当前位置： SCI文献检索 > JOURNAL OF ASSISTED REPRODUCTION AND GENETICS期刊下所有文献 > Association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and susceptibility to idiopathic recurrent pregnancy loss.

Association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and susceptibility to idiopathic recurrent pregnancy loss.

Abstract：

BACKGROUND:A growing body of evidence suggests that microRNAs play fundamental regulatory roles in embryo implantation and maintenance of pregnancy. The aim of this study was to investigate the possible association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and genetic susceptibility to recurrent pregnancy loss (RPL). MATERIAL AND METHODS:One hundred and twenty women with a history of two or more unexplained consecutive miscarriages and 90 ethnically matched healthy women with a history of at least two successful pregnancy outcomes and without a history of miscarriage were enrolled in a case-control study. Genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS:Our findings showed that the prevalence of miR-149 T > C polymorphism in RPL patients was significantly higher than those in healthy controls (p < 0.05). We also found that the presence of miR-149 C and miR-499 G alleles was significantly associated with susceptibility to RPL (p < 0.05). The miR-146a CC/miR-499 GG, miR-149 TC/miR-499 AG, and miR-196a2 TT/miR-499 GG combined genotypes were associated with the high risk of RPL (p < 0.05). CONCLUSION:This study suggests that miR-149 T > C polymorphism and the presence of miR-149 C, and miR-499 G alleles are a genetic determinant for the risk of idiopathic RPL.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Alipour M,Abtin M,Hosseinzadeh A,Maleki M

doi

10.1007/s10815-019-01573-z

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

2237-2244

issue

11

eissn

1058-0468

issn

1573-7330

pii

10.1007/s10815-019-01573-z

journal_volume

36

pub_type

杂志文章

相关文献

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS文献大全
  • Incidence of AZF (azoospermia factor) deletions and familial forms of infertility among patients requiring intracytoplasmic spermatozoa injection (ICSI).

    abstract：PURPOSE:The aim of our study was to determine the incidence of AZF deletions and familial forms of infertility suggesting autosomal mutations among patients requiring intracytoplasmic sperm injection with ejaculated sperm. METHODS:Cases with obstructive pathologies were excluded; 81 patients were classified according ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1022532718641

    authors： Selva J,Kanafani S,Prigent Y,Poncet V,Bergère M

    更新日期：1997-11-01 00:00:00

  • Clinical outcome of frozen blastocyst transfer; single vs. double transfer.

    abstract：PURPOSE:Frozen embryo transfer has been established as an indispensable ART procedure for both the effective use of surplus embryos and the prevention of ovarian hyperstimulation syndrome. The frequency of frozen embryo transfer is increasing in our clinic, and we report that frozen embryo transfer is effective for pat...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-008-9275-5

    authors： Yanaihara A,Yorimitsu T,Motoyama H,Ohara M,Kawamura T

    更新日期：2008-11-01 00:00:00

  • Intrauterine insemination: is the timing correct?

    abstract：OBJECTIVE:To evaluate the impact of follicle rupture on pregnancy rate in intrauterine insemination. MATERIAL AND METHOD:Retrospective cohort study. Evidence of follicle rupture was assessed by transvaginal ultrasonography following IUI. Two hundred ninety-six couples with unexplained infertility and 121 couples with ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-008-9247-9

    authors： Kucuk T

    更新日期：2008-08-01 00:00:00

  • The impact of peak estradiol during controlled ovarian stimulation on the cumulative live birth rate of IVF/ICSI in non-PCOS patients.

    abstract：OBJECTIVE:The study aimed to investigate the impact of the peak E2 level during controlled ovarian hyperstimulation (COS) on the cumulative live birth rate (cLBR) in non-PCOS women with normal ovarian reserve. MATERIALS AND METHODS:Women between 20 and 39 years were included. Donor cycles and patients who never experi...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01568-w

    authors： Zhang W,Tian Y,Xie D,Miao Y,Liu J,Wang X

    更新日期：2019-11-01 00:00:00

  • Multi-chorionic pregnancies following single embryo transfer at the blastocyst stage: a case series and review of the literature.

    abstract：OBJECTIVE:To report cases of in vitro fertilization-frozen embryo transfer (IVF-FET) with single blastocyst transfer resulting in di- or tri-chorionic pregnancies, and to review the literature on monozygotic, multi-chorionic pregnancies originating at the blastocyst stage. DESIGN:Retrospective case series and literatu...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章,评审

    doi：10.1007/s10815-018-1329-8

    authors： Sundaram V,Ribeiro S,Noel M

    更新日期：2018-12-01 00:00:00

  • Effect of inseminated volume on intrauterine insemination.

