Abstract：
:To compare the cytokine response to exhaustive running in recreationally-active (RA) and endurance-trained (ET) men. Eleven RA men (VO2max 55 ± 7 mL·min(-1)·kg(-1)) and 10 ET men (VO₂max 68 ± 7 mL·min(-1)·kg(-1)) followed a controlled diet and refrained from volitional exercise for 8 days. On the fourth day, participants completed 60 min of treadmill running (65 % VO₂max), followed by intermittent running to exhaustion (70 % VO₂max). Fasting blood was obtained at baseline, after 20, 40 and 60 min of exercise, at the end of intermittent exercise, during 2 h of recovery and on four follow-up days (FU1-FU4). Tumour necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra) and creatine kinase (CK) were measured. Exercise increased the concentrations of all cytokines and CK, but there were no significant differences between groups. IL-1β increased (2.2-2.5-fold, P < 0.001) during exercise, while TNF-α was increased (1.6-2.0-fold, P < 0.001) during exercise and for 2 h post-exercise. IL-6 (71-84-fold, P < 0.001) and IL-1ra (52-64-fold, P < 0.001) were increased throughout exercise and up to FU1, peaking immediately after exercise and at 1.5-2 h post-exercise, respectively. CK concentrations were increased (P < 0.001) throughout exercise and up to FU4, peaking at FU1, but were not associated with changes in any cytokines. Exhaustive running resulted in modest and transient increases in TNF-α and IL-1β, and more marked and prolonged increases in IL-6 and IL-1ra, but improved training status did not affect this response. Increased CK might indicate either exercise-induced muscle cell disruption or increased cell permeability, although neither appears to have contributed to the increased cytokine concentrations.
journal_name
Eur J Appl Physioljournal_title
European journal of applied physiologyauthors
Scott JP,Sale C,Greeves JP,Casey A,Dutton J,Fraser WDdoi
10.1007/s00421-013-2615-xsubject
Has Abstractpub_date
2013-07-01 00:00:00pages
1871-82issue
7eissn
1439-6319issn
1439-6327journal_volume
113pub_type
杂志文章abstract：:The role of exercise training (ET) on cardiac renin-angiotensin system (RAS) was investigated in 3-5 month-old mice lacking alpha(2A-) and alpha(2C-)adrenoceptors (alpha(2A)/alpha(2C)ARKO) that present heart failure (HF) and wild type control (WT). ET consisted of 8-week running sessions of 60 min, 5 days/week. In add...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0967-4
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:We analyzed the best performance times of master cycling athletes in the 200-3000 m track competitions to estimate the decay of maximal aerobic power (MAP) and anaerobic capacity (AnS) with aging. METHODS:In various decades of age (30-80 years), MAP and AnS were estimated using an iterative procedure as the va...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-016-3396-9
更新日期：2016-07-01 00:00:00
abstract：:The purpose of this study was to assess cardiac function and arteriovenous oxygen difference (a-vO(2) difference) at rest and during exercise in young, normal-weight (n = 20), and obese (n = 12) men and women who were matched for age and fitness level. Participants were assessed for body composition, peak oxygen consu...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1554-z
更新日期：2011-06-01 00:00:00
abstract：:The unwanted variability in dynamometric measurements limits accurate interpretation of these measurements. Although unpredictable variability in measurements has been identified repeatedly, few studies have investigated strategies for reducing measurement error. This study investigated the effect of preload on variab...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0557-1
更新日期：2002-02-01 00:00:00
abstract：:It is not known how the mode of exercise, dynamic and static exercises, affects the limb volume. Therefore, the purpose of this study was to investigate hand and wrist volume (HWV) after dynamic and static handgrip exercise. Nine healthy subjects (age 31.8 +/- 7.3 years; height 172.0 +/- 5.7 cm; body mass 66.9 +/- 8.1...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-008-0672-3
更新日期：2008-05-01 00:00:00
abstract：:It has been well demonstrated that the principal factor responsible for oxidative damage during exercise is the increase in oxygen consumption. However, other theoretical factors (acidosis, catecholamine autoxidation, ischemia-reperfusion syndrome, etc.) that are known to induce, in vitro, oxidative damage may also be...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-002-0767-1
更新日期：2003-03-01 00:00:00
abstract：:A number of mechanisms have been proposed to explain the elevation in oxygen consumption following exercise. Biochemical processes that return muscle to its pre-exercise state do not account for all of the extra oxygen consumed after exercise (excess post-exercise oxygen consumption, EPOC). Muscle at rest after aerobi...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0578-5
更新日期：2007-12-01 00:00:00
abstract：PURPOSE:The curvature constant (W') and asymptote (critical power; CP) of the power-duration relationship are important parameters for explaining cycling performance. Short-duration endurance cycling events rely more heavily on the W'; however, the full mechanistic underpinning of this parameter is yet to be determined...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-018-3807-1
更新日期：2018-03-01 00:00:00
