Intranasal dexmedetomidine in pediatrics: update of current knowledge.

Abstract:

:Intranasal dexmedetomidine, although still off-label, recently boasted an increasing consensus for different uses, namely, in diagnostic non-painful procedures, in painful procedures and in surgical premedication. However, at present, there is no consensus regarding indications, dosage and timing for administration. This article aims to provide a comprehensive literature analysis and summarize the more recent evidence of research on pediatric intranasal dexmedetomidine, in the effort to better delineate usefulness and limits for each specific indication. In summary, available pediatric evidence confirms efficacy and safety of dexmedetomidine for intranasal administration. Pharmacological profile for the various pediatric ages and procedures still needs quality studies and pharmacokinetic in-depth analysis.

journal_name

Minerva Anestesiol

journal_title

Minerva anestesiologica

authors

Mondardini MC,Amigoni A,Cortellazzi P,Di Palma A,Navarra C,Picardo SG,Puzzutiello R,Rinaldi L,Vitale F,Zito Marinosci G,Conti G

doi

10.23736/S0375-9393.19.13820-5

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1334-1345

issue

12

eissn

0375-9393

issn

1827-1596

pii

S0375-9393.19.13820-5

journal_volume

85

pub_type

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