Abstract:
:In most instances of tumour development, genetic instability plays a role in allowing cancer cell populations to respond to selection barriers, such as physical constraints or immune responses, and rapidly adapt to an always changing environment. Modelling instability is a nontrivial task, since by definition evolving instability leads to changes in the underlying landscape. In this article, we explore mathematically a simple version of unstable tumour progression using the formalism of adaptive dynamics (AD) where selection and mutation are explicitly coupled. Using a set of basic fitness landscapes, the so-called canonical equation for the evolution of genetic instability on a minimal scenario associated with a population of unstable cells is derived. We obtain explicit expressions for the evolution of mutation probabilities, and the implications of the model on further experimental studies and potential mutagenic therapies are discussed.
journal_name
Evol Appljournal_title
Evolutionary applicationsauthors
Aguadé-Gorgorió G,Solé Rdoi
10.1111/eva.12625subject
Has Abstractpub_date
2018-04-17 00:00:00pages
1283-1292issue
8issn
1752-4571pii
EVA12625journal_volume
11pub_type
杂志文章abstract::Temperature effects on the fatty acid (FA) profiles of phytoplankton, major primary producers in the ocean, have been widely studied due to their importance as industrial feedstocks and to their indispensable role as global producers of long-chain, polyunsaturated FA (PUFA), including omega-3 (ω3) FA required by organ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12798
更新日期:2019-04-23 00:00:00
abstract::Evolution has contributed to the successful invasion of exotic plant species in their introduced ranges, but how evolution affects particular control strategies is still under evaluation. For instance, classical biological control, a common strategy involving the utilization of highly specific natural enemies to contr...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12134
更新日期:2014-03-01 00:00:00
abstract::To investigate the evolution of clinal variation in an invasive plant, we compared cold hardiness in the introduced saltcedar (Tamarix ramosissima, Tamarix chinensis, and hybrids) and the native plains cottonwood (Populus deltoides subsp. monilifera). In a shadehouse in Colorado (41°N), we grew plants collected along ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2008.00044.x
更新日期:2008-11-01 00:00:00
abstract::Noug (Guizotia abyssinica) is a semidomesticated oil-seed crop, which is primarily cultivated in Ethiopia. Unlike its closest crop relative, sunflower, noug has small seeds, small flowering heads, many branches, many flowering heads, and indeterminate flowering, and it shatters in the field. Here, we conducted common ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12256
更新日期:2015-06-01 00:00:00
abstract::Genetic variation is fundamental to population fitness and adaptation to environmental change. Human activities are driving declines in many wild populations and could have similar effects on genetic variation. Despite the importance of estimating such declines, no global estimate of the magnitude of ongoing genetic v...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12810
更新日期:2019-06-05 00:00:00
abstract::Understanding the evolutionary consequences of anthropogenic change is an emerging topic in evolutionary biology. While highly sensitive species may go extinct in response to anthropogenic habitat alteration, those with broader environmental tolerances may persist and adapt to the changes. Here, we use morphological d...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2010.00170.x
更新日期:2011-03-01 00:00:00
abstract::Here, we compare the evolutionary routes by which bacteria and insects have evolved enzymatic processes for the degradation of four classes of synthetic chemical insecticide. For insects, the selective advantage of such degradative activities is survival on exposure to the insecticide, whereas for the bacteria the adv...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2010.00175.x
更新日期:2011-03-01 00:00:00
abstract::A species of Galápagos tortoise endemic to Española Island was reduced to just 12 females and three males that have been bred in captivity since 1971 and have produced over 1700 offspring now repatriated to the island. Our molecular genetic analyses of juveniles repatriated to and surviving on the island indicate that...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12014
更新日期:2013-02-01 00:00:00
abstract::Antibiotic resistance is a growing concern to public health. New treatment strategies may alleviate the situation by slowing down the evolution of resistance. Here, we evaluated sequential treatment protocols using two fully independent laboratory-controlled evolution experiments with the human pathogen Pseudomonas ae...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12330
更新日期:2015-12-01 00:00:00
abstract::Synergistic interactions between temperature and contaminants are a major challenge for ecological risk assessment, especially under global warming. While thermal evolution may increase the ability to deal with warming, it is unknown whether it may also affect the ability to deal with the many contaminants that are mo...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12637
更新日期:2018-05-07 00:00:00
abstract::The primary Afrotropical malaria mosquito vector Anopheles gambiae sensu stricto has a complex population structure. In west Africa, this species is split into two molecular forms and displays local and regional variation in chromosomal arrangements and behaviors. To investigate patterns of macrogeographic population ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12075
更新日期:2013-09-01 00:00:00
abstract::The distribution of Asian ancestry in the genome of Danish Duroc pigs was investigated using whole-genome sequencing data from European wild boars, Danish Duroc, Chinese Meishan and Bamaxiang pigs. Asian haplotypes deriving from Meishan and Bamaxiang occur widely across the genome. Signatures of selection on Asian hap...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12716
更新日期:2018-12-13 00:00:00
abstract::Natural enemies may go through genetic bottlenecks during the process of biological control introductions. Such bottlenecks are expected to be particularly detrimental in parasitoid Hymenoptera that exhibit complementary sex determination (CSD). CSD is associated with a severe form of inbreeding depression because hom...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2012.00270.x
更新日期:2012-07-01 00:00:00
