Abstract:
AIM:Recent experimental studies have suggested that chemokines, a subclass of chemoattractant cytokines which play an important role in regulating leukocyte migration and intercellular communication, participate in brain responses of traumatic injury. Fractalkine (CX3CL1) is a peculiar chemokine, the only one with a CX3C motif, existing both as a soluble and a membrane-anchored molecule. In the brain, Fractalkine has been suggested to have a role in neuroprotection under experimental conditions of brain injury. METHODS:Eighteen human brain samples were obtained during surgery of decompressive craniotomy for severe traumatic brain injury (TBI) or after spontaneous intracranial haemorrhage (ICH). Five normal brain samples were obtained during surgery for unruptured intracranial aneurysms (standard gyrectomy). Immunohistochemistry of formalin fixed and paraffin embedded tissues was performed in order to verify the expression of fractalkine and its receptor (CX3CR1). The values of chemokine and receptor expression were correlated with the clinical parameters of the patients. RESULTS:The chemokine fractalkine was significantly upregulated in the neural compartment after brain injury, compared to normal brain samples. Intensity scores were significantly higher when the interval between injury and surgery was >5 h, (P=0.015). In the glial compartment, Fractalkine expression was significantly associated with less severe clinical conditions and lower intracranial pressure at surgery (P=0.014). Expression of the receptor CX3CR1 was detected, at low intensity, on both glial and neurons. Higher expression in neurons was associated with better clinical conditions (Glasgow score) of patients at admission (P=0.037). CONCLUSION:The results of this study highlights for the first time that fractalkine and its receptor CX3CR1 are expressed in the human brain after TBI and ICH and may be involved in the limitation of tissue damage.
journal_name
J Neurosurg Scijournal_title
Journal of neurosurgical sciencesauthors
Gaetani P,Pisano P,Solinas G,Colombo P,Destro A,Levi D,Aimar E,Rodriguez R,Baena Y,Allavena Psubject
Has Abstractpub_date
2013-03-01 00:00:00pages
55-62issue
1eissn
0390-5616issn
1827-1855pii
R38132345journal_volume
57pub_type
杂志文章abstract:BACKGROUND:Peripheral nerve lesions in the upper limbs occur predominantly in reproductive-age men and are often caused by sharp objects. Microsurgery is the choice treatment for these injuries, and regeneration after surgery typically is evaluated with clinical and electrophysiological examinations. The aim of this st...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2016-09-01 00:00:00
abstract::Occurrence of internal carotid artery injuries associated with skull base fracture has been reported. A. report a case of fatal intracranial carotid dissection related to petrous fracture involving the carotid canal. Identification of carotid lesions may be difficult and generally related to appearance of unexpected n...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Accurately locating small subcortical brain lesions is very important for maximal surgical resection with minimal neurological damage. Intraoperative MRI has proved to be more precise than ultrasound, it is relatively expensive and is not available in all centers. Herein we describe a new, simple, safe and e...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.16.03336-1
更新日期:2019-06-01 00:00:00
abstract::(1) In a total of 100 patients with traumatic coma who were admitted to the intensive care unit of our Department of Neurosurgery we examined the effect of Encephabol after intravenous administration. (2) Compared to patients with the same clinico-neurological conditions who were, however, not treated with Encephabol,...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract::Intramedullary ependymomas are uncommon tumors that can occur within the medullary substance of the spinal cord. Despite this difficult location, they are typically benign tumors that can most often be removed completely with an acceptable surgical risk. Therefore, the recommended management approach is usually surgic...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:10.23736/S0390-5616.17.04162-5
更新日期:2018-02-01 00:00:00
abstract::Cavernous malformations are vascular lesions that occur in all parts of the central nervous system but most commonly in the cerebral hemispheres; unusually they may be found along the midline (basal ganglia, pineal region or brain stem), into the ventricle possibly encroaching upon the fourth and third ventricle. We r...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1998-12-01 00:00:00
abstract:: ...
journal_title:Journal of neurosurgical sciences
pub_type: 信件
doi:10.23736/S0390-5616.17.04285-0
更新日期:2018-12-01 00:00:00
abstract::There is a growing body of evidence that the insulin-like growth factor-1 (IGF-1) is dynamically involved in the regulation of body homeostasis and glucose regulation. Traumatic brain injury (TBI) is considered to be a risk factor for Alzheimer's disease (AD). As alterations of IGF-1 have been implicated in both TBI a...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:10.23736/S0390-5616.16.03431-7
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:The traditional approach to patients suffering from cervical spondylotic myelopathy (CSM) consists of mere assessment of radiological standard magnetic resonance (MR) images and evaluation of surgical indication, depending on clinical symptoms and degree of radiological stenosis. Identification of prognostic...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.16.03724-3
更新日期:2019-02-01 00:00:00
abstract::The authors tried to assess neurotic traits of 19 consecutive patients having micro-lumbar discectomy and to verify the relation between psychic distress and surgical outcome. All subjects had unequivocal clinical and myelographic evidence of lumbar disc herniation. Neurotic distress was measured by Middlesex Hospital...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Cavernous angiomas of the orbit are benign vascular growths, commonly occurring in adults and usually causing a slowly progressive proptosis from their mass effect. These lesions have behavioural and radiological findings different from those of brain cavernous angiomas, probably due to their particular origin and str...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1995-12-01 00:00:00
abstract:AIM:The novel YL-1 hollow needle aspiration drainage system is an effective minimally invasive treatment in chronic subdural hematoma (CSDH). In order to find the risk prognosis factors of chronic subdural hematoma (CSDH) performed by the novel YL-1 hollow needle aspiration drainage system, a logistic analysis of posto...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Navigated instrumented spine surgery is burden by a low but significant screw mispositioning risks, respectively, for the 2D imaging system from 15 to 40% and, for the 3D imaging system, ranging from 4.1 to 11.5%. The primary objective of this study was to demonstrate the efficacy of a new "screw-like" tool i...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.20.04957-7
更新日期:2020-04-29 00:00:00
abstract:AIM:Mesenchymal stem cells (MSCs) migrate in response to chemokines and possess extensive tropism for experimental glioma. Antitumor effects have been reported following intracranial and intravenous administration of gene-modified MSCs. Among the different routes for cell transplant, the intraventricular (IV) approach ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
abstract:: ...