abstract：PURPOSE:The purpose of this double-blind, placebo-controlled study was to examine the effect of two fish oil supplements, one high in EPA (750 mg EPA, 50 mg DHA) and one low in EPA (150 mg EPA, 100 mg DHA), taken acutely as a recovery strategy following EIMD. METHODS:Twenty-seven physically active males (26 ± 4 year, ...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3543-y
更新日期：2017-03-01 00:00:00
abstract：:The purpose of the present study was to investigate motor unit (MU) recruitment and firing rate, and the MU action potential (MUAP) characteristics of the human supraspinatus muscle during prolonged static contraction and subsequent recovery. Eight female subjects sustained a 30 degrees shoulder abduction, requiring 1...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000278
更新日期：2000-10-01 00:00:00
abstract：:Using an improved Peronnet-Thibault model to analyse the maximal power available during exercise, it was found that a 3rd-order relaxation process for the decreasing dynamics of aerobic power can describe accurately the data available for world track records and aerobic-to-total energy ratio (ATER). It was estimated t...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-001-0555-3
更新日期：2002-04-01 00:00:00
abstract：:Tendon stiffness increases as the magnitude and rate of loading increases, according to its viscoelastic properties. Thus, under some loading conditions tendons should become exceptionally stiff and act almost as rigid force transducers. Nonetheless, observations of tendon behavior during multi-joint sprinting and jum...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-013-2744-2
更新日期：2014-01-01 00:00:00
abstract：:To determine if there is a sex dimorphism in the skeletal muscle signaling response to sprint exercise, 17 men and ten women performed a 30-s Wingate test. Muscle biopsies were taken before, immediately after the exercise and at 30 and 120 min during the recovery period. Thr(172)-AMPKα, Ser(221)-ACCβ, Thy(705)-STAT3, ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2164-0
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:23Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles wou...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-017-3647-4
更新日期：2017-08-01 00:00:00
abstract：:We aimed to analyze the association between changes in total and regional fat (FM) and fat-free mass (FFM) over a season with resting (REE) and total energy expenditure (TEE) in elite basketball players. At the beginning of the pre-season and at the final of the competitive period, measures of total and regional FM, F...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-2221-8
更新日期：2012-07-01 00:00:00
abstract：PURPOSE:A previous study observed a joint passive torque increase above baseline ~30 min after a high-intensity stretching. This study examined the effect of a high-intensity stretching on ankle dorsiflexion passive torque, medial gastrocnemius (MG) shear modulus, and plantar flexors maximal voluntary isometric force (...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-016-3410-2
更新日期：2016-08-01 00:00:00
abstract：:This study was performed to examine the effect of diurnal normobaric hypoxia on hematological parameters. Eleven healthy male volunteers were randomly selected to be in either the hypoxic group (n=6) or the control group (n=5). The hypoxic group was exposed to 8 h of normobaric hypoxia in hypoxic tent systems that eli...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-005-0125-1
更新日期：2006-04-01 00:00:00
abstract：:Thirty-two untrained men [mean (SD) age 22.5 (5.8) years, height 178.3 (7.2) cm, body mass 77.8 (11.9) kg] participated in an 8-week progressive resistance-training program to investigate the "strength-endurance continuum". Subjects were divided into four groups: a low repetition group (Low Rep, n = 9) performing 3-5 ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-002-0681-6
更新日期：2002-11-01 00:00:00
abstract：:Cardiovascular autonomic function is associated with physical performance and exercise training adaptation. The association between physical performance and sympathetic regulation is not well known. We hypothesized that sympathetic nervous system activity is associated with physical performance among male runners. The...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-007-0618-1
更新日期：2008-03-01 00:00:00
abstract：:Although pacing-related research is widely reported, no studies have described the consistency of pacing strategies or their associated energetic contributions. This study aimed to investigate the consistency of pacing and energetic outlay by establishing the typical within and between trial variations during simulate...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-010-1818-7
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Cold injuries are more prevalent in individuals of African descent (AFD). Therefore, we investigated the effect of extremity cooling on skin blood flow (SkBF) and temperature (T sk) between ethnic groups. METHODS:Thirty males [10 Caucasian (CAU), 10 Asian (ASN), 10 AFD] undertook three tests in 30 °C air whils...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-014-2962-2
更新日期：2014-11-01 00:00:00
abstract：PURPOSE:The aims of this study were to: (1) determine the relationships between maximum oxygen uptake ([Formula: see text]O2max) and walking economy during non-graded and graded walking among overweight women and (2) examine potential differences in [Formula: see text]O2max and walking economy before and after weight l...
