Peto's paradox revisited: theoretical evolutionary dynamics of cancer in wild populations.

Abstract:

:If the occurrence of cancer is the result of a random lottery among cells, then body mass, a surrogate for cells number, should predict cancer incidence. Despite some support in humans, this assertion does not hold over the range of different natural animal species where cancer incidence is known. Explaining the so-called 'Peto's paradox' is likely to increase our understanding of how cancer defense mechanisms are shaped by natural selection. Here, we study how body mass may affect the evolutionary dynamics of tumor suppressor gene (TSG) inactivation and oncogene activation in natural animal species. We show that the rate of TSG inactivation should evolve to lower values along a gradient of body mass in a nonlinear manner, having a threshold beyond which benefits to adaptive traits cannot overcome their costs. We also show that oncogenes may be frequently activated within populations of large organisms. We then propose experimental settings that can be employed to identify protection mechanisms against cancer. We finally highlight fundamental species traits that natural selection should favor against carcinogenesis. We conclude on the necessity of comparing genomes between populations of a single species or genomes between species to better understand how evolution has molded protective mechanisms against cancer development and associated mortality.

journal_name

Evol Appl

authors

Roche B,Sprouffske K,Hbid H,Missé D,Thomas F

doi

10.1111/eva.12025

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

109-16

issue

1

issn

1752-4571

journal_volume

6

pub_type

杂志文章
  • Habitat-mediated size selection in endangered Atlantic salmon fry: selectional restoration assessment.

    abstract::Preservation of adaptive variation is a top priority of many species restoration programs, but most restoration activities are conducted without direct knowledge of selection that might foster or impair adaptation and restoration goals. In this study, we quantified geographic variation in selection on fry size of enda...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2010.00126.x

    authors: Bailey MM,Kinnison MT

    更新日期:2010-07-01 00:00:00

  • Human activities and landscape features interact to closely define the distribution and dispersal of an urban commensal.

    abstract::The rock pigeon, Columba livia, is a cosmopolitan human commensal, domesticated thousands of years ago. However, the human-mediated factors governing its distribution and dispersal are not well understood. In this study, we performed (a) hierarchical distance sampling on ~400 island-wide point transects, (b) a populat...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12650

    authors: Tang Q,Low GW,Lim JY,Gwee CY,Rheindt FE

    更新日期:2018-07-21 00:00:00

  • Long-term on-farm participatory maize breeding by stratified mass selection retains molecular diversity while improving agronomic performance.

    abstract::Modern maize breeding programs gave rise to genetically uniform varieties that can affect maize's capacity to cope with increasing climate unpredictability. Maize populations, genetically more heterogeneous, can evolve and better adapt to a broader range of edaphic-climatic conditions. These populations usually suffer...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12549

    authors: Alves ML,Belo M,Carbas B,Brites C,Paulo M,Mendes-Moreira P,Brites C,Bronze MDR,Šatović Z,Vaz Patto MC

    更新日期:2017-10-14 00:00:00

  • Latitudinal variation in cold hardiness in introduced Tamarix and native Populus.

    abstract::To investigate the evolution of clinal variation in an invasive plant, we compared cold hardiness in the introduced saltcedar (Tamarix ramosissima, Tamarix chinensis, and hybrids) and the native plains cottonwood (Populus deltoides subsp. monilifera). In a shadehouse in Colorado (41°N), we grew plants collected along ...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2008.00044.x

    authors: Friedman JM,Roelle JE,Gaskin JF,Pepper AE,Manhart JR

    更新日期:2008-11-01 00:00:00

  • Introgression of Chinese haplotypes contributed to the improvement of Danish Duroc pigs.

    abstract::The distribution of Asian ancestry in the genome of Danish Duroc pigs was investigated using whole-genome sequencing data from European wild boars, Danish Duroc, Chinese Meishan and Bamaxiang pigs. Asian haplotypes deriving from Meishan and Bamaxiang occur widely across the genome. Signatures of selection on Asian hap...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12716

    authors: Chen M,Su G,Fu J,Wang A,Liu JF,Lund MS,Guldbrandtsen B

    更新日期:2018-12-13 00:00:00

  • Toward responsible stock enhancement: broadcast spawning dynamics and adaptive genetic management in white seabass aquaculture.