journal_title:Journal of neurosurgical sciences
pub_type: 信件
doi:10.23736/S0390-5616.17.04270-9
更新日期:2019-10-01 00:00:00
abstract::Endoscopic endonasal approaches (EEA) to the skull base have significantly impacted the management of lesions located in the cranial base. Specifically, lesions arising from the anterior cranial fossa, such as pituitary macroadenomas, craniopharyngiomas meningiomas and craniofacial malignancies have benefited from the...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.20.05086-9
更新日期:2020-11-27 00:00:00
abstract::Isolated abducens nerve palsy following lumbar puncture is a very rare condition. In this case we discussed the probable causes of abducens nerve palsy and review the mechanism of action in anatomical relevant literature. A 53-year old hypertensive female patient with a saccular aneursym on the left middle cerebral ar...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:Economical studies on surgery of intracranial aneurysms have considered only the significant benefit of surgical approach on unruptured aneurysms and no studies have been performed comparing cost/benefit analysis of early vs delayed surgery. The present study was retrospectively performed in order to verify ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Brain metastases are a common problem in solid malignancies and still represent a major cause of morbidity and mortality. With the ongoing improvement in systemic therapies, the expectations on the efficacy of brain metastases directed treatment options are growing. As local therapies against brain metastases continue...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2016-09-01 00:00:00
abstract::Subependymoma was first described by Scheinker in 1945; it frequently occurs in the ventricles and rarely in the spinal canal representing 0.7% of all central nervous system tumours. Most of these intraventricular tumours are subclinical entities, remaining of small size and discovered at autopsy with 0.4%incidence. W...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:2007-06-01 00:00:00
abstract::If pragmatic recommendations for treatment of severely head-injured patients could really be applied, they would probably have a considerable impact in terms of reduction in mortality and disability. Since 1995 a Group of Italian Neurointensivists and Neurosurgeons belonging to the Italian Societies of Neurosurgery (S...
journal_title:Journal of neurosurgical sciences
pub_type: 指南,杂志文章,实务指引
doi:
更新日期:2000-03-01 00:00:00
abstract::Nowadays, extradural vertebral neoplasms which compress the spinal cord are being diagnosed earlier and therefore laminectomy for decompression relieves many patients of their neurological deficits before permanent cord damage has set in. In addition, radiotherapy and oncological treatment have prolonged life expectan...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1985-07-01 00:00:00
abstract::The improved knowledge of clinical and emodynamical aspects of extracranial arteriovenous malformations in the 18 th century provided a foundation for the understanding and treatment of cerebrovascular pathology. It was not until the late 19 th century that detailed clinicopathological reports of intracranial arteriov...
journal_title:Journal of neurosurgical sciences
pub_type: 传,历史文章,杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract::Multidisciplinary efforts are being made to provide surgical teams with sensitive and specific tasks for language mapping in awake surgery. Researchers and clinicians have elaborated different tasks over time. A fair amount of work has been directed to study the neurofunctional correlates of some of these tasks, and t...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:2015-12-01 00:00:00
abstract::Four cases of acute spontaneous subdural haematoma are described. A review of the literature reveals the rarity of this pathology. The several etiological possibilities are discussed. The clinical onset may simulate other cerebrovascular diseases. The prognosis is correlate to the neurological findings at the operatio...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:1991-04-01 00:00:00
abstract:BACKGROUND:This study aimed to compare the accuracy of screw placement between open pedicle screw fixation and percutaneous pedicle screw fixation (MIS) for the treatment of thoracolumbar spine fractures (TSF). METHODS:forty-nine patients with acute TSF who were treated with transpedicular screw fixation from January ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:10.23736/S0390-5616.18.04439-9
更新日期:2021-02-01 00:00:00
abstract::A preliminary report on the immunological monitoring of primary intracranial neoplasms is presented. The most important findings concerning B-cells and T-cells mediated immunity and delayed hypersensitivity reactions in this kind of patients, are discussed. Among the fairly significant immunobiological pictures, the A...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1979-07-01 00:00:00
abstract::A selected panel of monoclonal antibodies (MoAbs) directed to distinct tumor associated antigens (TAA) has been tested to define the capability of these reagents to differentiate among metastatic carcinoma, lymphoma and primary brain tumor on cytologic specimens obtained with stereotactic techniques. Results obtained ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::The authors present a case of spinal epidural hematoma during anticoagulant therapy. Clinical presentation is characterized by classic paravertebral back pain, followed by progressive neurological deficit due to spinal cord and radicular compression, with sensory deficits and bladder disturbance. From the literature, ...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章,评审
doi:
更新日期:1995-03-01 00:00:00
abstract::The Authors report 4 cases of spinal lipomas: 2 intradural, 2 completely intrarachidian extradural. The intradural lipomas observed were 2 cases in the lumbo-sacral area, both operated on by the partial removal of the lesion with very good clinical results; histologically they were found to be 2 fibrolipomas. The 2 ca...
journal_title:Journal of neurosurgical sciences
pub_type: 杂志文章
doi:
更新日期:1974-04-01 00:00:00