Abstract：
BACKGROUND:Devices that limit microaspiration through the cuffs of endotracheal tubes could help prevent ventilator-associated pneumonia (VAP). The amount of tracheal microaspirations could be a relevant study endpoint. The aim of our study was to assess whether amylase measured in tracheal secretions constituted a relevant marker for microaspiration. METHODS:Twenty-six patients, intubated for at least 48 h and supplied with a subglottic secretion-suctioning device, constituted a group with a high risk of microaspiration. Twelve non-ventilated patients that required a bronchoscopy procedure constituted a group with a low risk of microaspiration (the control group). Tracheal (T) amylase was compared between the groups. In the intubated group, a series of oral (O), subglottic (Sg) and tracheal (T) suction samples were collected and T/O, T/Sg, Sg/O amylase ratios were determined. RESULTS:Amylase was measured in 277 (89 Sg, 96 B, 92 T) samples from the intubated group and in 12 T samples from the control group. Tracheal amylase was lower in the control group than the intubated group (191 [10-917] vs. 6661 [2774-19,358] IU/L, P<0.001). Amylase gradually increased from tracheal (6661 [2774-19,358] IU/L), to subglottic (130,750 [55,257-157,717] IU/L), to oral samples (307,606 [200,725-461,300] IU/L), resulting in a median 5.5% T/O ratio. In a subset of intubated patients, T amylase samples were assessed in two different laboratories, and gave reproducible results. CONCLUSION:Tracheal amylase was easy to collect, transport, and measure. The T/O amylase ratio is a first step towards quantifying oropharyngeal to tracheal microaspiration in mechanically-ventilated patients.
journal_name
Minerva Anestesioljournal_title
Minerva anestesiologicaauthors
Filloux B,Bedel A,Nseir S,Mathiaux J,Amadéo B,Clouzeau B,Pillot J,Saghi T,Vargas F,Hilbert G,Gruson D,Boyer Asubject
Has Abstractpub_date
2013-09-01 00:00:00pages
1003-10issue
9eissn
0375-9393issn
1827-1596pii
R02138516journal_volume
79pub_type
杂志文章abstract：AIM:The aim of this paper is to describe the anesthesiological management and the outcome of beating heart revascularization. METHODS:A prospective study has been performed in a tertiary teaching hospital on 100 consecutive patients undergoing off-pump coronary artery revascularization. The main features of anesthetic...
journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Paracetamol is widely used in the management of acute and chronic pain. The purpose of this review is to give anesthesiologists answers to some of the most common questions about paracetamol, specifically the following questions. What is the mechanism of action of paracetamol? Is paracetamol a NSAID? Which endogenous ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Thrombocytopenia is associated with worse outcomes in critically ill patients. The clinical relevance of other platelets indices is less studied. We investigated the ability of the platelets distribution width (PDW) and the mean platelet volume (MPV) to predict mortality in critically ill patients. We hypoth...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：10.23736/S0375-9393.20.14528-0
更新日期：2020-09-22 00:00:00
abstract：:Drugs used in anesthesia do not always produce the expected neurophysiological results. By studying those cases in which the reappearance of intraoperative awareness is most common, an attempt was made to estimate how many and which levels of cerebral function could be identified. Four levels were recognised: awarenes...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:An account is given of the employment of althesin as an induction and maintenance anaesthetic. It is free of the drawbacks observed with thiopentone induction, and has negligible haemodynamic and respiratory effects. Its association with leptophen permitted excellent analgesia at minimal leptophen doses, without secon...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1980-02-01 00:00:00
abstract：:The authors analyze the physiological basis, technical aspects and clinical usefulness of several methods for pressure-volume curves determinations in mechanically ventilatory, acute respiratory failure patients. ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2000-05-01 00:00:00
abstract：AIM:Heat shock proteins (HSPs), induced by thermal stress, make the cells more resistant to following stress. We aimed to verify if rats heating reduces the production of TNF-alpha in a model of acute respiratory distress syndrome (ARDS). METHODS:We divided 34 Wistar rats in Group A and Group B. The rats of Group A re...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2005-10-01 00:00:00
abstract：:Intranasal dexmedetomidine, although still off-label, recently boasted an increasing consensus for different uses, namely, in diagnostic non-painful procedures, in painful procedures and in surgical premedication. However, at present, there is no consensus regarding indications, dosage and timing for administration. T...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
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journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-05-01 00:00:00
abstract：: ...
journal_title：Minerva anestesiologica
pub_type： 评论,信件
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abstract：BACKGROUND:GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the CNS and well-known target for general anesthetics. In addition, the dysregulation of GABA could be involved in the etiology of major depressive disorder (MDD). In this study, we aimed to determine whether MDD has any effect on anest...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
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journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2002-12-01 00:00:00
abstract：:The purpose of the case is to report the clinical value of the ultrasound-guided posterior approach to the brachial plexus in the treatment of phantom limb syndrome after an upper extremity amputation. The author experienced ultrasound guidance as sole technique to localize the brachial plexus for the purpose of placi...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Multiple patient and clinical characteristics contribute to the variable outcome of spinal anesthesia (SPA). Acute reduction of cerebrospinal fluid (CSF) volume may alter the effect of SPA. The objective of the present study was to test if aspiration of 10 mL CSF immediately prior to SPA is associated with h...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：10.23736/S0375-9393.20.14138-5
更新日期：2020-06-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：10.23736/S0375-9393.18.12188-2
更新日期：2019-04-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2007-06-01 00:00:00
abstract：:Systemic air embolisms are a rare but often a fatal complication of endoscopic retrograde cholangiopancreatography (ERCP). Only few cases have been reported in scientific studies. This paper concerns a case of a systemic air embolism that occurred during endoscopic sphincterotomy for gallstone removal in a 79-year-old...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：2013-12-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2015-10-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-10-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-11-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1996-12-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-10-01 00:00:00
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journal_title：Minerva anestesiologica
pub_type： 杂志文章,评审
doi：
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Maximal inspiratory pressure (MIP) can help to evaluate inspiratory muscle strength. However its determination in ventilated patients is cumbersome and needs special equipment. We hypothesized that MIP could be obtained by using the expiratory hold knob of the ventilator. The aim of this study was to verify ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Pneumonia is the primary source of sepsis and is significantly associated with mortality. However, only a few studies focus on its clinical characteristics and outcomes. METHODS:We evaluated 500 intensive care unit patients who met severe sepsis or septic shock criteria, dividing them into two distinct grou...
journal_title：Minerva anestesiologica
pub_type： 杂志文章,多中心研究
doi：
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Based on available data, there is no definite clinical research describing option, timing and effects of assisted as opposed to controlled ventilation to successfully treat acute severely brain-injured patients. This study demonstrates pressure support ventilation as a possible alternative to controlled vent...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：2002-04-01 00:00:00
abstract：:Two cases of Paraquat poisoning of anticonservative origin are described. A brief account of the chemical composition and mechanism of action of Paraquat is followed by a discussion of the clinical and therapeutic features of the two cases. The anatomopathological findings obtained from lung specimens examined during ...
journal_title：Minerva anestesiologica
pub_type： 杂志文章
doi：
更新日期：1979-12-01 00:00:00