abstract::Invertebrate pest invasions and outbreaks are associated with high social, economic, and ecological costs, and their significance will intensify with an increasing pressure on agricultural productivity as a result of human population growth and climate change. New molecular genetic and genomic techniques are available...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12071
更新日期:2013-04-24 00:00:00
abstract::When populations of a rare species are small, isolated and declining under climate change, some populations may become locally maladapted. Detecting this maladaptation may allow effective rapid conservation interventions, even if based on incomplete knowledge. Population maladaptation may be estimated by finding genom...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12883
更新日期:2019-11-24 00:00:00
abstract::Correlated genetic responses have been hypothesized as important components of fishery-induced evolution, although predictive data from wild populations have been difficult to obtain. Here, we demonstrate substantial genetic correlations between a trait often subjected to fishery selection (adult body length) and trai...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2011.00185.x
更新日期:2011-09-01 00:00:00
abstract::Gene flow in crop-wild complexes between phenotypically differentiated ancestors may transfer adaptive genetic variation that alters the fecundity and, potentially, the population growth (λ) of weeds. We created biotypes with potentially invasive traits, early flowering or long leaves, in wild radish (Raphanus raphani...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12366
更新日期:2016-02-28 00:00:00
abstract::Preservation of adaptive variation is a top priority of many species restoration programs, but most restoration activities are conducted without direct knowledge of selection that might foster or impair adaptation and restoration goals. In this study, we quantified geographic variation in selection on fry size of enda...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2010.00126.x
更新日期:2010-07-01 00:00:00
abstract::Salmon lice Lepeophtheirus salmonis are an ecologically and economically important parasite of wild and farmed salmon. In Scotland, Norway, and Eastern Canada, L. salmonis have developed resistance to emamectin benzoate (EMB), one of the few parasiticides available for salmon lice. Drug resistance mechanisms can be co...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12237
更新日期:2015-02-01 00:00:00
abstract::A major challenge of evolutionary ecology over the next decades is to understand and predict the consequences of the current rapid and important environmental changes on wild populations. Extinction risk of species is linked to populations' evolutionary potential and to their ability to express adaptive phenotypic pla...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12928
更新日期:2020-02-14 00:00:00
abstract::Fast increase of fish aquaculture production to meet consumer demands is accompanied by important ecological concerns such as disease outbreaks. Meanwhile, food waste is an important concern with fish products since they are highly perishable. Recent aquaculture and fish product microbiology, and more recently, microb...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.13027
更新日期:2020-06-09 00:00:00
abstract::Recurrently invading pests provide unique challenges for pest management, but also present opportunities to utilize genomics to understand invasion dynamics and inform regulatory management through pathway analysis. In the southern United States, the Mexican fruit fly Anastrepha ludens is such a pest, and its incursio...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12824
更新日期:2019-06-13 00:00:00
abstract::Heart disease is common in both humans and chimpanzees, manifesting typically as sudden cardiac arrest or progressive heart failure. Surprisingly, although chimpanzees are our closest evolutionary relatives, the major cause of heart disease is different in the two species. Histopathology data of affected chimpanzee he...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2008.00064.x
更新日期:2009-02-01 00:00:00
abstract::Fungicide resistance is a constant threat to agricultural production worldwide. Molecular mechanisms of fungicide resistance have been studied extensively in the wheat pathogen Zymoseptoria tritici. However, less is known about the evolutionary processes driving resistance development. In vitro evolutionary studies gi...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12511
更新日期:2017-09-03 00:00:00
abstract::Interest in the evolution of invasive species has grown in recent years, yet few studies have investigated sources of variation in invasive species traits experiencing natural selection. The spiny water flea, Bythotrephes longimanus, is an invasive zooplankton in the Great Lakes that exhibits seasonal changes in tail ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2011.00221.x
更新日期:2012-04-01 00:00:00
abstract::Biological control is the main purpose of intentionally introducing non-native invertebrate species. The evolutionary changes that occur in the populations of the introduced biological control agents may determine the agent's efficiency and the environmental safety. Here, to explore the pattern and extent of potential...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12774
更新日期:2019-02-11 00:00:00
abstract::Human-induced trait change has been documented in freshwater, marine, and terrestrial ecosystems worldwide. These trait changes are driven by phenotypic plasticity and contemporary evolution. While efforts to manage human-induced trait change are beginning to receive some attention, managing its ecological consequence...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2011.00212.x
更新日期:2012-02-01 00:00:00
abstract::Habitat fragmentation is a major extinction driver. Despite dramatically increasing fragmentation across the globe, its specific impacts on population connectivity across species with differing life histories remain difficult to characterize, let alone quantify. Here, we investigate patterns of population connectivity...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12918
更新日期:2020-03-05 00:00:00
abstract::Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain competitive advantage via their fitness in relation to micro-environmental selective pressures. In this context, the 'unit' of selection i...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12017
更新日期:2013-01-01 00:00:00
abstract::Due to its impact on local adaptation, population functioning or range shifts, dispersal is considered a central process for population persistence and species evolution. However, measuring dispersal is complicated, which justifies the use of dispersal proxies. Although appealing, and despite its general relationship ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12049
更新日期:2013-06-01 00:00:00