Blunted inflammatory response to lipopolysaccharide endotracheal instillation due to thermal preconditioning.

Abstract:

AIM:Heat shock proteins (HSPs), induced by thermal stress, make the cells more resistant to following stress. We aimed to verify if rats heating reduces the production of TNF-alpha in a model of acute respiratory distress syndrome (ARDS). METHODS:We divided 34 Wistar rats in Group A and Group B. The rats of Group A received thermal shock and tracheal instillation of lipopolysaccharide (LPS), the rats of Group B only tracheal instillation of LPS. All the rats have been then subdivided in 6 subgroups sacrificed at different times after instillation of LPS: A30 and B30 at 30 min, A90 and B90 at 90 min and A180 and B180 at 180 min. We dosed the serum concentration of TNF-alpha and the values of every subgroup have been compared with the Student t-test. RESULTS:The serum concentration of TNF-alpha in the subgroup A90 resulted significantly lower than in the subgroup B90. CONCLUSIONS:The exposure to thermal stress resulting in the production of HSPs reduced the concentration of TNF-alpha in this model of ARDS.

journal_name

Minerva Anestesiol

journal_title

Minerva anestesiologica

authors

Di Filippo A,Rinaldi S,Pascente C,Messeri D,De Gaudio AR

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

601-7

issue

10

eissn

0375-9393

issn

1827-1596

journal_volume

71

pub_type

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