Abstract:
:Recent advances in research on gene drives have produced genetic constructs that could theoretically spread a desired gene (payload) into all populations of a species, with a single release in one place. This attribute has advantages, but also comes with risks and ethical concerns. There has been a call for research on gene drive systems that are spatially and/or temporally self-limiting. Here, we use a population genetics model to compare the expected characteristics of three spatially self-limiting gene drive systems: one-locus underdominance, two-locus underdominance and daisy-chain drives. We find large differences between these gene drives in the minimum release size required for successfully driving a payload into a population. The daisy-chain system is the most efficient, requiring the smallest release, followed by the two-locus underdominance system, and then the one-locus underdominance system. However, when the target population exchanges migrants with a nontarget population, the gene drives requiring smaller releases suffer from higher risks of unintended spread. For payloads that incur relatively low fitness costs (up to 30%), a simple daisy-chain drive is practically incapable of remaining localized, even with migration rates as low as 0.5% per generation. The two-locus underdominance system can achieve localized spread under a broader range of migration rates and of payload fitness costs, while the one-locus underdominance system largely remains localized. We also find differences in the extent of population alteration and in the permanence of the alteration achieved by the three gene drives. The two-locus underdominance system does not always spread the payload to fixation, even after successful drive, while the daisy-chain system can, for a small set of parameter values, achieve a temporally limited spread of the payload. These differences could affect the suitability of each gene drive for specific applications.
journal_name
Evol Appljournal_title
Evolutionary applicationsauthors
Dhole S,Vella MR,Lloyd AL,Gould Fdoi
10.1111/eva.12583subject
Has Abstractpub_date
2018-01-04 00:00:00pages
794-808issue
5issn
1752-4571pii
EVA12583journal_volume
11pub_type
杂志文章abstract::A species of Galápagos tortoise endemic to Española Island was reduced to just 12 females and three males that have been bred in captivity since 1971 and have produced over 1700 offspring now repatriated to the island. Our molecular genetic analyses of juveniles repatriated to and surviving on the island indicate that...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12014
更新日期:2013-02-01 00:00:00
abstract::Genetic chimerism is rarely considered in the analysis of population genetics data, because assumed to be an exceptionally rare, mostly benign, developmental accident. An unappreciated source of chimerism is transmissible cancer, when malignant cells have become independent parasites and can infect other individuals. ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12439
更新日期:2016-12-16 00:00:00
abstract::Oceanic islands have reduced resources and natural enemies and potentially affect life history traits of arriving organisms. Among the most spectacular invasions in the Western hemisphere is that of the Africanized honeybee. We hypothesized that in the oceanic island Puerto Rico, Africanized bees will exhibit differen...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2012.00252.x
更新日期:2012-11-01 00:00:00
abstract::Pathogens are ubiquitous in insect populations and yet few studies examine their dynamics and impacts on host populations. We discuss four lepidopteran systems and explore their contributions to disease ecology and evolution. More specifically, we elucidate the role of pathogens in insect population dynamics. For thre...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12328
更新日期:2015-11-23 00:00:00
abstract::Here, we compare the evolutionary routes by which bacteria and insects have evolved enzymatic processes for the degradation of four classes of synthetic chemical insecticide. For insects, the selective advantage of such degradative activities is survival on exposure to the insecticide, whereas for the bacteria the adv...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2010.00175.x
更新日期:2011-03-01 00:00:00
abstract::Artificial propagation programs focused on production, such as commercial aquaculture or forestry, entail strong domestication selection. Spillover from such programs can cause unintended fitness and demographic consequences for wild conspecifics. The range of possible management practices to minimize such consequence...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12089
更新日期:2013-11-01 00:00:00
abstract::Marine protected areas (MPAs) are increasingly implemented worldwide to maintain and restore depleted populations. However, despite our knowledge on the myriad of positive responses to protection, there are few empirical studies on the ability to conserve species' mating patterns and secondary sexual traits. In male E...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12992
更新日期:2020-05-22 00:00:00
abstract::Heart disease is common in both humans and chimpanzees, manifesting typically as sudden cardiac arrest or progressive heart failure. Surprisingly, although chimpanzees are our closest evolutionary relatives, the major cause of heart disease is different in the two species. Histopathology data of affected chimpanzee he...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2008.00064.x
更新日期:2009-02-01 00:00:00
abstract::Population dynamics of marine species that are sessile as adults are driven by oceanographic dispersal of larvae from spawning to nursery grounds. This is mediated by life-history traits such as the timing and frequency of spawning, larval behaviour and duration, and settlement success. Here, we use 1725 single nucleo...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12932
更新日期:2020-02-24 00:00:00
abstract::Elucidation of genetic mechanisms underpinning migratory behavior could help predict how changes in genetic diversity may affect future spatiotemporal distribution of a migratory species. This ability would benefit conservation of one such declining species, anadromous Pacific lamprey (Entosphenus tridentatus). Nonphi...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12203
更新日期:2014-12-01 00:00:00
abstract::Neutral genetic markers are routinely used to define distinct units within species that warrant discrete management. Human-induced changes to gene flow however may reduce the power of such an approach. We tested the efficiency of adaptive versus neutral genetic markers in differentiating temporally divergent migratory...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12095
更新日期:2013-12-01 00:00:00
abstract::The influence of human harvest on evolution of secondary sexual characteristics has implications for sustainable management of wildlife populations. The phenotypic consequences of selectively removing males with large horns or antlers from ungulate populations have been a topic of heightened concern in recent years. H...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12841
更新日期:2019-07-29 00:00:00
