Challenges in the therapy of chromoblastomycosis.

Abstract:

:Chromoblastomycosis (CBM) is an implantation mycosis mainly occurring in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long-term therapy with systemic antifungals flanked by various physical treatment regimens. As in other neglected endemic mycoses, comparative clinical trials have not been performed for this disease; nowadays, therapy is mainly based on a few open trials and on expert opinions. Itraconazole, either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been employed successfully in combination with antifungals in patients presenting with CBM. In the present paper, the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.

journal_name

Mycopathologia

journal_title

Mycopathologia

authors

Queiroz-Telles F,Santos DW

doi

10.1007/s11046-013-9648-x

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

477-88

issue

5-6

eissn

0301-486X

issn

1573-0832

journal_volume

175

pub_type

杂志文章,评审
  • Determination of the minimal inhibitory concentration of amphotericin B and miconazole for 21 strains of Aspergillus.

    abstract::The susceptibility of 21 strains of Aspergillus (11 of A. fumigatus, 8 of A, niger, and 2 of A. flavus) isolated from human pathologic specimens to Amphotericin B and Miconazole has been comparatively studied. Determination of the minimal inhibitory concentration of both drugs in a liquid medium showed a noticeably va...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00576365

    authors: Martinez J,Torres JM,Arteaga F,Foz-Tena A

    更新日期:1978-11-10 00:00:00

  • Further toxic properties of the fungal metabolite dothistromin.

    abstract::The toxicity of the fungal phytotoxin dothistromin (l) to microorganisms, its lysis of human red blood corpuscles and beetroot tissue, and its unexpectedly selective inhibition of radicle elongation for Trigonella foenum-graecum were strongly light-dependent. Dothistromin was also toxic to Artemia salina but without r...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436652

    authors: Stoessl A,Abramowski Z,Lester HH,Rock GL,Towers GH

    更新日期:1990-12-01 00:00:00

  • A new fumonisin from solid cultures of Fusarium moniliforme.

    abstract::A new fumonisin has been isolated from Fusarium moniliforme isolate MRC826 grown on corn. It was shown by NMR and mass spectrometry to be an isomer of fumonisin B2 that has free hydroxyl groups at C-3 and C-10 instead of the normal C-3 and C-5. This new fumonisin was detected in cultures of most isolates of F. monilif...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00497275

    authors: Plattner RD,Weisleder D,Shackelford DD,Peterson RP,Powell RG

    更新日期:1992-02-01 00:00:00

  • Occurrence and population size of Malassezia spp. in the external ear canal of dogs and cats both healthy and with otitis.

    abstract::Malassezia yeasts are commensal organisms of human and animal skin that occasionally act as pathogens; lipid-dependent species are associated with human skin disorders. The aim of this work was to evaluate the occurrence, risk factors and population size of different species of Malassezia in the external ear canal of ...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-005-0151-x

    authors: Cafarchia C,Gallo S,Capelli G,Otranto D

    更新日期:2005-09-01 00:00:00

  • Detection of satratoxin g and h in indoor air from a water-damaged building.

    abstract::The occurrence of Stachybotrys chartarum in indoor environments has been linked to adverse health effects as well as few cases of pulmonary haemorrhages in humans. Although the highly toxic secondary metabolites of this fungus, like satratoxin G and H, were frequently claimed with outbreaks of such diseases, these tox...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-008-9126-z

    authors: Gottschalk C,Bauer J,Meyer K

    更新日期:2008-08-01 00:00:00

  • Pichia anomala (Candida pelliculosa) fungemia in a patient with sickle cell disease.

    abstract::This case report discusses a patient with sickle cell disease who presented with fungemia from Pichia anomala (teleomorph: Candida pelliculosa). The organism was identified as P. anomala by MALDI-TOF VITEK mass spectrometry and VITEK 2 yeast identification card. Pichia anomala should be considered in sickle cell patie...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-013-9677-5

    authors: Chan AW,Cartwright EJ,Reddy SC,Kraft CS,Wang YF

    更新日期:2013-10-01 00:00:00

  • Digestion of killed Paracoccidioides brasiliensis by neutrophils.

    abstract::We previously described an in vitro assay showing that neutrophils (PMNs) from patients with paracoccidioidomycosis (PARA) have a specific digestive deficiency against suspensions of live Paracoccidioides brasiliensis. We now report that this defect is equally detectable against autoclaved, but not Amphotericin B-kill...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436927

    authors: Goihman-Yahr M,Rothenberg A,Bretaña A,Istúriz G,Rosquete R,Avila-Millán E,Viloria N,Saavedra de Borges N,Carrasquero M,Pérez de Fernández B