    abstract：PURPOSE:Intrauterine insemination (IUI) is a method for the treatment of marital infertility involving the intrauterine or fallopian deposition of washed spermatozoa, depending on the amount of inseminated semen. In view of the divergent opinions about the inseminated volume, the objective of this study was to compare ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1016678519490

    authors： Do Amaral VF,Ferriani RA,Dos Reis RM,De Sala MM,De Moura MD

    更新日期：2001-08-01 00:00:00

  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes.

    abstract：OBJECTIVE:The aim of this study was to assess the fertilizability of unfertilized aged human oocytes from failed in vitro fertilization (IVF) cycles using SUZI and ICSI. METHODS:A total of 363 oocytes which showed no fertilization after conventional IVF was subjected to assisted fertilization using SUZI or ICSI. The m...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02211724

    authors： Tsirigotis M,Bennett V,Nicholson N,Khalifa Y,Hogewind G,Yazdani N,Craft I

    更新日期：1994-09-01 00:00:00

  • Does the genetic and familial background of males undertaking ICSI affect the outcome?

    abstract：PURPOSE:To investigate whether the success rate of ICSI is (1) related to the etiology of infertility or (2) adversely affected by a family history of potential genetic disorders. METHODS:All men with an ICSI indication in our hospital between 1994 and 2005 were included in our cohort study. Data on the ICSI process, ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-009-9315-9

    authors： Maiburg M,Alizadeh B,Kastrop P,Lock M,Lans S,Giltay J

    更新日期：2009-06-01 00:00:00

  • Seasonal changes in human sperm chromatin condensation.

    abstract：PURPOSE:The aim of this study was to investigate possible seasonal changes in human sperm parameters, especially chromatin condensation. METHOD:In a first run, 3155 patients attending the andrological outpatient clinic at the Centre of Dermatology and Andrology at Justus Liebig University, Giessen, Germany, from Janua...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1016618405570

    authors： Henkel R,Menkveld R,Kleinhappl M,Schill WB

    更新日期：2001-07-01 00:00:00

  • Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

    abstract：BACKGROUND:Polycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, is the most common endocrine disorder in women and it typically develops during adolescence. The aim of this study is to investigate the possible association between single nucleotide polymorphisms (SNPs) of FSHR, CYP17,...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-009-9308-8

    authors： Unsal T,Konac E,Yesilkaya E,Yilmaz A,Bideci A,Ilke Onen H,Cinaz P,Menevse A

    更新日期：2009-04-01 00:00:00

  • Diagnostic laparoscopy in primary and secondary infertility.

    abstract：PURPOSE:Our purpose was to compare the diagnostic efficacy of laparoscopy between primary and secondary infertility and to define a subgroup in which the positive findings are low. METHODS:A retrospective review of the cases of 206 infertile women who underwent laparoscopy was conducted. RESULTS:Eighty-two (39.8%) pa...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1022578019260

    authors： Hovav Y,Hornstein E,Almagor M,Yaffe C

    更新日期：1998-10-01 00:00:00

  • Serum progesterone before and after human chorionic gonadotropin injection depends on the estradiol response to ovarian hyperstimulation during in vitro fertilization-embryo transfer cycles.

    abstract：PURPOSE:Our purpose was to assess if periovulatory serum progesterone is reflective of ovarian responsiveness in controlled ovarian hyperstimulation (COH). METHODS:One-hundred forty-two in vitro fertilization-embryo transfer cycles in women using GnRH-a suppression and human menopausal gonadotropin (hMG) stimulation w...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1020311328182

    authors： Lindheim SR,Cohen MA,Chang PL,Sauer MV

    更新日期：1999-05-01 00:00:00

  • The impact of environmental exposure to perfluorinated compounds on oocyte fertilization capacity.

    abstract：:In an attempt to assess the effect of perfluorinated compounds (PFC) on oocytes quality and fertilization rate, we studied follicular fluid (FF) PFC levels in 18 patients undergoing IVF-ET cycles. A significant correlation (R = 0.75; P < 0.001) was observed between FF PFC levels and fertilization rate. Moreover, patie...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-011-9548-2

    authors： Governini L,Orvieto R,Guerranti C,Gambera L,De Leo V,Piomboni P

    更新日期：2011-05-01 00:00:00

  • Improved responsiveness of PCOS patients to clomiphene after CYP17a inhibitor.

    abstract：PURPOSE:To study the effect of CYP17a inhibitor, "ketoconazole," on clomiphene responsiveness in PCOS patients. METHODS:Prospective analysis was employed with the setup at Alexandria IVF/ICSI center. Ninety-seven insulin-resistant PCOS patients undergoing ovulation induction using clomiphene citrate were randomly divi...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1023/a:1013165006406

    authors： Ali Hassan H,El-Gezeiry D,Nafaa TM,Baghdady I

    更新日期：2001-11-01 00:00:00

  • Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments.

