当前位置： SCI文献检索 > JOURNAL OF ASSISTED REPRODUCTION AND GENETICS期刊下所有文献 > Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.

Association study between FSHR Ala307Thr and Ser680Asn variants and polycystic ovary syndrome (PCOS) in Northern Chinese Han women.

Abstract：

BACKGROUND:Polycystic ovary syndrome (PCOS) is a common complex genetic endocrinopathy. It has high heritability, and twin studies indicate that it is a complex polygenic disorder. Searching for major genes of PCOS is crucial to clarify its molecular pathogenesis. A previous genome-wide association study in Chinese women with PCOS identified a region on chromosome 2p16.3 that encodes the follicle-stimulating hormone receptor (FSHR) genes as a reproducible PCOS susceptibility locus. In the present study, we performed a replication analysis of the association between two common variants of the FSHR gene and PCOS in Northern Chinese Han women. RESULTS:We recruited 384 unrelated PCOS patients and 768 healthy individuals from the Shaanxi province in the northern part of China. Two polymorphisms (Ala307Thr and Ser680Asn) of the FSHR gene and the clinical characteristics of the study subjects were analyzed in the case-control sample. The frequency of FSHR Ala307Thr and Ser680Asn variants along with the haplotype was not significantly different between the PCOS patients and the controls; however, the Ser680 variants may be associated with high levels of FSH and low E2 levels. CONCLUSION:The variant of Ser680 was not associated with PCOS but it may be related to high FSH levels. The present study suggests that the two variants of the FSHR gene are not a causative factor of PCOS in Northern Chinese Han women.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Fu L,Zhang Z,Zhang A,Xu J,Huang X,Zheng Q,Cao Y,Wang L,Du J

doi

10.1007/s10815-013-9979-z

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

717-21

issue

5

eissn

1058-0468

issn

1573-7330

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS文献大全
  • Ovum donation--an overview.

    abstract：:Ovum donation is now an integral part of the management of infertility, providing a solution for patients previously considered permanently infertile. The indications now include not only patients with premature ovarian failure, but also patients who are carriers of genetic disorders, patients with repeated failures i...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章,评审

    doi：10.1007/BF01207729

    authors： Benshushan A,Schenker JG

    更新日期：1993-02-01 00:00:00

  • Correction to: How common is germinal mosaicism that leads to premeiotic aneuploidy in the female?

    abstract：:The original article unfortunately contained a mistake. In the online version of the paper, the words "MII (metaphase II)-PB1 (1st polar body) complex (MII-PB1 complex)" in table 1 are incorrectly placed. ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 已发布勘误

    doi：10.1007/s10815-019-01644-1

    authors： Delhanty JD,SenGupta SB,Ghevaria H

    更新日期：2019-12-01 00:00:00

  • Optimization of a dilution method for human expanded blastocysts vitrified using EM grids after artificial shrinkage.

    abstract：PURPOSE:To verify a more effective dilution method that can be applied to human expanded blastocysts that are vitrified after artificial shrinkage. METHODS:Surplus expanded blastocysts that remained after embryo transfer (ET) in in vitro fertilization (IVF) cycles, were cryopreserved. The blastocysts were vitrified on...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-005-9006-0

    authors： Lee SY,Kim HJ,Park SJ,Yoon HJ,Yoon SH,Lee KH,Lee WD,Lim JH

    更新日期：2006-02-01 00:00:00

  • The combination of pronuclear and blastocyst morphology: a strong prognostic tool for implantation potential.

    abstract：PURPOSE:To (i) investigate a possible association between different features of pronuclear (PN) morphology and different features of blastocyst morphology, (ii) evaluate the combination of PN and blastocyst morphologies as a predictive factor for ICSI outcomes and (iii) identify possible contributing factors to poor PN...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-013-0073-3

    authors： Braga DP,Setti AS,Figueira Rde C,Iaconelli A Jr,Borges E Jr

    更新日期：2013-10-01 00:00:00

  • A comparison of the Cook single lumen immature ovum IVM needle to the Steiner-Tan pseudo double lumen flushing needle for oocyte retrieval for IVM.

    abstract：PURPOSE:This study compared the impact of using the Steiner-Tan pseudo double lumen needle for antral follicle oocyte retrieval to using a conventional non-flushing needle. The Steiner-Tan needle has a much smaller dead space than the needles commonly used for IVM oocyte retrievals. METHODS:This was a retrospective co...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-013-0006-1

    authors： Rose BI,Laky D

    更新日期：2013-06-01 00:00:00

  • Adjusted mitochondrial DNA quantification in human embryos may not be applicable as a biomarker of implantation potential.

