当前位置： SCI文献检索 > Cell Death & Disease期刊下所有文献 > Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.

Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.

Abstract：

:In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before implantation. The genetic stability of human stem cells is critical for their clinical use. However, the relationship between stem-cell expansion and genetic stability is poorly understood. Here, we demonstrate that within the normal expansion period, hMSC cultures show a high percentage of aneuploid cells that progressively increases until senescence. Despite this accumulation, we show that in a heterogeneous culture the senescence-prone hMSC subpopulation has a lower proliferation potential and a higher incidence of aneuploidy than the non-senescent subpopulation. We further show that senescence is linked to a novel transcriptional signature that includes a set of genes implicated in ploidy control. Overexpression of the telomerase catalytic subunit (human telomerase reverse transcriptase, hTERT) inhibited senescence, markedly reducing the levels of aneuploidy and preventing the dysregulation of ploidy-controlling genes. hMSC-replicative senescence was accompanied by an increase in oxygen consumption rate (OCR) and oxidative stress, but in long-term cultures that overexpress hTERT, these parameters were maintained at basal levels, comparable to unmodified hMSCs at initial passages. We therefore propose that hTERT contributes to genetic stability through its classical telomere maintenance function and also by reducing the levels of oxidative stress, possibly, by controlling mitochondrial physiology. Finally, we propose that aneuploidy is a relevant factor in the induction of senescence and should be assessed in hMSCs before their clinical use.

journal_name

Cell Death Dis

journal_title

Cell death & disease

authors

Estrada JC,Torres Y,Benguría A,Dopazo A,Roche E,Carrera-Quintanar L,Pérez RA,Enríquez JA,Torres R,Ramírez JC,Samper E,Bernad A

doi

10.1038/cddis.2013.211

subject

Has Abstract

pub_date

2013-06-27 00:00:00

pages

e691

issn

2041-4889

pii

cddis2013211

journal_volume

4

pub_type

杂志文章

相关文献

Cell Death & Disease文献大全
  • Arachidonic acid promotes skin wound healing through induction of human MSC migration by MT3-MMP-mediated fibronectin degradation.

    abstract：:Arachidonic acid (AA) is largely released during injury, but it has not been fully studied yet how AA modulates wound repair with stem cells. Therefore, we investigated skin wound-healing effect of AA-stimulated human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in vivo and its molecular mechanism i...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.114

    authors： Oh SY,Lee SJ,Jung YH,Lee HJ,Han HJ

    更新日期：2015-05-07 00:00:00

  • Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor.

    abstract：:Mesothelin (MSLN) is an attractive antigen for chimeric antigen receptor (CAR) T therapy and the epitope selection within MSLN is essential. In this study, we constructed two types of CARs targeting either region I of MSLN (meso1 CAR, also known as a membrane-distal region) or region III of MSLN (meso3 CAR, also known...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1711-1

    authors： Zhang Z,Jiang D,Yang H,He Z,Liu X,Qin W,Li L,Wang C,Li Y,Li H,Xu H,Jin H,Qian Q

    更新日期：2019-06-17 00:00:00

  • POPX2 phosphatase regulates apoptosis through the TAK1-IKK-NF-κB pathway.

    abstract：:Chemoresistance is one of the leading causes that contributes to tumor relapse and poor patient outcome after several rounds of drug therapy. The causes of chemoresistance are multi-factorial. Ultimately, it is the balance of pro- and anti-apoptotic activities in the cells. We have previously reported links between PO...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.443

    authors： Weng T,Koh CG

    更新日期：2017-09-14 00:00:00

  • SOCE induced calcium overload regulates autophagy in acute pancreatitis via calcineurin activation.

    abstract：:Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is characterized by inflammation, edema, vacuolization and necrosis, which has significant morbidity and lethality. The pathogenesis of AP has not been established completely. An early and critical feature of AP is the aberrant signaling of ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-017-0073-9

    authors： Zhu ZD,Yu T,Liu HJ,Jin J,He J

    更新日期：2018-01-19 00:00:00

  • SPATS2, negatively regulated by miR-145-5p, promotes hepatocellular carcinoma progression through regulating cell cycle.

