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Identification of Candidates for Active Surveillance: Should We Change the Current Paradigm?

Abstract：

:Active surveillance (AS) has been claimed to avoid overtreatment of prostate cancer (PCa). It remains unclear which patients may benefit from AS. One way to clarify this is to improve the definition of insignificant PCa. PSA and Gleason score--the basic instruments used to select patients for AS--suffer from systematic errors. The nomograms used to define insignificant PCa are based on patients whose disease was classified before changes were introduced in the 2005 Consensus Conference on Gleason Grading; thus, the experience obtained cannot be directly applied to today's patients. Additionally, despite the standardization of prostate-specific antigen assays promoted by the World Health Organization, differences persist and could lead to misclassification of patients. These factors lead to an incorrect classification of patients into risk groups. Although new variables would increase risk group classification, the necessary first step is to optimize the use of both prostate-specific antigen serum levels and Gleason score.

journal_name

Clin Genitourin Cancer

journal_title

Clinical genitourinary cancer

authors

Alcover J,Filella X

doi

10.1016/j.clgc.2015.06.001

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

499-504

issue

6

eissn

1558-7673

issn

1938-0682

pii

S1558-7673(15)00126-3

journal_volume

13

pub_type

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