    abstract：OBJECTIVE:To evaluate the feasibility of adjusted mitochondrial DNA quantification in human embryos as a biomarker for implantation potential. DESIGN:Double-blind, observational, prospective analysis of an Asian population in a single university-affiliated in vitro fertilization center. A total of 1617 embryos derived...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01542-6

    authors： Lee YX,Chen CH,Lin SY,Lin YH,Tzeng CR

    更新日期：2019-09-01 00:00:00

  • Reflections on the cost-effectiveness of recombinant FSH in assisted reproduction. The clinician's perspective.

    abstract：PURPOSE:To analyze the relative cost-effectiveness of recombinant FSH (rFSH) and urinary FSH (uFSH) in assisted reproduction techniques (ART). METHODS:Calculation of the average cost-effectiveness ratio and the incremental cost-effectiveness ratio to compare costs and effects (pregnancy rates) of the two therapeutic o...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1026501821849

    authors： Balasch J,Barri PN

    更新日期：2001-02-01 00:00:00

  • Sex determination in single mouse blastomeres by polymerase chain reaction.

    abstract：:In sex determination of mammalian preimplantation embryos, viability of biopsied embryos and accuracy of sexing are together important. In consideration of this point, single blastomeres were mechanically isolated from mouse embryos using a micromanipulator and then sexed by polymerase chain reaction (PCR) using mouse...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF01207739

    authors： Han YM,Yoo OJ,Lee KK

    更新日期：1993-02-01 00:00:00

  • Localization of parathyroid hormone-related protein in the preimplantation mouse embryo is associated with events of blastocyst hatching.

    abstract：PURPOSE:To determine the pattern of expression of parathyroid hormone-related protein (PTHrP) and its receptor, parathyroid hormone receptor 1 (PTHR1), in mouse embryos in different stages of preimplantation development. METHODS:Embryos were cultured from the pronuclear zygote stage and harvested as 2-cell, 4-cell and...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-013-0094-y

    authors： Erbach GT,Biggers JD,Manning PC,Nowak RA

    更新日期：2013-08-01 00:00:00

  • In vitro development of human primordial follicles to preantral stage after vitrification.

    abstract：PURPOSE:The aim was to culture primordial follicles in vitro to reach preantral stage in vitrified human ovarian tissue. METHODS:Ovarian tissue samples were obtained from six women. Tissue strips were vitrified by infiltration with a cryoprotectant followed by mounting on a stainless steel carrier. After culturing for...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-013-0105-z

    authors： Khosravi F,Reid RL,Moini A,Abolhassani F,Valojerdi MR,Kan FW

    更新日期：2013-11-01 00:00:00

  • Association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and susceptibility to idiopathic recurrent pregnancy loss.

    abstract：BACKGROUND:A growing body of evidence suggests that microRNAs play fundamental regulatory roles in embryo implantation and maintenance of pregnancy. The aim of this study was to investigate the possible association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and genetic susce...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01573-z

    authors： Alipour M,Abtin M,Hosseinzadeh A,Maleki M

    更新日期：2019-11-01 00:00:00

  • Morphokinetic parameters from a time-lapse monitoring system cannot accurately predict the ploidy of embryos.

    abstract：PURPOSE:This study aimed to test whether there is an association between embryo morphokinetic parameters and ploidy status. METHODS:Patients with high risk of aneuploidy were analyzed by time-lapse microscopy combined with preimplantation genetic screening (PGS). Accordingly, 256 blastocysts from 75 patients were subj...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-017-0965-8

    authors： Zhang J,Tao W,Liu H,Yu G,Li M,Ma S,Wu K

    更新日期：2017-09-01 00:00:00

  • Transfer of IVF-contaminated blastocysts with removal of the zona pellucida resulted in live births.

    abstract：PURPOSE:Bacterial contamination may cause loss or damage to cultured oocytes or embryos, resulting in cancelation or delaying of a fresh embryo transfer. While live births have been reported following the transfer of embryos contaminated with yeast, very little information is available on how to handle embryos with bac...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-016-0776-3

    authors： Shu Y,Prokai D,Berga S,Taylor R,Johnston-MacAnanny E

    更新日期：2016-10-01 00:00:00

  • Investigation of effects of pregnant mare serum gonadotropin (PMSG) on the chromosomal complement of CD-1 mouse embryos.

    abstract：PURPOSE:The objective of this study was to examine the effect of superovulatory doses of gonadotropins on the frequency of chromosomal abnormalities of mouse embryos. METHODS:Chromosome analysis of 8- to 16-cell stage mouse embryos and zygotes was performed by a cytogenetic method. RESULTS:There was no significant ef...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF02766134

    authors： Ma S,Kalousek DK,Yuen BH,Moon YS

    更新日期：1997-03-01 00:00:00

  • Y chromosome structural variation in infertile men detected by targeted next-generation sequencing.