    更新日期:1989-04-01 00:00:00

  • Aerosolized Lipid Amphotericin B for Complementary Therapy and/or Secondary Prophylaxis in Patients with Invasive Pulmonary Aspergillosis: A Single-Center Experience.

    abstract:BACKGROUND:Experience with aerosolized lipid amphotericin B (aeLAB) as therapy or secondary prophylaxis in patients with invasive pulmonary aspergillosis (IPA) is anecdotal. METHODS:We performed a single-center retrospective cohort study to evaluate the efficacy of systemic antifungal therapy with and without aeLAB in...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-019-00331-0

    authors: Venanzi E,Martín-Dávila P,López J,Maiz L,de la Pedrosa EG,Gioia F,Escudero R,Filigheddu E,Moreno S,Fortún J

    更新日期:2019-04-01 00:00:00

  • Antifungal susceptibility profile of cryptic species of Aspergillus.

    abstract::The use of molecular tools has led to the description of new cryptic species among different Aspergillus species complexes. Their frequency in the clinical setting has been reported to be between 10 and 15%. The susceptibility to azoles and amphotericin B of many of these species is low, and some of them, such as Aspe...

    journal_title:Mycopathologia

    pub_type: 杂志文章,评审

    doi:10.1007/s11046-014-9775-z

    authors: Alastruey-Izquierdo A,Alcazar-Fuoli L,Cuenca-Estrella M

    更新日期:2014-12-01 00:00:00

  • Transformation of sterigmatocystin and O-methylsterigmatocystin by aflatoxigenic and nonaflatoxigenic field isolates of the Aspergillus flavus group.

    abstract::Transformation of sterigmatocystin and O-methylsterigmatocystin (two metabolic aflatoxin precursors) to aflatoxins by aflatoxigenic and nonaflatoxigenic field isolates of Aspergillus flavus was studied. The 24 nonaflatoxigenic isolates investigated failed to transform both precursors. Among the 8 aflatoxin-producing i...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436367

    authors: Pro MJ,Moreno MA,Suárez G

    更新日期:1991-11-01 00:00:00

  • Cryptococcal capsular polysaccharide clearance in nonimmune mice.

    abstract::Clearance of cryptococcal polysaccharide (CP) from tissues and body fluids of nonimmune mice was studied. Mice were injected intravenously only with one mg of purified CP, and serum, urine and tissues were obtained from each animal at various intervals for a period of 84 days. Tissue extracts, serum and urine were tes...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436580

    authors: Muchmore HG,Scott EN,Felton FG,Fromtling RA

    更新日期:1982-04-23 00:00:00

  • [Paracoccidioidomycosis: apropos of 3 new Uruguayan cases].

    abstract::Three new Uruguayan paracoccidioidomycosis human cases are presented. Two of them correspond to the disseminated form with metastatic lesions at the oral mucosa; the remaining one, with important pulmonary bilateral lesions corresponds to the pure chronic pulmonary form of the disease which is recognized by the first ...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00466070

    authors: Asconeguy FR,Bonasse J,Calegari LF,Conti Díaz IA

    更新日期:1982-06-18 00:00:00

  • Phylogenetic Diversity and In Vitro Susceptibility Profiles of Human Pathogenic Members of the Fusarium fujikuroi Species Complex Isolated from South India.

    abstract::Availability of molecular methods, gene sequencing, and phylogenetic species recognition have led to rare fungi being recognized as opportunistic pathogens. Fungal keratitis and onychomycosis are fairly common mycoses in the tropics, especially among outdoor workers and enthusiasts. The frequently isolated etiological...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-018-0248-7

    authors: Tupaki-Sreepurna A,Thanneru V,Natarajan S,Sharma S,Gopi A,Sundaram M,Kindo AJ

    更新日期:2018-06-01 00:00:00

  • Evaluation of pathological effects in broilers during fumonisins and clays exposure.

    abstract::This study was conducted to evaluate the possible protector effect of bentonite and zeolite in Bovans chicks fed a diet containing 59 mg kg(-1) of fumonisin B1 (FB1) during 3 weeks. A total of 200 one-day-old male chicks were treated varying the amount of bentonite and zeolite. Chick weight was registered weekly. At t...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-012-9534-y

    authors: Vizcarra-Olvera JE,Astiazarán-García H,Burgos-Hernández A,Parra-Vergara NV,Cinco-Moroyoqui FJ,Sánchez-Mariñez RI,Quintana-Obregón EA,Cortez-Rocha MO

    更新日期:2012-09-01 00:00:00

  • Scenario of chronic dermatophytosis: an Indian study.

