Abstract:
PURPOSE:There is a need for methods that would enable monitoring of the effects of immunosuppression on the recipient's immune system to avoid rejection, immunodeficiency-related complications and non-immune toxicities of the drugs used in therapy. METHODS:This prospective trial included thirty patients who underwent renal transplantation in our center. All patients received an interleukin-2 receptor (IL-2R) antagonist in combination with mycophenolate, corticosteroid and calcineurin inhibitor. During the first 6 weeks after transplantation, the anti-CD3-stimulated proliferative response of peripheral blood T lymphocytes (PBTL) was studied by cell cycle analysis. The proportion of PBTL in different phases of the cell cycle and expression of IL-2R were determined by flow cytometry. RESULTS:As an effect of quadruple immunosuppressive therapy including IL-2R antagonists, cell cycle analysis showed an incremental decrease in the proliferative response of PBTL during the first 6 weeks after renal transplantation. A sudden drop in the proportion of IL-2R-positive cells was observed immediately after the first dose of the IL-2R antagonist and a significant antiproliferative effect on PBTL after the second dose. In vitro, IL-2R antagonists showed a dose-dependent inhibition of the anti-CD3-stimulated proliferation of PBTL of healthy blood donors. CONCLUSIONS:Cell cycle analysis of the immune reactivity of renal allograft recipients may represent a valuable tool for the immunological posttransplant follow-up and optimization of the immunosuppressive therapy.
journal_name
Int Urol Nephroljournal_title
International urology and nephrologyauthors
Zivčić-Ćosić S,Lisjak J,Rački S,Trobonjača Zdoi
10.1007/s11255-013-0413-3subject
Has Abstractpub_date
2014-01-01 00:00:00pages
191-200issue
1eissn
0301-1623issn
1573-2584journal_volume
46pub_type
临床试验,杂志文章abstract:PURPOSE:Residual diuresis progressively decreases with longer dialysis vintage, and higher incidence of renal and urinary tract cancers was often observed in hemodialyzed patients compared to the general population so we hypothesized that patients without preserved residual diuresis have higher risk of renal and urinar...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1723-7
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:To evaluate the association of shock-wave lithotripsy (SWL) for kidney stones and hypertension or diabetes. METHODS:Patients with urolithiasis treated by SWL were retrospectively identified. To assess whether shock-wave application to the kidney is associated with long-term adverse effects, patients after SWL ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1857-2
更新日期:2018-07-01 00:00:00
abstract::During transurethral electroresection in the posterolateral bladder neck, trigone and posterior urethra, unintentional contractions of the thigh-adductor muscles may occur due to irritation of the obturator nerve. The sudden displacement of the bladder wall against the cutting loop may cause a perforation of the bladd...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02085445
更新日期:1983-01-01 00:00:00
abstract:PURPOSE:To suggest a different method for diagnosing vesicoureteral reflux (VUR) in lieu of voiding cystourethrography (VCU), in order to prevent radiation exposure. MATERIALS AND METHODS:Fifty-two ureterorenal units of 26 patients were evaluated ultrasonographically for visualizing the renal collecting systems, both ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550307
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. MATERIALS AND METHODS:Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-007-9296-5
更新日期:2008-01-01 00:00:00
abstract::Penile cancer is an uncommon disease in the industrialized world that most frequently presents at low stage and is cured with treatment of local and regional surgery. In cases of advanced cancer, the use of more aggressive surgical techniques and the addition of adjuvant therapy may be warranted. So far, few agents ha...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-011-0011-1
更新日期:2012-02-01 00:00:00
abstract:PURPOSE:We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients. METHODS:SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-rea...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0233-x
更新日期:2013-08-01 00:00:00
abstract::In 21 men suffering from acute or chronic epididymitis who underwent scrotal surgical exploration, diagnostic microbiological studies consisting in cultures of the epididymal tissues and mid-stream urine specimens, as well as examination of the urethral swabs--before and after prostatic massage--were performed. Labora...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549519
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:There is evidence that chronic local ischemia may be one possible etiology of prostatic atrophy (PA). Our aim was to study the expression of hypoxia induced factors in areas of PA. DESIGN:The immunohistochemical expression of hypoxia-inducible factor-1 alpha (HIF-1) and vascular endothelial growth factor (V...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-006-6657-4
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:This study investigated the frequency of malnutrition in geriatric hemodialysis patients according to biochemical, anthropometric, bioelectrical impedance analysis (BIA), modified quantitative subjective global assessment (MQSGA), and geriatric nutritional risk index (GNRI) methods, and the effect of gender on ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-014-0776-0
更新日期:2014-12-01 00:00:00
abstract:BACKGROUND:Although frequent use of prophylactic antibiotics for patients undergoing transrectal prostate biopsy (TRPB), incidences of urinary tract infection (UTI) and bacterial resistance are still increasing. We evaluated the efficacy of augmented prophylactic antibiotics in patients undergoing TRPB. METHODS:A syst...