    abstract：PURPOSE:To provide a validated method to identify copy number variation (CNV) in regions of the Y chromosome of infertile men by next-generation sequencing (NGS). METHODS:Semen analysis was used to determine the quality of semen and diagnose infertility. Deletion of the azoospermia factor (AZF) region in the Y chromos...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-020-02031-x

    authors： Liu X,Zhang H,Zhang X,Zhang H,Jiang Y,Liu R,Fei J,Wang Y,Yu Y

    更新日期：2021-01-16 00:00:00

  • CD200-dependent and nonCD200-dependent pathways of NK cell suppression by human IVIG.

    abstract：PROBLEM:Intravenous immunoglobulin (IVIG) has been used to suppress autoimmune and inflammatory disorders by a variety of mechanisms. Recently, the CD200 tolerance-promoting signal has been found to play a role in IVIG suppression of blood natural killer (NK) cells. Further, different types of IVIG have been reported t...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-008-9202-9

    authors： Clark DA,Wong K,Banwatt D,Chen Z,Liu J,Lee L,Gorczynski RM,Blajchman MA

    更新日期：2008-02-01 00:00:00

  • Follicular fluid soluble receptor for advanced glycation endproducts (sRAGE): a potential protective role in polycystic ovary syndrome.

    abstract：PURPOSE:To explore the relationships between the soluble receptor for advanced glycation endproducts (sRAGE) and the outcome parameters following in vitro fertilization-embryo transfer (IVF-ET) in patients with polycystic ovary syndrome (PCOS) and investigate the protective effect of sRAGE in PCOS development regarding...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-016-0704-6

    authors： Wang B,Hao M,Yang Q,Li J,Guo Y

    更新日期：2016-07-01 00:00:00

  • Guidelines informing counseling on female age-related fertility decline: a systematic review.

    abstract：PURPOSE:To identify, appraise, and assess clinical practice guidelines informing patient counseling on female age-related fertility decline. METHODS:Searched electronic database records from January 1, 2006, to September 10, 2018, and professional society websites. The search terms included iterations of "guideline," ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-020-01967-4

    authors： Trawick E,Pecoriello J,Quinn G,Goldman KN

    更新日期：2021-01-01 00:00:00

  • Serum anti-Müllerian hormone predicts ovarian response and cycle outcome in IVF patients.

    abstract：PURPOSE:This prospective study was designed to investigate whether anti-Müllerian hormone (AMH) levels at basal and ovulation triggering day are associated with ovarian response and pregnancy outcome for in vitro fertilization (IVF). METHOD:60 infertility women undergoing IVF were prospectively studied. On day 3 of th...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-009-9332-8

    authors： Wu CH,Chen YC,Wu HH,Yang JG,Chang YJ,Tsai HD

    更新日期：2009-07-01 00:00:00

  • Area under the curve for estradiol levels do not consistently reflect estradiol levels on the day of hCG administration in patients undergoing controlled ovarian hyperstimulation for IVF-ET.

    abstract：PURPOSE:Most studies reported estradiol (E2) levels attained on day of hCG administration when investigating effect of E2 on IVF outcome. We studied whether a relationship exists between the area under the curve for E2 levels (AUC-E2) and E2 levels on hCG day during IVF-ET. METHODS:Retrospectively, we analyzed data fo...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-005-1494-4

    authors： Mitwally MF,Bhakoo HS,Crickard K,Sullivan MW,Batt RE,Yehl J

    更新日期：2005-02-01 00:00:00

  • MiR-148a-3p may contribute to flawed decidualization in recurrent implantation failure by modulating HOXC8.

    abstract：PURPOSE:To evaluate whether miR-148a-3p overexpression is associated with disrupted decidualization of recurrent implantation failure (RIF). METHODS:Endometrial miRNA and mRNA expression profiles during the implantation window derived from women with and without RIF were identified using microarray and RT-qPCR. Immort...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-020-01900-9

    authors： Zhang Q,Ni T,Dang Y,Ding L,Jiang J,Li J,Xia M,Yu N,Ma J,Yan J,Chen ZJ

    更新日期：2020-10-01 00:00:00

  • Retrieval, maturation, and fertilization of immature oocytes obtained from unstimulated patients with polycystic ovary syndrome.

    abstract：PURPOSE:Our purpose was to determine whether immature oocytes could be retrieved under local anesthesia, whether these oocytes would mature and fertilize in vitro, and whether adequate endometrium development could be obtained after hormonal supplementation. METHODS:Ovum pick-up was performed under local anesthesia. I...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1022516806423

    authors： Beckers NG,Pieters MH,Ramos L,Zeilmaker GH,Fauser BC,Braat DD

    更新日期：1999-02-01 00:00:00

  • Maternal physical activity and sedentary behaviour before and during in vitro fertilization treatment: a longitudinal study exploring the associations with controlled ovarian stimulation and pregnancy outcomes.