    abstract：:Spermatogenesis associated serine rich 2 (SPATS2) has been reported to contribute to the tumorigenesis of multiple malignancies. The molecular function of SPATS2 in hepatocellular carcinoma (HCC) is still not fully understood. In this study, we aimed to investigate the expression pattern and function roles of SPATS2 i...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03039-y

    authors： Dong G,Zhang S,Shen S,Sun L,Wang X,Wang H,Wu J,Liu T,Wang C,Wang H,Lu T,Rao B,Ren Z

    更新日期：2020-10-09 00:00:00

  • KLF5 inhibits STAT3 activity and tumor metastasis in prostate cancer by suppressing IGF1 transcription cooperatively with HDAC1.

    abstract：:KLF5 is frequently deleted and downregulated in prostate cancer, and recently it has been reported that KLF5 loss is enriched in the aggressive branches of prostate cancer evolution. However, why KLF5 loss is associated with prostate cancer aggressiveness is still not clear. Herein, we analyzed KLF5 expression in TCGA...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2671-1

    authors： Ma JB,Bai JY,Zhang HB,Jia J,Shi Q,Yang C,Wang X,He D,Guo P

    更新日期：2020-06-16 00:00:00

  • The p75 receptor mediates axon growth inhibition through an association with PIR-B.

    abstract：:The Nogo receptor and paired immunoglobulin-like receptor B (PIR-B) are receptors for three myelin-derived axon-growth inhibitors, including myelin-associated glycoprotein (MAG). In this study, we report that the p75 receptor is required for the signal transduction of PIR-B, which interacted with p75 upon ligand bindi...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2011.85

    authors： Fujita Y,Takashima R,Endo S,Takai T,Yamashita T

    更新日期：2011-09-01 00:00:00

  • Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury.

    abstract：:Traumatic brain injury (TBI) activates multiple neuronal cell death mechanisms, leading to post-traumatic neuronal loss and neurological deficits. TBI-induced cell cycle activation (CCA) in post-mitotic neurons causes regulated cell death involving cyclin-dependent kinase (CDK) activation and initiation of an E2F tran...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1156-y

    authors： Aubrecht TG,Faden AI,Sabirzhanov B,Glaser EP,Roelofs BA,Polster BM,Makarevich O,Stoica BA

    更新日期：2018-11-06 00:00:00

  • Eosinophil differentiation in the bone marrow is promoted by protein tyrosine phosphatase SHP2.

    abstract：:SHP2 participates in multiple signaling events by mediating T-cell development and function, and regulates cytokine-dependent granulopoiesis. To explore whether and how SHP2 can regulate bone-marrow eosinophil differentiation, we investigate the contribution of SHP2 in the bone-marrow eosinophil development in allergi...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.74

    authors： Xia LX,Hua W,Jin Y,Tian BP,Qiu ZW,Zhang C,Che LQ,Zhou HB,Wu YF,Huang HQ,Lan F,Ke YH,Lee JJ,Li W,Ying SM,Chen ZH,Shen HH

    更新日期：2016-04-07 00:00:00

  • Regulation and biological role of the peptide/histidine transporter SLC15A3 in Toll-like receptor-mediated inflammatory responses in macrophage.

    abstract：:The peptide/histidine transporter SLC15A3 is responsible for transporting histidine, certain dipeptide and peptidomimetics from inside the lysosome to cytosol. Previous studies have indicated that SLC15A3 transcripts are mainly expressed in the lymphatic system, however, its regulation and biological role in innate im...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-0809-1

    authors： Song F,Yi Y,Li C,Hu Y,Wang J,Smith DE,Jiang H

    更新日期：2018-07-10 00:00:00

  • HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer.

    abstract：:Dysfunctional mitochondria have been shown to enhance cancer cell proliferation, reduce apoptosis, and increase chemoresistance. Chemoresistance develops in nearly all patients with colorectal cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. However, the effect of dynamin-related prote...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1019-6

    authors： Huang CY,Chiang SF,Chen WT,Ke TW,Chen TW,You YS,Lin CY,Chao KSC,Huang CY

    更新日期：2018-09-26 00:00:00

  • Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis.

    abstract：:Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal-fetal interface has not been clarified yet. In th...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.301

    authors： Wu F,Tian F,Zeng W,Liu X,Fan J,Lin Y,Zhang Y

    更新日期：2017-06-29 00:00:00

  • Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.