journal_title:International urology and nephrology
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11255-016-1299-7
更新日期:2016-08-01 00:00:00
abstract::Genitourinary organs are at greater risk for multiple primary malignant neoplasms because of the high incidence of these tumours as primaries among all other organs. We present a case of prostate and bladder carcinoma metastasized to a single pelvic lymph node, called a "collision" metastasis, in a patient with four p...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02552140
更新日期:1995-01-01 00:00:00
abstract::In developing countries, renal transplantation is offered to young end-stage renal disease (ESRD) patients, while the older ones face limitations due to higher mortality risk. We retrospectively analyzed 225 patients who underwent renal transplantation from living donors, aged 40-60 years (Group A) and >60 years (Grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-010-9887-4
更新日期:2011-03-01 00:00:00
abstract::Primary CNS lymphoma (PCNSL) is a rare B cell variant non-Hodgkins lymphoma that is confined to the brain, leptomeninges, spinal cord and eyes. Its incidence is increasing, primarily due to increase in the number of organ transplantations being undertaken. The majority of the PTLD (post-transplant lymphoproliferative ...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-012-0146-8
更新日期:2013-08-01 00:00:00
abstract::Fournier's gangrene (FG) is a rapidly progressive, fulminant infection of the scrotum, perineum and the abdominal wall. FG is caused by synergic aerobic and anaerobic organisms. Modern surgical series report mortality of up to 67%. This originally rare disease has become more frequent. Aggressive treatment including a...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1019554327341
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Recently, great progress has been made in understanding the pathogenesis of membranous nephropathy (MN) with the discovery of autoantibodies (Abs) to M-type phospholipase A2 receptor (PLA2R) in serum and in immunocomplexes deposited in glomerulus in most adult patients with primary MN. OBJECTIVE:To evaluate...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02682-w
更新日期:2020-10-31 00:00:00
abstract:PURPOSE:Our aim was to compare the different characteristics and outcomes of the Amplatz sheaths and single-step metallic dilators which were used for mini-PCNL procedure in a single institution. METHODS:Retrospective medical records of 236 patients who underwent mini-PCNL were reviewed and divided into Amplatz (n = 1...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1516-z
更新日期:2017-04-01 00:00:00
abstract::Serum and urine levels of tumour necrosis factor (TNF) which is a lymphokine was measured in patients with genitourinary cancer (either prostatic, bladder or testicular carcinoma) in order to find out whether there were elevated levels of TNF in those patients and if it was related to disease status. Although the prel...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02549736
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:According to current guidelines, radical cystectomy (RC) should be combined with an extended pelvic lymphadenectomy (PLND) as therapeutic and staging instrument. Objective of this study was to analyze the influence of PLND on survival rates and complication rates in a selected group of elderly patients with ...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-017-1699-3
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Brown tumor, a non-neoplastic process resulting from excess osteoclast activity, is found in primary hyperparathyroidism (HPTP) and secondary hyperparathyroidism (HPTS). We report a rare case of multiple spinal cord compression by brown tumors. CASE REPORT:A 47-year-old male with end-stage renal disease cau...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-012-0123-2
更新日期:2013-06-01 00:00:00
abstract::The concentrations of prostaglandin E2 (PGE2), sodium, potassium and creatinine were determined in the blood and urine of 50 renal transplant recipients treated with cyclosporine A or azathioprine, as immunosuppressive agents, for at least one year post transplantation. Fourteen healthy subjects served as control grou...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02550640
更新日期:1992-01-01 00:00:00
abstract::Varicocele, the leading cause of male infertility, can impair sperm quality and fertility via various oxidative stress mechanisms. An imbalance between excessive reactive oxygen species production and antioxidant protection causes alterations in nuclear and mitochondrial sperm DNA, thus rendering a subset of varicocel...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-018-1839-4
更新日期:2018-04-01 00:00:00
abstract::Accurate knowledge about the morphology and degree of infiltration of a bladder tumor is an essential prerequisite to correctly plan, and forecast the results of, the treatment of these tumors. Among the radiological investigations double contrast cystography is superior to excretory cystogram or conventional cystogra...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02082014
更新日期:1977-01-01 00:00:00
abstract::The incidence of cytomegalovirus infection in Chinese patients was reviewed in a retrospective study of 99 renal transplant recipients. CMV infection occurred in 18 patients (18.2%). In 4 the infection was considered primary and in 14 it was thought to be reactivation. Of the infections 88.9% occurred within the first...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02767664
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:To share our 7-year experiences of a safe and effective method for tract creation in percutaneous nephrolithotomy (PCNL). METHODS:A total of 143 patients had received this kind of method for renal stone disease at our institute from May 2010 to December 2016. Finally, 130 patients with complete data were inclu...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-018-1949-z
更新日期:2018-09-01 00:00:00
abstract::This is the first prospective study to investigate the association between kidney stones, bone mineral density, serum testosterone, colon cancer and O. formigenes colonization. 40 kidney stone patients and 85 controls were enrolled. O. formigenes colonization was established. BMD was examined from T- and Z-scores usin...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/s11255-020-02627-3
更新日期:2021-01-01 00:00:00
abstract::A patient with bladder carcinoma, subjected to cystectomy and bilateral ureterosigmoidostomy, survived for the length of 31 years. The Coffey method of anastomosis was applied in a form modified by the authors. The patient succumbed to acute circulatory insufficiency at the age of 85. Metastases were not discovered ei...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1007/BF02081864
更新日期:1984-01-01 00:00:00
abstract::Evaluation of potential candidates for testosterone replacement therapy (TRT) includes a complete medical history, physical examination, and hormonal screening. The choice of testosterone assay is important in clinical decision making. TRT should, in theory, approximate natural endogenous production of the hormone. Th...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1007/s11255-010-9879-4
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To investigate the association of retrocaval ureter with other congenital abnormalities. METHODS AND PATIENTS:Two new cases of retrocaval ureter are discussed and a detailed electronic search of the literature was mainly focused on the concomitant abnormalities. The first of our patients had also a glandular...
journal_title:International urology and nephrology
pub_type: 杂志文章,评审
doi:10.1023/a:1014436432109
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Smooth muscle fibres are found within the superficial lamina propria of urinary bladder (Muscularis Mucosa). These muscle fibres of muscularis mucosa should be distinguished from the muscularis propria in cases with urothelial carcinoma, because the depth of infiltration affects prognosis and therapy modaliti...
journal_title:International urology and nephrology
pub_type: 杂志文章
doi:10.1023/a:1024493518202
更新日期:2002-01-01 00:00:00