    abstract::The evolutionary effects captive-bred individuals that can have on wild conspecifics are necessary considerations for stock enhancement programs, but breeding protocols are often developed without the knowledge of realized reproductive behavior. To help fill that gap, parentage was assigned to offspring produced by a ...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2011.00234.x

    authors: Gruenthal KM,Drawbridge MA

    更新日期:2012-06-01 00:00:00

  • Assessing early fitness consequences of exotic gene flow in the wild: a field study with Iberian pine relicts.

    abstract::Gene flow from plantations of nonlocal (genetically exotic) tree provenances into natural stands of the same species is probably a widespread phenomenon, but its effects remain largely unexamined. We investigated early fitness consequences of intraspecific exotic gene flow in the wild by assessing differences in survi...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12333

    authors: Unger GM,Heuertz M,Vendramin GG,Robledo-Arnuncio JJ

    更新日期:2016-01-09 00:00:00

  • Invasion and migration of spatially self-limiting gene drives: A comparative analysis.

    abstract::Recent advances in research on gene drives have produced genetic constructs that could theoretically spread a desired gene (payload) into all populations of a species, with a single release in one place. This attribute has advantages, but also comes with risks and ethical concerns. There has been a call for research o...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12583

    authors: Dhole S,Vella MR,Lloyd AL,Gould F

    更新日期:2018-01-04 00:00:00

  • A continuously changing selective context on microbial communities associated with fish, from egg to fork.

    abstract::Fast increase of fish aquaculture production to meet consumer demands is accompanied by important ecological concerns such as disease outbreaks. Meanwhile, food waste is an important concern with fish products since they are highly perishable. Recent aquaculture and fish product microbiology, and more recently, microb...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.13027

    authors: Derome N,Filteau M

    更新日期:2020-06-09 00:00:00

  • Adaptive genetic markers discriminate migratory runs of Chinook salmon (Oncorhynchus tshawytscha) amid continued gene flow.

    abstract::Neutral genetic markers are routinely used to define distinct units within species that warrant discrete management. Human-induced changes to gene flow however may reduce the power of such an approach. We tested the efficiency of adaptive versus neutral genetic markers in differentiating temporally divergent migratory...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12095

    authors: O'Malley KG,Jacobson DP,Kurth R,Dill AJ,Banks MA

    更新日期:2013-12-01 00:00:00

  • Adaptive dynamics of unstable cancer populations: The canonical equation.

    abstract::In most instances of tumour development, genetic instability plays a role in allowing cancer cell populations to respond to selection barriers, such as physical constraints or immune responses, and rapidly adapt to an always changing environment. Modelling instability is a nontrivial task, since by definition evolving...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12625

    authors: Aguadé-Gorgorió G,Solé R

    更新日期:2018-04-17 00:00:00

  • Phylogeny meets ecotoxicology: evolutionary patterns of sensitivity to a common insecticide.

    abstract::Pesticides commonly occur in aquatic systems and pose a substantial challenge to the conservation of many taxa. Ecotoxicology has traditionally met this challenge by focusing on short-term, single-species tests and conducting risk assessments based on the most sensitive species tested. Rarely have ecotoxicology data b...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2011.00237.x

    authors: Hammond JI,Jones DK,Stephens PR,Relyea RA

    更新日期:2012-09-01 00:00:00

  • Cancer stem cells as 'units of selection'.

    abstract::Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain competitive advantage via their fitness in relation to micro-environmental selective pressures. In this context, the 'unit' of selection i...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12017

    authors: Greaves M

    更新日期:2013-01-01 00:00:00

  • Transcriptomic responses to emamectin benzoate in Pacific and Atlantic Canada salmon lice Lepeophtheirus salmonis with differing levels of drug resistance.

    abstract::Salmon lice Lepeophtheirus salmonis are an ecologically and economically important parasite of wild and farmed salmon. In Scotland, Norway, and Eastern Canada, L. salmonis have developed resistance to emamectin benzoate (EMB), one of the few parasiticides available for salmon lice. Drug resistance mechanisms can be co...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12237

    authors: Sutherland BJ,Poley JD,Igboeli OO,Jantzen JR,Fast MD,Koop BF,Jones SR

    更新日期:2015-02-01 00:00:00

  • Domestication of cattle: Two or three events?