    abstract::Chronic dermatophytosis was observed in 2276 (10.02%) of 22,692 patients with dermatophytosis during a period of 5.5 years. Males were affected at least 3 times more frequently than females. The age group most commonly affected was between 20 and 40 years of age. Females were affected more between the ages of 30 to 40...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1023/a:1006843418759

    authors: Sentamilselvi G,Kamalam A,Ajithadas K,Janaki C,Thambiah AS

    更新日期:1997-01-01 00:00:00

  • Retrospective analysis of 15 cases of Penicilliosis marneffei in a southern China hospital.

    abstract::We retrospectively analyzed the medical records and clinical characteristics of 15 patients diagnosed with Penicilliosis marneffei (PSM) between January 1, 1993, and December 31, 2012, at the Third Affiliated Hospital of Sun Yat-sen University. The most common symptoms of PSM were fever (14/15, 93 %), cough (13/15, 87...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-014-9737-5

    authors: Zhou F,Bi X,Zou X,Xu Z,Zhang T

    更新日期:2014-06-01 00:00:00

  • Primary cutaneous mucormycosis in a patient with burn wounds due to Lichtheimia ramosa.

    abstract::Mucormycosis is usually an invasive mycotic disease caused by fungi in the class mucormycetes. Here we report a case of cutaneous mucormycosis due to Lichtheimia ramosa in a 20-year-old female patient with burn injuries. She was admitted to the hospital with accidental flame burns covering 60 % total burn surface area...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-014-9805-x

    authors: Kaur R,Bala K,Ahuja RB,Srivastav P,Bansal U

    更新日期:2014-10-01 00:00:00

  • Cryptococcal meningitis in Senegal: epidemiology, laboratory findings, therapeutic and outcome of cases diagnosed from 2004 to 2011.

    abstract:BACKGROUND:Cryptococcal meningitis is one of the most important opportunistic infection and a major contributor to early mortality. In sub-Saharan Africa, particularly in Senegal, prevalence of cryptococcal meningitis remains high. This study aimed to describe the epidemiology, laboratory profile, therapeutic and outco...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-013-9710-8

    authors: Sow D,Tine RC,Sylla K,Djiba M,Ndour CT,Dieng T,Ndiaye JL,Faye B,Ndiaye D,Gaye O,Dieng Y

    更新日期:2013-12-01 00:00:00

  • Resistance of Histoplasma capsulatum to killing by human neutrophils. Evasion of oxidative burst and lysosomal-fusion products.

    abstract::The basis for resistance of yeast form of Histoplasma capsulatum to antifungal activity of human neutrophils was studied. In limiting dilution assays and short term coculture assays human neutrophils were ineffective in killing H. capsulatum whereas Candida albicans was readily killed. By contrast, in a cell free hydr...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00462229

    authors: Kurita N,Terao K,Brummer E,Ito E,Nishimura K,Miyaji M

    更新日期:1991-09-01 00:00:00

  • Broth microdilution and time-kill testing of Caspofungin, voriconazole, amphotericin B and their combinations against clinical isolates of Candida krusei.

    abstract::Treatment of invasive Candida krusei infections can be difficult due to its intrinsic fluconazole resistance and its reduced susceptibility to amphotericin B and flucytosine. Caspofungin (CAS) acts on a different cellular target, and its combination with voriconazole (VOR) or amphotericin B (AmB) appears promising. We...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-011-9459-x

    authors: Oz Y,Dag I,Kiraz N

    更新日期:2012-01-01 00:00:00

  • Identification of a DNA fragment encoding a putative membrane transporter protein expressed in Sporothrix schenckii.

    abstract::We have isolated two DNA fragments from Sporothrix schenckii. These fragments were nonspecifically amplified from the whole-cell DNA using polymerase chain reaction (PCR) primers originally designed in the gene encoding heat shock protein 70 of Mycobacterium leprae. Reverse transcription PCR demonstrated that the smal...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1023/a:1006999508574

    authors: Sugita Y,Fukushima J,Murakami M,Takahashi I,Nakajima H

    更新日期:1998-01-01 00:00:00

  • Enzyme-linked immunosorbent assay for secalonic acid D.

    abstract::A competitive enzyme-linked immunosorbent assay was developed for the xanthone dimer secalonic acid D. The immunogen and enzyme marker were prepared by direct reaction of secalonic acid D with bovine serum albumin and horseradish peroxidase, respectively. The resultant conjugates were characterized by UV/VIS spectra a...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00437013

    authors: Neucere JN

    更新日期:1986-01-01 00:00:00

  • Cryptococcosis associated with AIDS in the Muñiz Hospital of Buenos Aires.