    abstract：:Treatment for cancer has the potential to significantly diminish fertility and, further, to negatively impact the obstetrical outcomes of pregnancies that do occur. Cancer survivors have decreased rates of fertility and increased rates of pregnancy complications, such as preterm birth and low birth weight, after expos...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章,评审

    doi：10.1007/s10815-020-01792-9

    authors： Garg D,Johnstone EB,Lomo L,Fair DB,Rosen MP,Taylor R,Silver B,Letourneau JM

    更新日期：2020-06-01 00:00:00

  • Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis.

    abstract：PURPOSE:The study aimed to investigate key intrafollicular prognostic factors among various cytokines and angiogenic molecules for prediction of mature oocytes and good-quality embryos in women with endometriosis undergoing in vitro fertilization (IVF). METHODS:Paired follicular fluid and serum samples were collected ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-016-0782-5

    authors： Singh AK,Dutta M,Chattopadhyay R,Chakravarty B,Chaudhury K

    更新日期：2016-10-01 00:00:00

  • Early timed follicular aspiration prevents severe ovarian hyperstimulation syndrome.

    abstract：PURPOSE:Early timed follicular aspiration (ETFA) of one ovary 10-12 hr after administration of chorionic gonadotropin (hCG) is an attempt to prevent severe ovarian hyperstimulation syndrome (OHSS). After the introduction of early timed follicular aspiration ETFA of one ovary in IVF/ET cycles at high risk for severe OHS...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02070139

    authors： Tomazevic T,Meden-Vrtovec H

    更新日期：1996-04-01 00:00:00

  • Maternal serum C-reactive protein level does not change significantly after fetal reduction: it could be used as an indicator of chorioamnionitis.

    abstract：PURPOSE:This study was aimed at investigating the diagnostic value of maternal serum C-reactive protein (CRP) in the recognition of chorioamnionitis in patients undergoing fetal reduction. METHODS:Seventy-one gravidas with high-order multifetal pregnancies, including 46 with triplets, 18 with quadruplets, and 7 with q...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1016684605522

    authors： Chen SU,Ko TM,Hwa HL,Lu PJ,Ho HN,Yang YS

    更新日期：2001-06-01 00:00:00

  • Embryonic platelet activating factor production in the rabbit increases during the preimplantation phase.

    abstract：OBJECTIVE:This study measured platelet activating factor (PAF) production by rabbit embryos in vitro and ascertained if there is increased PAF production associated with advancing embryonic development. STUDY DESIGN:Two-cell rabbit embryos were recovered from superovulated New Zealand White does and cultured in vitro ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF01213432

    authors： Minhas BS,Zhu YP,Kim HN,Burwinkel TH,Ripps BA,Buster JE

    更新日期：1993-07-01 00:00:00

  • For whom the egg thaws: insights from an analysis of 10 years of frozen egg thaw data from two UK clinics, 2008-2017.

    abstract：PURPOSE:To better understand the characteristics of patients who returned to thaw their frozen eggs to attempt conception and their outcomes. METHODS:A retrospective analysis of clinical records for all own egg thaw patients in two UK fertility clinics across 10 years, 2008-2017. RESULTS:There were 129 patients who r...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01429-6

    authors： Gürtin ZB,Morgan L,O'Rourke D,Wang J,Ahuja K

    更新日期：2019-06-01 00:00:00

  • Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies.

    abstract：PURPOSE:The aim of this study was to provide a comprehensive follow-up of fetal and perinatal outcome and the incidence of congenital anomalies in babies born after fresh embryo transfers compared to those conceived spontaneously in infertile couples. METHODS:Retrospective comparative analysis of all clinical pregnanc...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-016-0714-4

    authors： Levi Setti PE,Moioli M,Smeraldi A,Cesaratto E,Menduni F,Livio S,Morenghi E,Patrizio P

    更新日期：2016-06-01 00:00:00

  • Assessing the impact of delayed blastulation using time lapse morphokinetics and preimplantation genetic testing in an IVF patient population.

    abstract：PURPOSE:There is clinical evidence that early cleavage timing parameters predictive of blastocyst development also correlate with embryo implantation potential. The aim of this study is to determine the developmental competency of embryos with delayed blastulation. METHODS:Retrospective study performed from 2015 to 20...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01501-1

    authors： Kimelman D,Confino R,Okeigwe I,Lambe-Steinmiller J,Confino E,Shulman LP,Zhang JX,Pavone ME

    更新日期：2019-08-01 00:00:00

  • Azoospermia and embryo morphokinetics: testicular sperm-derived embryos exhibit delays in early cell cycle events and increased arrest prior to compaction.