    abstract::Cattle have been invaluable for the transition of human society from nomadic hunter-gatherers to sedentary farming communities throughout much of Europe, Asia and Africa since the earliest domestication of cattle more than 10,000 years ago. Although current understanding of relationships among ancestral populations re...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12674

    authors: Pitt D,Sevane N,Nicolazzi EL,MacHugh DE,Park SDE,Colli L,Martinez R,Bruford MW,Orozco-terWengel P

    更新日期:2018-07-23 00:00:00

  • Tracing the origin of the early wet-season Anopheles coluzzii in the Sahel.

    abstract::In arid environments, the source of the malaria mosquito populations that re-establish soon after first rains remains a puzzle and alternative explanations have been proposed. Using genetic data, we evaluated whether the early rainy season (RS) population of Anopheles coluzzii is descended from the preceding late RS g...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12486

    authors: Lehmann T,Weetman D,Huestis DL,Yaro AS,Kassogue Y,Diallo M,Donnelly MJ,Dao A

    更新日期:2017-05-26 00:00:00

  • Recovery of a nearly extinct Galápagos tortoise despite minimal genetic variation.

    abstract::A species of Galápagos tortoise endemic to Española Island was reduced to just 12 females and three males that have been bred in captivity since 1971 and have produced over 1700 offspring now repatriated to the island. Our molecular genetic analyses of juveniles repatriated to and surviving on the island indicate that...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12014

    authors: Milinkovitch MC,Kanitz R,Tiedemann R,Tapia W,Llerena F,Caccone A,Gibbs JP,Powell JR

    更新日期:2013-02-01 00:00:00

  • Evolutionary rescue in a host-pathogen system results in coexistence not clearance.

    abstract::The evolutionary rescue of host populations may prevent extinction from novel pathogens. However, the conditions that facilitate rapid evolution of hosts, in particular the population variation in host susceptibility, and the effects of host evolution in response to pathogens on population outcomes remain largely unkn...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12568

    authors: Christie MR,Searle CL

    更新日期:2017-11-20 00:00:00

  • Weird genotypes? Don't discard them, transmissible cancer could be an explanation.

    abstract::Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. ...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12439

    authors: Riquet F,Simon A,Bierne N

    更新日期:2016-12-16 00:00:00

  • Temporal variation in antibiotic environments slows down resistance evolution in pathogenic Pseudomonas aeruginosa.

    abstract::Antibiotic resistance is a growing concern to public health. New treatment strategies may alleviate the situation by slowing down the evolution of resistance. Here, we evaluated sequential treatment protocols using two fully independent laboratory-controlled evolution experiments with the human pathogen Pseudomonas ae...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12330

    authors: Roemhild R,Barbosa C,Beardmore RE,Jansen G,Schulenburg H

    更新日期:2015-12-01 00:00:00

  • Human-induced morphological shifts in an island lizard.

    abstract::Understanding the evolutionary consequences of anthropogenic change is an emerging topic in evolutionary biology. While highly sensitive species may go extinct in response to anthropogenic habitat alteration, those with broader environmental tolerances may persist and adapt to the changes. Here, we use morphological d...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2010.00170.x

    authors: Marnocha E,Pollinger J,Smith TB

    更新日期:2011-03-01 00:00:00

  • Crop-to-wild hybridization in cherries-Empirical evidence from Prunus fruticosa.

    abstract::Crop cultivation can lead to genetic swamping of indigenous species and thus pose a serious threat for biodiversity. The rare Eurasian tetraploid shrub Prunus fruticosa (ground cherry) is suspected of hybridizing with cultivated allochthonous tetraploid P. cerasus and autochthonous diploid P. avium. Three Prunus taxa ...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12677

    authors: Macková L,Vít P,Urfus T

    更新日期:2018-07-26 00:00:00

  • The ethical dimensions of wildlife disease management in an evolutionary context.