journal_title：European journal of applied physiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00421-018-3888-x
更新日期：2018-08-01 00:00:00
abstract：:This case study reports the results of a 6-year (2005-2010) follow-up study of a world-class rowing crew, the current world champions. The rowers were 15-16 years old and prospective competitors at the junior level when the study began in 2005, and we monitored their physical, physiological, and rowing ergometer perfo...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-011-1870-y
更新日期：2011-09-01 00:00:00
abstract：:No previous studies have investigated the effect of lower body compression garments (CG) on running performance in the heat. This study tested the hypothesis that CG would negatively affect running performance in the heat by comparing CG and non-CG conditions for running performance and physiological responses in hot ...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-010-1705-2
更新日期：2011-05-01 00:00:00
abstract：:The influence of fatigue on the stretch reflex evoked in ankle extensor muscles by hopping was investigated in six healthy men. The men hopped on a force platform, at spontaneous frequency and amplitude, until they were unable to maintain the initial frequency or amplitude of the jumps. This task was done with the kne...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210000324
更新日期：2001-01-01 00:00:00
abstract：:The objective of this study was to evaluate the viability of using a single test in which cardiorespiratory variables are measured, to establish training guidelines in running and/or cycling training activities. Six triathletes (two females and four males), six runners (two females and four males) and six males cyclis...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s004210050033
更新日期：2000-02-01 00:00:00
abstract：PURPOSE:We investigated the effect of post-exercise sauna bathing on plasma volume (PV) expansion and whether such responses can be tracked by changes in heart rate (HR)-based measures. METHODS:Seven, well-trained male cyclists were monitored for 35 consecutive days (17 days baseline training, 10 days training plus sa...
journal_title：European journal of applied physiology
pub_type： 杂志文章
doi：10.1007/s00421-014-3060-1
更新日期：2015-04-01 00:00:00
abstract：:No studies have considered whether a firefighter's boots are a factor influencing physiological responses. The purpose of this study was to examine physiological responses to a fire simulation activity (stair climb) in professional firefighters wearing rubber boots (RB) and leather boots (LB). Twelve professional fire...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-009-1092-8
更新日期：2009-09-01 00:00:00
abstract：:Breath-hold divers report transient, severe neurological symptoms that could be caused by arterial gas embolism after glossopharyngeal insufflation. This technique is often used to overinflate the lungs and stretch the chest prior to breath-holding and can increase the transpulmonary pressure to around 7-8 kPa, so int...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s00421-012-2494-6
更新日期：2013-03-01 00:00:00
abstract：:The purpose of this study was to evaluate the effects of various modes of training on the time-course of changes in lipoprotein-lipid profiles in the blood, cardiovascular fitness, and body composition after 16 weeks of training and 6 weeks of detraining in young women. A group of 48 sedentary but healthy women [mean ...
journal_title：European journal of applied physiology
pub_type： 临床试验,杂志文章
doi：10.1007/s004210000234
更新日期：2000-08-01 00:00:00