    abstract：:Metastasis is the leading cause of death for colorectal cancer (CRC). However, the protein transport process involved in CRC metastasis remains unclear. In this report, we use whole-exome sequencing and bioinformatics analysis to identify somatic mutations in CRC samples and found mutations of the protein transport ge...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2358-7

    authors： Yang C,Chen N,Li X,Lu D,Hou Z,Li Y,Jin Y,Gu J,Yin Y

    更新日期：2020-03-02 00:00:00

  • GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions.

    abstract：:Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD), there are early hippocampal deficits both in patients and transgenic mouse models, which prompted us to investigate whether disease-specific...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.104

    authors： L'Episcopo F,Drouin-Ouellet J,Tirolo C,Pulvirenti A,Giugno R,Testa N,Caniglia S,Serapide MF,Cisbani G,Barker RA,Cicchetti F,Marchetti B

    更新日期：2016-04-28 00:00:00

  • Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells.

    abstract：:The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads to loss of viability...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1830-8

    authors： Willbold R,Wirth K,Martini T,Sültmann H,Bolenz C,Wittig R

    更新日期：2019-08-09 00:00:00

  • CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells.

    abstract：:Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1306-x

    authors： Silva-Pavez E,Villar P,Trigo C,Caamaño E,Niechi I,Pérez P,Muñoz JP,Aguayo F,Burzio VA,Varas-Godoy M,Castro AF,Colombo MI,Tapia JC

    更新日期：2019-01-25 00:00:00

  • Intraperitoneal injection of IFN-γ restores microglial autophagy, promotes amyloid-β clearance and improves cognition in APP/PS1 mice.

    abstract：:Autophagy is a major self-degradative process that maintains cellular homeostasis and function in mammalian cells. Autophagic dysfunction occurs in the early pathogenesis of Alzheimer's disease (AD) and directly regulates amyloid-β (Aβ) metabolism. Although it has been proven that the cytokine IFN-γ enhances autophagy...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2644-4

    authors： He Z,Yang Y,Xing Z,Zuo Z,Wang R,Gu H,Qi F,Yao Z

    更新日期：2020-06-08 00:00:00

  • MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells.

    abstract：:Mammalian folliculogenesis is a complex process in which primordial follicles develop into pre-ovulatory follicles, followed by ovulation to release mature oocytes. In this study, we explored the role of miR-144 in ovulation. miR-144 was one of the differentially expressed microRNAs, which showed 5.59-fold changes, in...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.24

    authors： Zhou J,Lei B,Li H,Zhu L,Wang L,Tao H,Mei S,Li F

    更新日期：2017-02-09 00:00:00

  • MiR-485-3p and miR-485-5p suppress breast cancer cell metastasis by inhibiting PGC-1α expression.

    abstract：:Breast cancer is the worldwide leading cause of cancer mortality in women. The majority of deaths from breast cancer arise from metastasis of local tumors. Cancer cells support their rapid proliferation by diverting metabolites into anabolic pathways, but during cancer metastasis, the proliferative program of invasive...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.27

    authors： Lou C,Xiao M,Cheng S,Lu X,Jia S,Ren Y,Li Z

    更新日期：2016-03-24 00:00:00

  • Increased expression of EHF via gene amplification contributes to the activation of HER family signaling and associates with poor survival in gastric cancer.

    abstract：:The biological function of E26 transformation-specific (ETS) transcription factor EHF/ESE-3 in human cancers remains largely unknown, particularly gastric cancer. The aim of this study was to explore the role of EHF in tumorigenesis and its potential as a therapeutic target in gastric cancer. By using quantitative RT-...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.346

    authors： Shi J,Qu Y,Li X,Sui F,Yao D,Yang Q,Shi B,Ji M,Hou P

    更新日期：2016-10-27 00:00:00

  • CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

    abstract：:Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor-associated macrophages (TAMs) are the most abundant immune cell population within the tumor microenvironment (TME). Systematic investigation o...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-2435-y

    authors： Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

    更新日期：2020-04-16 00:00:00

  • Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype.

    abstract：:Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream transducers of the ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2016.195

    authors： Infante P,Alfonsi R,Ingallina C,Quaglio D,Ghirga F,D'Acquarica I,Bernardi F,Di Magno L,Canettieri G,Screpanti I,Gulino A,Botta B,Mori M,Di Marcotullio L

    更新日期：2016-09-22 00:00:00

  • MicroRNA-153-5p promotes the proliferation and metastasis of renal cell carcinoma via direct targeting of AGO1.