    abstract::Some epidemiologic, diagnostic and immunologic aspects of 93 (75 males and 18 women) cases of cryptococcosis (CRY) associated with AIDS, hospitalized in the Muñiz Hospital (MH) in Buenos Aires during 1994, were retrospectively studied. The median age (MA) of the patients under study was 28 years (17-49 y); 30 (17-49) ...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1023/a:1006801502246

    authors: Bava AJ,Negroni R,Arechavala A,Robles AM,Bianchi M

    更新日期:1997-01-01 00:00:00

  • The first clinical isolates of Candida dubliniensis in Slovakia.

    abstract::Candida dubliniensis, yeast closely related to Candida albicans, is a new pathogen associated mainly with infections of immunocompromised hosts. In this study, we report the first isolation of three isolates of C. dubliniensis in Slovakia. The first selection of both C. albicans and C. dubliniensis from the other Cand...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-004-7399-4

    authors: Melkusovà S,Lisalovà M,Pavlìk P,Bujdàkovà H

    更新日期:2005-04-01 00:00:00

  • Emergence of azole-resistant Candida albicans in small ruminants.

    abstract::Small ruminant production is a common agricultural activity worldwide. However, studies on the fungal microbiota of these animals are scarce. Therefore, this study aimed at isolating yeasts from goats and sheep and evaluating the antifungal susceptibility of the recovered Candida albicans. A total of 120 animals from ...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-015-9888-z

    authors: Brilhante RS,Silva ST,Castelo-Branco DS,Teixeira CE,Borges LC,Bittencourt PV,de Oliveira JS,Monteiro AJ,Bandeira TJ,Cordeiro RA,Moreira JL,Sidrim JJ,Rocha MF

    更新日期:2015-10-01 00:00:00

  • Correlations among culture times, sugar composition and biological activities of Sporothrix schenckii antigens.

    abstract::Glycoproteins were isolated by ethanol precipitation, Con A-sepharose 4B and DEAE-sephadex A-50 chromatography from culture filtrates of Sporothrix schenckii ATCC 10268 at incubation periods of 2, 7, and 14 days, and their chemical and immunological properties investigated. Sugar composition of the isolated glycoprote...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436994

    authors: Takata M,Ishizaki H

    更新日期:1983-12-01 00:00:00

  • Effect of medicating ingredients and other additives on microflora present on swine and chicken feeds from a Manitoba mill.

    abstract::The occurrence of microfloral components on medicated and non-medicated swine and chicken feed pellets and crumbles, produced in a Manitoba feed mill between June 1991 and October 1992, was determined. Addition of medicates to feeds generally decreased bacterial incidence and increased that of Eurotium spp. fungi. The...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436571

    authors: Mills JT,White ND,Woods SM

    更新日期:1996-01-01 00:00:00

  • A mycological and bacteriological survey on feed ingredients and mixed poultry feeds in Reunion island.

    abstract::A survey was carried out in Reunion island to obtain data on the occurrence of fungi, aflatoxigenic strains of Aspergillus flavus, aflatoxins, total aerobic bacteria and salmonellae of 150 samples of mixed poultry feeds and raw materials. These were collected at five farms over a 3-month period during the warm rainy s...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/BF00436804

    authors: Bauduret P

    更新日期:1990-03-01 00:00:00

  • In vitro susceptibility of Candida isolates from organ transplant recipients to newer antifungals.

    abstract::Organ transplant recipients (OTR) are at higher risk of developing life-threatening infections. In this study, we tested 527 Candida isolates obtained from the oral and genital mucosa from OTR and healthy controls in order to monitor antifungal susceptibility patterns in this particular risk group. Testing was carried...

    journal_title:Mycopathologia

    pub_type: 杂志文章

    doi:10.1007/s11046-014-9738-4

    authors: Geusau A,Antoniewicz L,Poitschek C,Presterl E,Willinger B

    更新日期:2014-04-01 00:00:00

  • Cutaneous Chromoblastomycosis Caused by Veronaea botryosa in a Patient with Pemphigus Vulgaris and Review of Published Reports.

    abstract::Chromoblastomycosis and phaeohyphomycosis represent two poles of a disease spectrum caused by melanized fungi. Veronaea botryosa belongs to a small genus of saprobic fungi that occasionally cause human infections. To date, 11 cases of V. botryosa-induced cutaneous phaeohyphomycosis have been actually reported since 19...

    journal_title:Mycopathologia

    pub_type: 杂志文章,评审

    doi:10.1007/s11046-015-9887-0

    authors: Zhu CY,Yang YP,Sheng P,Li W,Huang WM,Fan YM

    更新日期:2015-08-01 00:00:00