Abstract:
:Domchek and colleagues provide a case report of a 28-year-old woman with congenital abnormalities, inherited ovarian cancer, and carboplatin hypersensitivity. Interestingly, the woman had validated germline mutations in both BRCA1 alleles. These findings further implicate BRCA1 in the Fanconi anemia/BRCA pathway and have important implications for BRCA1 genetic testing.
journal_name
Cancer Discovjournal_title
Cancer discoveryauthors
D'Andrea ADdoi
10.1158/2159-8290.CD-13-0044subject
Has Abstractpub_date
2013-04-01 00:00:00pages
376-8issue
4eissn
2159-8274issn
2159-8290pii
3/4/376journal_volume
3pub_type
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