abstract::We review the results of a series of experiments involving Aedes aegypti and its microsporidian parasite Vavraia culicis to illustrate how intra-specific competition and parasitism shape life history traits. More specifically these experiments showed that some major components of virulence are host condition-dependent...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2007.00004.x
更新日期:2008-02-01 00:00:00
abstract::While nonanadromous males (stream-resident and/or mature male parr) contribute to reproduction in anadromous salmonids, little is known about their impacts on key population genetic parameters. Here, we evaluated the contribution of Atlantic salmon mature male parr to the effective number of breeders (Nb) using both d...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12172
更新日期:2014-11-01 00:00:00
abstract::Salmon life histories are finely tuned to local environmental conditions, which are intimately linked to climate. We summarize the likely impacts of climate change on the physical environment of salmon in the Pacific Northwest and discuss the potential evolutionary consequences of these changes, with particular refere...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2008.00033.x
更新日期:2008-05-01 00:00:00
abstract::Spatial and temporal trends and variation in life-history traits, including age and length at maturation, can be influenced by environmental and anthropogenic processes, including size-selective exploitation. Spawning adults in many wild Alaskan sockeye salmon populations have become shorter at a given age over the pa...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12123
更新日期:2014-02-01 00:00:00
abstract::Human-modified habitats rarely yield outcomes that are aligned with conservation ideals. Landscapes that are subdivided by roads are no exception, precipitating negative impacts on populations due to fragmentation, pollution, and road kill. Although many populations in human-modified habitats show evidence for local a...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12751
更新日期:2019-01-18 00:00:00
abstract::Rapid evolution has rarely been assessed in biological control systems despite the similarity with biological invasions, which are widely used as model systems. We assessed post-introduction climatic adaptation in a population of Longitarsus jacobaeae, a biological control agent of Jacobaea vulgaris, which originated ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2012.00264.x
更新日期:2012-12-01 00:00:00
abstract::The emergence and spread of antibiotic resistance is a crisis in health care today. Antibiotic resistance is often horizontally transferred to susceptible bacteria by means of multidrug resistance plasmids that may or may not persist in the absence of antibiotics. Because bacterial pathogens often grow as biofilms, th...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12480
更新日期:2017-05-08 00:00:00
abstract::Restoration of lost species ranges to their native distribution is key for the survival of endangered species. However, reintroductions often fail and long-term genetic consequences are poorly understood. Alpine ibex (Capra ibex) are wild goats that recovered from <100 individuals to ~50,000 within a century by popula...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12490
更新日期:2017-10-27 00:00:00
abstract::Invertebrate pest invasions and outbreaks are associated with high social, economic, and ecological costs, and their significance will intensify with an increasing pressure on agricultural productivity as a result of human population growth and climate change. New molecular genetic and genomic techniques are available...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12071
更新日期:2013-04-24 00:00:00
abstract::Fungicide resistance is a constant threat to agricultural production worldwide. Molecular mechanisms of fungicide resistance have been studied extensively in the wheat pathogen Zymoseptoria tritici. However, less is known about the evolutionary processes driving resistance development. In vitro evolutionary studies gi...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12511
更新日期:2017-09-03 00:00:00
abstract::The distribution of Asian ancestry in the genome of Danish Duroc pigs was investigated using whole-genome sequencing data from European wild boars, Danish Duroc, Chinese Meishan and Bamaxiang pigs. Asian haplotypes deriving from Meishan and Bamaxiang occur widely across the genome. Signatures of selection on Asian hap...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12716
更新日期:2018-12-13 00:00:00
abstract::Although microbes have been evolving resistance to antimicrobials for millennia, the spread of resistance in pathogen populations calls for the development of new drugs and treatment strategies. We propose that successful, long-term resistance management requires a better understanding of how resistance evolves in the...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12254
更新日期:2015-03-01 00:00:00
abstract::Synergistic interactions between temperature and contaminants are a major challenge for ecological risk assessment, especially under global warming. While thermal evolution may increase the ability to deal with warming, it is unknown whether it may also affect the ability to deal with the many contaminants that are mo...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12637
更新日期:2018-05-07 00:00:00
abstract::As pest species may evolve resistance to chemical controls, they may also evolve resistance to cultural control methods. Yearly rotation of corn (Zea mays) with another crop interrupts the life cycle of the western corn rootworm beetle (Diabrotica virgifera virgifera, Coleoptera: Chrysomelidae), but behavioral resista...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2009.00094.x
更新日期:2010-01-01 00:00:00
abstract::The aetiological agent of Chagas disease, Trypanosoma cruzi, is a key human pathogen afflicting most populations of Latin America. This vectorborne parasite is transmitted by haematophageous triatomines, whose control by large-scale insecticide spraying has been the main strategy to limit the impact of the disease for...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12582
更新日期:2017-12-25 00:00:00
abstract::Mounting evidence of climatic effects on riverine environments and adaptive responses of fishes have elicited growing conservation concerns. Measures to rectify population declines include assessment of local extinction risk, population ecology, viability, and genetic differentiation. While conservation planning has b...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12174
更新日期:2014-06-01 00:00:00
abstract::Drought is one of the most important selection pressures for forest trees in the context of climate change. Yet, the different evolutionary mechanisms, and their environmental drivers, by which certain populations become more drought tolerant than others is still little understood. We studied adaptation to drought in ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.13029
更新日期:2020-06-17 00:00:00
abstract::Currently, the effects of chronic, continuous low dose environmental irradiation on the mitochondrial genome of resident small mammals are unknown. Using the bank vole (Myodes glareolus) as a model system, we tested the hypothesis that approximately 50 generations of exposure to the Chernobyl environment has significa...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12475
更新日期:2017-06-22 00:00:00