies in prostate cancer to date have been promising. We are just beginning to understand the molecular mechanisms and clinical effects of COX-2 function and its inhibition and the potential for COX-2-specific inhibitors to affect tumor biology and growth, and thereby serve as antitumor drugs in therapeutic and chemopreventive roles in prostate cancer. The absence of complete scientific understanding in these areas presents an exciting opportunity for innovative and important scientific study.
journal_name
Clin Genitourin Cancerjournal_title
Clinical genitourinary cancerauthors
Pruthi RS,Wallen EMdoi
10.3816/CGC.2005.n.034keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
203-11issue
3eissn
1558-7673issn
1938-0682pii
S1558-7673(11)70125-2journal_volume
4pub_type
杂志文章,评审abstract：INTRODUCTION:There is scarce information regarding nivolumab treatment for metastatic renal cell carcinoma (mRCC) in patients with end-stage renal disease (ESRD). This study investigated the safety and efficacy of nivolumab in patients with mRCC and ESRD. MATERIALS AND METHODS:This 2-center retrospective study evaluat...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,多中心研究
doi：10.1016/j.clgc.2019.04.004
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Consistent with other data sets, our own institutional series suggests that survival in patients aged ≥ 75 years with metastatic renal cell carcinoma (mRCC) is inferior to that in patients < 75 years. We sought to confirm these trends through exploration of the Surveillance, Epidemiology and End Results (SEE...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2013.04.011
更新日期：2013-09-01 00:00:00
abstract：:The spontaneous intraperitoneal rupture of the urinary bladder is an extremely rare and life-threatening event. Often, there are difficulties in establishing the diagnosis. A patient with spontaneous perforation of the urinary bladder, 17 years after successful treatment of an adenocarcinoma of the prostate by pelvic ...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.3816/CGC.2007.n.006
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:We comprehensively tested contemporary incidence and mortality rates in patients with germ cell tumor of the testis (GCTT). MATERIALS AND METHODS:Within the Surveillance, Epidemiology, and End Results database (2004-2015), statistical analyses included estimated annual percentage changes, multivariable logi...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2019.06.003
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Neutrophil-to-lymphocyte ratio (NLR) might reflect an increased neutrophilic inflammatory response, and urothelial tumors with squamous-cell features (SqD) have been linked to inflammation. We hypothesized that NLR could be prognostic in these patients. PATIENTS AND METHODS:In patients with SqD muscle-invas...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2017.01.024
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:We evaluated the influence of perinephric fat invasion (PFI) compared with sinus fat invasion (SFI) on disease-free survival (DFS) and cancer-specific survival (CSS) after partial nephrectomy (PN) for stage pT3a renal cell carcinoma (RCC). MATERIALS AND METHODS:Data were recorded from the consecutive reco...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2017.07.019
更新日期：2018-10-01 00:00:00
abstract：INTRODUCTION:A major question concerning cancer is its cells of origin. We hypothesized that distinct cancer subtypes arise from unique cancer-initiating cells. By performing a microarray meta-analysis of seminomas and spermatogonial stem cells, we investigated a putative cell of origin for seminoma. MATERIALS AND MET...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,meta分析
doi：10.1016/j.clgc.2013.04.015
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Limited information is available about the effect of bleomycin administration on the development of pulmonary toxicity in metastatic germ cell tumors (GCT). PATIENTS AND METHODS:A literature search was conducted to identify randomized trials of first-line chemotherapy for GCT. We conducted univariate and mu...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,meta分析
doi：10.1016/j.clgc.2016.08.021
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the outcome of patients with translocation renal cell carcinoma (RCC) treated with partial nephrectomy. PATIENTS AND METHODS:Our institutional review board-approved renal mass registry was queried for patients who underwent partial nephrectomy for a pathologically confi...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2014.12.008
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:Myalgia and arthralgia immune-related adverse events (irAEs) in patients treated with checkpoint inhibitors (CPIs) present a clinical challenge. We describe the clinical characteristics and treatment of myalgia and arthralgia irAEs in CPI-treated patients with genitourinary (GU) malignancies. PATIENTS AND M...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2019.01.021
更新日期：2019-06-01 00:00:00
abstract：OBJECTIVE:To prospectively assess the ideal dosing and the value of fluorescent sentinel lymph node (LN) detection with indocyanine green (ICG) for the detection of LN metastases in intermediate- and high-risk patients undergoing robot-assisted prostatectomy and extended pelvic LN dissection (ePLND). PATIENTS AND METH...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2016.10.014
更新日期：2017-08-01 00:00:00
abstract：INTRODUCTION:The aim of this study was to validate contemporary grading systems, in particular, the Gleason grade group (GGG) 5. PATIENTS AND METHODS:We retrospectively reviewed the clinicopathologic data of 176 patients who underwent radical prostatectomy and whose pathologic results were GGG 4 or 5. The endpoints we...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2020.08.001
更新日期：2020-08-07 00:00:00
abstract：INTRODUCTION:Tumor regression grades (TRGs) quantify the pathologic response to neoadjuvant chemotherapy (NAC). The aim of the study was to investigate the prognostic value of TRGs in combination with the TNM classification in an independent cohort of patients with muscle-invasive bladder cancer (MIBC) treated with NAC...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2019.09.003
更新日期：2019-12-01 00:00:00
abstract：INTRODUCTION:Circulating tumor cells (CTCs) have great potential as circulating biomarkers for solid malignancies. Currently available assays for CTC detection rely on epithelial markers with somewhat limited sensitivity and specificity. We found that the staining pattern of nucleolin, a common nucleolar protein in pro...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2016.12.004