    abstract：:MicroRNAs (miRNAs) have been demonstrated to affect the biological processes of cancers and showed great potential for prognostic biomarkers. In this study, we screened differentially expressed miRNAs in ccRCC based on three dimensions of metastasis, prognosis, and differential expression compared to normal tissue usi...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03306-y

    authors： Li Z,Zhao S,Zhu S,Fan Y

    更新日期：2021-01-04 00:00:00

  • Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy.

    abstract：:Hippo signalling regulates eye growth during embryogenesis through its effectors YAP and TAZ. Taking advantage of a Yap heterozygous mouse line, we here sought to examine its function in adult neural retina, where YAP expression is restricted to Müller glia. We first discovered an unexpected temporal dynamic of gene c...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-02860-9

    authors： Masson C,García-García D,Bitard J,Grellier ÉK,Roger JE,Perron M

    更新日期：2020-08-14 00:00:00

  • IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling.

    abstract：:Uncontrollable inflammatory response acts as a driver of sepsis-associated liver injury (SALI). IL-22 plays an important role in regulating inflammatory responses, but its role in SALI remains unknown. The aim of the study was to assess the association of serum IL-22 with SALI in pediatric patients and to enclose the ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-020-03176-4

    authors： Shao L,Xiong X,Zhang Y,Miao H,Ren Y,Tang X,Song J,Wang C

    更新日期：2020-11-11 00:00:00

  • miR-181d and c-myc-mediated inhibition of CRY2 and FBXL3 reprograms metabolism in colorectal cancer.

    abstract：:Colorectal cancer (CRC) is the second major cause of tumor-related deaths. MicroRNAs (miRNAs) have pivotal roles in CRC progression. Here, we describe the effect of miR-181d on CRC cell metabolism and underlying molecular mechanism. Our data firmly demonstrated that knockdown of miR-181d suppressed CRC cell proliferat...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2017.300

    authors： Guo X,Zhu Y,Hong X,Zhang M,Qiu X,Wang Z,Qi Z,Hong X

    更新日期：2017-07-27 00:00:00

  • Angiopoietin 2 induces astrocyte apoptosis via αvβ5-integrin signaling in diabetic retinopathy.

    abstract：:The vascular leakage in diabetic retinopathy leads to macular edema and vision loss. Although astrocyte play an important role in regulating blood-brain barrier integrity in the brain, the precise role of astrocyte in blood-retinal barrier was yet to be elucidated. This study aimed to investigate the role of angiopoie...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2015.347

    authors： Yun JH,Park SW,Kim JH,Park YJ,Cho CH,Kim JH

    更新日期：2016-02-18 00:00:00

  • Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells.

    abstract：:Our previous study demonstrated that angiogenesis increased during the recovery of heat-denatured endothelial cells. However, the mechanism is still unclear. This study aimed to investigate the relation of autophagy and angiogenesis during the recovery of heat-denatured endothelial cells. A rat deep partial-thickness ...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-018-1194-5

    authors： Liang P,Jiang B,Li Y,Liu Z,Zhang P,Zhang M,Huang X,Xiao X

    更新日期：2018-11-19 00:00:00

  • SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis.

    abstract：:The sex-determining region Y (SRY)-box (SOX) family has a crucial role in carcinogenesis and cancer progression. However, the role of SOX12 and the mechanism by which it is dysregulated in colorectal cancer (CRC) remain unclear. Here we analyzed SOX12 expression patterns in two independent CRC cohorts (cohort I, n = 3...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/s41419-019-1481-9

    authors： Du F,Chen J,Liu H,Cai Y,Cao T,Han W,Yi X,Qian M,Tian D,Nie Y,Wu K,Fan D,Xia L

    更新日期：2019-03-11 00:00:00

  • Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma.

    abstract：:Multiple myeloma (MM) is an incurable malignancy with an unmet need for innovative treatment options. Histone deacetylase inhibitors (HDACi) are a new class of anticancer agent that have demonstrated activity in hematological malignancies. Here, we investigated the efficacy and safety of HDACi (vorinostat, panobinosta...

    journal_title：Cell death & disease

    pub_type： 杂志文章

    doi：10.1038/cddis.2013.306

    authors： Matthews GM,Lefebure M,Doyle MA,Shortt J,Ellul J,Chesi M,Banks KM,Vidacs E,Faulkner D,Atadja P,Bergsagel PL,Johnstone RW

    更新日期：2013-09-12 00:00:00