    abstract：PURPOSE:Sperm play an essential role in embryonic genome activation and embryonic progression to blastocyst. In the present work, we focus on development of embryos created as a result of ICSI with testicular or epididymal sperm from azoospermic males and compare this to outcomes from normospermic males. The objective ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-018-1183-8

    authors： Desai N,Gill P,Tadros NN,Goldberg JM,Sabanegh E,Falcone T

    更新日期：2018-07-01 00:00:00

  • Neuropsychologic dysfunction in women following leuprolide acetate induction of hypoestrogenism.

    abstract：OBJECTIVE:The study investigated the neuropsychological status of women with induced hypoestrogenism. DESIGN:An ABA design was employed in which neuropsychological measures were repeated prior to, during, and after induction of hypoestrogenism with leuprolide acetate. SETTING:The study took place in a medical school ...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF01204441

    authors： Varney NR,Syrop C,Kubu CS,Struchen M,Hahn S,Franzen K

    更新日期：1993-01-01 00:00:00

  • Respirometric reserve capacity of cumulus cell mitochondria correlates with oocyte maturity.

    abstract：PURPOSE:Oocyte competence is critical in success of assisted reproduction. Metabolic signaling between oocyte and cumulus cells within the cumulus-oocyte complex procure oocyte development. This study evaluated the relationship between respirometric activity of cumulus cells and maturity of corresponding oocytes. METH...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-018-1271-9

    authors： Anderson SH,Glassner MJ,Melnikov A,Friedman G,Orynbayeva Z

    更新日期：2018-10-01 00:00:00

  • The effect of ease of transfer and type of catheter used on pregnancy and implantation rates in an IVF program.

    abstract：PURPOSE:To test the effects of type of embryo transfer catheter, transfer difficulty, and observations after the transfer procedure on pregnancy and implantation rates in an IVF programme. METHODS:Patients were prepared for IVF using standard protocols. Embryo transfer was performed using either Edwards-Wallace or TDT...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1023/a:1014054421789

    authors： De Placido G,Wilding M,Stina I,Mollo A,Alviggi E,Tolino A,Colacurci N,De ML,Marino M,Dale B

    更新日期：2002-01-01 00:00:00

  • Derivation, culture and retinal pigment epithelial differentiation of human embryonic stem cells using human fibroblast feeder cells.

    abstract：PURPOSE:Retinal pigment epithelium cells derived from human embryonic stem cells (ESCs) could be useful for restoring retinal function in age-related macular degeneration. However the use of non-human feeder cells to support the growth of ESCs for clinical applications raises the concern of possible contamination becau...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-012-9802-2

    authors： Zhang YS,Lu ZY,Yu Y,Li XR,Li WB,Wang YN,Geng Y

    更新日期：2012-08-01 00:00:00

  • Epidermal growth factor (EGF) receptor localization in cultured human granulosa lutein cells and the stimulation of progesterone production by EGF and transforming growth factor-alpha (TGF-alpha).

    abstract：PURPOSE:The purpose of this study was to investigate the expression of EGF receptor (EGF-R) in human granulosa cells undergoing luteinization and progesterone production by these cells in response to EGF an TGF-alpha alone or in combination with luteinizing hormone (LH). Granulosa cells were obtained from IF patients f...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/BF02212900

    authors： Tekpetey FR,Daniel SA,Yuzpe A

    更新日期：1995-11-01 00:00:00

  • Retrieval, maturation, and fertilization of immature oocytes obtained from unstimulated patients with polycystic ovary syndrome.

    abstract：PURPOSE:Our purpose was to determine whether immature oocytes could be retrieved under local anesthesia, whether these oocytes would mature and fertilize in vitro, and whether adequate endometrium development could be obtained after hormonal supplementation. METHODS:Ovum pick-up was performed under local anesthesia. I...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 临床试验,杂志文章

    doi：10.1023/a:1022516806423

    authors： Beckers NG,Pieters MH,Ramos L,Zeilmaker GH,Fauser BC,Braat DD

    更新日期：1999-02-01 00:00:00

  • Unbalanced X;9 translocation in an infertile male with de novo duplication Xp22.31p22.33.

    abstract：PURPOSE:Male carriers of an X-autosome translocation are generally infertile, regardless of the position of the breakpoint on the X chromosome while the pathogenicity of Xp22.3 subtelomeric duplications is under debate. To shed light into this controversy, we present a rare case, of an azoospermic male with no other si...

    journal_title：Journal of assisted reproduction and genetics

    pub_type： 杂志文章

    doi：10.1007/s10815-019-01405-0

    authors： Roumelioti FM,Louizou E,Karras S,Neroutsou R,Velissariou V,Gagos S

    更新日期：2019-04-01 00:00:00