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Frontline treatment of metastatic castration-resistant prostate cancer (mCRPC) consists of docetaxel-based chemotherapy. The median time to progression (TTP) from chemotherapy initiation is 6 to 8 months. Ketoconazole, a nonspecific cytochrome P17 inhibitor (CYP17i), blocks adrenal androgen synthesis. Low-do...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2012.11.003
更新日期：2013-06-01 00:00:00
abstract：:The use of sunitinib in dialysis patients is poorly described but is of clinical importance. We report 2 cases of patients receiving sunitinib for metastatic renal cell carcinoma while undergoing dialysis. The first patient is undergoing hemodialysis and, though responding to sunitinib, is having significant fatigue a...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.3816/CGC.2009.n.035
更新日期：2009-10-01 00:00:00
abstract：:Targeted therapy has changed the treatment of metastatic renal cell carcinoma (mRCC). However, it is unclear if patients need to start systemic therapy immediately or if treatment can be deferred. Identification of the appropriate time to discontinue therapy is also uncertain. We reviewed treatment guidelines and tria...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clgc.2012.06.002
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Therapeutic options for renal cell cancer are inadequate. Depsipeptide is a histone deacetylase inhibitor with promising preclinical and early clinical activity. PATIENTS AND METHODS:Patients with refractory renal cell cancer with normal organ function and no history of significant cardiovascular disease we...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,多中心研究
doi：10.3816/CGC.2006.n.018
更新日期：2006-06-01 00:00:00
abstract：:Testicular germ cell tumors (TGCTs) represent the most common solid tumors among men aged 15 to 34 years. Fortunately, recent advances have made testicular cancer a highly curable disease. Despite the high cure rates, there are still several areas in testis cancer care where treatment decisions are controversial and g...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clgc.2018.10.007
更新日期：2019-02-01 00:00:00
abstract：OBJECTIVE:The spectrum of diseases associated with human immunodeficiency virus (HIV) infection has changed dramatically following the introduction of highly active antiretroviral therapy (HAART). Non-AIDS-defining cancers, including renal cell carcinoma (RCC), are being recognized increasingly in this population. Our ...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.3816/CGC.2008.n.013
更新日期：2008-09-01 00:00:00
abstract：:We present a case of a 73-year-old female with metastatic renal cell carcinoma, clear cell histologic subtype, who developed pruritic rash after 2 weeks of 25 mg weekly infusions of temsirolimus. Rash was located on bilateral antecubital areas and posterior knees. Skin biopsy showed spongiotic dermatitis with eosinoph...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.3816/CGC.2009.n.019
更新日期：2009-08-01 00:00:00
abstract：:Ewing sarcoma typically presents as a skeletal-based tumor, with rare instances of peripheral primitive neuroectodermal tumor (PNET) arising in the soft tissues. Few examples of organ-based PNETs have been previously described in the literature. These tumors are exceedingly rare as a primary renal neoplasm. To our kno...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.3816/CGC.2009.n.032
更新日期：2009-10-01 00:00:00
abstract：:Nephrectomy is the reference-standard treatment for renal-cell carcinoma (RCC). For patients with unresectable disease, tumor may be shrunk by using chemotherapy, thereby permitting surgical resection, which can be curative. We provided neoadjuvant cabozantinib, the preferred tyrosine kinase inhibitor for advanced RCC...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,评审
doi：10.1016/j.clgc.2020.04.003
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Nonurothelial carcinoma (UC) malignancies have traditionally been considered to have a more aggressive clinical course, and little is known about their response to neoadjuvant therapy. We examined the effect of neoadjuvant chemotherapy (NAC) on a large population of patients with bladder cancer (BCa) with di...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2020.01.007
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:This study aimed to determine the prognostic and risk factors for bladder and systemic recurrence after nephroureterectomy (NU) in patients with upper urinary tract (UUT) transitional cell carcinoma (TCC). PATIENTS AND METHODS:Data from 101 patients with nonmetastatic UUT TCC who underwent NU between 1987 a...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2012.08.009
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Pelvic lymph node dissection (PLND) is not recommended for low-risk prostate cancer (PCa) patients. However, the rate of PLND in this population is unknown. METHODS:We queried the National Cancer Data Base for PCa patients who underwent robot-assisted radical prostatectomy from 2010 to 2013 and stratified...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2017.05.013
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Smoking and obesity are known risk factors for renal cell carcinoma (RCC). We determined the influence of smoking, body mass index (BMI), and symptoms on the survival of patients with RCC. PATIENTS AND METHODS:In this retrospective study, the relative overall survival (OS) up to 25 years was calculated amon...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2013.04.017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Peritoneal washing cytology is a technique performed during surgery for genital neoplasms to detect subclinical intraperitoneal metastases from these tumors. The aim of this study was to evaluate PWC utility in presumed benign and malignant female genital tract neoplasms by comparing the results of peritonea...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2013.11.010
更新日期：2014-06-01 00:00:00
abstract：INTRODUCTION:Patients who undergo surgical treatment for malignancy often receive perioperative blood transfusion (PBT). We examined the association between PBT and mortality in patients who received surgical treatment of prostate, bladder, and kidney cancer. MATERIALS AND METHODS:Using the Surveillance, Epidemiology,...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章
doi：10.1016/j.clgc.2014.12.006
更新日期：2015-06-01 00:00:00
abstract：UNLABELLED:The present multicenter phase II study evaluated the efficacy and safety of weekly docetaxel as second-line chemotherapy for metastatic urothelial carcinoma. Weekly docetaxel was well tolerated but demonstrated modest activity, with a response rate of 6%, a median progression-free survival (PFS) of 1.4 month...
journal_title：Clinical genitourinary cancer
pub_type： 杂志文章,多中心研究
doi：10.1016/j.clgc.2015.09.008
更新日期：2016-02-01 00:00:00