    abstract::Best practices in wildlife disease management require robust evolutionary ecological research (EER). This means not only basing management decisions on evolutionarily sound reasoning, but also conducting management in a way that actively contributes to the on-going development of that research. Because good management...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12171

    authors: Crozier G,Schulte-Hostedde AI

    更新日期:2014-08-01 00:00:00

  • Eco-genetic model to explore fishing-induced ecological and evolutionary effects on growth and maturation schedules.

    abstract::Eco-genetic individual-based models involve tracking the ecological dynamics of simulated individual organisms that are in part characterized by heritable parameters. We developed an eco-genetic individual-based model to explore ecological and evolutionary interactions of fish growth and maturation schedules. Our mode...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2009.00088.x

    authors: Wang HY,Höök TO

    更新日期:2009-08-01 00:00:00

  • Evolutionary ecology of Chagas disease; what do we know and what do we need?

    abstract::The aetiological agent of Chagas disease, Trypanosoma cruzi, is a key human pathogen afflicting most populations of Latin America. This vectorborne parasite is transmitted by haematophageous triatomines, whose control by large-scale insecticide spraying has been the main strategy to limit the impact of the disease for...

    journal_title:Evolutionary applications

    pub_type: 杂志文章,评审

    doi:10.1111/eva.12582

    authors: Flores-Ferrer A,Marcou O,Waleckx E,Dumonteil E,Gourbière S

    更新日期:2017-12-25 00:00:00

  • The sexually dimorphic on the Y-chromosome gene (sdY) is a conserved male-specific Y-chromosome sequence in many salmonids.

    abstract::All salmonid species investigated to date have been characterized with a male heterogametic sex-determination system. However, as these species do not share any Y-chromosome conserved synteny, there remains a debate on whether they share a common master sex-determining gene. In this study, we investigated the extent o...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12032

    authors: Yano A,Nicol B,Jouanno E,Quillet E,Fostier A,Guyomard R,Guiguen Y

    更新日期:2013-04-01 00:00:00

  • Fitter frogs from polluted ponds: The complex impacts of human-altered environments.

    abstract::Human-modified habitats rarely yield outcomes that are aligned with conservation ideals. Landscapes that are subdivided by roads are no exception, precipitating negative impacts on populations due to fragmentation, pollution, and road kill. Although many populations in human-modified habitats show evidence for local a...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/eva.12751

    authors: Brady SP,Zamora-Camacho FJ,Eriksson FAA,Goedert D,Comas M,Calsbeek R

    更新日期:2019-01-18 00:00:00

  • Common garden comparisons of native and introduced plant populations: latitudinal clines can obscure evolutionary inferences.

    abstract::Common garden studies are increasingly used to identify differences in phenotypic traits between native and introduced genotypes, often ignoring sources of among-population variation within each range. We re-analyzed data from 32 common garden studies of 28 plant species that tested for rapid evolution associated with...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2008.00053.x

    authors: Colautti RI,Maron JL,Barrett SC

    更新日期:2009-05-01 00:00:00

  • Genetic correlations between adults and larvae in a marine fish: potential effects of fishery selection on population replenishment.

    abstract::Correlated genetic responses have been hypothesized as important components of fishery-induced evolution, although predictive data from wild populations have been difficult to obtain. Here, we demonstrate substantial genetic correlations between a trait often subjected to fishery selection (adult body length) and trai...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2011.00185.x

    authors: Johnson DW,Christie MR,Moye J,Hixon MA

    更新日期:2011-09-01 00:00:00

  • Potential responses to climate change in organisms with complex life histories: evolution and plasticity in Pacific salmon.

    abstract::Salmon life histories are finely tuned to local environmental conditions, which are intimately linked to climate. We summarize the likely impacts of climate change on the physical environment of salmon in the Pacific Northwest and discuss the potential evolutionary consequences of these changes, with particular refere...

    journal_title:Evolutionary applications

    pub_type: 杂志文章

    doi:10.1111/j.1752-4571.2008.00033.x

    authors: Crozier LG,Hendry AP,Lawson PW,Quinn TP,Mantua NJ,Battin J,Shaw RG,Huey RB

    更新日期:2008-05-01 00:00:00