    abstract：PURPOSE:To evaluate the association of objectively measured physical activity (PA) and sedentary behaviour before and during in vitro fertilization (IVF) with controlled ovarian stimulation (COS) and pregnancy outcomes. METHODS:This longitudinal study involved 107 infertile women undergoing IVF treatment. PA and seden...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-020-01864-w

    authors： Sõritsa D,Mäestu E,Nuut M,Mäestu J,Migueles JH,Läänelaid S,Ehrenberg A,Sekavin A,Sõritsa A,Salumets A,Ortega FB,Altmäe S

    更新日期：2020-08-01 00:00:00

  • Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

    abstract：:A recent study published in Human Reproduction claimed that uterine lavage offers a non-surgical, minimally invasive strategy for the recovery of human embryos from fertile women who do not want or need IVF for medical reasons but who desire preimplantation genetic testing (PGT) for embryos. To prove this hypothesis, ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-020-01954-9

    authors： Murtinger M,Wirleitner B,Hradecký L,Comploj G,Okhowat J,Spitzer D,Stadler J,Haidbauer R,Schuff M,Yildirim S,Soepenberg T,Eibner K,Gagsteiger F

    更新日期：2020-11-01 00:00:00

  • Follicular fluid hydrogen peroxide and lipid hydroperoxide in bovine antral follicles of various size, atresia, and dominance status.

    abstract：PURPOSE:To avoid inducing a state of oxidative stress (OS), assisted reproductive technologies (ART) must maintain a balance of reactive oxygen species (ROS) and antioxidants during the in vitro culture of oocytes. However, oocyte requirements and tolerance thresholds for ROS during in vivo development are still unclea...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-012-9925-5

    authors： Hennet ML,Yu HY,Combelles CM

    更新日期：2013-03-01 00:00:00

  • Microinsemination techniques for the treatment of patients suffering agenesia of the vas deferens.

    abstract：:Thirty cycles of microsurgical epididymal sperm aspiration were performed on 27 patients presenting agenesia of the vas deferens. Two techniques of microinsemination were used, depending on the quality of the sperm preparation: subzonal sperm microinjection and microdroplet insemination. The results obtained by both m...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF02070149

    authors： Gianaroli L,Magli MC,Colpi G,Vitali G,Fortini D,Negri L,Ferraretti AP

    更新日期：1996-04-01 00:00:00

  • The impact of early testicular sperm extraction or cryopreservation on the outcome of intracytoplasmic sperm injection--a randomized controlled study.

    abstract：PURPOSE:To compare the outcome of sperm extraction 24 h before ovum pickup and on the day of oocyte retrieval. METHODS:A controlled study was performed to compare the outcome of 90 sperm extractions and in vitro sperm injection cycles performed in 54 patients. RESULTS:Available fresh sperm for the sperm injection pro...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1023/a:1024116326465

    authors： Dirnfeld L,Paz M,Yshai D,Calderon I,Lahav-Baratz S,Koifman M,Shiloh H,Abramovici H,Bider D

    更新日期：2003-06-01 00:00:00

  • National survey on use of time-lapse imaging systems in IVF laboratories.

    abstract：PURPOSE:Several time-lapse imaging (TLI) systems for non-invasive continuous monitoring of developing embryos are currently available. The present study explored the prevalence, means of acquisition, and clinical application of TLI systems in USA in vitro fertilization (IVF) laboratories. METHODS:An online cross-secti...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-017-0964-9

    authors： Dolinko AV,Farland LV,Kaser DJ,Missmer SA,Racowsky C

    更新日期：2017-09-01 00:00:00

  • Does subtle progesterone rise on the day of HCG affect pregnancy rate in long agonist ICSI cycles?

    abstract：PURPOSE:To evaluate the impact of subtle progesterone (P4) rise on the day of HCG on pregnancy outcome in ICSI patients stimulated with long agonist protocol. METHODS:One hundred forty-nine consecutive controlled ovarian hyperstimulation cycles for ICSI using long luteal agonist protocol. RESULTS:Mean serum progester...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-009-9309-7

    authors： Saleh HA,Omran MS,Draz M

    更新日期：2009-05-01 00:00:00

  • The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation.

    abstract：PURPOSE:To determine the prevalence of positive test for Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) infections, and their corresponding Rubella status when undergoing workup for infertility. METHODS:Retrospective chart review to determine infection stat...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-007-9192-z

    authors： Imudia AN,Detti L,Puscheck EE,Yelian FD,Diamond MP

    更新日期：2008-01-01 00:00:00