Metabolic syndrome as a peculiar target for management of prostate cancer patients.

Abstract:

:An interesting and reciprocal association between the metabolic syndrome and prostate cancer has been identified. Metabolic alterations, such as hyperinsulinemia, increased levels of insulin growth factor-1, and insulin resistance could be on the basis of development and progression of many tumors, including prostate cancer, and changes in body composition, in turn, can represent some side effects of androgen deprivation therapy and novel drugs, such as mammalian target of rapamycin inhibitors. This review evaluates this interrelation between metabolic syndrome and prostate tumor scanning in many clinical and preclinical epidemiological studies and describes possible pathogenetic biological mechanisms. Finally, this article discusses feasible clinical implications for the management, prevention, diagnosis, prognosis, and treatment of patients affected by metabolic syndrome and prostate cancer, with particular attention to the metformin action.

journal_name

Clin Genitourin Cancer

authors

Conteduca V,Di Lorenzo G,Bozza G,Ardito R,Aieta M

doi

10.1016/j.clgc.2013.04.009

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

211-20

issue

3

eissn

1558-7673

issn

1938-0682

pii

S1558-7673(13)00055-4

journal_volume

11

pub_type

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